ZA981079B - Amino acid ester containing azole antifungals. - Google Patents

Amino acid ester containing azole antifungals.

Info

Publication number
ZA981079B
ZA981079B ZA9801079A ZA981079A ZA981079B ZA 981079 B ZA981079 B ZA 981079B ZA 9801079 A ZA9801079 A ZA 9801079A ZA 981079 A ZA981079 A ZA 981079A ZA 981079 B ZA981079 B ZA 981079B
Authority
ZA
South Africa
Prior art keywords
amino acid
acid ester
ester containing
azole antifungals
forms
Prior art date
Application number
ZA9801079A
Other languages
English (en)
Inventor
Lieven Meerpoel
Jan Heeres
Robert Jozef Maria Hendrickx
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA981079B publication Critical patent/ZA981079B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA9801079A 1997-02-11 1998-02-10 Amino acid ester containing azole antifungals. ZA981079B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97200374 1997-02-11
EP97203228 1997-10-15
EP98908064A EP0958289B1 (en) 1997-02-11 1998-02-03 Amino acid ester containing azole antifungals

Publications (1)

Publication Number Publication Date
ZA981079B true ZA981079B (en) 1999-08-10

Family

ID=26146124

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9801079A ZA981079B (en) 1997-02-11 1998-02-10 Amino acid ester containing azole antifungals.

Country Status (31)

Country Link
US (3) US6262052B1 (xx)
EP (1) EP0958289B1 (xx)
JP (1) JP4347911B2 (xx)
KR (1) KR100509171B1 (xx)
CN (1) CN1238353C (xx)
AT (1) ATE270290T1 (xx)
AU (1) AU725302C (xx)
BG (1) BG63872B1 (xx)
BR (1) BR9809744A (xx)
CA (1) CA2262791C (xx)
CZ (1) CZ297197B6 (xx)
DE (1) DE69824834T2 (xx)
DK (1) DK0958289T3 (xx)
EE (1) EE03876B1 (xx)
ES (1) ES2224364T3 (xx)
HU (1) HU227744B1 (xx)
ID (1) ID21755A (xx)
IL (2) IL128513A (xx)
MY (1) MY129537A (xx)
NO (1) NO316668B1 (xx)
NZ (1) NZ334477A (xx)
PL (1) PL191152B1 (xx)
PT (1) PT958289E (xx)
RU (1) RU2197489C2 (xx)
SI (1) SI0958289T1 (xx)
SK (1) SK284910B6 (xx)
TR (1) TR199900584T2 (xx)
TW (1) TW495508B (xx)
UA (1) UA61919C2 (xx)
WO (1) WO1998034934A1 (xx)
ZA (1) ZA981079B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
AU1915500A (en) 1998-11-20 2000-06-13 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
CN1349540A (zh) 1999-05-04 2002-05-15 詹森药业有限公司 抗真菌的醚类
WO2003052117A2 (en) * 2001-09-19 2003-06-26 Massachusetts Institute Of Technology Methods and products related to non-viral transfection
ITMI20032020A1 (it) * 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
CA2798002C (en) * 2010-05-19 2019-12-03 Sandoz Ag Process for the preparation of chiral triazolones
BR102019004480B1 (pt) * 2018-03-08 2023-03-28 Dow Agrosciences Llc Picolinamidas como fungicidas
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4791111A (en) * 1985-12-23 1988-12-13 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
US4916134A (en) 1987-03-25 1990-04-10 Janssen Pharmacuetica N.V. 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones
CA1331757C (en) 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
SK283118B6 (sk) 1992-03-18 2003-02-04 Janssen Pharmaceutica N. V. Stereoizomérne formy itrakonazolu a saperkonazolu, spôsob ich výroby, ich komplexy, spôsob výroby týchto komplexov, farmaceutický prípravok a ich použitie
SK283035B6 (sk) * 1993-12-21 2003-02-04 Schering Corporation Tetrahydrofuránová zlúčenina, spôsob jej prípravy, jej farmaceuticky prijateľný ester, soľ a farmaceutický prostriedok
NZ278882A (en) 1994-01-24 1997-06-24 Janssen Pharmaceutica Nv Piperazine-containing azole antifungal compounds
ATE240319T1 (de) 1995-06-02 2003-05-15 Schering Corp Antifungale tetrahydrofurane
DE69629474T2 (de) * 1995-06-19 2004-06-24 Schering Corp. Antifungale tetrahydrofurane

Also Published As

Publication number Publication date
WO1998034934A1 (en) 1998-08-13
NO990484L (no) 1999-10-11
NZ334477A (en) 2001-05-25
PL332008A1 (en) 1999-08-16
NO316668B1 (no) 2004-03-29
IL128513A0 (en) 2000-01-31
CZ297197B6 (cs) 2006-09-13
ES2224364T3 (es) 2005-03-01
SK105999A3 (en) 2000-06-12
HU227744B1 (en) 2012-02-28
AU6620798A (en) 1998-08-26
EE9900100A (et) 1999-10-15
PT958289E (pt) 2004-11-30
KR100509171B1 (ko) 2005-08-22
CZ283599A3 (cs) 2000-02-16
TR199900584T2 (xx) 1999-10-21
JP4347911B2 (ja) 2009-10-21
DE69824834D1 (de) 2004-08-05
EP0958289B1 (en) 2004-06-30
US6262052B1 (en) 2001-07-17
KR20000068526A (ko) 2000-11-25
PL191152B1 (pl) 2006-03-31
SK284910B6 (sk) 2006-02-02
EP0958289A1 (en) 1999-11-24
US6703506B2 (en) 2004-03-09
ATE270290T1 (de) 2004-07-15
BR9809744A (pt) 2000-06-20
JP2001508080A (ja) 2001-06-19
EE03876B1 (et) 2002-10-15
CA2262791A1 (en) 1998-08-13
SI0958289T1 (en) 2004-12-31
US20030158210A1 (en) 2003-08-21
HUP0001050A2 (hu) 2001-04-28
CN1236366A (zh) 1999-11-24
RU2197489C2 (ru) 2003-01-27
CA2262791C (en) 2008-10-28
BG103171A (en) 1999-09-30
MY129537A (en) 2007-04-30
IL149285A0 (en) 2002-11-10
ID21755A (id) 1999-07-22
BG63872B1 (bg) 2003-04-30
NO990484D0 (no) 1999-02-02
DE69824834T2 (de) 2005-07-21
AU725302C (en) 2001-08-23
US6512116B2 (en) 2003-01-28
UA61919C2 (uk) 2003-12-15
HUP0001050A3 (en) 2001-07-30
AU725302B2 (en) 2000-10-12
IL149285A (en) 2007-08-19
TW495508B (en) 2002-07-21
IL128513A (en) 2002-11-10
US20010039281A1 (en) 2001-11-08
CN1238353C (zh) 2006-01-25
DK0958289T3 (da) 2004-11-01

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