TW201722445A - Glycerol production promoter derived from staphylococcus epidermidis, antimicrobial peptide production promoter derived from skin epidermal keratinocytes, and utilization thereof in external preparation for skin protection - Google Patents
Glycerol production promoter derived from staphylococcus epidermidis, antimicrobial peptide production promoter derived from skin epidermal keratinocytes, and utilization thereof in external preparation for skin protection Download PDFInfo
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Abstract
Description
發明領域 本發明係關於一種經由促進源自皮膚常駐菌、即作為益菌之表皮葡萄球菌(Staphylococcus epidermidis)之甘油產生、及源自皮膚表皮角化細胞之抗菌胜肽產生之一者或一系列之功能而保護皮膚免於乾燥等來自外界之壓力、或害菌之藥劑與皮膚保護用外用劑。FIELD OF THE INVENTION The present invention relates to a production or a series of antibacterial peptides produced by promoting the production of glycerol derived from the resident bacteria of the skin, ie, Staphylococcus epidermidis as a beneficial bacteria, and from keratinocytes of the skin epidermis The function is to protect the skin from external stress such as dryness, or a drug for external use and a topical agent for skin protection.
發明背景 人類皮膚中共生微生物以皮膚常駐菌群之形式形成群落。作為皮膚常駐菌,生存有表皮葡萄球菌、金黃色葡萄球菌、棒狀桿菌等,藉由該等菌之平衡而維持保護皮膚免受外界損害之功能。然而,已知作為環境性因素之急遽之溫度變化、乾燥、強力之洗淨劑或藥品、或者作為身心因素之外傷、精神壓力、疾病引起之全身狀態不良會導致該等菌群平衡瓦解,而破壞該保護功能(非專利文獻1)。BACKGROUND OF THE INVENTION Symbiotic microorganisms in human skin form a community in the form of a resident flora of the skin. As a resident bacteria of the skin, Staphylococcus epidermidis, Staphylococcus aureus, Corynebacterium, and the like survive, and the function of protecting the skin from external damage is maintained by the balance of the bacteria. However, it is known that environmental changes, rapid changes in temperature, dryness, strong detergents or medicines, or physical and mental factors such as trauma, mental stress, and general malaise caused by diseases can lead to a balanced collapse of these flora. This protection function is broken (Non-Patent Document 1).
例如,作為皮膚之益菌而已知之表皮葡萄球菌會分解皮脂而產生甘油,發揮防止乾燥肌膚或調節皮膚表面之pH值而抑制雜菌之繁殖等物理保護功能之作用。因此,若表皮葡萄球菌之比例減少,則無法發揮該等保護功能,有時亦成為皮膚疾病之原因。為了防止該皮膚疾病,皮膚外用劑中逐漸廣泛使用保濕劑或抗菌劑、殺菌劑成分等,但根據該等藥劑成分,亦會有連作為好氧菌之表皮葡萄球菌之保護功能被抑制之虞。For example, Staphylococcus epidermidis, which is known as a probiotic case of the skin, decomposes sebum to produce glycerin, and functions to prevent dry skin or to adjust the pH of the skin surface to inhibit the physical protection function such as the growth of the bacteria. Therefore, if the ratio of Staphylococcus epidermidis is reduced, such a protective function cannot be exerted, and it may become a cause of skin diseases. In order to prevent the skin disease, a moisturizing agent, an antibacterial agent, a bactericidal ingredient, and the like are gradually used in the external preparation for skin, but according to the pharmaceutical ingredients, the protective function of Staphylococcus epidermidis, which is an aerobic bacteria, is suppressed. .
又,表皮葡萄球菌亦發揮刺激皮膚表皮角化細胞、促進源自皮膚表皮角化細胞之抗菌性胜肽之產生、強化活體之生物保護功能的作用。作為由皮膚表皮角化細胞產生之抗菌性胜肽,已知有人類β-防禦素-2(hBD2:human β-defensin-2)與人類β-防禦素-3(hBD3:human β-defensin-3),且有報告指出該等抗菌性胜肽對作為皮膚之害菌之金黃色葡萄球菌表現出抗菌作用,成為生物屏障而保護皮膚免於害菌(非專利文獻2)。In addition, Staphylococcus epidermidis also acts to stimulate skin epidermal keratinocytes, promote the production of antibacterial peptides derived from skin epidermal keratinocytes, and enhance the biological protective function of living organisms. As an antibacterial peptide produced by keratinocytes of the skin epidermis, human β-defensin-2 (hBD2: human β-defensin-2) and human β-defensin-3 (hBD3: human β-defensin- are known). 3), and it has been reported that these antibacterial peptides exhibit an antibacterial action against Staphylococcus aureus which is a harmful bacteria of the skin, and become a biological barrier to protect the skin from harmful bacteria (Non-Patent Document 2).
先前,在促進表皮葡萄球菌之增殖之目的下,而使用葡萄糖寡糖等糖分作為同化源(專利文獻1),但由於其不僅對有益之表皮葡萄球菌,對其他金黃色葡萄球菌等害菌亦表現出同化性,因此亦存在達不到皮膚之保護功能之情形。又,將糖分塗佈於皮膚時多呈現出黏膩感,而產生觸感上之配方困難之類的其他問題。In the past, in order to promote the proliferation of S. epidermidis, sugars such as glucose oligosaccharides were used as an assimilation source (Patent Document 1), but since it is not only beneficial to Staphylococcus epidermidis, but also to other Staphylococcus aureus and other harmful bacteria. It shows assimilation, so there is also a situation in which the protective function of the skin is not achieved. Further, when the sugar is applied to the skin, it tends to be sticky, and other problems such as difficulty in formulating the touch are caused.
已知金黃色葡萄球菌多存在於處於乾燥肌膚或肌膚皸裂狀態之人、或異位性皮膚炎患者之皮膚。亦已知金黃色葡萄球菌所產生之毒素會引起皮膚狀態之進一步惡化。可認為,為了保持皮膚表面狀態健康,重要的是有效地殺死該金黃色葡萄球菌,且維持具有皮膚保護功能之表皮葡萄球菌。Staphylococcus aureus is known to be present in the skin of people with dry skin or chapped skin, or patients with atopic dermatitis. It is also known that toxins produced by S. aureus cause further deterioration of the skin condition. It is considered that in order to maintain the skin surface state health, it is important to effectively kill the S. aureus and maintain S. epidermidis having a skin protective function.
表皮葡萄球菌於皮膚中之作用類似於作為腸道之益菌之乳酸菌或比菲德氏菌(bifidus)之作用。已知腸道之該等益菌調整腸道內之pH值,抑制產氣莢膜梭菌(clostridium perfringens)或大腸桿菌等害菌之增殖,具有腸道之保護功能。The effect of Staphylococcus epidermidis in the skin is similar to that of lactic acid bacteria or bifidus which are beneficial bacteria of the intestinal tract. It is known that these beneficial bacteria in the intestinal tract adjust the pH value in the intestinal tract to inhibit the proliferation of harmful bacteria such as Clostridium perfringens or Escherichia coli, and have a protective function of the intestinal tract.
於腸道中,為了改善腸內環境而攝取乳酸菌或比菲德氏菌等益菌,通常為了使該等益菌以存活狀態到達腸內並固定於其上,必須選擇耐酸性株或進行腸溶型之膠囊化等。又,為了增加腸內之益菌,亦進行攝取調配有膳食纖維或益菌選擇性同化之各種寡糖之飲食品的方法。然而,該等方法因個人體質不同亦存在引起過量之腸內醱酵或下痢之情況。作為解決此種問題之一方法,提供有使用乳酸球菌之加熱處理死菌體之方法(專利文獻2)。In the intestinal tract, in order to improve the intestinal environment, ingestion of lactic acid bacteria or probiotic bacteria such as F. faecalis, in order to allow the beneficial bacteria to reach the intestine and be fixed on the intestine, it is necessary to select an acid-resistant strain or enteric solution. Type of encapsulation, etc. Further, in order to increase the beneficial bacteria in the intestine, a method of ingesting a food or drink containing various oligosaccharides which are selectively assimilated by dietary fiber or beneficial bacteria is also carried out. However, these methods also cause excessive intestinal fermentation or diarrhea due to differences in personal physique. As a method for solving such a problem, a method of heat-treating a dead cell using a lactic acid bacteria is provided (Patent Document 2).
糞腸球菌之加熱處理死菌體藉由製成飲食物而攝取,可於腸道內促進比菲德氏菌之增殖、抑制害菌之增殖,而改善腸內保護功能。又,由於為死菌,因此作為飲食品之加工亦容易,不會進行不需要之醱酵,因此對飲食品之保存穩定性造成影響之情況亦較少。Heat treatment of Enterococcus faecalis The inoculum is ingested by making a food or drink, which promotes the proliferation of F. faecalis in the intestinal tract, inhibits the proliferation of harmful bacteria, and improves the intestinal protective function. In addition, since it is a dead animal, it is easy to process as a food or drink, and it does not carry out unnecessary fermentation. Therefore, there are few cases in which the storage stability of foods and drinks is affected.
作為乳酸菌之加熱處理死菌體,可適宜地例示被分類為糞腸球菌之微生物,尤其較佳為使用糞腸球菌(Enterococcus faecalis)EC-12株(寄存編號FERM BP-10284),糞腸球菌EC-12株(寄存編號FERM BP-10284)之16SrDNA於日本國立遺傳研究所登記為「AB15482」。 先前技術文獻 專利文獻As the heat-treated dead cells of the lactic acid bacteria, microorganisms classified as Enterococcus faecalis can be suitably exemplified, and it is particularly preferable to use Enterococcus faecalis EC-12 strain (registered number FERM BP-10284), Enterococcus faecalis The 16SrDNA of the EC-12 strain (registered number FERM BP-10284) was registered as "AB15482" by the National Institute of Genetics of Japan. Prior Technical Literature Patent Literature
[專利文獻1]日本專利特開2005-002087號公報 [專利文獻2]日本專利特開2004-051530號公報 [非專利文獻][Patent Document 1] Japanese Laid-Open Patent Publication No. 2005-002087 [Patent Document 2] Japanese Patent Laid-Open Publication No. 2004-051530 [Non-Patent Document]
[非專利文獻1]Gallo, R.L.等人,Journal of Investigative Dermatology 131, P1974-1980(2011) [非專利文獻2]Kisich, K.O.等人,Journal of Investigative Dermatology 127:2368-2380(2007)[Non-Patent Document 1] Gallo, R. L., et al., Journal of Investigative Dermatology 131, P1974-1980 (2011) [Non-Patent Document 2] Kisich, K. O. et al., Journal of Investigative Dermatology 127: 2368-2380 (2007)
發明概要 發明欲解決之課題 於保持皮膚表面狀態健康之方面,不可或缺的是保護皮膚免於乾燥等來自外界之壓力、或害菌之手段及方法。本發明之課題在於提供一種經由促進源自表皮葡萄球菌之甘油之產生、與源自皮膚表皮角化細胞之針對金黃色葡萄球菌等害菌之抗菌胜肽之產生中的一者或一系列之功能,而保護皮膚免於乾燥等來自外界之壓力、或害菌之藥劑與皮膚保護用外用劑。 用以解決課題之手段SUMMARY OF THE INVENTION Problems to be Solved by the Invention In order to maintain the health of the surface of the skin, it is indispensable to protect the skin from pressure or bacteria from the outside, such as drying. An object of the present invention is to provide one or a series of antibacterial peptides which are produced by promoting the production of glycerol derived from Staphylococcus epidermidis and against harmful bacteria such as Staphylococcus aureus derived from skin epidermal keratinocytes. It protects the skin from external stress such as dryness, or a drug for external use and a topical agent for skin protection. Means to solve the problem
本發明者等人對各種乳酸菌進行調查並反覆進行努力研究,結果發現,作為乳酸球菌之糞腸球菌EC-12之菌體、尤其是其加熱處理死菌體具有促進源自表皮葡萄球菌之甘油之產生及源自皮膚表皮角化細胞之抗菌胜肽之產生的作用。又,其於應用於皮膚時為乾爽而觸感性非常優異,對水性系、油性系、乳液系、粉末系之任一類型之外用劑均會賦予感覺改善效果。The inventors of the present invention investigated various lactic acid bacteria and repeatedly conducted an effort to study, and as a result, it was found that the fungus of Enterococcus faecalis EC-12, which is a lactic acid-derived bacterium, has a glycerol derived from Staphylococcus epidermidis. The production and action of the antibacterial peptide derived from the epidermal keratinocytes of the skin. Moreover, when applied to the skin, it is very dry and very excellent in touch, and it imparts a feeling-improving effect to any of the aqueous, oily, emulsion, and powder-based external preparations.
即,本發明包括以下之項。 [1]一種促進源自表皮葡萄球菌之甘油產生的促進劑,其含有腸球菌屬乳酸球菌作為有效成分。 [2]如項1所記載之促進源自表皮葡萄球菌之甘油產生的促進劑,其中上述腸球菌屬乳酸球菌為糞腸球菌(Enterococcus faecalis)。 [3]如項1至2所記載之促進源自表皮葡萄球菌之甘油產生的促進劑,其中上述腸球菌屬乳酸球菌為糞腸球菌EC-12(寄存編號FERM BP-10284)。 [4]如項1至3所記載之促進源自表皮葡萄球菌之甘油產生的促進劑,其中上述腸球菌屬乳酸球菌為死菌體。 [5]如項1至4所記載之促進源自表皮葡萄球菌之甘油產生的促進劑,其中上述腸球菌屬乳酸球菌為加熱處理死菌體。 [6]一種促進源自皮膚表皮角化細胞之抗菌胜肽產生的促進劑,其含有腸球菌屬乳酸球菌作為有效成分。 [7]如項6所記載之促進源自皮膚表皮角化細胞之抗菌胜肽產生的促進劑,其中上述腸球菌屬乳酸球菌為糞腸球菌(Enterococcus faecalis)。 [8]如項6至7所記載之促進源自皮膚表皮角化細胞之抗菌胜肽產生的促進劑,其中上述腸球菌屬乳酸球菌為糞腸球菌EC-12(寄存編號FERM BP-10284)。 [9]如項6至8所記載之促進源自皮膚表皮角化細胞之抗菌胜肽產生的促進劑,其中上述腸球菌屬乳酸球菌為死菌體。 [10]如項6至9所記載之促進源自皮膚表皮角化細胞之抗菌胜肽產生的促進劑,其中上述腸球菌屬乳酸球菌為加熱處理死菌體。 [11]如請求項6至10所記載之抗菌胜肽產生促進劑,其中上述抗菌胜肽為人類β-防禦素-2(hBD2:human β-defensin-2)、人類β-防禦素-3(hBD3:human β-defensin-3)。 [12]一種皮膚保護用外用劑,其調配有如項1至11所記載之促進源自表皮葡萄球菌之甘油產生的促進劑、促進源自皮膚表皮角化細胞之抗菌胜肽產生的促進劑。 發明之效果That is, the present invention includes the following items. [1] An accelerator for promoting the production of glycerol derived from Staphylococcus epidermidis, which comprises Enterococcus genus Lactococcus as an active ingredient. [2] The promoter for promoting the production of glycerol derived from Staphylococcus epidermidis according to Item 1, wherein the Enterococcus genus Enterococcus faecalis is Enterococcus faecalis. [3] The promoter for promoting the production of glycerol derived from Staphylococcus epidermidis according to the item 1 to 2, wherein the Enterococcus genus is Enterococcus faecalis EC-12 (registered number FERM BP-10284). [4] The promoter for promoting the production of glycerol derived from Staphylococcus epidermidis according to any one of Items 1 to 3, wherein the Enterococcus genus Lactococcus is a dead cell. [5] The accelerator for promoting the production of glycerol derived from Staphylococcus epidermidis according to any one of Items 1 to 4, wherein the Enterococcus genus Lactococcus is a heat-treated dead cell. [6] An accelerator for promoting the production of an antibacterial peptide derived from epidermal keratinocytes of the skin, which comprises Enterococcus genus Lactococcus as an active ingredient. [7] The accelerating agent for promoting the production of an antibacterial peptide derived from cutaneous keratinocytes of the genus Enterococcus faecalis according to Item 6, wherein the Enterococcus faecalis is Enterococcus faecalis. [8] The agent for promoting the production of an antibacterial peptide derived from cutaneous keratinocytes of the genus Escherichia coli according to the items 6 to 7, wherein the Enterococcus genus is Enterococcus faecalis EC-12 (registered number FERM BP-10284) . [9] The accelerating agent for promoting the production of an antibacterial peptide derived from cutaneous keratinocytes of the skin according to any one of Items 6 to 8, wherein the Enterococcus genus Lactococcus is a dead cell. [10] The accelerating agent for promoting the production of an antibacterial peptide derived from cutaneous keratinocytes of the skin according to the items 6 to 9, wherein the Enterococcus genus Lactococcus is a heat-treated dead cell. [11] The antibacterial peptide production promoter according to any one of claims 6 to 10, wherein the antibacterial peptide is human β-defensin-2 (hBD2: human β-defensin-2), human β-defensin-3 (hBD3: human β-defensin-3). [12] An external preparation for skin protection comprising the accelerator for promoting the production of glycerol derived from Staphylococcus epidermidis according to items 1 to 11, and an accelerator for promoting the production of an antibacterial peptide derived from cutaneous keratinocytes of the skin. Effect of invention
本發明之藥劑或皮膚保護用外用劑可促進源自表皮葡萄球菌之甘油之產生,及作為源自皮膚表皮角化細胞之針對金黃色葡萄球菌之抗菌性胜肽的人類β-防禦素-2、人類β-防禦素-3之產生。即,藉由促進甘油之產生,可防止乾燥肌膚,又,可促進調節皮膚表面之pH值而抑制雜菌之繁殖等皮膚之保護功能。另一方面,可促進源自皮膚表皮角化細胞之針對金黃色葡萄球菌之抗菌性胜肽的產生,保護皮膚免受皮膚上之害菌損害。因此,經由該等一者或一系列之促進功能,可保持皮膚表面狀態之健康性。進一步,於應用於皮膚時為乾爽而觸感性非常優異,對水性系、油性系、乳液系、粉末系之任一類型之外用劑均可賦予感覺改善效果。The agent for external use for skin or skin protection of the present invention can promote the production of glycerol derived from Staphylococcus epidermidis, and human β-defensin-2 which is an antibacterial peptide against Staphylococcus aureus derived from skin epidermal keratinocytes. , the production of human beta-defensin-3. In other words, by promoting the production of glycerin, it is possible to prevent dry skin, and it is also possible to promote the protective function of the skin such as regulating the pH of the skin surface and suppressing the growth of the bacteria. On the other hand, it is possible to promote the production of an antibacterial peptide against S. aureus derived from skin epidermal keratinocytes, and to protect the skin from harmful bacteria on the skin. Therefore, the health of the skin surface state can be maintained via the one or a series of promoting functions. Further, when applied to the skin, it is dry and very excellent in touch, and can impart a feeling-improving effect to any of the aqueous, oily, emulsion, or powder-based external preparations.
