TW570811B - Stabilized teriparatide solutions - Google Patents
Stabilized teriparatide solutions Download PDFInfo
- Publication number
- TW570811B TW570811B TW087120429A TW87120429A TW570811B TW 570811 B TW570811 B TW 570811B TW 087120429 A TW087120429 A TW 087120429A TW 87120429 A TW87120429 A TW 87120429A TW 570811 B TW570811 B TW 570811B
- Authority
- TW
- Taiwan
- Prior art keywords
- pth
- solution
- mannitol
- quot
- human
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6907597P | 1997-12-09 | 1997-12-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW570811B true TW570811B (en) | 2004-01-11 |
Family
ID=22086574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW087120429A TW570811B (en) | 1997-12-09 | 1998-12-09 | Stabilized teriparatide solutions |
Country Status (32)
Country | Link |
---|---|
EP (2) | EP1417972B2 (cs) |
JP (1) | JP4405666B2 (cs) |
KR (1) | KR100482703B1 (cs) |
CN (1) | CN1198644C (cs) |
AR (1) | AR018526A1 (cs) |
AT (1) | ATE260113T1 (cs) |
AU (1) | AU759726B2 (cs) |
BR (1) | BR9813463A (cs) |
CA (1) | CA2314313C (cs) |
CY (1) | CY1114000T1 (cs) |
CZ (1) | CZ302401B6 (cs) |
DE (1) | DE69821872T2 (cs) |
DK (2) | DK1417972T4 (cs) |
EA (1) | EA004761B1 (cs) |
EG (1) | EG23675A (cs) |
ES (2) | ES2405994T5 (cs) |
HK (1) | HK1021798A1 (cs) |
HU (1) | HU230784B1 (cs) |
ID (1) | ID27741A (cs) |
IL (1) | IL136662A (cs) |
MY (1) | MY120063A (cs) |
NO (1) | NO327302B1 (cs) |
NZ (1) | NZ505222A (cs) |
PE (1) | PE20000001A1 (cs) |
PL (1) | PL194268B1 (cs) |
PT (2) | PT920873E (cs) |
SK (1) | SK288203B6 (cs) |
TR (1) | TR200002134T2 (cs) |
TW (1) | TW570811B (cs) |
UA (1) | UA72884C2 (cs) |
WO (1) | WO1999029337A1 (cs) |
ZA (1) | ZA9811127B (cs) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4719357B2 (ja) * | 1998-07-23 | 2011-07-06 | アレス トレイディング ソシエテ アノニム | Fsh及びfsh変異体の製剤、製品及び方法 |
US20030166525A1 (en) | 1998-07-23 | 2003-09-04 | Hoffmann James Arthur | FSH Formulation |
AR033639A1 (es) | 1998-08-19 | 2004-01-07 | Lilly Co Eli | Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis |
US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
US20020061838A1 (en) * | 2000-05-17 | 2002-05-23 | Barton Holmquist | Peptide pharmaceutical formulations |
EP1301200A2 (en) * | 2000-05-19 | 2003-04-16 | Bionebraska, Inc. | Peptide pharmaceutical formulations |
US20040156835A1 (en) * | 2001-05-30 | 2004-08-12 | Taiji Imoto | Protein preparation |
EP1767213A3 (en) * | 2001-11-05 | 2007-04-25 | Eli Lilly & Company | Method for improving stability of a bone-connecting implant |
AU2002363412A1 (en) * | 2001-11-05 | 2003-05-19 | Eli Lilly And Company | Method for improving stability of a bone-connecting implant |
US8088734B2 (en) | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
WO2004087213A1 (en) | 2003-04-02 | 2004-10-14 | Ares Trading S.A. | Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant |
PT1638595E (pt) | 2003-06-20 | 2013-04-26 | Ares Trading Sa | Fsh liofilizada / formulações de hl |
US7329725B1 (en) | 2003-10-29 | 2008-02-12 | Nastech Pharmaceutical Company Inc. | Phage displayed Trp cage ligands |
