TWI627967B - 抗ｈｅｒ２抗體－藥物結合物 - Google Patents

抗ｈｅｒ２抗體－藥物結合物 Download PDF

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Publication number
TWI627967B
TWI627967B TW104103127A TW104103127A TWI627967B TW I627967 B TWI627967 B TW I627967B TW 104103127 A TW104103127 A TW 104103127A TW 104103127 A TW104103127 A TW 104103127A TW I627967 B TWI627967 B TW I627967B
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Taiwan
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antibody
cancer
drug
compound
drug conjugate
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TW104103127A
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English (en)
Chinese (zh)
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TW201613649A (en
Inventor
內藤博之
Hiroyuki Naito
扇谷祐輔
Yusuke OGITANI
益田剛
Takeshi Masuda
中田隆
Takashi Nakada
吉田昌生
Masao Yoshida
蘆田真二
Shinji Ashida
森田浩司
Koji Morita
宮崎秀樹
Hideki Miyazaki
粕谷裕司
Yuji Kasuya
早川市郎
Ichiro Hayakawa
阿部有生
Yuki Abe
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日商第一三共股份有限公司
Daiichi Sankyo Company, Limited
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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