TW201900633A - Kras之共價抑制劑 - Google Patents
Kras之共價抑制劑 Download PDFInfo
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- TW201900633A TW201900633A TW107117823A TW107117823A TW201900633A TW 201900633 A TW201900633 A TW 201900633A TW 107117823 A TW107117823 A TW 107117823A TW 107117823 A TW107117823 A TW 107117823A TW 201900633 A TW201900633 A TW 201900633A
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- 0 Cc(c(I)c(C)c1nc(*)n2)c(*)c1c2IC Chemical compound Cc(c(I)c(C)c1nc(*)n2)c(*)c1c2IC 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762511163P | 2017-05-25 | 2017-05-25 | |
| US62/511,163 | 2017-05-25 | ||
| US201862625889P | 2018-02-02 | 2018-02-02 | |
| US62/625,889 | 2018-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201900633A true TW201900633A (zh) | 2019-01-01 |
Family
ID=63586845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW107117823A TW201900633A (zh) | 2017-05-25 | 2018-05-24 | Kras之共價抑制劑 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10745385B2 (enExample) |
| EP (1) | EP3630745A2 (enExample) |
| JP (1) | JP2020521742A (enExample) |
| KR (1) | KR20200010306A (enExample) |
| CN (1) | CN110869358A (enExample) |
| AU (1) | AU2018271990A1 (enExample) |
| BR (1) | BR112019024674A2 (enExample) |
| CA (1) | CA3063440A1 (enExample) |
| MX (1) | MX2019013954A (enExample) |
| PH (1) | PH12019550248A1 (enExample) |
| SG (1) | SG10202113146UA (enExample) |
| TW (1) | TW201900633A (enExample) |
| WO (1) | WO2018218070A2 (enExample) |
| ZA (1) | ZA202101138B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112707846A (zh) * | 2019-10-25 | 2021-04-27 | 成都伊诺达博医药科技有限公司 | 一种达克替尼关键中间体的制备方法 |
| TWI760919B (zh) * | 2019-11-15 | 2022-04-11 | 大陸商四川海思科製藥有限公司 | 一種嘧啶並環衍生物及其在醫藥上的應用 |
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| US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
| TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Ｋｒａｓ ｇ１２ｃ之抑制劑 |
| AU2016245864C1 (en) | 2015-04-10 | 2021-09-09 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| ES2856880T3 (es) | 2015-04-15 | 2021-09-28 | Araxes Pharma Llc | Inhibidores tricíclicos condensados de KRAS y métodos de uso de los mismos |
| WO2017058728A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| EP3356359B1 (en) | 2015-09-28 | 2021-10-20 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| US10975071B2 (en) | 2015-09-28 | 2021-04-13 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| WO2017058902A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| EP3356347A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| US10730867B2 (en) | 2015-09-28 | 2020-08-04 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| WO2017058768A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| KR102932353B1 (ko) | 2015-11-16 | 2026-02-27 | 아락세스 파마 엘엘씨 | 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법 |
| WO2017172979A1 (en) | 2016-03-30 | 2017-10-05 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
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| JP2019529484A (ja) | 2016-09-29 | 2019-10-17 | アラクセス ファーマ エルエルシー | Ｋｒａｓ ｇ１２ｃ変異体タンパク質の阻害剤 |
| US10377743B2 (en) | 2016-10-07 | 2019-08-13 | Araxes Pharma Llc | Inhibitors of RAS and methods of use thereof |
| JP7327802B2 (ja) | 2017-01-26 | 2023-08-16 | アラクセス ファーマ エルエルシー | 縮合ヘテロ－ヘテロ二環式化合物およびその使用方法 |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
