AR082189A1 - Formas de dosificacion gastrorretentivas, procedimiento - Google Patents
Formas de dosificacion gastrorretentivas, procedimientoInfo
- Publication number
- AR082189A1 AR082189A1 ARP110102414A ARP110102414A AR082189A1 AR 082189 A1 AR082189 A1 AR 082189A1 AR P110102414 A ARP110102414 A AR P110102414A AR P110102414 A ARP110102414 A AR P110102414A AR 082189 A1 AR082189 A1 AR 082189A1
- Authority
- AR
- Argentina
- Prior art keywords
- dosage form
- release
- opioid
- pharmaceutical dosage
- administration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Forma de dosificación farmacéutica gastrorretentiva que comprende una cantidad terapéuticamente efectiva de por lo menos un análogo de GABA, por lo menos un opioide, y por lo menos un excipiente farmacéuticamente aceptable, en la que dicha forma de dosificación resulta retenida en el estómago durante por lo menos cuatro horas y resulta adecuada para la administración de dos o una vez al día. Método de tratamiento de un trastorno mediante la administración en un paciente que lo necesita de una forma de dosificación que comprende una cantidad terapéuticamente efectiva de por lo menos un análogo de GABA, por lo menos un opioide, y por lo menos un excipiente farmacéuticamente aceptable, en la que dicha forma de dosificación resulta retenida en el estómago durante por lo menos cuatro horas y resulta adecuada para la administración de dos o una vez al día. Dicho opioide se encuentra en forma de liberación lenta o en forma de liberación inmediata.Reivindicación 4: Forma de dosificación farmacéutica según uno o más de las reivindicaciones 1 - 3, que comprende: a) un núcleo comprimido que comprende por lo menos dos capas de liberación, en el que una primera capa de liberación comprende por lo menos un análogo de GABA dispersado en una matriz de liberación lenta, y una segunda capa de liberación que comprende un opioide dispersado en una segunda matriz de liberación, b) por lo menos un saco de membrana permeable que comprende dicho núcleo, c) una capa encapsuladora y dicha forma de dosificación resulta adecuada para la administración de una o dos veces al día. Reivindicación 9: Forma de dosificación farmacéutica según uno o más de las reivindicaciones 1 a 8, en la que la liberación de análogo de GABA es bifásica. Reivindicación 10: Forma de dosificación farmacéutica según uno o más de las reivindicaciones 1 a 9, en la que la segunda capa de liberación comprende una mezcla física de acetato de polivinilo y polivinilpirrolidona. Reivindicación 17: Forma de dosificación farmacéutica según uno o más de las reivindicaciones 1 a 16, en la que dicho análogo de GABA es pregabalina, gabapentina y tiagabina, y el opioide es axomadol, morfina, oxicodona, tapentadol, faxeladol o tramadol.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39904510P | 2010-07-06 | 2010-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR082189A1 true AR082189A1 (es) | 2012-11-21 |
Family
ID=44503685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110102414A AR082189A1 (es) | 2010-07-06 | 2011-07-06 | Formas de dosificacion gastrorretentivas, procedimiento |
Country Status (9)
Country | Link |
---|---|
US (2) | US20120009261A1 (es) |
EP (1) | EP2590636A1 (es) |
JP (3) | JP6005636B2 (es) |
AR (1) | AR082189A1 (es) |
AU (2) | AU2011276170B2 (es) |
BR (1) | BR112013000190A2 (es) |
CA (1) | CA2801620A1 (es) |
MX (1) | MX2013000024A (es) |
WO (1) | WO2012003968A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6005636B2 (ja) * | 2010-07-06 | 2016-10-12 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Gaba類似体及びオピオイドを含む新規胃内滞留型剤形 |
EP2845625A1 (en) * | 2013-09-04 | 2015-03-11 | Grünenthal GmbH | Tapentadol for use in the treatment of fibromyalgia and chronic fatigue syndrome |
WO2016187718A1 (en) | 2015-05-26 | 2016-12-01 | Isa Odidi | Controlled extended release pregabalin |
EP3364946A4 (en) | 2015-10-23 | 2019-06-26 | Lyndra, Inc. | STOMACH DISTRIBUTION SYSTEMS FOR DELAYED RELEASE OF THERAPEUTIC ACTIVE SUBSTANCES AND METHOD FOR THEIR USE |
EP3452024A1 (en) * | 2016-05-05 | 2019-03-13 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
WO2018064630A1 (en) | 2016-09-30 | 2018-04-05 | Lyndra, Inc. | Gastric residence systems for sustained delivery of adamantane-class drugs |
AU2018279853A1 (en) * | 2017-06-09 | 2020-01-02 | Lyndra Therapeutics, Inc. | Gastric residence systems with release rate-modulating films |
AU2019330782B2 (en) | 2018-08-28 | 2023-04-13 | Enterprises International, Inc. | Repulpable paper strap with enhanced moisture resistance and methods to make the same |
EP3760190B1 (en) | 2019-07-03 | 2023-05-24 | Alvogen, Inc. | Controlled-release tablets of pregabalin, method of making, and method of use thereof |
MX2022015331A (es) | 2020-12-04 | 2023-02-01 | Laboratorios Silanes S A De C V | Composicion farmaceutica solida recubierta y estable de un analgesico opioide y un antiepileptico para el dolor. |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
