TWI793062B - Ｄｌｌ３及ｃｄ３抗體構築體 - Google Patents

Ｄｌｌ３及ｃｄ３抗體構築體 Download PDF

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TWI793062B
TWI793062B TW105124267A TW105124267A TWI793062B TW I793062 B TWI793062 B TW I793062B TW 105124267 A TW105124267 A TW 105124267A TW 105124267 A TW105124267 A TW 105124267A TW I793062 B TWI793062 B TW I793062B
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Taiwan
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seq
depicted
cdr
antibody construct
dll3
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TW105124267A
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Chinese (zh)
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TW201708261A (zh
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托拜耳斯 瑞烏
彼德 庫佛
喬恩 潘茲亞雷克
克勞蒂亞 布魯梅爾
克里斯多夫 達霍夫
派翠克 霍夫曼
勞夫 路特布斯
伊麗莎貝斯 那爾沃德
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德商安美基研究（慕尼黑）公司
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00113—Growth factors
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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TW105124267A 2015-07-31 2016-07-29 Ｄｌｌ３及ｃｄ３抗體構築體 TWI793062B (zh)

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Application Number Priority Date Filing Date Title
US201562199930P 2015-07-31 2015-07-31
US62/199,930 2015-07-31
US201662290896P 2016-02-03 2016-02-03
US62/290,896 2016-02-03

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TW201708261A TW201708261A (zh) 2017-03-01
TWI793062B true TWI793062B (zh) 2023-02-21

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TW105124267A TWI793062B (zh) 2015-07-31 2016-07-29 Ｄｌｌ３及ｃｄ３抗體構築體
TW112104976A TW202346349A (zh) 2015-07-31 2016-07-29 Dll3及cd3抗體構築體

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US (6) US10294300B2 (OSRAM)
EP (3) EP3865514A1 (OSRAM)
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KR (4) KR20250008980A (OSRAM)
CN (3) CN119371549A (OSRAM)
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