較佳實施例之詳細說明 於本發明之促進源自表皮葡萄球菌之甘油產生的促進劑、促進源自皮膚表皮角化細胞之抗菌胜肽產生的促進劑、或皮膚保護用外用劑中,含有腸球菌屬乳酸球菌作為有效成分。以該腸球菌屬乳酸球菌為糞腸球菌、尤其是糞腸球菌EC-12之加熱處理死菌體作為較佳之態樣。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS In the present invention, an accelerator for promoting the production of glycerol derived from Staphylococcus epidermidis, an accelerator for promoting the production of an antibacterial peptide derived from epidermal keratinocytes, or an external preparation for skin protection is contained in the present invention. Enterococcus genus Lactococcus is an active ingredient. The preferred method is to use the Enterococcus genus Lactococcus as the Enterococcus faecalis, especially the heat-treating dead cells of Enterococcus faecalis EC-12.
本發明之藥劑或皮膚保護用外用劑具有如下特徵。 1.促進源自表皮葡萄球菌之甘油產生。 2.進而藉由與植物性多糖類組合使用,而協同地促進源自表皮葡萄球菌之甘油產生。 3.促進源自皮膚表皮角化細胞之針對金黃色葡萄球菌等害菌之抗菌性胜肽產生。 4.經由該等之一者或一系列之促進功能,而使保護皮膚免受乾燥等來自外界之壓力、或害菌損害之功能亢進。 5.於應用於皮膚時,為乾爽之觸感性非常優異者,對於水性系、油性系、乳液系、粉末系之任一類型之外用劑均可賦予感覺改善效果。The agent for external use of the present invention or skin protection has the following characteristics. 1. Promote glycerol production from Staphylococcus epidermidis. 2. Further, by using in combination with a vegetable polysaccharide, synergistic promotion of glycerol production derived from Staphylococcus epidermidis is promoted. 3. Promote the production of antibacterial peptides against harmful bacteria such as Staphylococcus aureus derived from skin epidermal keratinocytes. 4. The function of protecting the skin from pressure or damage from the outside, such as drying, through one of the functions or a series of promoting functions. 5. When applied to the skin, it is excellent in dry touch, and it can impart a feeling-improving effect to any of the aqueous, oily, emulsion, and powder-based external preparations.
作為腸球菌屬乳酸球菌之培養方法,亦包括先前公知之乳酸菌之培養方法,並無特別限制,加熱處理死菌體可藉由以下方法而製造。可藉由例如過濾、離心分離等方法自依照常規方法培養腸球菌屬乳酸球菌而獲得之培養物中回收菌體,水洗後將其懸浮於水等中進行加熱處理後,視需要進行濃縮、乾燥,藉此製備加熱處理死菌體。可使用通常所使用之噴霧乾燥機、冷凍乾燥機等而進行。視情形亦可於利用加熱等之殺菌處理之前後、或乾燥處理之前後進行酵素處理、界面活性劑處理、磨碎或粉碎處理,藉由該等處理而獲得者亦包括於本發明之死菌體或其處理物中。The method for culturing the bacterium of the genus Enterococci, which is a well-known method for culturing lactic acid bacteria, is not particularly limited, and the heat-treated dead cells can be produced by the following method. The cells can be recovered from the culture obtained by culturing the Enterococcus genus Lactococcus according to a conventional method by, for example, filtration, centrifugation, etc., washed with water, suspended in water or the like, heated, and then concentrated and dried as needed. Thereby, heat treatment of the dead cells is prepared. This can be carried out using a spray dryer, a freeze dryer or the like which is usually used. The enzyme treatment, the surfactant treatment, the grinding or the pulverization treatment may be carried out before or after the sterilization treatment by heating or the like, as the case may be, and the obtained by the treatment is also included in the dead bacteria of the present invention. Body or its treatment.
水洗及懸浮所使用之水除了包括純水、自來水、井水、礦泉水、礦水、溫泉水、泉水、淡水等以外,亦包括對該等實施各種處理而得者。作為對水所實施之處理,例如包括精製、加熱、殺菌、過濾、離子交換、滲透壓之調整、緩衝化等。因此,本發明中可用作萃取溶劑之水亦包括純化水、加熱處理水、離子交換水、生理食鹽水、各種緩衝液等。The water used for washing and suspending includes, in addition to pure water, tap water, well water, mineral water, mineral water, hot spring water, spring water, fresh water, etc., including those in which various treatments are carried out. The treatment to be performed on water includes, for example, purification, heating, sterilization, filtration, ion exchange, adjustment of osmotic pressure, buffering, and the like. Therefore, the water usable as the extraction solvent in the present invention also includes purified water, heat-treated water, ion-exchanged water, physiological saline, various buffers, and the like.
藉由上述方式獲得之腸球菌屬乳酸球菌可用作促進源自表皮葡萄球菌之甘油產生的促進劑、源自皮膚表皮角化細胞之針對金黃色葡萄球菌等害菌之抗菌性胜肽產生促進劑、或者經由該等一者或一系列之促進功能而保護皮膚表面狀態之健康性之皮膚保護用外用劑。The Enterococcus genus Lactococcus obtained by the above method can be used as an accelerator for promoting the production of glycerol derived from Staphylococcus epidermidis, and an antibacterial peptide production promoting against a bacterium such as Staphylococcus aureus derived from cutaneous keratinocytes. An external preparation for skin protection which protects the skin surface state by the one or a series of promoting functions.
較佳為以本發明之促進源自表皮葡萄球菌之甘油產生的促進劑、源自皮膚表皮角化細胞之抗菌性胜肽產生促進劑中每1克含有上述之加熱處理死菌體5×1011 個以上、尤佳為5×1012 個以上之方式進行懸浮製備。又,對於日常使用之皮膚保護用外用劑而言,較佳為以每次使用應用其三分之一~相同程度量之方式進行調配製備。Preferably, the accelerator for promoting the production of glycerol derived from Staphylococcus epidermidis, the antibacterial peptide production promoter derived from cutaneous keratinocytes of the skin of the present invention contains 5×10 of the above-mentioned heat-treated dead cells per gram. The suspension preparation is carried out in a manner of 11 or more, particularly preferably 5 × 10 12 or more. Further, the external preparation for skin protection which is used daily is preferably prepared by blending one-third to the same amount per application.
(皮膚保護用外用劑之形態) 本發明之皮膚保護用外用劑可列舉安瓿劑、膠囊劑、粉末劑、顆粒劑、液體劑、凝膠劑、氣泡劑、乳液劑、片劑、霧劑、噴霧劑等利用上適當之形態之1)醫藥品類、2)準藥品類、3)局部用或全身用之皮膚外用劑類(例如化妝水、乳液、乳霜、軟膏、洗劑、油劑、面膜等基礎化妝材料、固體皂、液體皂、洗手液等洗面乳或潔膚乳、按摩用劑、潔面用劑、除毛劑、脫毛劑、剃鬚處理物、鬚後水、剃鬚液、剃鬚膏、粉底、口紅、胭脂、眼影、眼線、睫毛膏等彩妝化妝材料、香水類、美甲劑、指甲油、指甲油去除劑、敷劑、硬膏劑、貼劑、片劑、貼附劑、氣溶膠劑等)、4)應用於頭皮、頭髮之藥用或/及化妝用之製劑類(例如洗髮劑、清洗劑、護髮素、洗前護髮素、定型液、染毛劑、整髮劑、養髮劑、育髮/養髮物、敷劑、硬膏劑、貼劑、片劑、氣溶膠劑等)、5)投入洗澡水中使用之浴用劑、6)以及防腋臭劑或消臭劑、止汗劑、衛生用品、衛生棉類、濕巾等。(Form of the external preparation for skin protection) The external preparation for skin protection of the present invention may, for example, be an ampule, a capsule, a powder, a granule, a liquid, a gel, a bubble, an emulsion, a tablet, an aerosol, Sprays, etc. 1) pharmaceuticals, 2) quasi-drugs, 3) topical or systemic skin external preparations (such as lotions, lotions, creams, ointments, lotions, oils, etc.) Basic makeup materials such as masks, solid soaps, liquid soaps, hand lotions and other facial cleansers or cleansing lotions, massage agents, cleansing agents, hair removal agents, depilatory agents, shaving treatments, aftershave, shaving lotion, Shaving cream, foundation, lipstick, rouge, eye shadow, eyeliner, mascara and other make-up materials, perfumes, nails, nail polish, nail polish remover, dressing, plaster, patch, tablet, patch , aerosols, etc.), 4) medicinal or/and cosmetic preparations for scalp, hair (eg shampoos, cleansers, conditioners, pre-wash conditioners, styling solutions, hair dyes) , hair styling, hair growth, hair care / hair care, dressing, plaster, patch, Tablets, aerosols, etc.), 5) bathing agents for use in bath water, 6) anti-squeaking agents or deodorants, antiperspirants, hygiene products, sanitary napkins, wipes, and the like.
(皮膚保護用外用劑之構成成分) 又,此種皮膚保護用外用劑中可視需要任意地選擇、併用以下所例示之成分或添加劑而製造,該等於配方系中之調配量並無特別規定,通常認為較佳為0.0001~50%左右。(Compositional component of the external preparation for skin protection) Further, such an external preparation for skin protection can be arbitrarily selected and used in the following exemplified components or additives, and the amount of the formulation is not particularly limited. It is generally considered to be about 0.0001 to 50%.
(1)各種油脂類 萼梨油、杏仁油、茴香油、紫蘇油、橄欖油、甜橙油、大西洋胸棘鯛油、芝麻油、可可脂、洋甘菊油、胡蘿蔔油、青瓜油、牛油脂肪酸、夏威夷核果油、紅花油、牛油樹油脂、液狀牛油樹油脂、大豆油、山茶油、玉米油、菜籽油、桃仁油、蓖麻油、棉籽油、花生油、龜油、貂油、蛋黃油、棕櫚油、棕櫚仁油、木蠟、椰子油、牛油、豬油、角鯊烯、角鯊烷、姥鮫烷或該等油脂類之氫化物(氫化油等)等。(1) various oils and fats such as avocado oil, almond oil, fennel oil, perilla oil, olive oil, orange oil, Atlantic chestnut oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid , Hawaiian stone fruit oil, safflower oil, shea oil, liquid avocado oil, soybean oil, camellia oil, corn oil, rapeseed oil, peach kernel oil, castor oil, cottonseed oil, peanut oil, turtle oil, oyster sauce, Egg butter, palm oil, palm kernel oil, wood wax, coconut oil, butter, lard, squalene, squalane, decane or a hydride of such oils (hydrogenated oil, etc.).
(2)蠟類 蜂蠟、巴西棕櫚蠟、鯨蠟、羊毛脂、液狀羊毛脂、還原羊毛脂、硬質羊毛脂、小燭樹蠟、褐煤蠟、蟲膠蠟、米糠蠟等。(2) Wax Beeswax, carnauba wax, cetyl wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice bran wax, and the like.
(3)礦物油 液態石蠟、凡士林、石蠟、地蠟(ozokerite)、純地蠟(ceresin)、微晶蠟等。(3) Mineral oil Liquid paraffin, petroleum jelly, paraffin wax, ozokerite, ceresin, microcrystalline wax, and the like.
(4)脂肪酸類 月桂酸、肉豆蔻酸、棕櫚酸、硬脂酸、山萮酸、油酸、亞麻油酸、次亞麻油酸、二十二碳六烯酸、二十碳五烯酸、12-羥基硬脂酸、十一碳烯酸、妥爾油、羊毛脂脂肪酸等天然脂肪酸、異壬酸、己酸、2-乙基丁酸、異戊酸、2-甲基戊酸、2-乙基己酸、異戊酸等合成脂肪酸。(4) fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linoleic acid, docosahexaenoic acid, eicosapentaenoic acid, Natural fatty acids such as 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isophthalic acid, caproic acid, 2-ethylbutyric acid, isovaleric acid, 2-methylpentanoic acid, 2 - Synthetic fatty acids such as ethylhexanoic acid and isovaleric acid.
(5)醇類 乙醇、異丙醇、月桂醇、鯨蠟醇、硬脂醇、油醇、羊毛脂醇、膽固醇、植固醇、苯氧基乙醇等天然醇;2-己基癸醇、異硬脂醇、2-辛基十二烷醇等合成醇。(5) Alcoholic alcohol, isopropanol, lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytol, phenoxyethanol and other natural alcohols; 2-hexyl decyl alcohol, A synthetic alcohol such as stearyl alcohol or 2-octyldodecanol.
(6)多元醇類 環氧乙烷、乙二醇、二乙二醇、三乙二醇、乙二醇單乙醚、乙二醇單丁醚、二乙二醇單甲醚、二乙二醇單乙醚、聚乙二醇、環氧丙烷、丙二醇、聚丙二醇、1,3-丁二醇、戊二醇、甘油、季戊四醇、蘇糖醇、阿拉伯糖醇、木糖醇、核糖醇、半乳糖醇、山梨糖醇、甘露糖醇、乳糖醇、麥芽糖醇等。(6) Polyols such as ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol Monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butanediol, pentanediol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactose Alcohol, sorbitol, mannitol, lactitol, maltitol, and the like.
