EA202090402A1 - Фармацевтическая композиция, содержащая пальбоциклиб - Google Patents

Фармацевтическая композиция, содержащая пальбоциклиб

Info

Publication number
EA202090402A1
EA202090402A1 EA202090402A EA202090402A EA202090402A1 EA 202090402 A1 EA202090402 A1 EA 202090402A1 EA 202090402 A EA202090402 A EA 202090402A EA 202090402 A EA202090402 A EA 202090402A EA 202090402 A1 EA202090402 A1 EA 202090402A1
Authority
EA
Eurasian Patent Office
Prior art keywords
composition containing
palbocyclib
pharmaceutical composition
free base
relates
Prior art date
Application number
EA202090402A
Other languages
English (en)
Inventor
Марта Виванкос Мартинес
Лисардо Альварес Фернандес
Рохит Кумар
Хосе Велада Кальсада
Original Assignee
Синтон Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Синтон Б.В. filed Critical Синтон Б.В.
Publication of EA202090402A1 publication Critical patent/EA202090402A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение относится к фармацевтической композиции гранулята, содержащей свободное основание пальбоциклиба, имеющей улучшенную биодоступность.
EA202090402A 2017-07-28 2018-07-25 Фармацевтическая композиция, содержащая пальбоциклиб EA202090402A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17183861 2017-07-28
PCT/EP2018/070227 WO2019020715A1 (en) 2017-07-28 2018-07-25 PHARMACEUTICAL COMPOSITION COMPRISING PALBOCICLIB

Publications (1)

Publication Number Publication Date
EA202090402A1 true EA202090402A1 (ru) 2020-05-19

Family

ID=59485295

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090402A EA202090402A1 (ru) 2017-07-28 2018-07-25 Фармацевтическая композиция, содержащая пальбоциклиб

Country Status (4)

Country Link
US (1) US11529353B2 (ru)
EP (1) EP3658119A1 (ru)
EA (1) EA202090402A1 (ru)
WO (1) WO2019020715A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021220295A1 (en) * 2020-04-29 2021-11-04 Natco Pharma Limited Immediate release pharmaceutical compositions comprising palbociclib
CN114246872B (zh) * 2020-09-24 2024-02-06 南京济群医药科技股份有限公司 一种改善羟乙磺酸哌柏西利流动性的工艺方法及组合物
CN112274493A (zh) * 2020-11-18 2021-01-29 石药集团中奇制药技术（石家庄）有限公司 一种哌柏西利胶囊的制备方法
EP4302832A1 (en) * 2022-07-07 2024-01-10 Lotus Pharmaceutical Co., Ltd. Palbociclib formulation containing glucono delta lactone

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1470124T3 (da) 2002-01-22 2006-04-18 Warner Lambert Co 2-(Pyridin-2-yl amino)-pyrido[2,3]pyrimidin-7-oner
PL1648889T3 (pl) 2003-07-11 2009-03-31 Warner Lambert Co Sól izetionian selektywnego inhibitora CDK4
MX363715B (es) 2013-02-21 2019-03-29 Pfizer Formas solidas de un inhbidor de cdk4/6 selectivo.
WO2014137789A1 (en) * 2013-03-07 2014-09-12 Dow Global Technologies Llc Novel esterified cellulose ethers of low viscosity and high molecular weight
US20170240543A1 (en) 2014-08-14 2017-08-24 Sun Pharmaceutical Industries Limited Crystalline forms of palbociclib
EP3186252A1 (en) * 2014-08-28 2017-07-05 ratiopharm GmbH Method of producing palbociclib and pharmaceutical compositions comprising the same
WO2016156070A1 (en) 2015-04-02 2016-10-06 Sandoz Ag Modified particles of palbociclib
KR102369405B1 (ko) 2015-06-04 2022-03-02 화이자 인코포레이티드 팔보시클립의 고체 투여 형태
CN105213322A (zh) 2015-10-30 2016-01-06 南京正大天晴制药有限公司 一种干法制粒工艺制备的药物组合物
WO2017145054A1 (en) * 2016-02-24 2017-08-31 Lupin Limited Modified particles of crystalline palbociclib free base and process for the preparation thereof
WO2018073574A1 (en) * 2016-10-20 2018-04-26 Cipla Limited Polymorphic forms of palbociclib

Also Published As

Publication number Publication date
EP3658119A1 (en) 2020-06-03
US11529353B2 (en) 2022-12-20
US20200147089A1 (en) 2020-05-14
WO2019020715A1 (en) 2019-01-31

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