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| MX2020010836A (es) | 2018-05-04 | 2021-01-08 | Amgen Inc | Inhibidores de kras g12c y métodos para su uso. |
| BR112021001709A2 (pt) | 2018-08-01 | 2021-05-04 | Araxes Pharma Llc | compostos espiro heterocíclicos e métodos de uso dos mesmos para o tratamento de câncer |
| AU2019364417A1 (en) | 2018-10-24 | 2021-05-20 | Araxes Pharma Llc | 2-(2-acryloyl-2,6-diazaspiro[3.4]octan-6-yl)-6-(1H-indazol-4-yl)-benzonitrile derivatives and related compounds as inhibitors of G12C mutant KRAS protein for inhibiting tumor metastasis |
| EP3887373A1 (en) | 2018-11-29 | 2021-10-06 | Araxes Pharma LLC | Compounds and methods of use thereof for treatment of cancer |
-
2018
- 2018-05-24 CN CN201880034569.6A patent/CN110869358A/zh active Pending
- 2018-05-24 SG SG10202113146UA patent/SG10202113146UA/en unknown
- 2018-05-24 TW TW107117823A patent/TW201900633A/zh unknown
- 2018-05-24 US US15/989,015 patent/US10745385B2/en active Active
- 2018-05-24 BR BR112019024674-6A patent/BR112019024674A2/pt not_active Application Discontinuation
- 2018-05-24 AU AU2018271990A patent/AU2018271990A1/en not_active Abandoned
- 2018-05-24 EP EP18769873.3A patent/EP3630745A2/en not_active Withdrawn
- 2018-05-24 JP JP2019564538A patent/JP2020521742A/ja active Pending
- 2018-05-24 MX MX2019013954A patent/MX2019013954A/es unknown
- 2018-05-24 KR KR1020197036394A patent/KR20200010306A/ko not_active Ceased
- 2018-05-24 CA CA3063440A patent/CA3063440A1/en not_active Abandoned
- 2018-05-24 WO PCT/US2018/034471 patent/WO2018218070A2/en not_active Ceased
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2019
- 2019-11-19 PH PH12019550248A patent/PH12019550248A1/en unknown
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2020
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2021
- 2021-02-19 ZA ZA2021/01138A patent/ZA202101138B/en unknown
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2022
- 2022-05-17 US US17/746,801 patent/US20230203018A1/en not_active Abandoned
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2024
- 2024-07-05 US US18/764,948 patent/US20250154133A1/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112707846A (zh) * | 2019-10-25 | 2021-04-27 | 成都伊诺达博医药科技有限公司 | 一种达克替尼关键中间体的制备方法 |
| CN112707846B (zh) * | 2019-10-25 | 2023-04-21 | 成都伊诺达博医药科技有限公司 | 一种达克替尼关键中间体的制备方法 |
| TWI760919B (zh) * | 2019-11-15 | 2022-04-11 | 大陸商四川海思科製藥有限公司 | 一種嘧啶並環衍生物及其在醫藥上的應用 |
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| US20190062313A1 (en) | 2019-02-28 |
| CA3063440A1 (en) | 2018-11-29 |
| US20230203018A1 (en) | 2023-06-29 |
| WO2018218070A2 (en) | 2018-11-29 |
| US20210024501A1 (en) | 2021-01-28 |
| ZA202101138B (en) | 2022-09-28 |
| SG10202113146UA (en) | 2021-12-30 |
| AU2018271990A1 (en) | 2019-12-12 |
| CN110869358A (zh) | 2020-03-06 |
| KR20200010306A (ko) | 2020-01-30 |
| US11377441B2 (en) | 2022-07-05 |
| EP3630745A2 (en) | 2020-04-08 |
| WO2018218070A3 (en) | 2019-02-07 |
| BR112019024674A2 (pt) | 2020-06-16 |
| MX2019013954A (es) | 2020-08-31 |
| US20250154133A1 (en) | 2025-05-15 |
| JP2020521742A (ja) | 2020-07-27 |
| US10745385B2 (en) | 2020-08-18 |
| PH12019550248A1 (en) | 2021-01-11 |
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