(7)酯類 肉豆蔻酸異丙酯、棕櫚酸異丙酯、硬脂酸丁酯、月桂酸己酯、肉豆蔻酸肉豆蔻酯、油酸油酯、油酸癸酯、肉豆蔻酸辛基十二烷基酯、二甲基辛酸己基癸酯、乳酸鯨蠟酯、乳酸肉豆蔻酯、鄰苯二甲酸二乙酯、鄰苯二甲酸二丁酯、乙醯化羊毛脂、乙二醇單硬脂酸酯、丙二醇單硬脂酸酯、丙二醇二油酸酯等。(7) Ester isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleic acid ester, decyl oleate, octyl myristate Dodecyl ester, hexyl decyl dimethyl octanoate, cetyl lactic acid, myristyl lactate, diethyl phthalate, dibutyl phthalate, acetylated lanolin, ethylene glycol Stearate, propylene glycol monostearate, propylene glycol dioleate, and the like.
(8)金屬皂類 硬脂酸鋁、硬脂酸鎂、硬脂酸鋅、硬脂酸鈣、棕櫚酸鋅、肉豆蔻酸鎂、月桂酸鋅、十一碳烯酸鋅等。(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.
(9)膠質、糖類或水溶性高分子化合物 阿拉伯膠、安息香膠、丹馬膠(dammar gum)、癒創木樹脂、愛爾蘭苔(Irish moss)、刺梧桐樹膠、黃耆膠、刺槐豆膠、榅桲籽、瓊脂、酪蛋白、乳糖、果糖、蔗糖或其酯、海藻糖或其衍生物、糊精、明膠、果膠、澱粉、角叉菜膠、羧甲基甲殼素或殼聚糖、加成有環氧乙烷等環氧烷(C2 ~C4 )之羥基烷基(C2 ~C4 )甲殼素或殼聚糖、低分子甲殼素或殼聚糖、殼聚糖鹽、硫酸化甲殼素或殼聚糖、磷酸化甲殼素或殼聚糖、海藻酸或其鹽、玻尿酸或其鹽、軟骨素硫酸或其鹽、肝素、乙基纖維素、甲基纖維素、羧甲基纖維素、羧乙基纖維素、羧乙基纖維素鈉、羥基乙基纖維素、羥基丙基纖維素、硝基纖維素、結晶纖維素、聚乙烯醇、聚乙烯基甲基醚、聚乙烯基吡咯啶酮、聚乙烯基甲基丙烯酸酯、聚丙烯酸鹽、聚環氧乙烷或聚環氧丙烷等聚環氧烷或其交聯聚合物、羧乙烯聚合物、聚伸乙基亞胺等。(9) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac resin, Irish moss, karaya gum, tragacanth, locust bean gum, Quercetin, agar, casein, lactose, fructose, sucrose or its ester, trehalose or its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, Addition of hydroxyalkyl (C 2 -C 4 ) chitin or chitosan, low molecular chitin or chitosan, chitosan salt, alkylene oxide (C 2 -C 4 ) such as ethylene oxide Sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl Cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, poly Vinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide or polypropylene oxide Polyalkylene oxide or a cross-linked polymer, carboxyvinyl polymer, polyethyleneimine and the like extend.
(10)界面活性劑 陰離子界面活性劑(烷基羧酸鹽、烷基磺酸鹽、烷基硫酸酯鹽、烷基磷酸酯鹽)、陽離子界面活性劑(烷基胺鹽、烷基四級銨鹽)、兩性界面活性劑:羧酸型兩性界面活性劑(胺基型、甜菜鹼型)、硫酸酯型兩性界面活性劑、磺酸型兩性界面活性劑、磷酸酯型兩性界面活性劑、非離子界面活性劑(醚型非離子界面活性劑、醚酯型非離子界面活性劑、酯型非離子界面活性劑、嵌段聚合物型非離子界面活性劑、含氮型非離子界面活性劑)、其他界面活性劑(天然界面活性劑、蛋白質水解物之衍生物、高分子界面活性劑、含有鈦-矽之界面活性劑、氟化碳系界面活性劑)等。(10) Surfactant anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkylamine salt, alkyl quaternary Ammonium salt), amphoteric surfactant: carboxylic acid type amphoteric surfactant (amine type, betaine type), sulfate type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate type amphoteric surfactant, Nonionic surfactant (ether type nonionic surfactant, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing nonionic surfactant) Other surfactants (natural surfactants, derivatives of protein hydrolysates, polymer surfactants, surfactants containing titanium-rhodium, fluorinated carbon-based surfactants).
(11)各種維生素類 維生素A群:視網醇、視網醛(維生素A1)、脫氫視網醛(維生素A2)、胡蘿蔔素、茄紅素(原維生素A)、維生素B群:鹽酸硫胺素、硫酸硫胺素(維生素B1)、核黃素(維生素B2)、吡哆醇(維生素B6)、氰鈷胺素(維生素B12)、葉酸類、煙鹼酸類、泛酸類、生物素類、膽鹼、肌醇類、維生素C群:維生素C酸或其衍生物、維生素D群:麥角鈣化醇(維生素D2)、膽鈣化醇(維生素D3)、二氫速固醇、維生素E群:維生素E或其衍生物、泛醌類、維生素K群:植物甲萘醌(維生素K1)、甲萘醌(menaquinone)(維生素K2)、甲萘醌(menadione)(維生素K3)、甲萘二酚類(menadiol)(維生素K4)、以及必需脂肪酸(維生素F)、肉鹼、阿魏酸、γ-穀醇、乳清酸、維生素P類(芸香苷、聖草次甙、橙皮苷)、維生素U等。(11) Various vitamins and vitamin A group: retinol, retinol (vitamin A1), dehydrogenation aldehyde (vitamin A2), carotene, lycopene (original vitamin A), vitamin B group: sulfuric acid Amine, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acid, pantothenic acid, biotin , choline, inositol, vitamin C group: vitamin C acid or its derivatives, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydro tachysterol, vitamin E group : Vitamin E or its derivatives, ubiquinones, vitamin K group: phytomenadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), carbaryl Menadiol (vitamin K4), and essential fatty acids (vitamin F), carnitine, ferulic acid, γ-solanol, orotic acid, vitamin P (rutin, erionine, hesperidin) , vitamin U and so on.
(12)各種胺基酸類 纈胺酸、白胺酸、異白胺酸、蘇胺酸、甲硫胺酸、苯丙胺酸、色胺酸、離胺酸、甘胺酸、丙胺酸、天冬醯胺、麩醯胺、絲胺酸、半胱胺酸、胱胺酸、酪胺酸、脯胺酸、羥基脯胺酸、天冬胺酸、麩胺酸、羥基離胺酸、精胺酸、鳥胺酸、組胺酸等或該等之硫酸鹽、磷酸鹽、硝酸鹽、檸檬酸鹽、或吡咯啶酮羧酸之類的胺基酸衍生物等。(12) various amino acids valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, aspartate Amine, glutamine, serine, cysteine, cystine, tyrosine, valine, hydroxyproline, aspartic acid, glutamic acid, hydroxy lysine, arginine, Ornithic acid, histidine or the like or an amino acid derivative such as a sulfate, a phosphate, a nitrate, a citrate or a pyrrolidone carboxylic acid.
(13)源自植物或動物系原料之各種添加物 該等可根據欲添加之製品種別、形態而進行常規方法所進行之加工(任意選擇例如粉碎、製粉、洗淨、水解、醱酵、精製、壓榨、萃取、區分、過濾、乾燥、粉末化、造粒、溶解、殺菌、pH值調節、除臭、脫色等進行組合而成之處理),自各種素材中任意選擇而提供。(13) Various additives derived from plant or animal raw materials These can be processed by a conventional method depending on the type and form of the product to be added (arbitrarily selected, for example, pulverized, pulverized, washed, hydrolyzed, fermented, refined) , pressing, extracting, distinguishing, filtering, drying, powdering, granulating, dissolving, sterilizing, pH adjustment, deodorization, decolorization, etc., are combined and selected from various materials.
再者,關於萃取所使用之溶劑,可考慮所提供之製品之使用目的、種類、或其後進行之加工處理等後進行選擇,通常較理想為使用選自水、甲醇、乙醇、丙醇、異丙醇、丁醇、異丁醇等低級醇或含水低級醇、丙二醇、1,3-丁二醇、甘油等多元醇或含水多元醇、丙酮、乙酸乙酯等各種有機溶劑中之一種或兩種以上之混液。但根據用途於不宜含有有機溶劑之情形時,可僅使用水,或選用萃取後容易去除之乙醇,單獨使用或以與水之任意混液使用,又,亦可為榨取萃取而獲得者。Further, the solvent to be used for the extraction may be selected in consideration of the purpose of use, the type of the product to be provided, or the subsequent processing, etc., and it is usually preferred to use a solvent selected from the group consisting of water, methanol, ethanol, and propanol. a lower alcohol such as isopropanol, butanol or isobutanol or a polyhydric alcohol such as an aqueous lower alcohol, propylene glycol, 1,3-butylene glycol or glycerin or one of various organic solvents such as an aqueous polyol, acetone or ethyl acetate; Two or more kinds of mixed liquid. However, when it is not suitable to contain an organic solvent, it may be used only by using water, or ethanol which is easily removed after extraction, alone or in any mixture with water, or may be obtained by extracting and extracting.
再者,於將源自植物或動物系原料之添加物供於全身用或局部用之外用劑、化妝品類之情形時,除了可期待皮膚或頭髮之保護以及保濕、觸感/質感之改善、柔軟性之賦予、刺激之緩和、利用芳香之壓力之緩和、細胞活化(防止細胞老化)、炎症之抑制、膚質/髮質之改善、肌膚皸裂防止及其改善、生髮、育髮、防止脫髮、光澤之賦予、清潔效果、疲勞之緩和、促進血流、溫浴效果等美容效果以外,亦可期待矯味、消臭、增黏、防腐、緩衝等效果。In addition, when the additive derived from the plant or animal raw material is supplied to a systemic or topical external preparation or a cosmetic, in addition to the protection of the skin or hair and the moisturizing and tactile/texture improvement, Softness, relaxation of stimuli, relaxation of stress by aroma, cell activation (prevention of cell aging), inhibition of inflammation, improvement of skin texture/hair quality, prevention and improvement of skin splitting, hair growth, hair growth, prevention of hair loss In addition to the cosmetic effects such as the imparting of luster, the cleaning effect, the relaxation of fatigue, the promotion of blood flow, and the warm bath effect, effects such as flavor, deodorization, viscosity increase, antisepsis, and cushioning can also be expected.
進而,除此以外,可期待迄今已知之各原料素材的各種美容、藥劑效果,藉由將該等進行組合,亦可製成實現本發明之目標效果之增進、期待多功能效果之製品。Further, in addition to the above, various cosmetic and pharmaceutical effects of the raw material materials known so far can be expected, and by combining these, it is possible to obtain a product which achieves the improvement of the intended effect of the present invention and which is expected to have a multi-functional effect.
作為設為原料之具體之植物(天然藥),例如可列舉:杏仁(扁桃)、蓼藍(藍葉)、清風藤、珊瑚木、梧桐或無毛梧桐、木防己、青天麻、洋槐、紅升麻、紅醋栗「果實」、紅三葉草、紅葡萄、墨水樹(蘇木)、野梧桐(野桐)、紅茜草或西洋茜草或茜草(茜草根)、赤矢地黃或地黃(Rehmannia glutinosa)、阿魏、東亞唐松草、榔榆(榔榆皮)、Pouteria gardneriana、毛瑞櫚、通草(木通)、麻籽仁、紫花牽牛或牽牛花、繡球花(紫陽花)、明日葉、紅豆(紅小豆)、羅漢柏、西印度櫻桃(acerola)、兒茶、食用美人蕉、大茴香(anise)、加蜜蛋黃果(abiu)、abiurana、油菜、栓皮櫟「果實」、酪梨、亞麻、甘茶、七葉膽、萎蕤(玉竹)、山慈姑(光慈姑)、莧屬(Amaranthus)(莧、雁來紅、尾穗莧、仙人穀、繁穗莧、綠穗莧、反枝莧、刺莧、綠花柿蘭、千穗穀)、編笠百合或貝母、六出花(Alstromeria)、牛舌草(Alkanna tinctoria)、牧豆樹(Algarrobo)、蜀葵、山金車、草豆蔻(Alpinia katsumadai)、蘆薈、真蘆薈、當歸、杏(杏仁)、安息香、蛋黃果(yellow sapote)、地膽頭、小檗(淫羊藿(Epimedium grandiflorum))、燈心草、虎杖(虎杖根)、紫杉、草莓、無花果「果實、葉」、鳶尾(Iris tectorum)、檾麻(Abutilon avicennae)(冬葵子)、鹿蹄草、銀杏「種子、葉」、遠志(Polygala tenuifolia)、角豆、葶藶子(Draba nemorosa)、凹頭莧(Amaranthus blitum)、稻「種子、種皮」、時蘿(Anethum graveolens)「種子」、山胡椒(Thymus quinquecostatus)、蕁麻、依蘭、苦苣苔(Conandron ramondioides)、卷柏或岩松、四季豆、烏龍茶、茴香、格尼帕樹(Huito、genipap)、荊三稜(三稜)、鶯藤「果實」、藏茴香(Carum carvi)、薑黃(郁金)、水萍(浮萍)、華細辛或遼細辛或歐細辛(細辛)、錦葵(Malva sylvestris)、藥蜀葵(Althaea officinalis)、羽蝶蘭(Ponerorchis graminifolia)、夏枯草、獨活(Aralia cordata)(羌活、唐獨活)、貓爪藤(Uncaria Tomentosa)、烏瓦茶、梅(烏梅「種子、果肉」)、白背櫟(Quercus salicina)、熊葡萄葉、溫州蜜柑(陳皮)、溫朴、香艾菊、刺五加、綠花柿蘭、紫錐菊(紫錐花)、金雀花(Cytisus scoparius)、冬菇(Flammulina velutipes)、決明子(Senna obtusifolia)或決明、Hercampure、接骨木(Sambucus nigra)「果實」、欖香脂、杏鮑菇(Pleurotus eryngii)、槐(槐花、槐花米)、豌豆、黃耆、黃精(Polygonatum falcatum)、維多利亞女王龍舌蘭(Agave victoriae-reginae)、黃連、仙人掌、槭葉括樓(Trichosanthes bracteata)(括樓根)、土木香(Inula helenium)、青藤(防己)、車前子(車前草)、漏蘆(Rhaponticum uniflorum)(祁州漏蘆、白頭翁)、榛子(Corylus heterophylla)、弁慶柱(Cereus giganteus)、白術(Atractylodes macrocephala)、大花紫薇(Lagerstroemia speciosa)、旅順榿木(Alnus sieboldiana)「果實」、穀精草(Eriocaulon buergerianum)、馬米果(Pouteria sapota)、山楂子、大實椰子(Lodoicea maldivica)、大麥、酢漿草(Oxalis tuberosa)、蛇床子(Cnidium monnieri)、秋葵「果實」、歐亞旋覆花(Inula britannica)(旋覆)、禹州漏蘆(Echinops latifolius)(藍刺頭)、人參或竹節參、小連翹或貫葉連翹(Hypericum perforatum)(弟切草)、野芝麻(續斷)、蒼耳(蒼耳子)、胡桃楸(Juglans mandshurica)、山萆薢或薯蕷(Dioscorea)(萆薢)、天麻(Gastrodia elata)、卷丹百合(Lilium lancifolium)或日本百合(Lilium japonicum)或野百合(Lilium brownii)(百合)、尾上蘭(Chondradenia fauriei)、芒柄花、裂葉榆(Ulmus laciniata)、黃花龍芽、塊莖藜(Olluco)、西洋菜(Nasturtium officinale)(Cresson)、荷蘭芹(Petroselinum crispum)、補骨脂(Psoralea corylifolia)、旱芹(Apium graveolens)、油橄欖「果實、種子、葉」、牛至(oregano)、橙「果實、果皮」、熟地黃(Rehmannia glutinosa Libosch)、可可「果實、果皮、種子」、柿(柿蒂「葉」)、鉤藤(釣藤鉤)、金錢薄荷(Glechoma hederacea)(蓮錢草)、柿蘭、繡球花(Hydrangea macrophylla)、決明子、構樹(Broussonetia papyrifera)(楮實「果實」)、莪術、槲樹(槲葉)、卡藜(cascarilla)、美鼠李皮(Cascara sagrada)、霞草、柳葉旋覆花(Inula salicina)、海金沙(金沙藤)、藜(Chenopodium pallidicaule)、 康乃馨、纈草、樺、樺樹或銀樺(Betula pendula)(白樺)、非洲菊、南瓜、吉貝「種子」、花椒(Zanthoxylum bungeanum)(蜀椒)、香蒲(蒲黃)、洋甘菊或羅馬洋甘菊(Roman chamomile)、通草、卡姆果(Myrciaria dubia)、馬蹄蓮、毬果紫堇(Fumaria officinalis)、王瓜(Trichosanthes cucumeroides)、半夏(Pinellia ternata)、燕麥、瓜拿納「種子」、厚樸(Magnolia officinalis)、刺梧桐、臥龍、木瓜、藤黃果、藿香(Agastache rugosa)、委陵菜(Potentilla chinensis Ser.)