UA52679C2 - Фармацевтична композиція, що містить велику кількість одиниць трамадолу, і спосіб її приготування - Google Patents

Фармацевтична композиція, що містить велику кількість одиниць трамадолу, і спосіб її приготування Download PDF

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Publication number
UA52679C2
UA52679C2 UA99021086A UA99021086A UA52679C2 UA 52679 C2 UA52679 C2 UA 52679C2 UA 99021086 A UA99021086 A UA 99021086A UA 99021086 A UA99021086 A UA 99021086A UA 52679 C2 UA52679 C2 UA 52679C2
Authority
UA
Ukraine
Prior art keywords
release
pharmaceutical composition
composition according
active substance
granules
Prior art date
Application number
UA99021086A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Гельмут Момбергер
Марк Рабер
Дітер Кухн
Вольфганг Шмід
Original Assignee
Аста Медіка Акціенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аста Медіка Акціенгезельшафт filed Critical Аста Медіка Акціенгезельшафт
Publication of UA52679C2 publication Critical patent/UA52679C2/uk

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glanulating (AREA)
UA99021086A 1996-07-25 1997-07-19 Фармацевтична композиція, що містить велику кількість одиниць трамадолу, і спосіб її приготування UA52679C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19630035A DE19630035A1 (de) 1996-07-25 1996-07-25 Tramadol Multiple Unit Formulierungen
PCT/EP1997/003934 WO1998004249A2 (fr) 1996-07-25 1997-07-19 Formulations de tramadol a unites multiples

Publications (1)

Publication Number Publication Date
UA52679C2 true UA52679C2 (uk) 2003-01-15

Family

ID=7800815

Family Applications (1)

Application Number Title Priority Date Filing Date
UA99021086A UA52679C2 (uk) 1996-07-25 1997-07-19 Фармацевтична композиція, що містить велику кількість одиниць трамадолу, і спосіб її приготування

Country Status (29)

Country Link
US (2) US5955104A (fr)
EP (1) EP0917463B1 (fr)
JP (1) JP3631762B2 (fr)
KR (1) KR100474793B1 (fr)
CN (1) CN1111402C (fr)
AR (1) AR008002A1 (fr)
AT (1) ATE213408T1 (fr)
AU (1) AU737121B2 (fr)
BG (1) BG63708B1 (fr)
BR (1) BR9710761A (fr)
CA (1) CA2211284C (fr)
CZ (1) CZ296964B6 (fr)
DE (2) DE19630035A1 (fr)
DK (1) DK0917463T3 (fr)
EE (1) EE03742B1 (fr)
ES (1) ES2171268T3 (fr)
HK (1) HK1020876A1 (fr)
HU (1) HU227971B1 (fr)
IL (1) IL127915A (fr)
NO (1) NO324207B1 (fr)
NZ (1) NZ333822A (fr)
PL (1) PL188834B1 (fr)
PT (1) PT917463E (fr)
RU (1) RU2201223C2 (fr)
SK (1) SK285300B6 (fr)
TW (1) TW495363B (fr)
UA (1) UA52679C2 (fr)
WO (1) WO1998004249A2 (fr)
ZA (1) ZA975408B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9034377B2 (en) 2004-09-01 2015-05-19 Purdue Pharma, L.P. Opioid dosage forms having dose proportional steady state Cave and AUC and less than dose proportional single dose Cmax