CN104826116A (zh) | 2003-11-20 | 2015-08-12 | 诺沃挪第克公司 | 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂 |
JP4869077B2 (ja) | 2003-12-23 | 2012-02-01 | インフィニティー ディスカヴァリー インコーポレイテッド | 癌治療に使用するベンゾキノン包含アンサマイシン類のアナログ |
US8642564B2 (en) | 2004-08-25 | 2014-02-04 | Aegis Therapeutics, Llc | Compositions for drug administration |
US20060046962A1 (en) | 2004-08-25 | 2006-03-02 | Aegis Therapeutics Llc | Absorption enhancers for drug administration |
US20140162965A1 (en) | 2004-08-25 | 2014-06-12 | Aegis Therapeutics, Inc. | Compositions for oral drug administration |
US9895444B2 (en) | 2004-08-25 | 2018-02-20 | Aegis Therapeutics, Llc | Compositions for drug administration |
US9114069B2 (en) | 2004-08-25 | 2015-08-25 | Aegis Therapeutics, Llc | Antibacterial compositions for drug administration |
US8268791B2 (en) | 2004-08-25 | 2012-09-18 | Aegis Therapeutics, Llc. | Alkylglycoside compositions for drug administration |
EP1789075A4 (en) * | 2004-08-25 | 2009-07-01 | Uab Research Foundation | ABSORPTION ENHANCER FOR DRUG ADMINISTRATION |
KR100700869B1 (ko) * | 2005-06-03 | 2007-03-29 | 재단법인 목암생명공학연구소 | Pth, 완충제 및 안정제를 포함하는 안정한 pth조성물 |
EP1945245A2 (en) | 2005-11-10 | 2008-07-23 | The Board of Control of Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
US8226949B2 (en) | 2006-06-23 | 2012-07-24 | Aegis Therapeutics Llc | Stabilizing alkylglycoside compositions and methods thereof |
USRE49444E1 (en) | 2006-10-03 | 2023-03-07 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
US7803770B2 (en) | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
BRPI0719821B8 (pt) * | 2006-10-03 | 2021-05-25 | Ipsen Pharma Sas | composição estável na armazenagem apropriada para administração a pacientes |
EP1958618A1 (de) | 2007-02-15 | 2008-08-20 | Octapharma AG | Verfahren zur Gefriertrocknung mit optimierter Rekonstitution von Biopolymeren |
US20080255080A1 (en) * | 2007-04-12 | 2008-10-16 | Wright James L | Hydroquinone Ansamycin Formulations |
US20080299228A1 (en) * | 2007-05-29 | 2008-12-04 | Alan Gerald Harris | Topical compositions comprising a macromolecule and methods of using same |
AU2008269086B2 (en) | 2007-06-25 | 2014-06-12 | Amgen Inc. | Compositions of specific binding agents to hepatocyte growth factor |
JP5613657B2 (ja) | 2008-03-28 | 2014-10-29 | ヘイル バイオファーマ ベンチャーズ,エルエルシー | ベンゾジアゼピン組成物の投与 |
EP2348845A4 (en) | 2008-10-15 | 2013-01-23 | Infinity Pharmaceuticals Inc | ANSAMYCIN HYDROQUINONE COMPOSITIONS |
US8440631B2 (en) | 2008-12-22 | 2013-05-14 | Aegis Therapeutics, Llc | Compositions for drug administration |
EP2682125B1 (en) * | 2009-09-09 | 2020-11-04 | Asahi Kasei Pharma Corporation | Pth-containing therapeutic/prophylactic agent for osteoporosis, characterized in that pth is administered once a week at unit dose of 200 units |
AU2009356227A1 (en) | 2009-12-07 | 2012-06-21 | Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
CN107737100A (zh) | 2011-06-14 | 2018-02-27 | 哈尔生物药投资有限责任公司 | 苯二氮卓组合物的投与 |
CN102731643A (zh) * | 2012-06-26 | 2012-10-17 | 深圳翰宇药业股份有限公司 | 一种治疗骨质疏松多肽的制备方法 |
CN103301058A (zh) * | 2013-06-17 | 2013-09-18 | 深圳翰宇药业股份有限公司 | 一种特立帕肽注射用组合物及其制备方法和制剂 |
