TWI670269B - 選擇性ｃｄｋ４／６抑制劑之固態形式 - Google Patents

選擇性ｃｄｋ４／６抑制劑之固態形式 Download PDF

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TWI670269B
TWI670269B TW106131041A TW106131041A TWI670269B TW I670269 B TWI670269 B TW I670269B TW 106131041 A TW106131041 A TW 106131041A TW 106131041 A TW106131041 A TW 106131041A TW I670269 B TWI670269 B TW I670269B
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free base
compound
particle size
methyl
cyclopentyl
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TW106131041A
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TW201803872A (zh
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布萊恩 查可
南森 艾德
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輝瑞股份有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW106131041A 2013-02-21 2014-02-18 選擇性ｃｄｋ４／６抑制劑之固態形式 TWI670269B (zh)

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US201361767761P 2013-02-21 2013-02-21
US61/767,761 2013-02-21

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TW103105287A TWI633103B (zh) 2013-02-21 2014-02-18 選擇性ｃｄｋ４／６抑制劑之固態形式
TW106131041A TWI670269B (zh) 2013-02-21 2014-02-18 選擇性ｃｄｋ４／６抑制劑之固態形式

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US (2) US20160002223A1 (OSRAM)
EP (2) EP3431475B1 (OSRAM)
JP (3) JP6381016B2 (OSRAM)
KR (2) KR20150107872A (OSRAM)
CN (3) CN111253394A (OSRAM)
AR (1) AR094842A1 (OSRAM)
AU (1) AU2014220354B2 (OSRAM)
BR (1) BR112015019508A8 (OSRAM)
CA (1) CA2900322C (OSRAM)
CY (2) CY1120734T1 (OSRAM)
DK (2) DK2958916T3 (OSRAM)
ES (2) ES2869277T3 (OSRAM)
HK (2) HK1211032A1 (OSRAM)
HU (2) HUE054212T2 (OSRAM)
IL (1) IL240277B (OSRAM)
MX (2) MX386473B (OSRAM)
PL (2) PL3431475T3 (OSRAM)
PT (2) PT2958916T (OSRAM)
RU (1) RU2619944C2 (OSRAM)
SG (1) SG11201505680RA (OSRAM)
SI (2) SI2958916T1 (OSRAM)
TR (1) TR201816077T4 (OSRAM)
TW (2) TWI633103B (OSRAM)
WO (1) WO2014128588A1 (OSRAM)

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