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DE19630035A1 (de) * 1996-07-25 1998-01-29 Asta Medica Ag Tramadol Multiple Unit Formulierungen
US6197347B1 (en) * 1998-06-29 2001-03-06 Andrx Pharmaceuticals, Inc. Oral dosage for the controlled release of analgesic
US6312728B1 (en) * 1998-07-07 2001-11-06 Cascade Development, Inc. Sustained release pharmaceutical preparation
DE19901686A1 (de) * 1999-01-18 2000-07-20 Gruenenthal Gmbh Retardierte Tramadolzubereitungen mit einem lagerstabilen Freisetzungsprofil und Verfahren zu deren Herstellung
DE19901687B4 (de) * 1999-01-18 2006-06-01 Grünenthal GmbH Opioide Analgetika mit kontrollierter Wirkstofffreisetzung
CN1202815C (zh) * 1999-08-31 2005-05-25 格吕伦塔尔有限公司 含有曲马朵糖精盐的持续释放给药剂型
DE19940944B4 (de) * 1999-08-31 2006-10-12 Grünenthal GmbH Retardierte, orale, pharmazeutische Darreichungsformen
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
KR20130010512A (ko) 1999-10-29 2013-01-28 유로-셀티크 소시에떼 아노뉨 서방성 하이드로코돈 제형
AR030557A1 (es) * 2000-04-14 2003-08-27 Jagotec Ag Una tableta en multicapa de liberacion controlada y metodo de tratamiento
US6620431B1 (en) 2000-04-17 2003-09-16 Charles Signorino Shellac film coatings providing release at selected pH and method
US20030157247A1 (en) * 2000-06-14 2003-08-21 Yoshiro Chikami Method for producing coated bioactive granule
HUP0301416A2 (hu) * 2000-07-06 2003-09-29 Delsys Pharmaceutical Corporation Javított tiroid hormon gyógyszerformák
KR100960200B1 (ko) 2000-10-30 2010-05-27 유로-셀티크 소시에떼 아노뉨 서방성 하이드로코돈 제형
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
US20030104976A1 (en) * 2001-07-23 2003-06-05 Gudarz Davar Analgesic methods using endothelin receptor ligands
PE20030527A1 (es) 2001-10-24 2003-07-26 Gruenenthal Chemie Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen
US20050182056A9 (en) * 2002-02-21 2005-08-18 Seth Pawan Modified release formulations of at least one form of tramadol
SI1476138T1 (sl) * 2002-02-21 2012-07-31 Valeant Internat Barbados Srl Formulacije s prirejenim sproščanjem vsaj ene oblike tramadola
US8128957B1 (en) * 2002-02-21 2012-03-06 Valeant International (Barbados) Srl Modified release compositions of at least one form of tramadol
DE60335426D1 (de) * 2002-08-15 2011-01-27 Euro Celtique Sa Pharmazeutische Zusammensetzungen enthaltend einen Opioidantagonisten
DK1424068T3 (da) * 2002-11-27 2006-11-27 Oramon Arzneimittel Gmbh & Co Fremgangsmåde til fremstilling af pellets indeholdende et tri- eller tetra-cyklisk antidepressivum samt farmaceutiske tilberedninger indeholdende disse pellets
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US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
DE10341414A1 (de) * 2003-09-05 2005-03-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Oral zu applizierende Darreichungsform für schwerlösliche saure und amphotere Wirkstoffe
US20050053669A1 (en) * 2003-09-05 2005-03-10 Boehringer Ingelheim International Gmbh Administration form for the oral application of poorly soluble acidic and amphorteric drugs
WO2005034859A2 (fr) * 2003-10-03 2005-04-21 Elite Laboratories Inc. Formulations d'opioides a liberation prolongee et methode d'utilisation des formulations
US8163114B2 (en) * 2004-04-07 2012-04-24 New Jersey Institute Of Technology Netshape manufacturing processes and compositions
US20070224281A1 (en) * 2004-07-22 2007-09-27 Amorepacific Corporation Sustained-Release Preparations Containing Topiramate and the Producing Method Thereof
US8481565B2 (en) 2004-12-27 2013-07-09 Eisai R&D Management Co., Ltd. Method for stabilizing anti-dementia drug
US20060246003A1 (en) * 2004-12-27 2006-11-02 Eisai Co. Ltd. Composition containing anti-dementia drug
US20070129402A1 (en) * 2004-12-27 2007-06-07 Eisai Research Institute Sustained release formulations
US11311490B2 (en) * 2005-08-10 2022-04-26 Add Advanced Drug Delivery Technologies Ltd. Oral preparation with controlled release
WO2007132293A2 (fr) * 2005-11-10 2007-11-22 Circ Pharma Research And Development Limited Administration à prise unique quotidienne de médicaments agissant sur le système nerveux central
US20070185145A1 (en) * 2006-02-03 2007-08-09 Royds Robert B Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same
US20070190141A1 (en) * 2006-02-16 2007-08-16 Aaron Dely Extended release opiate composition
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US10888521B2 (en) * 2007-03-02 2021-01-12 Farnam Companies, Inc. Sustained release compositions using wax-like materials
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CZ300468B6 (cs) * 2007-09-20 2009-05-27 Zentiva, A. S Léková forma obsahující tramadol s kontrolovaným uvolnováním po dobu 24 hodin a zpusob její prípravy
WO2009087690A2 (fr) * 2008-01-11 2009-07-16 Jubilant Organosys Limited Composition pharmaceutique multiparticulaire à libération prolongée de carbamazépine et son procédé de fabrication
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
ES2536736T3 (es) * 2008-09-04 2015-05-28 Farnam Companies, Inc. Formulaciones masticables de liberación sostenida
FR2938431B1 (fr) * 2008-11-14 2013-12-20 Debregeas Et Associes Pharma Nouvelle composition a base d'acide gamma-hydroxybutyrique
EP2358360B1 (fr) 2008-11-18 2016-09-14 UCB Biopharma SPRL Formules à libération prolongée comprenant un dérivé de 2-oxo-1-pyrrolidine
US20100233259A1 (en) * 2008-12-12 2010-09-16 Pascal Grenier Dosage form of ropinirole
FR2949062B1 (fr) 2009-08-12 2011-09-02 Debregeas Et Associes Pharma Nouvelles formulations pharmaceutiques contre le mesusage des medicaments
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9034377B2 (en) 2004-09-01 2015-05-19 Purdue Pharma, L.P. Opioid dosage forms having dose proportional steady state Cave and AUC and less than dose proportional single dose Cmax
US9326959B2 (en) 2004-09-01 2016-05-03 Purdue Pharma, L.P. Opioid dosage forms having dose proportional steady state Cave and AUC and less than dose proportional single dose Cmax