(翻白草)、水苦蕒(Veronica undulata)、雲芝、石竹或瞿麥(瞿麥子)、青蒿(Artemisia apiacea)、河原蓬(茵陳蒿)、甘遂、甘草、坎塔拉龍舌蘭、小燭樹、款冬(Tussilago farfara)、美人蕉、橄欖、懸鉤子(覆盆子、荷蘭莓、白里葉莓、紅梅消、樹莓、紅懸鉤子)、幾維果「果實、葉」、黃烏瓜(括樓根)、桔梗(桔梗根)、菊(菊花、寒菊、朝鮮野菊)、甘野菊、梓樹(梓實)、羊蹄(羊蹄根)、枳實、菱葉常春藤、木立蘆薈、風輪草(Satureja)、奎寧、奎寧樹、藜麥(Chenopodium quinoa)、黃檗(黃柏)、木豆、武靴葉(Gymnema sylvestre)、六角柱仙人掌(Cereus peruvianus)、甘藍、整株甘藍「未成熟果實」、葛縷子、黃瓜、檉柳(西河柳)、皂皮樹(Quillaja saponaria)、皂樹、石鬆(金瘡小草)、金橘「果實」、金龜樹、山茶、金武扇仙人掌(Opuntia tuna)、老藤(Piper betle)、龍牙草(仙鶴草)、金蘭、銀蘭、金稜邊、Pouteria laurifolia、番石榴「果實」、灰白銀膠菊(Parthenium Argentatum)、沒食子(Quercus infectoria)、夏威夷核果、頭蕊蘭(Cephalanthera longifolia)、枸杞(枸杞子、枸杞葉、地骨皮)、天門冬、葛(葛根)、樟樹、鵝莓(Ribes uva-crispa)「果實」、黃花蒿(Artemisia annua)、Parashorea macrophylla、梔子(山梔子)、柞樹、古樸阿蘇(Theobroma grandiflorum)、蓽澄茄、熊笹草、馬鞭草、苦參、蔓越莓「果實」、板栗「種子、果實、內皮」、光葉仙茅(Curculigo Latifolia)「果實」、葡萄柚「果實、葉」、鼠李、鐵冬青(Ilex rotunda Thunb.)(救必應)、延命草、丁香(丁子香)、羅漢菜(菥蓂、菥蓂子)、荊芥(荊芥穗)、雞冠花(雞冠子)、曇花、月桂樹、土茯苓(山歸來)、龍膽、牻牛兒苗(老鸛草)、枳椇(枳椇子)、原種春石斛(Dendrobium nobile)、紀州蜜橘(Citrus kinokuni)(柑子、柑橘、甌柑、福來蜜柑、相模柑子、柚子、橘皮)、月季花、蜜蜂花(Melissa officinalis)、楮樹「果實」、紅茶、萍蓬草(川骨)、槁本、高粱、高良姜、胡荽「果實」、胡黃連、黃芩(Scutellaria baicalensis Georgi)、越橘、椰子「果實」、吳茱萸、掌葉覆盆子(Rubus chingii)(覆盆子)、胡椒、大波斯菊、古巴香脂(Copaifera officinalis)、咖啡「種子、葉」、辛夷或木蘭(辛夷)、牛蒡(牛蒡子)、女萎(Clematis apiifolia)、胡麻、玄參、五味子、南五味子或二色五味子、小麥、米或米糠「紅糠、白糠」、米糠油、蘇丹可樂果「種子」、可樂果「種子」、黃楊葉對刺藤(Coronilha)、葫蘆巴「果實」、非洲防己根、南美牛奶藤皮、海帶、蒟蒻、康富力、瓊麻(sisal fibre)、采配蘭、鳥巢蘭(北海道鳥巢蘭)、威靈仙(Clematis chinensis)、櫻(大島櫻、山櫻、大山櫻、江戶彼岸櫻、豆櫻、深山櫻、染井吉野櫻、高嶺櫻、霞櫻、小彼岸櫻、里櫻、寒櫻「葉、花、果實、樹皮(櫻皮)」)、櫻桃、石榴、細竹、長苞頭蕊蘭(Cephalanthera longibracteata)、茶梅、歐澤瀉(澤瀉)、甘薯、甘蔗、甜菜、酸棗(酸棗仁)、番紅花(西紅花)、人心果、蛋黃果(Pouteria campechiana)、朱欒「果實」、皂草、美洲大樹莓「果實」、升麻、砂藍刺頭、鼠尾草(sage)、大種半邊蓮(山梗菜)、水胡桃(山胡桃)、量天尺、秘魯龍血(巴豆)、三枝九葉草、三七人參、山茱萸、山椒、山豆根、牛油果、牛油果樹(Butyrospermum parkii)「果實」、香菇(椎茸)、 紫苑、四稜豆、洋地黃、使君子、紫蘇或綠紫蘇或縮緬紫蘇或單面紫蘇(紫蘇葉、紫蘇子)、紫檀、椴樹、厚樸樹(Magnolia officinalis)、金鐘花(連翹)、姬菇(棕灰口蘑、煙色離褶傘、荷葉離褶傘、銀白離褶傘、鴻喜菇、真姬離褶傘、玉蕈)、紫玉蘭(辛夷)、繡線菊、馬鈴薯、珊瑚菜(沙參)、茉莉(茉莉花)、沿階草(麥門冬)、長豇豆、滿天星、縮砂密(砂仁、縮砂)、川穀、棕櫚「果實」、春蘭、皇後葵、生薑、常山、菖蒲(菖蒲根)、小豆蔻「果實」、青栲「種子」、白及、白蝴蝶「種子」、白車軸草(三葉草)、雞骨草(Abrus fruticulosus)、香鳶尾(Iris florentina)、白花藤「花」、白羽扇豆、南天竹(Nandina domestica)、紅金雞納樹(Cinchona succirubra)、瑞香(瑞香花、沈丁花)、桂皮(cinnamon)、肉桂(桂皮)、西瓜、金銀花(忍冬)、酸模、Swim berry「果實」、星蘋果、甜菊、草莓「果實」、鈴柴胡(徐長卿)、木賊(問荊)、馬齒莧(馬齒莧子)、李子「果實」、建蘭(雄蘭)、歐洲赤松「毬果」、歐洲落葉松、常春藤、波斯胡桃、西洋山楂子、西洋蒲公英、歐洲七葉樹(七葉樹)、西洋梨「果實」、繡線菊、歐洲接骨木(接骨木)、歐洲刺柏(杜松)、歐蓍(西洋蓍草)、洋薔薇、續隨子、歐洲槲寄生、胡椒薄荷或香蜂草、辣根、石菖蒲(石菖根)、石斛(櫻石斛、原種春石斛、大花石斛、沖繩石斛、鐵皮石斛、蝴蝶石斛、四角石斛、黃花石斛)(石斛(dendrobium))、檸檬馬鞭草(防臭木)、錦葵、寬葉美遠志、美遠志、水芹、旱芹、川芎、穿心蓮、旃檀、縮刺仙人掌、番瀉「果實、葉」、葡萄葉鐵線蓮(大蓼)、當藥、川樸、草果、Lemaireocereus griseus、素心臘梅、蕎麥「種實」、薯莨、蠶豆、大黃、蘿蔔、大豆、酸橙(橙皮、枳實)、華東藍刺頭(東南藍刺頭)、鱧腸(旱蓮草)、大戟、金狗毛蕨(狗脊)、黑甜櫻桃「果實」、蜀葵、百里香(麝香草)、纖細薯蕷(萆薢)、立柳、羅望子「種子」、洋蔥、香辛夷(辛夷)、楤木「果實、葉、根皮」、大葉冬青(一葉茶、苦丁茶、苦燈茶)、大麗花(西番蓮)、雜色羽扇豆、痰切豆、單刺仙人掌、丹參、蒲公英或白花蒲公英或蒙古蒲公英、丹馬、櫻桃「果實」、白茅「果實、根、芽」、竹節人參、菊苣、珠子草(Phyllanthus niruri)、鬱金香、Chocolate roh stay、朝鮮薊(artichoke)、朝鮮大黃(大黃)、朝鮮蕪荑(蕪荑)、朝鮮艾(艾葉)、舞茸(豬苓)、草石蠶、月見草、Neottia kiusiana、雙孢蘑菇(蘑菇)、土通草、山茶、雷公根、爪槌草(漆姑草)、鴨蹠草、紅小豆、垂枝石斛蘭、何首烏、番杏、羊乳(四葉參)、蔓豆、橐吾、刺桐、普通胡桃、露珠莓「果實」、石花菜、甜茶、天臺烏藥(烏藥)、冬瓜(冬瓜子)、華鉤藤、辣椒(番椒)、當歸、金盞花(marigold)、皂莢、川續斷(川斷)、玉米或玉米鬚(玉蜀黍鬚)、女貞(女貞子)、龍膽或朝鮮龍膽、木賊、魚腥草、吐根、菟絲子或無根葛、杜仲「樹皮、葉、根」、梣(秦皮)、番茄、黃芪、皂莢「種子」、洋桔梗、洋委陵菜、遼楊、木芙蓉、零陵香豆、Niger berry「果實」、家山芋或山藥、假葉樹(butcher's broom)、香薷、薺菜、菜籽、刀豆、酸橙、棗(大棗)、金櫻子、續斷、樸蕈、花生(落花生)、南天竹(南天竹果實)、苧麻、香堇、苦木、苦艾、肉豆蔻、桂樹或肉桂或錫蘭肉桂或天竺桂(桂皮)或桂枝、Orchis joo-iokiana、韭蔥(韭子)、接骨木「果實、花、莖、葉」、蒜(大蒜)、鹽膚木(五倍子)、蔥、合歡樹或合歡或地獄花、野薊(大薊)、野薔薇(營實)、紫葳(淩霄花)、野雞冠、歐蓍草、土當歸(前胡)、野薔薇、碧桃、鳳梨「果實」、木槿(朱槿、吊燈扶桑、洛神花)、斜升秦艽、羽扇、Glycoxylon praealtum、槲蕨(骨碎補)、白花油麻藤、Orchis aristata、白癬皮、酸越橘「果實」、繁縷、榛(榛子)、東莨菪(莨菪根)、羅勒、蓮(蓮肉、蓮子)、洋芫荽(荷蘭芹)、裸麥、番薯、淡竹或苦竹(竹茹)、天主薄荷、薄荷(薄荷葉)、八升豆、薏苡(薏苡仁)、知母、香蕉、牛至、花菱草(蒺藜、刺蒺藜)、香莢蘭豆、番木瓜、鼠曲草、Paharobobo、波布草「全草、莖、葉」、紅辣椒、細毛火燒蘭、單葉蔓荊或三葉蔓荊(蔓荊子)、香附子、蒺藜(蒺藜子)、玫瑰(玫瑰花)、珊瑚菜(濱防風)、金縷梅、棕櫚、薔薇、巴拉塔、巴拉塔樹、食用傘菌(馬蘑菇、球基蘑菇)、蜘蛛抱蛋、青錢柳(濱棗)、牆草、春寒蘭、苦瓜(蔓荔枝)、春榆(榆皮、榆白皮、榆葉)、尼古矛果(Lonchocarpus nicou)、春龍膽、胖大海、麵包樹、射干、素花黨參(黨參)、碧根果、彼岸花(石蒜、曼珠沙華)、紅大麗花、糙毛藍刺頭、菱(菱實)、阿月渾子、糖蘿蔔、石葦、染料木、雛菊(延命菊)、牛膝、Orchis chidori、扁柏、扁柏葉、蓖麻、向日葵、甜椒、天葵、香蒲、姬松茸(Agaricus blazei Murrill)、尖唇鳥巢蘭、多香果「果實」、白芷、白芨、莧菜「果實」、鷹嘴豆、小扁豆、藥蜀葵、白頭翁、枇杷「果實、葉、莖」、檳榔(大腹皮、檳榔子)、普洱茶(普洱茶)、細葉青蔞藤(南藤)、蜂鬥菜、款冬蒲公英(款冬花、款冬葉)、澤蘭(蘭草)、菜豆(扁豆)、芫花(丁字櫻、芫花)、葡萄「果實、果皮、種子、葉」、山毛櫸、蟲草(冬蟲夏草)、巴西甘草、巴西人參、巴西椰子、巴西象牙果、黑加侖「果實」、黑莓、Pradosia lactescens、洋李「果實」、Furcellariaceae、藍莓(西洋越橘)、西梅、Floral blanca、洋車前草、文豆(綠豆)、榛子、絲瓜、鳳蘭、紅花、黃條龍舌蘭、顛茄、莓「果實」、鱷梨、Peruvianberg、櫻麒麟、景天、加州黑莓「果實」、地膚或掃帚草(地膚子)、報歲蘭、鳳仙花(鳳仙、急性子、透骨草)、馬米果、蛋黃果、日本厚樸、防風、菠菜、酸漿、日本厚朴(樸)、木瓜、細裂野菊(苦薏)、條葉旋覆花、蒼術、細葉費菜(景天三七)、狹葉紫錐菊、菩提樹、牡丹「花、葉、莖、樹皮」、牡丹皮、忽布、荷荷芭、琉璃苣、波耳多葉(Boldo)、鳥嘴莓「果實」、鹽生肉蓯蓉(肉蓯蓉、大芸)、鐵皮石斛(霍山石斛)、羽葉天南星(天南星)、舞茸、麻黃、瑪卡、夏威夷果、瑪格麗特花(木春菊)、鷓鴣菜(海人草)、白桑(桑白皮「樹皮、葉」)、武當玉蘭、巴拉塔樹、Massaranduba rufula、Sideroxylon rugosum、塊莖金蓮花(Tropaeolum tuberosum)(球根金蓮花)、木天蓼、松球、松「葉、樹皮、根」、Pouteria salicifolia、雲苓(茯苓)、狹葉胡椒樹(Piper angustifolium)、墨角蘭(牛至)、柳葉沙參(苦參)、桑椹「果實」、榅桲樹、毛蕊花(Verbascum thapsus)、芒果、莽吉柿、洋甘菊(安第斯洋甘菊)、胡桃楸、柑橘「果實」、靈芝、枳實「果實」、三島柴胡(柴胡)、水車前(龍舌草)、半邊蓮(Lobelia chinensis)、日本千屈菜(千屈菜)、扁蓄、睡菜、鴨兒芹、綠美果欖、綠薄荷、含羞草、蘘和、神秘果「果實」、沒藥、呵梨勒、蠟菊、木槿、糙葉樹、無患子(延命皮)、Muna(Minthostachys mollis)、紫丁香(紫根)、紫珠或日本紫珠、紫玉米、老荊藤(昆明雞血藤)、Opuntia Megacantha、益母草、羅勒、白千層、蜜蜂花、黃香草木樨、甜瓜「果實」、蒙古艾、孟宗竹、木麒麟、乳香木(Schinus molle)、細葉冬青、木香、掌葉大黃、桃「葉、種子、花、果實」、豆芽、莫利洛黑櫻桃「果實」、長蒴黃麻(黃麻)、紫薯、益智、鬼燈檠(矢車菊)、擬美國薄荷、雪蓮果、夜叉五倍子(矢車)或垂榿木或旅順榿木「果實、果皮、果穗」、洋楊梅、八角金盤、槲寄生(柳寄生)、柳(杞柳、立柳、垂柳、腺柳、褪色柳、綿柳、絹柳、尖葉紫柳、雲龍柳、深山柳、椰子、山柳、大葉柳、蒿柳、狐色柳(Salix vulpina)、遼楊)、水柳蓼「葉、莖」、烏蘞莓、紫金牛、天名精(鶴虱、天名精)、商陸、遼東榿木(Alnus hirsuta)、楊梅(楊梅皮)、艾蒿、桉樹、虎耳草、絲蘭或短葉絲蘭、柚「果實」、百合、白芷、艾(艾葉)、雷丸、酸橙「果實」、黑麥、羅漢果「果實」、懸鉤子「葉、果實」、秘魯拉坦尼(Krameria triandra)、藠頭或亞實基隆蔥(薤白)、薰衣草、龍眼(龍眼肉)、龍舌蘭(青龍舌蘭、覆輪龍舌蘭)、綠茶、蘋果「果實、種子、葉、根」、龍膽、甜茶懸鉤子(rubus suavissimus)、硬葉藍刺頭(琉璃玉薊、新疆藍刺頭)、荔枝(荔枝核)、萵苣、紅加侖「果實」、紅龍果、檸檬「果實」、檸檬草、金鐘花(連翹)、紫雲英、臘梅、臘椰子、蘆根(葦子)、大楊梅「果實」、迷迭香、玫瑰果(野薔薇)、山崳菜、密蒙花、地榆等。Specific examples of the plant (natural medicine) to be used as a raw material include almond (almond), indigo (blue leaf), breeze, coral, paulownia or paulownia, wood defense, qingtianma, artichoke, and red liter. Hemp, red currant "fruit", red clover, red grape, ink tree (hematoxylin), wild paulownia (wild paulownia), red sedge or yarrow or yarrow (grass root), red radix rehmannia or rehmannia (Rehmannia Glutinosa), Awei, East Asian T. chinensis, medlar (skin), Pouteria gardneriana, Maurui Palm, Tongcao (Mutong), Hemp Seed, Purple Flower, Morning Glory, Morning Glory, Hydrangea (Ziyanghua), Tomorrow Leaf, Red Bean ( Red Bean), Rohan cypress, Acerola, catechin, canna, anise, abiu, abiurana, rape, cork “fruit”, avocado, flax, sweet tea , esculentus, wilting (Yuzhu), Shanci Gu (Guangzigu), Amaranthus (Amaranthus) (苋, Yanlaihong, Taisui, Xianren Valley, Shiyan, Green Spike, Anti-branches, Hedgehog, Green Persimmon, Chiba Valley), Lily or Fritillaria, Alstromeria, and Betula (Alka) Nna tinctoria), Algarrobo, hollyhock, arnica, Alpinia katsumadai, aloe vera, real aloe vera, angelica, apricot (almond), benzoin, yellow sapote, gentian head, small E (Epimedium grandiflorum), rush grass, Polygonum cuspidatum (polygonum cuspidatum), yew, strawberry, fig "fruit, leaf", iris (Iris tectorum), ramie (Abutilon avicennae) (witch), deer Hoof grass, ginkgo "seed, leaf", Polygala tenuifolia, carob, scorpion (Draba nemorosa), Amaranthus blitum, rice "seed, seed coat", Aloehum graveolens "seed , Thymus quinquecostatus, ramie, ylang-ylang, Conandron ramondioides, Selaginella or rock pine, green beans, oolong tea, fennel, genipap (Huito, genipap), Jing Sanling (triangle) ), 莺藤 "fruit", fennel (Carum carvi), turmeric (turmeric), hydrang (duckweed), huaxinxin or liaxinxin or eusin (asaxin), malva (Malva sylvestris) , Althaea officinalis, Ponerorchis graminifolia, summer Grass, Aralia cordata (羌活, 唐独活), Uncaria Tomentosa, Uwa tea, plum (Ume "seed, flesh"), White-backed Quercus salicina, Bear grape leaf, Wenzhou mandarin orange (Chen's skin), Wenpu, Acacia, Acanthopanax, Green Persimmon, Echinacea (Echinacea), Cytisus scoparius, Flammulina velutipes, Senna obtusifolia or Ming, Hercampure, Sambucus nigra "fruit", eucalyptus, Pleurotus eryngii, 槐 (槐花, 槐花米), pea, scutellaria, Polygonatum falcatum, Queen Victoria Agave victoriae-reginae, berberine, cactus, Trichosanthes bracteata (including roots), Inula helenium, vine (anti-self), psyllium (Plantago), stagnation ( Rhaponticum uniflorum), Corylus heterophylla, Cereus giganteus, Atractylodes macrocephala, Lagerstroemia speciosa, Alnus sieboldiana, fruit Cereal grass (Eriocaulon b Uergerianum), Pouteria