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US3490742A (en) | 1966-01-14 | 1970-01-20 | Staley Mfg Co A E | Compressed tablets |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4034758A (en) | 1975-09-08 | 1977-07-12 | Alza Corporation | Osmotic therapeutic system for administering medicament |
US4077407A (en) | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
US4571333A (en) | 1983-06-14 | 1986-02-18 | Syntex (U.S.A.) Inc. | Controlled release naproxen and naproxen sodium tablets |
GB8812490D0 (en) | 1988-05-26 | 1988-06-29 | Agricultural & Food Res | Delayed release formulations |
US5071607A (en) | 1990-01-31 | 1991-12-10 | Alza Corporatino | Method and apparatus for forming a hole in a drug dispensing device |
CA2041774C (en) | 1990-11-27 | 1994-04-19 | Mircea A. Mateescu | Use of cross-linked amylose as a matrix for the slow release of biologically active compounds |
CA2032385A1 (en) | 1990-12-17 | 1992-06-18 | Chung Wai-Chiu | Enzymatically debranched starches as tablet excipients |
US5266331A (en) | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
PL173249B1 (pl) | 1992-07-24 | 1998-02-27 | Labopharm Inc | Tabletka o kontrolowanym uwalnianiu leku |
US5616343A (en) | 1993-03-25 | 1997-04-01 | Labopharm, Inc. | Cross-linked amylose as a binder/disintegrant in tablets |
SE9301057L (sv) | 1993-03-30 | 1994-10-01 | Pharmacia Ab | Beredning med kontrollerad frisättning |
IL119660A (en) | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
DE4329794C2 (de) | 1993-09-03 | 1997-09-18 | Gruenenthal Gmbh | Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung |
US5811126A (en) | 1995-10-02 | 1998-09-22 | Euro-Celtique, S.A. | Controlled release matrix for pharmaceuticals |
DE19630035A1 (de) | 1996-07-25 | 1998-01-29 | Asta Medica Ag | Tramadol Multiple Unit Formulierungen |
US6284273B1 (en) | 1998-02-24 | 2001-09-04 | Vincent Lenaerts | Cross-linked high amylose starch resistant to amylase as a matrix for the slow release of biologically active compounds |
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DE10029201A1 (de) * | 2000-06-19 | 2001-12-20 | Basf Ag | Verfahren zur Herstellung fester oraler Darreichungsformen mit retardierender Wirkstoffreisetzung |
US6607748B1 (en) * | 2000-06-29 | 2003-08-19 | Vincent Lenaerts | Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture |
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EP1928484B1 (en) * | 2005-08-26 | 2010-02-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treatment of headaches by administration of oxytocin |
NL2000281C2 (nl) | 2005-11-02 | 2007-08-07 | Pfizer Prod Inc | Vaste farmaceutische samenstellingen die pregabaline bevatten. |
JP2009522294A (ja) * | 2005-12-29 | 2009-06-11 | デポメッド, インコーポレイテッド | 胃保持型ガバペンチン投薬形態およびその使用方法 |
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EP2184986A4 (en) * | 2007-08-06 | 2010-12-15 | Trinity Lab Inc | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CHRONIC PAIN AND PAIN RELATING TO NEUROPATHY |
KR101784777B1 (ko) | 2007-11-23 | 2017-11-06 | 그뤼넨탈 게엠베하 | 타펜타돌 조성물 |
PE20110291A1 (es) | 2008-09-05 | 2011-06-04 | Gruenenthal Chemie | Combinacion farmaceutica de 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol y un antiepileptico |
WO2011008298A2 (en) * | 2009-07-16 | 2011-01-20 | Nectid, Inc. | Novel axomadol dosage forms |
JP6005636B2 (ja) * | 2010-07-06 | 2016-10-12 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Gaba類似体及びオピオイドを含む新規胃内滞留型剤形 |
-
2011
- 2011-07-06 JP JP2013517102A patent/JP6005636B2/ja not_active Expired - Fee Related
- 2011-07-06 US US13/176,798 patent/US20120009261A1/en not_active Abandoned
- 2011-07-06 WO PCT/EP2011/003343 patent/WO2012003968A1/en active Application Filing
- 2011-07-06 AU AU2011276170A patent/AU2011276170B2/en not_active Ceased
- 2011-07-06 BR BR112013000190A patent/BR112013000190A2/pt not_active Application Discontinuation
- 2011-07-06 AR ARP110102414A patent/AR082189A1/es unknown
- 2011-07-06 CA CA2801620A patent/CA2801620A1/en not_active Abandoned
- 2011-07-06 MX MX2013000024A patent/MX2013000024A/es not_active Application Discontinuation
- 2011-07-06 EP EP11746440.4A patent/EP2590636A1/en not_active Withdrawn
-
2016
- 2016-05-30 AU AU2016203567A patent/AU2016203567B2/en not_active Ceased
- 2016-09-06 JP JP2016173316A patent/JP6294420B2/ja not_active Expired - Fee Related
- 2016-12-13 US US15/377,363 patent/US20170119663A1/en not_active Abandoned
-
2018
- 2018-02-14 JP JP2018023944A patent/JP6550157B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
BR112013000190A2 (pt) | 2017-11-07 |
AU2016203567A1 (en) | 2016-06-16 |
AU2011276170B2 (en) | 2016-03-10 |
CA2801620A1 (en) | 2012-01-12 |
JP2013530193A (ja) | 2013-07-25 |
JP6294420B2 (ja) | 2018-03-14 |
JP6550157B2 (ja) | 2019-07-24 |
MX2013000024A (es) | 2013-02-01 |
JP2018109027A (ja) | 2018-07-12 |
US20120009261A1 (en) | 2012-01-12 |
JP6005636B2 (ja) | 2016-10-12 |
AU2011276170A1 (en) | 2012-12-06 |
EP2590636A1 (en) | 2013-05-15 |
US20170119663A1 (en) | 2017-05-04 |
WO2012003968A1 (en) | 2012-01-12 |
AU2016203567B2 (en) | 2017-12-07 |
JP2017039726A (ja) | 2017-02-23 |
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Legal Events
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FB | Suspension of granting procedure |