IL307981A (en) | 2015-04-29 | 2023-12-01 | Radius Pharmaceuticals Inc | Cancer treatment methods |
CN106309358A (zh) * | 2015-06-29 | 2017-01-11 | 成都金凯生物技术有限公司 | 含有人甲状旁腺激素的药物组合物及其制备方法与用途 |
JP6634758B2 (ja) * | 2015-09-25 | 2020-01-22 | ニプロ株式会社 | 液体組成物及び凍結乾燥製剤 |
EP3423103A1 (en) | 2016-03-01 | 2019-01-09 | Ascendis Pharma Bone Diseases A/S | Pth prodrugs |
CN109789189B (zh) | 2016-09-29 | 2024-01-23 | 阿森迪斯药物骨疾病股份有限公司 | 控释pth化合物的剂量方案 |
CN117257922A (zh) | 2016-09-29 | 2023-12-22 | 阿森迪斯药物骨疾病股份有限公司 | 具有低峰-谷比的pth化合物 |
JP7481115B2 (ja) | 2017-01-05 | 2024-05-10 | ラジウス ファーマシューティカルズ,インコーポレイテッド | Rad1901-2hclの多形性形態 |
US10996208B2 (en) | 2017-04-28 | 2021-05-04 | Radius Health, Inc. | Abaloparatide formulations and methods of testing, storing, modifying, and using same |
TWI762706B (zh) | 2017-08-24 | 2022-05-01 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1組成物及其用途 |
US20200289622A1 (en) * | 2017-09-22 | 2020-09-17 | Asahi Kasei Pharma Corporation | Teriparatide-containing liquid pharmaceutical composition having excellent pharmacokinetics and/or safety |
JP2019060866A (ja) * | 2017-09-22 | 2019-04-18 | 旭化成ファーマ株式会社 | 液状医薬組成物の体内動態を予測する方法 |
EP3685849A4 (en) * | 2017-09-22 | 2021-12-22 | Asahi Kasei Pharma Corporation | LIQUID PHARMACEUTICAL COMPOSITION CONTAINING TRIPARATIDE WITH EXCELLENT STABILITY |
CN108159404B (zh) * | 2018-01-05 | 2019-08-27 | 北京博康健基因科技有限公司 | 重组人甲状旁腺激素制剂及其制备方法 |
WO2019220654A1 (ja) * | 2018-05-17 | 2019-11-21 | 旭化成ファーマ株式会社 | N-ホルミルピぺリジン含有量が低減されている、及び/又は、凍結乾燥ケーキの崩潰又は収縮が抑制されている、製剤 |
US20220088149A1 (en) * | 2019-02-11 | 2022-03-24 | Ascendis Pharma Bone Diseases A/S | Liquid Pharmaceutical Formulations of PTH Conjugates |
CN112439054B (zh) * | 2019-08-28 | 2023-05-16 | 深圳翰宇药业股份有限公司 | 一种特立帕肽缓释凝胶注射液及其制备方法 |
WO2021144476A1 (en) | 2020-02-18 | 2021-07-22 | Novo Nordisk A/S | Pharmaceutical formulations |
EP4110370A4 (en) * | 2020-03-30 | 2023-06-07 | Sichuan Luzhou Buchang Bio-Pharmaceutical Co., Ltd. | FORMULATIONS OF HUMAN PARATHYROID HORMONE (PTH) AND METHODS OF MANUFACTURE THEREOF |
CN113967249A (zh) * | 2021-12-10 | 2022-01-25 | 深圳先进技术研究院 | 甲状旁腺激素在制备治疗男性抑郁症的药物或保健品中的应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6360940A (ja) * | 1986-09-01 | 1988-03-17 | Toyo Jozo Co Ltd | 白内障の予防または治療剤 |
JP2505812B2 (ja) * | 1987-07-10 | 1996-06-12 | 旭化成工業株式会社 | h―PTH(1―34)凍結乾燥組成物 |
US5059587A (en) * | 1987-08-03 | 1991-10-22 | Toyo Jozo Company, Ltd. | Physiologically active peptide composition for nasal administration |
DE3935738A1 (de) * | 1989-10-27 | 1991-05-08 | Forssmann Wolf Georg | Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff |
GB9020544D0 (en) * | 1990-09-20 | 1990-10-31 | Sandoz Ltd | Improvements in or relating to organic compounds |
ES2129048T3 (es) * | 1991-12-09 | 1999-06-01 | Asahi Chemical Ind | Composicion estabilizada de hormona paratiroide. |
ATE220327T1 (de) | 1992-09-29 | 2002-07-15 | Inhale Therapeutic Syst | Pulmonale abgabe von aktiven fragmenten des parathormons |