sapota, hawthorn, Lodiicea maldivica, barley, Oxalis tuberosa, Cnidium monnieri, okra "fruit", Eurasian flower (Inula) Britannica), Echinops latifolius (blue thorn), ginseng or bamboo ginseng, small forsythia or Hypericum perforatum (died cut grass), wild sesame (continued), Xanthium ( Xanthium), Juglans mandshurica, Hawthorn or Dioscorea (萆薢), Gastrodia elata, Lilium lancifolium or Lilium japonicum or Lilium brownii (Lily), Chondradia fauriei, Mangium flower, Ulmus laciniata, yellow dragon bud, Olluco, Nasturtium officinale (Cresson), Parsley (Petroselinum crispum), Psoralea corylifolia, Apium graveolens, olive "fruit, seed, leaf", oregano, orange "fruit, peel", Rehmannia glutinosa Libosch, cocoa "fruit, peel" Species , Persimmon (Persimmon "Leaf"), Uncaria (fishing hook), Glechoma hederacea (Lianqian), Persimmon, Hydrangea macrophylla, Cassia, Broussonetia papyrifera (楮 「 "fruit"), 莪 槲, eucalyptus (槲叶), cascarilla, Cascara sagrada, Xia Cao, Inula salicina, Haijinsha (金沙藤), Op (Chenopodium pallidicaule), carnation, valerian, birch, birch or Betula pendula (white birch), gerbera, pumpkin, jibe "seed", Zanthoxylum bungeanum (蜀 pepper), cattail (Pulver ), Chamomile or Roman chamomile, through grass, Myrciaria dubia, calla lily, Fumaria officinalis, Trichosanthes cucumeroides, Pinellia ternata, oats, melon Naina "Seed", Magnolia officinalis, Robinia pseudoacacia, Wolong, Papaya, Garcinia Cambogia, Agastache rugosa, Potentilla chinensis Ser. (White Grass), Water Bitter ( Veronica undulata), Yunzhi, Dianthus or Buckwheat (瞿 wheat) Artemisia apiacea, Heyuan Peng (Yin Chen), Ganzi, licorice, Cantala agave, candel tree, coltsfoot (Tussilago farfara), canna, olive, raspberry (raspberry, Dutch raspberry, White berry, red plum, raspberry, red raspberry), kiwi fruit "fruit, leaf", yellow squash (including root), platycodon (platform stem), chrysanthemum (chrysanthemum, chrysanthemum, Korean wild chrysanthemum), Gan Wild chrysanthemum, eucalyptus (salty), sheep's hoof (sheep hoof), medlar, ivy, ivy, Satureja, quinine, quinine, buckwheat (Chenopodium quinoa), jaundice (cork) ), pigeonpea, Gymnema sylvestre, Cereus peruvianus, cabbage, whole cabbage "immature fruit", caraway, cucumber, Tamarix (Xiheliu), saponaria (Quillaja saponaria) ), soap tree, stone pine (gold sore grass), kumquat "fruit", golden tortoise tree, camellia, Opuntia tuna, Piper betle, dragon tooth grass, golden orchid, silver Orchid, gold edge, Pouteria laurifolia, guava "fruit", gray and silver (Parthenium Argentatum), Quercus infectoria, Hawaiian drupe, Cephalanthera longifolia, medlar (scorpion, loquat leaf, ground bone), Asparagus, Ge (Pueraria), Eucalyptus, Gooseberry (Ribes uva-crispa) "fruit", Artemisia annua, Parashorea macrophylla, scorpion (Hawthorn), eucalyptus, Theobroma grandiflorum, 荜 茄, 笹 笹, verbena, Kushen, cranberry "fruit", chestnut" Seeds, fruits, endothelium, Curculigo Latifolia "fruit", grapefruit "fruit, leaf", buckthorn, iron holly (Ilex rotunda Thunb.) (salvation), sylvestris, clove (Ding Zixiang ), Luo Hancai (菥蓂, 菥蓂子), Nepeta (Schizonepeta), Celosia (Chicken), 昙花, Laurel, Bandit (Mountain Return), Gentian, Yak Seedling (Laoshan),枳椇 (枳椇子), the original species Dendrobium nobile, Citrus kinokuni (citrus, citrus, ponkan, citrus, citrus, grapefruit, orange peel), rose flowers, melissa ( Melissa officinalis), eucalyptus "fruit", black tea, palm grass ( Chuan Bone), Sakamoto, Sorghum, Galangal, Husong "fruit", Hu Huanglian, Scutellaria baicalensis Georgi, Bilberry, Coconut "fruit", Wusong, Raspberry cherries (Raspberry) , pepper, cosmos, Cuban balsam (Copaifera officinalis), coffee "seed, leaf", Magnolia or Magnolia (Xinyi), Burdock (Arctium sinensis), Female wilt (Clematis apiifolia), Flax, Scrophulariaceae, Schisandra, Schisandra Or schisandra, wheat, rice or rice bran "red peony, white peony", rice bran oil, Sudan cola fruit "seed", cola fruit "seed", boxwood leaves against vines (Coronilha), fenugreek "fruit", African anti-root, South American milk cane skin, kelp, medlar, Kang Fuli, sisal fibre, plucking orchid, bird's nest orchid (Hokkaido bird's nest orchid), Clematis chinensis, cherry blossom (Oshima cherry, mountain cherry, Dashan Sakura, Edo Sakura, Bean Sakura, Sakura Sakura, Sakura Yoshino Sakura, Kaolin Sakura, Kasama Sakura, Sakura Sakura, Sakura Sakura, Han Sakura "Leaf, Flower, Fruit, Bark (Sakura)", Cherry, Pomegranate, fine bamboo, long taro (Cephal) Anthera longibracteata), Chamei, Ou Zexie (Aesthesia), sweet potato, sugar cane, sugar beet, jujube (sautary jujube kernel), saffron (saffron), sapodilla, puffer fruit (Pouteria campechiana), cinnabar "fruit", soap Grass, American raspberry "fruit", cohosh, sand blue thorn, sage, large species of lobelia (mountain), water walnut (mountain), measuring scale, Peruvian dragon blood (croton) , three-leaf clover, panax notoginseng, hawthorn, mountain pepper, mountain bean root, avocado, avocado tree (Butyrospermum parkii) "fruit", shiitake mushroom (shii), asters, wings, digitalis, gentian, perilla or Green Perilla or Burmese Perilla or Single-sided Perilla (Perilla, Perilla), Rosewood, Eucalyptus, Magnolia officinalis, Admiralty (Forsythia), Shimeji (Brown-gray mushroom, smoke-colored pleated umbrella, Lotus leaf pleated umbrella, silver-white pleated umbrella, Hongxi mushroom, Zhenji pleated umbrella, maize, purple magnolia (Xinyi), spirea, potato, coral (salvia), jasmine (jasmine), along the order Grass (Maimendong), long kidney beans, starry sky, shrinking sand (Amomum, sand), Sichuan Valley, palm "fruit" Chunlan, Queen's Sunflower, Ginger, Changshan, Calamus (Calendula), Cardamom "fruit", green stalk "seed", white and white butterfly "seed", white clover (clover), chicken bone grass (Abrus fruticulosus ), Iris florentina, white flower vine "flower", white lupin, Nandina domestica, Cinchona succirubra, ruixiang (Ruixianghua, Shending), cinnamon (cinnamon), cinnamon ( Cinnamon), watermelon, honeysuckle (Lonicera), sorrel, Swim berry "fruit", star apple, stevia, strawberry "fruit", jingchaihu (Xu Changqing), thief (Qi Jing), purslane (purslane) ), plum "fruit", Jianlan (Xionglan), European red pine "fruit", European larch, ivy, Persian walnut, Western hazelnut, western dandelion, horse chestnut (conker), western pear Fruit", spirea, European elderberry (sambucus), European juniper (Juniper), European yam (western yarrow), yam, succulent, European mistletoe, peppermint or lemon balm, spicy Root, Shichangpu (Shijiegen), Shijie (Sakura 斛, original spring 斛, large Dendrobium, Okinawa Dendrobium, Dendrobium Dendrobium, Butterfly Dendrobium, Dendrobium Dendrobium, Dalbergia sinensis (dendrobium), lemon verbena (deodorant wood), mallow, broadleaf Meiyuanzhi, Meiyuanzhi, cress, celery, Chuanxiong , Andrographis paniculata, 旃 、, 刺 刺 cactus, senna "fruit, leaf", grape leaf clematis (Da 蓼), medicine, Chuan Pu, grass fruit, Lemaireocereus griseus, vegetarian heart plum, buckwheat "plant", potato Earthworms, broad beans, rhubarb, radish, soybeans, limes (orange peel, medlar), East China blue thorns (southern blue thorns), sputum (Eclipta prostrata), scorpion, golden dog hair fern (dog ridge) ), black sweet cherry "fruit", hollyhock, thyme (thyme), slender potato (萆薢), Liliu, tamarind "seed", onion, fragrant Xinyi (Xinyi), eucalyptus "fruit, leaf, root bark" , big leaf holly (one leaf tea, Kuding tea, bitter tea), dahlia (passiflora), variegated lupin, 痰 cut bean, single thorn cactus, salvia, dandelion or white flower dandelion or Mongolian dandelion, Danma, cherry "fruit", white stalk "fruit, root, bud", bamboo ginseng, chicory, bead grass (Phy Llanthus niruri), tulip, chocolate roh stay, artichoke, rhubarb (rhubarb), artichoke (artichoke), artichoke (芜荑), phoenix (Ai Ye), maitake (swine), grass worm, evening primrose , Neottia kiusiana, Agaricus bisporus (mushroom), Tutong grass, Camellia, Leigonggen, Xenopus laevis (lacquered grass), comfrey, red adzuki bean, Dendrobium chinensis, Polygonum, Apricot, goat milk (four leaves ), vine beans, lycopene, thorns, common walnuts, dew raspberry "fruit", stone cauliflower, sweet tea, Tiantai medicinal herbs (black medicinal), winter melon (winter melon), Huateng vine, chili (fan pepper), angelica , marigold, acacia, chuanchuan (chuanchuan), corn or corn mustard (maize), privet (femata), gentian or Korean gentian, wood thief, houttuynia, ipecac, dodder or Rootless, Eucommia bark, leaf, root, alfalfa (Qinpi), tomato, scutellaria, acacia "seed", eustoma, ocean sylvestris, Liaoyang, Mu Furong, Lingling Bean, Niger berry "fruit", Home yam or yam, butcher's broom, citron, leeks, rapeseed, bean, lime, jujube (jujube), Sakurako, Dioscorea, Park, Peanut (Rallow Peanut), Nantianzhu (South Tianzhu Fruit), Castor, Citron, Bitter Wood, Absinthe, Nutmeg, Gui or Cinnamon or Ceylon Cinnamon or Tiangui Gui (Cinnamon) or Gui Branch, Orchis joo-iokiana, leek (scorpion), elderberry "fruit, flower, stem, leaf", garlic (garlic), salted wood ( Gallic), onion, acacia or acacia or hell flower, wild donkey (大蓟), wild rose (camp), purple 葳 (霄霄花), pheasant crown, yarrow, earth