TWI667234B - 經取代之六氫吡啶基四氫喹啉 - Google Patents

經取代之六氫吡啶基四氫喹啉 Download PDF

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Publication number
TWI667234B
TWI667234B TW103143998A TW103143998A TWI667234B TW I667234 B TWI667234 B TW I667234B TW 103143998 A TW103143998 A TW 103143998A TW 103143998 A TW103143998 A TW 103143998A TW I667234 B TWI667234 B TW I667234B
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Taiwan
Prior art keywords
diabetic
compound
formula
azetidine
represents hydrogen
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TW103143998A
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English (en)
Chinese (zh)
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TW201609701A (zh
Inventor
培爾斯特 伊芙 貝克
菲利浦 布赫格雷柏
安雅 布赫穆勒
凱倫 恩格爾
沃爾克 蓋斯
安德烈斯 葛勒
赫伯特 希墨爾
萊蒙德 卡斯特
安德烈斯 克諾爾
迪特 連
高登 瑞德利奇
卡斯登 施梅克
哈納 蒂內爾
法蘭克 溫德
Original Assignee
德商拜耳製藥股份有限公司
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Publication of TW201609701A publication Critical patent/TW201609701A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW103143998A 2013-12-19 2014-12-17 經取代之六氫吡啶基四氫喹啉 TWI667234B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP13198385 2013-12-19
??13198385.0 2013-12-19
??14192877.0 2014-11-12
EP14192877 2014-11-12

Publications (2)

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TW201609701A TW201609701A (zh) 2016-03-16
TWI667234B true TWI667234B (zh) 2019-08-01

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US (3) US9944621B2 (hr)
EP (2) EP3083592B1 (hr)
JP (2) JP6487922B2 (hr)
KR (1) KR20160098425A (hr)
CN (1) CN106458978B (hr)
AP (1) AP2016009276A0 (hr)
AU (2) AU2014364732B2 (hr)
BR (1) BR112016014008A2 (hr)
CA (1) CA2934108C (hr)
CL (1) CL2016001578A1 (hr)
CR (1) CR20160276A (hr)
CU (1) CU24390B1 (hr)
CY (1) CY1120701T1 (hr)
DK (1) DK3083592T3 (hr)
DO (1) DOP2016000149A (hr)
EA (1) EA032250B1 (hr)
ES (1) ES2689023T3 (hr)
HR (1) HRP20181536T1 (hr)
HU (1) HUE039942T2 (hr)
IL (1) IL246246B (hr)
JO (2) JOP20200052A1 (hr)
LT (1) LT3083592T (hr)
MX (1) MX365289B (hr)
MY (1) MY177393A (hr)
NI (1) NI201600084A (hr)
NZ (1) NZ758272A (hr)
PE (1) PE20160846A1 (hr)
PH (1) PH12016501190B1 (hr)
PL (1) PL3083592T3 (hr)
PT (1) PT3083592T (hr)
RS (1) RS57835B1 (hr)
SG (1) SG11201604978QA (hr)
SI (1) SI3083592T1 (hr)
TN (1) TN2016000250A1 (hr)
TW (1) TWI667234B (hr)
UA (1) UA120702C2 (hr)
UY (1) UY35887A (hr)
WO (1) WO2015091414A2 (hr)

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JOP20200052A1 (ar) 2013-12-19 2017-06-16 Bayer Pharma AG بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c
US20190008867A1 (en) 2015-11-13 2019-01-10 Ph Pharma Co., Ltd. 4-(4-cyano-2-thioaryl)dihydropyrimidinones for treating chronic wounds
US20200230136A1 (en) 2017-04-27 2020-07-23 Bayer Aktiengesellschaft Selective adrenoreceptor alpha2c receptor antagonists alone, or in combination with chymase inhibitors for use in the treatment and/or prophylaxis of peripheral artery diseases (pad)
CN110917195A (zh) * 2018-08-20 2020-03-27 山西惠尔健生物科技有限公司 肌松剂阿库氯铵（Alcuronium chloride）可作为抗心律失常药物
BR112021007830A2 (pt) 2018-11-20 2021-08-03 Bayer Aktiengesellschaft antagonistas do adrenoceptor-alfa2 do subtipo c (al-fa-2c) para o tratamento da apneia do sono
WO2020165031A1 (de) 2019-02-15 2020-08-20 Bayer Aktiengesellschaft Substituierte isochinolin-piperidinylmethanon-derivate
CN113330009B (zh) * 2019-03-12 2024-02-09 四川科伦博泰生物医药股份有限公司 氮杂环化合物、其制备方法及用途
WO2022135335A1 (zh) * 2020-12-21 2022-06-30 上海济煜医药科技有限公司 三氮唑类三并环衍生物及其制备方法和应用

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