IT1255723B (it) † | 1992-10-09 | 1995-11-13 | Uso di paratormone,suoi frammenti biologicamente attivi e peptidi correlati, per la preparazione di composizioni farmaceutiche utili nella prevenzione e terapia dell'aborto e del parto pretermine ed in generale per il trattamento della gestazione | |
US5496801A (en) * | 1993-12-23 | 1996-03-05 | Allelix Biopharmaceuticals Inc. | Parathyroid hormone formulation |
DE19538687A1 (de) † | 1995-10-17 | 1997-04-24 | Boehringer Mannheim Gmbh | Stabile pharmazeutische Darreichungsformen enthaltend Parathormon |
-
1998
- 1998-12-04 MY MYPI98005507A patent/MY120063A/en unknown
- 1998-12-04 ZA ZA9811127A patent/ZA9811127B/xx unknown
- 1998-12-07 AT AT98123225T patent/ATE260113T1/de not_active IP Right Cessation
- 1998-12-07 EP EP03104219.5A patent/EP1417972B2/en not_active Expired - Lifetime
- 1998-12-07 DE DE69821872T patent/DE69821872T2/de not_active Revoked
- 1998-12-07 ES ES03104219T patent/ES2405994T5/es not_active Expired - Lifetime
- 1998-12-07 AR ARP980106213A patent/AR018526A1/es active IP Right Grant
- 1998-12-07 DK DK03104219.5T patent/DK1417972T4/en active
- 1998-12-07 EG EG151498A patent/EG23675A/xx active
- 1998-12-07 ES ES98123225T patent/ES2215268T3/es not_active Expired - Lifetime
- 1998-12-07 EP EP98123225A patent/EP0920873B1/en not_active Revoked
- 1998-12-07 DK DK98123225T patent/DK0920873T3/da active
- 1998-12-07 PT PT98123225T patent/PT920873E/pt unknown
- 1998-12-07 PT PT3104219T patent/PT1417972E/pt unknown
- 1998-12-08 KR KR10-2000-7006211A patent/KR100482703B1/ko not_active IP Right Cessation
- 1998-12-08 BR BR9813463-9A patent/BR9813463A/pt not_active Application Discontinuation
- 1998-12-08 HU HU0004447A patent/HU230784B1/hu unknown
- 1998-12-08 CZ CZ20002115A patent/CZ302401B6/cs not_active IP Right Cessation
- 1998-12-08 NZ NZ505222A patent/NZ505222A/en not_active IP Right Cessation
- 1998-12-08 JP JP2000524006A patent/JP4405666B2/ja not_active Expired - Lifetime
- 1998-12-08 CN CNB988119641A patent/CN1198644C/zh not_active Ceased
- 1998-12-08 EA EA200000629A patent/EA004761B1/ru not_active IP Right Cessation
- 1998-12-08 SK SK1532-2000A patent/SK288203B6/sk not_active IP Right Cessation
- 1998-12-08 AU AU17177/99A patent/AU759726B2/en not_active Expired
- 1998-12-08 TR TR2000/02134T patent/TR200002134T2/xx unknown
- 1998-12-08 CA CA002314313A patent/CA2314313C/en not_active Expired - Lifetime
- 1998-12-08 ID IDW20001318A patent/ID27741A/id unknown
- 1998-12-08 UA UA2000074034A patent/UA72884C2/uk unknown
- 1998-12-08 WO PCT/US1998/026043 patent/WO1999029337A1/en active IP Right Grant
- 1998-12-08 PL PL98340902A patent/PL194268B1/pl unknown
- 1998-12-08 IL IL13666298A patent/IL136662A/en not_active IP Right Cessation
- 1998-12-09 TW TW087120429A patent/TW570811B/zh not_active IP Right Cessation
- 1998-12-09 PE PE1998001200A patent/PE20000001A1/es not_active IP Right Cessation
-
1999
- 1999-12-09 HK HK99105809A patent/HK1021798A1/xx not_active IP Right Cessation
-
2000
- 2000-06-08 NO NO20002945A patent/NO327302B1/no not_active IP Right Cessation
-
2013
- 2013-05-17 CY CY20131100405T patent/CY1114000T1/el unknown
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