angelica (formerly Hu), wild rose, green peach, pineapple "fruit", hibiscus (Zhu, chandelier Fusang, Luoshen Flower), slanted scorpion, lupin, Glycoxylon praealtum, scorpion fern (Bone scutellaria), white flower sphagnum, Orchis aristata, white sable, sour bilberry "fruit", sorghum, scorpion (scorpion), scorpion ), basil, lotus (lian, lotus), artichoke (parsley), rye, sweet potato, light bamboo or bitter bamboo (bamboo), mint, mint (mint), eight liters of beans, glutinous rice , Zhimu, banana, oregano, California poppy (蒺藜, hedgehog), vanilla bean, papaya, rat grass, Paharobobo, Bob "All grass, stems, leaves", red peppers, fine-brown fire-burning orchids, single-leaved vines or three-leaf vines (vines), fragrant aconite, medlar (scorpion), rose (rose), coral (side Windproof), witch hazel, palm, rose, balata, balata, edible toadstool (horse mushroom, ball-based mushroom), spider egg, green money willow (binzao), wall grass, spring cold orchid, Bitter gourd (vine lychee), spring 榆 (榆皮, 榆白皮, 榆 leaf), 尼古矛果 (Lonchocarpus nicou), spring gentian, fat sea, bread tree, shoot dry, vegetarian flower Codonopsis (codonopsis), Pecan , Bianhuahua (Rye and Garlic, Manzhu Shahua), Red Dahlia, Rough Blue Thorn, Rhombus (Rose), Pistachio, Sugar Radish, Dendrobium, Dye Wood, Daisy (Marguerite), Achyranthes, Orchis chidori , cypress, cypress leaf, ramie, sunflower, sweet pepper, sunflower, cattail, Agaricus blazei Murrill, sharp-skinned bird, allspice "fruit", white peony, white peony, leeks "fruit", chickpea , lentils, hollyhocks, pulsatilla, medlar, "fruit, leaves, stems", betel nut (big belly, betel nut), Pu'er tea (Pu'er tea) Phyllostachys pubescens (Nanteng), butterbur, winter dandelion (cold winter, coltsfoot), Zeeland (bluegrass), kidney bean (lentil), silk flower (t-sakura, silk flower), grape "fruit, peel" , seeds, leaves, beech, Cordyceps (Cornoptera), Brazilian licorice, Brazilian ginseng, Brazilian coconut, Brazilian ivory, blackcurrant "fruit", blackberry, Pradosian lactescens, plum "fruit", Furcellariaceae, blueberry (western orange ), prune, Floral blanca, psyllium, wendou (mung bean), hazelnut, loofah, phoenix, safflower, yellow agave, belladonna, raspberry "fruit", avocado, Peruvianberg, cherry unicorn, sedum , California blackberry "fruit", Kochia or broom grass (Kochia scoparia), venomous orchid, impatiens (phoenix, acute, stalk), horseberry, yolk, Japanese magnolia, wind, spinach, physalis , Japanese Magnolia (Pak), Papaya, Trichosanthes (Bitter Bitter), Lobular Insect, Atractylodes, Fine Leaf (Dingye Sanqi), Echinacea, Bodhi, Peony "Flower, Leaf, Stem , bark, peony, virgin, jojoba, borage, pollo (Boldo), Beet Raspberry "fruit", salt raw Cistanche (Cistanche, Dendrobium), Dendrobium Dendrobium (Huoshan Dendrobium), Yuye Tiannanxing (Tiannan Star), Maitake, Ephedra, Maca, Macadamia, Margaret Special flower (wood chamomile), amaranth (sea man grass), white mulberry (mulberry white bark, bark), Wudang magnolia, balata tree, Massaranduba rufula, Sideroxylon rugosum, Tropaeolum tuberosum ( Bulbous Golden Lotus), Wood Scorpio, Pine Ball, Pine "Leaf, Bark, Root", Pouteria salicifolia, Cloud 苓 (茯苓), Piper angustifolium, Marjoram (Oregano), Salix (Bitter ginseng), mulberry "fruit", eucalyptus, verbascum thapsus, mango, sage, chamomile (andean chamomile), walnut, citrus "fruit", ganoderma lucidum, citrus "fruit", Mishima Hu (Bupleurum), waterwheel front (grass), Lobelia chinensis, Japanese lyrics (Kalli), flat storage, sleeping vegetables, duck celery, green beauty, green mint, mimosa , 蘘和, mysterious fruit "fruit", myrrh, 梨梨勒, helichrysum, hibiscus, rough leaf Tree, Sapindus (Derived Skin), Muna (Minthostachys mollis), Lilac (Purple Root), Purple Beads or Japanese Purple Beads, Purple Corn, Old Jingteng (Kunming Spatholobus), Opuntia Megacantha, Motherwort, Basil, Melaleuca , melissa, yellow vanilla hibiscus, melon "fruit", Mongolian AI, Mengzong bamboo, wood unicorn, scented wood (Schinus molle), fine leaf holly, woody, palm leaf rhubarb, peach "leaf, seed, flower, fruit" , bean sprouts, Morillo black cherry "fruit", long jute jute (jute), purple potato, puzzle, ghost lamp (vector), immortal mint, holly, night fork gallnut (yellow) or cocoon Or Lushun Elm "fruit, peel, ear", Yang Bayberry, aniseed golden plate, mistletoe (willow parasitic), willow (willow, willow, weeping willow, glandular willow, pussy willow, cotton willow, willow, sharp purple Willow, Yunlongliu, Deep Mountain Willow, Coconut, Mountain Willow, Big Leaf Willow, Artemisia, Willow Vulpina, Liaoyang), Water Willow, Leaf, Stem, Blackberry, Purple Golden Cattle, Tianmingjing (Heqi, Tianmingjing), Shanglu, Alnus hirsuta, Yangmei (yangmeipi), mugwort, eucalyptus , Saxifrage, yucca or short-leaf yucca, pomelo "fruit", lily, white peony, AI (Ai Ye), Lei Wan, lime "fruit", rye, mangosteen "fruit", raspberry "leaf, fruit , Krameria triandra, Taro or Ashkelon (white), lavender, longan (longan meat), agave (green agave, agave), green tea, apple "fruit, Seeds, leaves, roots, gentian, sweet tea raspberry (rubus suavissimus), hard leaf blue thorn head (glazed jade, Xinjiang blue thorn head), litchi (Litchi nucleus), lettuce, redcurrant "fruit", red dragon Fruit, lemon "fruit", lemon grass, Admiral flower (Forsythia), Chinese milk vetch, wax plum, waxed coconut, reed root (scorpion), big bayberry "fruit", rosemary, rose hip (wild rose), hawthorn, Mi Menghua, cellar, etc.
作為海藻類,可列舉以下作為具有代表性者:海藻[綠藻類:普通小球藻(Chlorella vulgaris)、蛋白核小球藻(Chlorella pyrenoidosa)、橢圓小球藻(Chlorella ellipsoidea)、滸苔(緣管滸苔(Enteromorpha linza)、海藻滸苔(Enteromorpha prolifera)、扁滸苔(Enteromorpha compressa)、腸滸苔(Enteromorpha intestinalis)、多毛滸苔(Enteromorpha crinita))、孔石蓴(石蓴)]、海藻[褐藻類:海帶(真海帶(Laminaria japonica)、利尻海帶(Laminaria ochotensis)、皺海帶(Laminaria religiosa)、狹葉海帶(Laminaria angustata))、裙帶菜、闊葉裙帶菜、綠裙帶菜、巨藻類(巨藻(Macrocystis pyrifera)、全緣葉巨藻(Macrocystis integrifolia)、腔囊藻(Macrocystis integrifolia))、羊棲菜、墨角藻、樹狀團扇藻、南方團扇藻、P.australis var. cuneata、包氏團扇藻、大團扇藻、日本團扇藻、小團扇藻、具柄團扇藻]、海藻[紅藻類:山茶花、石花菜、扁平石花菜、日本石花菜、雞毛菜、翼枝菜、硬毛矢氏藻、粗石花菜、匍枝凝花菜、雞冠菜、鋸齒麒麟菜、對生麒麟菜、麒麟菜、柏狀麒麟菜、角叉菜、巨角叉菜、皺波角叉菜(Chondrus crispus)、楔形角叉菜、刺狀角叉菜、羽片角叉菜、長角叉菜、異色角叉菜、日本角叉菜、羽片角叉菜、杉藻、紅軟刺藻、小杉藻、扇形頂群藻、具鉤頂群藻、細脈頂群藻、頂群藻、紅葉藻]等。As the seaweed, the following are exemplified: seaweed [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidea, Brassica (margin) Enteromorpha linza, Enteromorpha prolifera, Enteromorpha compressa, Enteromorpha intestinalis, Enteromorpha crinita, and sarcophagus (Dendrobium) Seaweed [Brown algae: kelp (Laminaria japonica), Laminaria ochotensis, Laminaria religiosa, Laminaria angustata), wakame, broadleaf wakame, green wakame, giant Algae (Macrocystis pyrifera, Macrocystis integrifolia, Macrocystis integrifolia), Sargassum fusiformis, Fucus algae, Dinoflagellates, Southern fanfish, P.australis var. cuneata, Cyanobacteria, large group of fan algae, Japanese group fan algae, small group fan algae, stalked fan algae], seaweed [red algae: camellia, stone cauliflower, flat stone cauliflower, Japanese cauliflower Chicken, Brassica, Hardy, Algae, Litchi, Litchi, Chick, Eucalyptus, Eucheuma, Eucheuma, Eucheuma, Carrageen, Giant Carrageen, Wrinkle Chondrus crispus, wedge-shaped carrageen, thorny carrageen, pinch carrageen, long carrageen, heterochromic carrageen, Japanese carrageen, pinch carrageen, cedar, Red soft thorn algae, small cedar algae, scalloped algae, algae with algae, algae, algae, red leaf algae, etc.
又,亦可列舉其他藻類,例如:綠藻類(衣藻屬:衣藻、極地雪藻、杜氏藻屬:杜氏藻、原綠球藻屬:原綠球藻、實球藻屬:實球藻、團藻屬:團藻(Volvox)、四集藻屬、四孢藻屬、水綿屬:轉板藻、水綿、竹枝藻屬、絲藻屬:絲藻、石蓴屬:孔石蓴、網石蓴、阿氏石蓴、溪菜屬:溪菜、費氏藻屬、剛毛藻屬:日本剛毛藻、薩氏剛毛藻、團集剛毛藻、毬藻、法囊藻屬:大泡法囊藻、法囊藻、香蕉菜屬:香蕉菜、蕨藻屬:厚葉蕨藻、總狀蕨藻、鋸葉蕨藻、剖刀狀蕨藻、羽藻屬、松藻屬:刺松藻、亞筒狀松藻、縊縮松藻、長松藻、扁平松藻、傘藻屬:琉球傘藻、硬毛藻屬:螺旋硬毛藻、珠狀硬毛藻、崗村硬毛藻、新月藻屬、莢毛藻屬、鼓藻屬、網球藻屬:網球藻、礁膜屬:礁膜、寬礁膜、格氏礁膜、薄科氏藻、鞘藻屬、盤星藻屬、橘色藻屬:橘色藻、雙星藻屬、無隔藻屬等)。Further, other algae may be mentioned, for example, green algae (Chlamydomonas: Chlamydomonas, Polar algae, Dunaliella: Dunaliella, Prototheca: Prototheca, S. cerevisiae: Shigella , group algae: Volvox, four algae, four-spore, genus: spirulina, water cotton, bamboo genus, genus: silk algae, sarcophagus: Kong Shizhen , Net sarcophagus, Ashishi sarcophagus, brook genus: brook, genus of genus, genus Cladosporium: Japanese clostridium, C. serrata, clumps, genus, algae, cyanobacteria: large bubble method Cyanobacteria, cyanobacteria, and banana genus: banana, fern, pteridophyte, pteridophyte, serrata, pterygium, genus, genus: thorn , sub-cylindrical pine algae, coniferous pine algae, long pine algae, flat pine algae, cyanobacteria: Phytophthora, genus Chaetoceros: Helicobacter pylori, Phyllostachys hirsutum, Phyllostachys pubescens, new Phyllostachys genus, genus Chaetoceros, genus Cyanophyta, cyanobacteria: tennis cyanobacteria, reef genus: reef membrane, wide reef membrane, Gu's reef, thin kohlrabi, spirulina, Panaxella, Orange algae: orange algae, double star Genera, no algae are separated, etc.).
藍藻類(隱桿藻屬:水前寺藍藻、微囊藻屬、念珠藻屬:裂褶念珠藻、普通念珠藻、髮狀念珠藻、顫藻屬、螺旋藻屬:螺旋藻、束毛藻屬等)。Cyanobacteria: Cryptophyta: Cyanophyta, Microcystis, Candida: Schizophyllum algae, Common Candida, Hairy Candida, Vibrio, Spirulina: Spirulina, Trameta, etc. ).
