UA124802C2 - Поліциклічні антагоністи tlr7/8 і їх застосування в лікуванні імунних розладів - Google Patents

Поліциклічні антагоністи tlr7/8 і їх застосування в лікуванні імунних розладів Download PDF

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UA124802C2
UA124802C2 UAA201807881A UAA201807881A UA124802C2 UA 124802 C2 UA124802 C2 UA 124802C2 UA A201807881 A UAA201807881 A UA A201807881A UA A201807881 A UAA201807881 A UA A201807881A UA 124802 C2 UA124802 C2 UA 124802C2
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compound
disease
chemical structure
compounds
inhibitor
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UAA201807881A
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Ukrainian (uk)
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Брайан А. ШЕРЕР
Надя Бруггер
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Мерк Патент Гмбх
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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UAA201807881A 2015-12-17 2016-12-16 Поліциклічні антагоністи tlr7/8 і їх застосування в лікуванні імунних розладів UA124802C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562268765P 2015-12-17 2015-12-17
US201662353603P 2016-06-23 2016-06-23
PCT/US2016/067112 WO2017106607A1 (en) 2015-12-17 2016-12-16 Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders

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TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
EP3484865B1 (en) 2016-07-14 2022-09-14 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof
CN109563075B (zh) 2016-08-08 2022-09-30 默克专利股份公司 Tlr7/8拮抗剂及其用途
US10662416B2 (en) 2016-10-14 2020-05-26 Precision Biosciences, Inc. Engineered meganucleases specific for recognition sequences in the hepatitis B virus genome
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