Also Published As

Publication number Publication date
JP2000515871A (ja) 2000-11-28
DE19630035A1 (de) 1998-01-29
IL127915A (en) 2001-08-08
SK9899A3 (en) 1999-09-10
EP0917463A2 (fr) 1999-05-26
PL188834B1 (pl) 2005-04-29
HK1020876A1 (en) 2000-05-26
CA2211284C (fr) 2001-10-23
AU3849197A (en) 1998-02-20
CZ296964B6 (cs) 2006-08-16
IL127915A0 (en) 1999-11-30
JP3631762B2 (ja) 2005-03-23
ES2171268T3 (es) 2002-09-01
CN1111402C (zh) 2003-06-18
NO990261L (no) 1999-01-21
PT917463E (pt) 2002-07-31
EP0917463B1 (fr) 2002-02-20
WO1998004249A2 (fr) 1998-02-05
TW495363B (en) 2002-07-21
ATE213408T1 (de) 2002-03-15
DE59706441D1 (de) 2002-03-28
AU737121B2 (en) 2001-08-09
WO1998004249A3 (fr) 1998-04-30
NO990261D0 (no) 1999-01-21
CA2211284A1 (fr) 1998-01-25
HU227971B1 (en) 2012-07-30
PL331387A1 (en) 1999-07-05
BG103158A (en) 1999-08-31
SK285300B6 (sk) 2006-10-05
DK0917463T3 (da) 2002-06-10
KR100474793B1 (ko) 2005-03-08
NO324207B1 (no) 2007-09-10
RU2201223C2 (ru) 2003-03-27
EE03742B1 (et) 2002-06-17
US5955104A (en) 1999-09-21
ZA975408B (en) 1998-01-05
HUP9903053A3 (en) 2000-02-28
CZ18599A3 (cs) 1999-04-14
KR20000029530A (ko) 2000-05-25
BR9710761A (pt) 1999-08-17
AR008002A1 (es) 1999-11-24
US6436438B1 (en) 2002-08-20
NZ333822A (en) 1999-11-29
BG63708B1 (bg) 2002-10-31
EE9900031A (et) 1999-08-16
CN1226824A (zh) 1999-08-25
HUP9903053A2 (hu) 2000-01-28

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