褐藻類(間囊藻屬:間囊藻、水雲屬:印度水雲、聚果藻屬:聚果藻、褐殼藻屬:蕈狀褐殼藻、黑頂藻屬:三角黑頂藻、海翼藻屬:絲狀海翼藻、馬鞭藻屬:柱狀馬鞭藻、馬鞭藻、散生馬鞭藻、網地藻屬:網地藻、寬葉網地藻、厚網藻屬:厚網藻、厚緣藻、褐舌藻屬:褐舌藻、網翼藻屬:叉開網翼藻、寬葉網翼藻、蕨狀網翼藻、棕葉藻屬:棕葉藻、團扇藻屬:樹狀團扇藻、大團扇藻、包氏團扇藻、短毛藻屬:帶狀短毛藻、褐毛藻屬:可疑褐毛藻、黏膜藻屬:黏膜藻、褐條藻屬:褐條藻、金魚藻屬:金魚藻、索藻屬:鞭狀索藻、枝管藻屬:崗村枝管藻、真絲藻屬:真絲藻、麵條藻屬:麵條藻、球毛藻屬:硬球毛藻、黑藻屬:黑藻、頂毛藻屬:頂毛藻、海蘊屬:海蘊、鐵釘菜屬:鐵釘菜、葉狀鐵釘菜、果冠藻屬:肋果冠藻、毛頭藻屬:毛頭藻、海神藻屬:纏結海神藻、酸藻屬:舌狀酸藻、酸藻、淺棕色酸藻、厚岸藻屬:平滑厚岸藻、點葉藻屬:點葉藻、鵝腸菜屬:鵝腸菜、幅葉藻屬:幅葉藻、粗粒藻屬:粗粒藻、中孔帶藻屬:日本中孔帶藻、囊藻屬:囊藻、長囊藻、千島囊藻屬:千島囊藻、網胰藻屬:網胰藻、毛孢藻屬:毛孢藻、列管藻屬:孢群斑管藻、岩鬚屬:岩鬚、環囊藻屬:纖細環囊藻、萱藻屬:萱藻、網管藻屬:網管藻、繩藻屬:繩藻、孔葉藻屬:孔葉藻、多肋藻屬:多肋藻、波動藻屬:波動藻、日本波動藻、海帶屬:革質海帶、長柄海帶、鬼海帶、蝦夷海帶、長海帶、遠藤海帶、Laminaria cichorioides Miyabe、解氏藻屬:環形解氏藻、擬昆布屬:擬昆布、昆布屬:穴昆布、匍匐昆布、昆布、菊花昆布屬:菊花昆布、Streptophyllum屬:Streptophyllum、擬扭葉藻屬:黑島擬扭葉藻、節枝藻屬:二裂節枝藻、愛氏藻屬:二輪愛氏藻、翅藻屬:延長翅藻、厚翅藻、鹿角菜屬:白氏鹿角菜、葉囊藻屬:楔形葉囊藻、喇叭藻屬:喇叭藻、囊鏈藻屬:函館囊鏈藻、囊鏈藻、Cystophyllum turneri Yendo、馬尾藻屬:日本馬尾藻、半葉馬尾藻、Sargassum segii Yoshida、銅藻、線形馬尾藻、無肋馬尾藻、相模馬尾藻、Sargassum nigrifolium Yendo、球囊馬尾藻、土佐馬尾藻、展枝馬尾藻、鼠尾藻、任氏馬尾藻、海蒿子、解氏馬尾藻、微刺馬尾藻、裂葉馬尾藻、大托馬尾藻、大葉馬尾藻、帶球藻屬:萊氏帶球藻、巨藻屬:巨藻、腔囊藻屬:腔囊藻、萱藻屬:萱藻等)。Brown algae (M. licheniformis: Phytophthora, water cloud genus: Indian water cloud, Polysaccharide: Polysaccharide, Brown plant: 褐-shaped brown-shelled algae, Phytophthora: Trichosanthes, sea wing Algae: filamentous seaweed, chlorella: cyanobacteria, chlorella, chlorella, and genus: genus algae, broadleaf genus, thick cyanobacteria: thick cyanobacteria, Thick-edged algae, Agaricus: Agaricus, Net-winged algae: Diptera, Hymenoptera: Diptera, Hymenoptera: Brown leaf algae, Cyanophyta: tree Cyanophyta, Cyanophyta, Cyanobacteria, Brachypodium, Brachypodium Genus: Ceratophyllum, Spirulina: Whip, Phytophthora: Phyllostachys pubescens: Phyllostachys pubescens, genus genus: genus, noodle genus: noodle algae, genus Chaetoceros: chlorella, Hydrilla verticillata Genus: Hydrilla verticillata, Phyllostachys genus: Dinoflagellate, Haiyun genus: Haiyun, Iron genus: Iron-nailed vegetables, leaf-shaped iron nails, and genus Pleurotus: Coronaria argentea, Trichophyton: Trichophyton : tangled seaweed algae, acid algae: lingual acid algae, acid algae, light brown acid algae, thick shore algae: smooth thick algae, genus genus: phylust, goose, genus: goose Leaf genus: Phyllostachys pubescens, Phytophthora: sphaerophyta, mesoporous genus: Japanese mesoporous algae, cyanobacteria: cyanobacteria, long cyanobacteria, Thousands of genus: Thousands of sacs, net Panax: Genus algae, Trichophyton sp.: Trichophyton sp., Neisseria genus: Species of Phyllostachys pubescens, Rock genus: Rock whiskers, Cyanophyta: Sphaerotheca fuliginea, Cercospora: 萱Algae, cyanobacteria: cyanobacteria, genus genus: spirulina, sphagnum: sphagnum, spirulina: spirulina, volcanic genus: wave algae, Japanese wave algae, kelp genus: leather kelp , Long-handled kelp, Ghost kelp, Shrimp kelp, Long kelp, Endo kelp, Laminaria cichorioides Miyabe, Lycium genus: Rhizoctonia solani, Quinum genus: Quinumbu, kelp genus: kelp, kelp, kelp, chrysanthemum Genus: Chrysanthemum kelp, Streptophyllum genus: Streptophyllum, Quercus genus: Heliconia genus, Rhizoctonia: Two-segment Algae, A. genus: two rounds of A. algae, winged algae: extended wing algae, thick-winged algae, carrageenan: white staghorn, leaf genus: Phytophthora, hornweed: trumpet algae, Cyanobacteria: Habitatella cerevisiae, Cyanobacteria, Cystophyllum turneri Yendo, Sargassum: Japanese sargasso, S. cerevisiae, Sargassum segii Yoshida, copper algae, linear Sargasso, striated sargasso, Sagitda , Sargassum nigrifolium Yendo, Sargasso, S. cerevisiae, Sargasso, Sargasso, Sargasso, Artemisia, S. cerevisiae, Spurs, Sargasso, S. , S. cerevisiae, genus genus: Phyllostachys praecox, macroalgae: macroalgae, genus Phytophthora: Phytophthora, genus genus: diatoms, etc.).
紅藻類(紅毛菜屬:暗紫紅毛菜、小紅毛菜、紫菜屬:甘紫菜、條斑紫菜、擬線形紫菜、長紫菜、田佐紫菜、多色紫菜、寬紫菜、紅線藻屬:豪氏旋體藻、絲黏藻屬:絲黏藻、粉枝藻屬:絲擬藻、日本粉枝藻、軟粉枝藻、海索面屬:海索面、多列海索面、叉枝海索面、蠕枝藻屬:蠕枝藻、叉枝蠕枝藻、皮絲藻屬:皮絲藻、鮮奈藻屬:日本鮮奈藻、鮮奈藻屬:崗村鮮奈藻、幅毛藻屬:易碎幅毛藻、果胞藻屬:圓果胞藻、鐮狀二叉藻、Ptilonia屬:Ptilonia okadae、櫛齒藻屬:櫛齒藻、海門冬屬:具鉤柏桉藻、紫杉狀海門冬、石花菜屬:小石花菜、細毛石花菜、大石花菜、亞帚石花菜、細弱石花菜、繡球花(Hydrangea macrophylla)、鬚狀石花菜、柔毛藻屬:日本柔毛藻、小柔毛藻(Dudresnaya minima)、亮管藻屬:亮管藻、皮氏藻屬:皮氏藻、膠黏藻屬:增厚膠黏藻、單條膠黏藻、增氏藻屬:不規則增氏藻、海薔薇藻屬(Constantinea):大葉海薔薇藻(Constantinea subulifera)、新擴藻屬:新擴藻(Neodilsea yendoana)、Neodilsea tenuipes、軟粒藻屬:美羽軟粒藻、日本軟粒藻、赤盾藻屬:北方赤盾藻、Contarinia屬:Contarinia okamurae、耳殼藻屬:Peyssonnelia caulifera Okamura、耳殼藻屬:日本耳殼藻、叉節藻屬:寬扁叉節藻、珊瑚藻屬:珊瑚藻、蜈蚣藻屬:亞洲蜈蚣藻、繁枝蜈蚣藻、叉枝蜈蚣藻、舌狀蜈蚣藻、崗村蜈蚣藻、複瓦蜈蚣藻、肉質蜈蚣藻、橢圓蜈蚣藻、帶形蜈蚣藻、披針形蜈蚣藻、黑木蜈蚣藻、海膜屬:叉分黏滑藻、Halymenia polydactyla、頂狀蜈蚣藻、鋸齒藻屬:鋸齒藻、海柏屬:海柏、盾果藻屬:硬盾果藻、狹枝盾果藻、盾果藻、多枝盾果藻、縐盾果藻、岐叉盾果藻、具節蜈蚣藻、角質蜈蚣藻、極高蜈蚣藻、繁枝蜈蚣藻、隱絲藻屬:史氏蜈蚣藻、黏管藻屬:黏管藻、Schimmelmannia屬:Schimmelmannia plumosa、海蘿屬:小海蘿、海蘿、鹿角海蘿、壁果藻屬:壁果藻、美葉藻屬:日本美葉藻、捲曲美葉藻、掌狀美葉藻、附著美葉藻、貼生美葉藻、雞冠美葉藻、Callophyllis hayamensis、紫色美葉藻、喙頭美葉藻、美葉屬:美葉藻、曲果藻屬:曲果藻、楷膜藻屬:無柄楷膜藻、Kallymenia sagamiana、Kallymenia callophylloides、史密藻屬:日本史密藻、滑枝藻屬:滑枝藻、Tsengia lancifolia、平滑藻屬:平滑藻、裂膜藻屬:裂膜藻、海網藻屬:海網藻、黏滑藻屬:山田黏滑藻、紅翎菜屬:粗壯紅翎菜、細弱紅翎菜、雞冠菜屬:氈毛狀雞冠菜、特納藻屬:特納藻、鏈藻屬:叢生鏈藻、海頭紅屬:海頭紅、軟骨海頭紅、沙菜屬:長枝沙菜、曲刺沙菜、變異沙菜、日本沙菜、束果藻屬:日本束果藻、莖刺藻屬:莖刺藻、海木耳屬:海木耳、江蘺屬:真江蘺、繩江蘺、脆江蘺、粗江蘺、內彎江蘺、扁江蘺、尾狀江蘺、縊江蘺、星狀江蘺、亞潮江蘺、山本江蘺、帚狀江蘺、鳳尾菜、龍鬚菜、斑江蘺、弓江蘺、芋根江蘺、傘房江蘺、楔葉江蘺、擬石花屬:叉枝擬石花、江蘺屬:縊江蘺、具突藻屬:具突藻、伴綿藻屬:伴綿藻、叉枝藻屬:扇形叉枝藻、擬伊藻屬:伊谷藻、美麗擬伊藻、近榮擬伊藻、溪邊蕨屬:溪邊蕨、杉藻屬:解藻、Gigartina ochotensis、太平洋杉藻、黑葉銀杏藻屬:黑葉銀杏藻、紅舌藻屬:日本紅舌藻、黏枝藻屬:日本黏枝藻、網囊藻屬:刺邊網囊藻、具柄網囊藻、金膜藻屬:金膜藻、崗村金膜藻、腔節藻屬:節腔節藻、布氏低串藻、葡萄藻屬:葡萄藻、隱蜘藻屬:隱蜘藻、掌形藻屬:掌形藻、錯綜紅皮藻、具乳紅皮藻、海金藻屬:光亮海金藻、囊管藻屬:遠藤囊管藻、節莢藻屬:鏈狀節莢藻、扁節莢藻、崗村節莢藻、環節藻屬:螢光環節藻、擴展環節藻、仙菜屬:三叉仙菜、柔質仙菜、圓錐仙菜、日本仙菜、波登仙菜、凝菜屬:鉤凝菜、凝菜、爬軟藻屬:優美爬軟藻、任寶藻屬:史氏任寶藻、紅葉藻科:史氏馬氏藻、千島密果藻、日本新膜葉藻、頂枝藻屬:匍匐頂枝藻、多脈藻屬:日本多脈藻、新葉下藻屬:米氏新葉下藻、Myriogramme屬:Myriogramme polyneura、Hideophyllum yezoense、頂群藻屬:具鉤頂群藻、扇形頂群藻、細脈頂群藻、頂群藻、Hymenena屬:Hymenena tenuis、紅網藻屬:脆紅網藻、鷓鴣菜屬:無隔鷓鴣菜、絨線藻屬:無柄絨線藻、異管藻屬:日本異管藻、美麗異管藻、擬絨線藻屬:羽狀擬絨線藻、多管藻屬:內枝多管藻、脆多管藻、鷓鴣菜屬:鷓鴣菜、軟骨藻屬:樹狀軟骨藻、粗枝軟骨藻、叢枝軟骨藻、纏結軟骨藻、琉球軟骨藻、匍匐軟骨藻、小軟骨藻、凹頂藻屬:異枝凹頂藻、波形凹頂藻、羽狀凹頂藻、紅羽凹頂藻、翼管藻屬:翼管藻、纖維翼管藻、鴨毛藻屬:苔狀鴨毛藻、鴨毛藻、線形鴨毛藻、爬管藻屬:裂齒爬管藻、二列爬管藻、旋花藻屬:黑旋花藻、日本旋花藻、Amansia mitsuii Segawa、初逢藻屬:崗村初逢藻、勒氏藻屬:勞瑞勒氏藻、派膜藻屬:派膜藻、新松節藻屬:皮刺新松節藻、齒海藻屬:Odonthalia corymbifera、串珠藻屬:膠串珠藻、扁圓串珠藻、黑色串珠藻、溫泉紅藻屬:溫泉紅藻、擬海索面屬:擬海索面、多管藻屬、紫球藻屬:紫球藻、紅索藻屬:紅索藻等)。Red algae (Red genus: dark purple red cabbage, small red cabbage, laver: sweet seaweed, stripe laver, pseudo-line laver, long laver, Tian Zuo laver, multi-color laver, broad laver, red algae: Spirulina genus, Spirulina: Spirulina, Syzygium: Silk algae, Japanese powder algae, soft powder algae, hyssop: sea surface, multi-column surface, fork Branches of the sea surface, genus Phytophthora: Phytophthora, Phytophthora, and genus Pythium: Pythium, Fresh genus: Japanese fresh cyanobacteria, fresh genus: freshwater algae Chaetoceros: Fragile genus, Phytophthora: Phytophthora, Brassica genus, Ptilonia genus: Ptilonia okadae, Sphaerotheca: Sphaerotheca, Hymenoptera: Hook cypress Algae, yew-like hymen, genus of broccoli: small stone cauliflower, succulent cauliflower, big stone cauliflower, yarrow cauliflower, fascinating cauliflower, hydrangea (Hydrangea macrophylla), whisker, cauliflower, genus: Japanese soft Dichaeta, Dudresnaya minima, Leymus: Bright tube algae, Pichia: Pichia, Adhesive: thickened algae, single strip Algae, Genus: Irregular growth algae, Constantinea: Constantinea subulifera, new algae: Neodilsea yendoana, Neodilsea tenuipes, Genus : Fuyu soft-sea algae, Japanese soft-sea algae, red-tanned algae: North Shielded porphyra, Contarinia genus: Contarinia okamurae, Auricularia: Peyssonnelia caulifera Okamura, Auricularia: Japanese aphid, P. : Phyllostachys pubescens, coral genus: coral algae, genus genus: Asian cyanobacteria, Phyllostachys pubescens, Phyllostachys pubescens, Phyllostachys pubescens, Phyllostachys pubescens, Fusarium oxysporum, Phytophthora , elliptic algae, scorpion algae, scorpion scorpion algae, black spirulina, sea genus: genus genus, halymenia polydactyla, diatom spirulina, spirulina: spirulina, cypress: sea Phyllostachys pubescens: Shielded fruit algae, scutellaria, scutellaria, scutellaria, scutellaria, scutellaria, scutellaria, scorpion algae, horny algae, very high Algae, Phytophthora, and Cyanobacteria: Shishi , Phytophthora: Phytophthora, Schimmelmannia genus: Schimmelmannia plumosa, Hydrangea: small sea radish, sea radish, antler hawthorn, wall fruit algae: wall fruit algae, genus genus: jatropha, jasmine , Palmetto algae, Algae, Algae, Algae, C. mellifera, Callophyllis hayamensis, Prunus persicae, Taro, T. genus: M. argyi, Quercus: Trichophyton, Cinerella : Sclerotium, Kallymenia sagamiana, Kallymenia callophylloides, Spirulina: Japanese Spirulina, Serratia: Serratia, Tsengia lancifolia, Smooth Alga: Smooth Algae, Schizophyllum: Schizophyllum , Hydrilla verticillata: seaweed algae, genus genus: Phytophthora serrata, red leeks: sturdy red leeks, thin red leeks, cockatoo: felt-like cockscombs, snails: Tina algae, algae: clumps of algae, sea head red genus: sea head red, cartilage sea head red, sand genus: long branch sand vegetables, koji sand vegetables, mutated sand vegetables, Japanese sand vegetables, bunch of fruit Algae: Japanese fruit algae, Stemella: Stem algae, Auricularia The sea fungus and the genus Ganoderma lucidum: Zhenjiang 绳, 蓠江蓠, 脆江蓠, 粗江蓠, 内弯江蓠, 扁江蓠, 尾江蓠, 缢江蓠, 状状江蓠, 亚潮江蓠, Yamamoto scorpion, scorpion scorpion, phoenix edulis, sylvestris, sylvestris, scorpion scorpion, scorpion scorpion, scorpion scorpion, scorpion scorpion, scorpion scorpion, stellate genus : 缢江蓠, 突 藻 genus: Phyllostachys pubescens, with Cyclosporium: Acne with algae, Forked genus: Spirulina platensis, Quercus genus: Yigu algae, beautiful pseudo-algae, near Rongyi Algae, creek genus: brookside fern, genus genus: algae, Gigartina ochotensis, pacific algae, gingko genus: gingko genus, red genus: red genus, genus : Japanese genus Algae, cyanobacteria: Phytophthora sphaeroides, Phytophthora sphaeroides, genus Phytophthora: Golden algae, ginseng algae, genus genus: ganglia, arsenic, Brinell Low-stomach algae, grape algae: grape algae, cryptophyta: cryptophyta, palm-shaped algae: palm-shaped algae, intricate red algae, erythrophyllum, seaweed: bright seaweed, Cymbidium: Endocyst Algae, Phytophthora: Phyllostachys pubescens, Phyllostachys pubescens, Phyllostachys pubescens, genus genus: genus fluorescens, extended phylum, and genus: trigeminal genus, soft sauerkraut, Cone celery, Japanese celery, Bodeng celery, condensed genus: hooked coagulation, coagulation, and soft algae: beautiful soft algae, Renbao algae: Shishi Renbao, red leaf algae: Streptomyces argentea, Thousand Island Drosophila, Japanese new leaf algae, Dictyophora: Trichophyton, Polygonum: Japanese venom, New genus: M. new leaf, Myriogramme genus: Myriogramme polyneura, Hideophyllum yezoense, genus algae: genus Hooked algae, scalloped algae, algae, algae, Hymenena genus: Hymenena tenuis, red genus: crisp red nettle, amaranth: none Amaranth, Trichoderma: Sphaerotheca fuliginea, Heterologous genus: Japanese spirulina, beautiful spirulina, Pseudomonas genus: Pleurotus ostreatus, Polygonum: Inner tube multi-algae, Bacillus subtilis, Amaranthus: Amaranth, Cartilage: Dendritic algae, Caragana, Phyllostachys, entanglement Cartilage algae, spheroidal cartilage, cartilage, cartilage, scutellaria, scutellaria, scutellaria, scutellaria, scutellaria, scutellaria, pterygium: pteropod , pteridophyte, Duchesta: genus Mossy, Dipterophyta, Lepidoptera, C. cerevisiae: C. elegans, C. elegans, Convolvulus: Black whirl Flower algae, Japanese spirulina, Amansia mitsuii Segawa, first genus: genus of the village, genus, genus: genus, genus, genus: genus, genus Phytophthora sinensis, Odonna: Odonthalia corymbifera, Phytophthora: Pleurotus ostreatus, Pleurotus ostreatus, Pleurotus ostreatus, Hot spring red algae: hot spring red algae, pseudo-Hyperthes: quasi-sea surface, Polygonum, Chlorella: Porphyridium, Red Solanum: Red Solanum, etc.).
