TWI289557B - A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole - Google Patents
A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole Download PDFInfo
- Publication number
- TWI289557B TWI289557B TW090111098A TW90111098A TWI289557B TW I289557 B TWI289557 B TW I289557B TW 090111098 A TW090111098 A TW 090111098A TW 90111098 A TW90111098 A TW 90111098A TW I289557 B TWI289557 B TW I289557B
- Authority
- TW
- Taiwan
- Prior art keywords
- methyl
- crystal
- trifluoroethoxy
- benzimidazole
- sulfinyl
- Prior art date
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- 239000013078 crystal Substances 0.000 title claims abstract description 35
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
- 238000002425 crystallisation Methods 0.000 claims description 15
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- QSQXISIULMTHLV-UHFFFAOYSA-N strontium;dioxido(oxo)silane Chemical compound [Sr+2].[O-][Si]([O-])=O QSQXISIULMTHLV-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17150999 | 1999-06-17 |
Publications (1)
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|---|---|
| TWI289557B true TWI289557B (en) | 2007-11-11 |
Family
ID=15924444
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW090111098A TWI289557B (en) | 1999-06-17 | 2000-05-30 | A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
| TW089110444A TWI275587B (en) | 1999-06-17 | 2000-05-30 | A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW089110444A TWI275587B (en) | 1999-06-17 | 2000-05-30 | A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
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| BE (1) | BE2014C017I2 (online.php) |
| BR (1) | BRPI0011674B8 (online.php) |
| CA (1) | CA2375201C (online.php) |
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| MX (1) | MXPA01012642A (online.php) |
| MY (1) | MY125399A (online.php) |
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| NZ (1) | NZ515702A (online.php) |
| PL (1) | PL201068B1 (online.php) |
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| SI (1) | SI1129088T1 (online.php) |
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| WO (2) | WO2000078745A2 (online.php) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US20040224989A1 (en) * | 1999-01-29 | 2004-11-11 | Barberich Timothy J. | S-lansoprazole compositions and methods |
| TWI289557B (en) | 1999-06-17 | 2007-11-11 | Takeda Chemical Industries Ltd | A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
| AU5705700A (en) * | 1999-06-30 | 2001-01-22 | Takeda Chemical Industries Ltd. | Crystals of benzimidazole compounds |
| CN1193024C (zh) | 2000-04-28 | 2005-03-16 | 武田药品工业株式会社 | 生产旋光的亚砜衍生物的方法 |
| EP1293507B1 (en) * | 2000-05-15 | 2007-11-28 | Takeda Pharmaceutical Company Limited | Process for producing crystal |
| CA2417311C (en) | 2000-08-04 | 2012-07-10 | Takeda Chemical Industries, Ltd. | Crystalline alkali metal salts of lansoprazole and their production and use |
| KR20100002278A (ko) | 2000-12-01 | 2010-01-06 | 다케다 야쿠힌 고교 가부시키가이샤 | (ｒ)- 또는 (ｓ)-란소프라졸의 결정 |
| US8105626B2 (en) | 2001-10-17 | 2012-01-31 | Takeda Pharmaceutical Company Limited | Granules containing acid-unstable chemical in large amount |
| KR100467100B1 (ko) * | 2002-03-20 | 2005-01-24 | 일양약품주식회사 | 2-[(4-메톡시-3-메틸)-2-피리디닐]메틸설피닐-5-(1Ｈ-피롤-1-릴)-1Ｈ-벤즈이미다졸 또는 이의 Ｎа염을 함유하는주사제의 제조방법 |
| AU2003224779A1 (en) * | 2002-03-27 | 2003-10-13 | Teva Pharmaceutical Industries Ltd. | Lansoprazole polymorphs and processes for preparation thereof |
| EP1552833B1 (en) * | 2002-10-16 | 2016-12-28 | Takeda Pharmaceutical Company Limited | Process for producing an amorphous optically active isomer of lansoprazole |
| MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| US20050220870A1 (en) * | 2003-02-20 | 2005-10-06 | Bonnie Hepburn | Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
| WO2004085424A1 (ja) | 2003-03-24 | 2004-10-07 | Eisai Co., Ltd. | スルホキシド誘導体またはその塩のアモルファスの製造方法 |
| US20070101907A1 (en) * | 2003-06-20 | 2007-05-10 | Ch Chemical (Pty) Ltd. | Liner |
| JP2006528181A (ja) * | 2003-07-18 | 2006-12-14 | サンタラス インコーポレイティッド | 酸分泌を阻害するために有用な薬学的製剤ならびにそれらを作製および使用する方法 |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| JP2006528182A (ja) * | 2003-07-18 | 2006-12-14 | サンタラス インコーポレイティッド | 薬学的製剤および酸に起因する消化器疾患の治療法 |
| US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
| JP2007522217A (ja) * | 2004-02-10 | 2007-08-09 | サンタラス インコーポレイティッド | プロトンポンプ阻害剤、緩衝剤および非ステロイド系抗炎症薬の組み合わせ |
| US20050239845A1 (en) * | 2004-04-16 | 2005-10-27 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and prokinetic agent |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8815916B2 (en) | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| EP1768668A2 (en) | 2004-06-16 | 2007-04-04 | Tap Pharmaceutical Products, Inc. | Multiple ppi dosage form |
| EP1790647B1 (en) | 2004-09-13 | 2013-05-08 | Takeda Pharmaceutical Company Limited | Method for producing oxidized compound |
| EP2275088B2 (en) | 2005-02-25 | 2018-09-26 | Takeda Pharmaceutical Company Limited | Method for producing granules |
| ES2259269B1 (es) | 2005-03-03 | 2007-11-01 | Esteve Quimica, S.A. | Procedimiento para la preparacion de derivados de 2-(2-piridilmetilsulfinil)-bencimidazol opticamente activos. |
| US7598273B2 (en) * | 2005-10-06 | 2009-10-06 | Auspex Pharmaceuticals, Inc | Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties |
| WO2007074909A1 (ja) | 2005-12-28 | 2007-07-05 | Takeda Pharmaceutical Company Limited | 放出制御固形製剤 |
| KR100758600B1 (ko) * | 2006-01-05 | 2007-09-13 | 주식회사 대웅제약 | 란소프라졸 결정형 ａ의 제조방법 |
| US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
| WO2008068767A2 (en) * | 2006-12-07 | 2008-06-12 | Hetero Drugs Limited | A novel crystalline form of lansoprazole |
| JP5366558B2 (ja) | 2006-12-28 | 2013-12-11 | 武田薬品工業株式会社 | 口腔内崩壊性固形製剤 |
| CN102014638A (zh) * | 2007-10-12 | 2011-04-13 | 武田制药北美公司 | 与食物摄入无关的治疗胃肠病症的方法 |
| EP2222663A1 (en) * | 2007-12-18 | 2010-09-01 | Watson Pharma Private Limited | A process for preparation of stable amorphous r-lansoprazole |
| EP2573082A1 (en) * | 2007-12-31 | 2013-03-27 | Takeda Pharmaceutical Company Limited | Crystalline solvated forms of (r)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1h-benzimidazole |
| AU2009224247B2 (en) * | 2008-03-10 | 2013-12-12 | Takeda Pharmaceutical Company Limited | Crystal of benzimidazole compound |
| CA2717947C (en) * | 2008-03-11 | 2020-07-07 | Takeda Pharmaceutical Company Limited | Orally-disintegrating solid preparation |
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