車軸藻類(輪藻屬、麗枝藻屬、擬麗藻屬:鈍節擬麗藻、燈枝藻屬、麗藻屬:柔曲麗藻、尖頭麗藻、鳥巢藻屬等)、黃色藻類(單鞭金藻屬:羅氏金光藻等)等。Axillary algae (Cyanophyta, Litsea, Pseudomonas: blunt-spotted Pseudomonas, Trichophyton, Liga: soft-curved algae, pointed-headed algae, avian algae, etc.), yellow algae (Singapore genus: Roche diatom, etc.) and so on.
又,作為源自動物系原料之素材,可列舉:雞冠提取物、牛或豬、人之胎盤提取物、牛或豬之胃、十二指腸、腸、脾臟之提取物或其分解物、牛或豬之腦組織之提取物、牛、豬或魚類之膠原蛋白水解物(酸、鹼、酵素等)或水溶性膠原蛋白或醯化膠原蛋白等膠原蛋白衍生物、牛或豬之彈力蛋白或彈力蛋白水解物(酸、鹼、酵素等)或水溶性彈力蛋白衍生物、角蛋白及其分解物或該等之衍生物、絲蛋白及其分解物或該等之衍生物、豬或牛血球蛋白分解物(珠肽粉)、牛或豬血紅蛋白分解物(氯原血紅素、血色素、原血紅素、本原血紅素、血紅素鐵等)、牛乳、酪蛋白及其分解物或該等之衍生物、脫脂乳粉及其分解物或該等之衍生物、乳鐵蛋白或其分解物、雞蛋成分、魚肉分解物、核酸相關物質(核糖核酸、脫氧核糖核酸)等。Further, examples of the material derived from the animal material include: cockscomb extract, bovine or pig, human placenta extract, bovine or swine stomach, duodenum, intestine, spleen extract or its decomposition product, cow or pig. Extract of brain tissue, collagen hydrolysate (acid, alkali, enzyme, etc.) of bovine, pig or fish, or collagen derivative such as water-soluble collagen or deuterated collagen, elastin or elastin of bovine or pig Hydrolysate (acid, alkali, enzyme, etc.) or water-soluble elastin derivative, keratin and its decomposition products or derivatives thereof, silk protein and its decomposition products or derivatives thereof, pig or bovine blood globulin Decomposition (bead peptide powder), bovine or porcine hemoglobin breakdown (chlorine hemoglobin, hemoglobin, prohemoglobin, native heme, heme iron, etc.), milk, casein and its decomposition products or derivatives thereof , skim milk powder and its decomposition products or derivatives thereof, lactoferrin or its decomposition products, egg components, fish decomposition products, nucleic acid related substances (ribonucleic acid, deoxyribonucleic acid) and the like.
又,作為源自植物或動物系原料之素材,亦可使用源自基因重組體或細胞融合物之任意部位、細胞、組織、器官、代謝物等。進而,亦可使用藉由將任意部位、細胞、組織、器官等進行細胞培養而獲得之例如未分化細胞群或分化途中之細胞群等。Further, as a material derived from a plant or animal material, any part derived from a genetic recombinant or a cell fusion, a cell, a tissue, an organ, a metabolite, or the like can be used. Further, for example, an undifferentiated cell population or a cell population in the middle of differentiation obtained by cell culture of an arbitrary site, a cell, a tissue, an organ or the like can be used.
(14)海洋成分 深層水等海水類,例如:海水鹽、海水乾燥物、自死海、大西洋或太平洋之海中獲得之無機鹽(氯化鈉、氯化鎂、氯化鉀等)、海泥或泥(fango)類,例如義大利泥、德國泥、艾菲爾(Eifel)泥、弗萊堡(Freiburg)泥等各地之海泥或泥(含有成分:二氧化矽、二氧化鈦、氧化鋁、氧化鐵、氧化錳、氧化鈉、氧化鉀、氧化鎂、氧化鈣、氧化鍶、鈉、鉀、鎂、鈣、鉻、鐵、銅、鎳、鋅、鉛、錳、砷、水)、聖德石等。(14) Seawater such as seawater deep water, such as seawater salt, seawater dry matter, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea, the Atlantic Ocean or the Pacific Ocean, sea mud or mud ( Class of fango), such as Italian mud, German mud, Eifel mud, Freiburg mud, etc. (including ingredients: cerium oxide, titanium dioxide, aluminum oxide, iron oxide, Manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, barium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Shengde stone, and the like.
(15)微生物培養代謝物 酵母代謝物、酵母菌萃取物、細菌代謝物、細菌萃取物、黴菌或放線菌代謝物、黴菌或放線菌萃取物、納豆菌代謝物、納豆萃取物、米醱酵萃取物、米糠(紅糠、白糠)醱酵萃取物、裸藻提取物或其分解物或該等之水溶性衍生物、海藻糖或其衍生物、生乳或脫脂乳粉之乳酸醱酵物、豆科植物之乳酸菌醱酵物、椰子屬植物之乳酸菌醱酵物等。(15) Microbial culture metabolites Yeast metabolites, yeast extracts, bacterial metabolites, bacterial extracts, mold or actinomycetes metabolites, mold or actinomycete extracts, natto metabolites, natto extracts, rice bran Extract, rice bran (red peony, white peony) fermentation extract, euglena extract or its decomposition product or such water-soluble derivatives, trehalose or its derivatives, lactose or skim milk powder, lactic acid mash, beans A lactic acid bacteria mash of a plant, a lactic acid bacterium of a coconut plant, and the like.
(16)α-羥酸類 乙醇酸、檸檬酸、蘋果酸、酒石酸、乳酸等。(16) α-hydroxy acid glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, and the like.
(17)無機顏料 矽酸酐、矽酸鎂、滑石、高嶺土、膨潤土、雲母、雲母鈦、氧氯化鉍、氧化鋯、氧化鎂、氧化鋅、氧化鈦、碳酸鈣、碳酸鎂、氧化鐵黃、鐵丹、氧化鐵黑、群青、氧化鉻、氫氧化鉻、碳黑、異極礦等。(17) Inorganic pigments phthalic anhydride, magnesium citrate, talc, kaolin, bentonite, mica, mica titanium, bismuth oxychloride, zirconia, magnesia, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, iron oxide yellow, Iron, iron oxide black, ultramarine blue, chromium oxide, chromium hydroxide, carbon black, heteropolar ore.
(18)紫外線吸收/阻斷劑 二苯甲酮衍生物(2-羥基-4-甲氧基二苯甲酮、2-羥基-4-甲氧基二苯甲酮-5-磺酸、2-羥基-4-甲氧基二苯甲酮-5-磺酸鈉、二羥基二甲氧基二苯甲酮、二羥基二甲氧基二苯甲酮-磺酸鈉、2,4-二羥基二苯甲酮、四羥基二苯甲酮等)、對胺基苯甲酸衍生物(對胺基苯甲酸、對胺基苯甲酸乙酯、對胺基苯甲酸甘油酯、對二甲胺基苯甲酸戊酯、對二甲胺基苯甲酸辛酯等)、甲氧基肉桂酸衍生物(對甲氧基肉桂酸乙酯、對甲氧基肉桂酸異丙酯、對甲氧基肉桂酸辛酯、對甲氧基肉桂酸2-乙氧基乙酯、對甲氧基肉桂酸鈉、對甲氧基肉桂酸鉀、二對甲氧基肉桂酸單2-乙基己酸甘油酯等)、水楊酸衍生物(水楊酸辛酯、水楊酸苯酯、水楊酸高*艸孟*酯、二丙二醇水楊酸酯、乙二醇水楊酸酯、水楊酸肉豆蔻酯、水楊酸甲酯等)、鄰胺苯甲酸衍生物(鄰胺苯甲酸甲酯等)、尿刊酸衍生物(尿刊酸、尿刊酸乙酯等)、香豆素衍生物、胺基酸系化合物、苯并三唑衍生物、四唑衍生物、咪唑啉衍生物、嘧啶衍生物、二*口咢*烷衍生物、樟腦衍生物、呋喃衍生物、吡喃酮衍生物、核酸衍生物、尿囊素衍生物、煙鹼酸衍生物、維生素B6衍生物、傘形酮、馬栗樹皮苷、肉桂酸苄酯、辛諾賽、氧苯酮、二氧苯酮、辛苯酮、磺異苯酮、苯醯間苯二酚、熊果苷、癒創薁、紫草甯、黃苓苷(baicalin)、黃芩素(Baicalein)、小檗鹼、丁基甲氧基二苯甲醯甲烷、Escalol、氧化鋅、滑石、高嶺土等。(18) Ultraviolet absorption/blocking agent benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2 -Sodium hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-di Hydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-aminobenzoic acid derivative (p-aminobenzoic acid, ethyl p-aminobenzoate, p-aminobenzoic acid, p-dimethylamino) Amyl benzoate, octyl p-dimethylaminobenzoate, etc.), methoxycinnamic acid derivative (ethyl p-methoxycinnamate, isopropyl p-methoxycinnamate, octyl p-methoxycinnamate) Ester, 2-ethoxyethyl p-methoxycinnamate, sodium p-methoxycinnamate, potassium p-methoxycinnamate, di-p-methoxycinnamic acid mono-2-ethylhexanoate, etc.) , salicylic acid derivatives (octyl salicylate, phenyl salicylate, salicylic acid high * 艸 * * ester, dipropylene glycol salicylate, ethylene glycol salicylate, salicyl myristate, Methyl salicylate, etc., an ortho-aminobenzoic acid derivative (methyl ortho-benzoate, etc.), urine Acid derivatives (urinary acid, uric acid ethyl ester, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, * 咢 咢 * alkane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, horse chestnut bark Glycosides, benzyl cinnamate, chinox, oxybenzone, benzophenone, octyl ketone, sulfonone, phenylhydrazone, arbutin, guaiac, shikonin, jaundice Baicalin, baicalein, berberine, butyl methoxybenzhydryl methane, Escalol, zinc oxide, talc, kaolin, and the like.
(19)美白劑 對胺基苯甲酸衍生物、水楊酸衍生物、鄰胺苯甲酸衍生物、香豆素衍生物、胺基酸系化合物、苯并三唑衍生物、四唑衍生物、咪唑啉衍生物、嘧啶衍生物、二*口咢*烷衍生物、樟腦衍生物、呋喃衍生物、吡喃酮衍生物、核酸衍生物、尿囊素衍生物、煙鹼酸衍生物、維生素C或其衍生物(維生素C磷酸酯鎂鹽、維生素C葡糖苷等)、維生素E或其衍生物、曲酸或其衍生物、氧苯酮、二苯甲酮、熊果苷、癒創薁、紫草甯、黃苓苷、黃芩素、小檗鹼、胎盤萃取物、土耳其鞣酸、白藜蘆醇(Rucinol)等。(19) a whitening agent-amino benzoic acid derivative, a salicylic acid derivative, an ortho-aminobenzoic acid derivative, a coumarin derivative, an amino acid compound, a benzotriazole derivative, a tetrazole derivative, Imidazoline derivative, pyrimidine derivative, bis-quinone* alkane derivative, camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin C Or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or a derivative thereof, kojic acid or a derivative thereof, oxybenzone, benzophenone, arbutin, guaiac, Zygoxin, baicalin, baicalein, berberine, placental extract, turmeric, ruthenium, etc.
(20)酪胺酸酶活性抑制劑 維生素C或其衍生物(維生素C磷酸酯鎂鹽、維生素C葡糖苷等)、對苯二酚或其衍生物(對苯二酚苄基醚等)、曲酸或其衍生物、維生素E或其衍生物、N-乙醯酪胺酸或其衍生物、麩胱甘肽、過氧化氫、過氧化鋅、胎盤萃取物、土耳其鞣酸、熊果苷、白藜蘆醇、絲綢提取物、植物萃取物(洋甘菊、桑、梔子、當歸、地榆、苦參、艾、金銀花、黃檗、魚腥草、雲苓、薏苡、野芝麻、忽布、山楂子、桉樹、歐蓍、蜀葵、桂皮、蔓荊子、金縷梅、雞桑、延命草、桔梗、菟絲子、續隨子、射干、麻黃、川芎、獨活、柴胡、防風、珊瑚菜、黃芩、牡丹皮、牻牛兒苗、葛根、甘草、五倍子、蘆薈、升麻、紅花、綠茶、紅茶、阿仙藥)等。(20) tyrosinase activity inhibitor vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), Kojic acid or a derivative thereof, vitamin E or a derivative thereof, N-acetyl tyrosine or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, citric acid, arbutin , resveratrol, silk extract, plant extracts (chamomile, mulberry, medlar, angelica, mantle, Sophora flavescens, Ai, honeysuckle, Astragalus, Houttuynia, sorghum, alfalfa, wild sesame, fluffy cloth , hawthorn, eucalyptus, eucalyptus, hollyhock, cinnamon, vine, medlar, chicken mulberry, marigold, platycodon, dodder, continuation, shoot, ephedra, Chuanxiong, Duhuo, Bupleurum, wind, Coral vegetables, Astragalus, Cortex, yak seedlings, Pueraria, licorice, gallnut, aloe, cohosh, safflower, green tea, black tea, Axian medicine, etc.
(21)黑色素色素還原/分解物質 苯基汞六氯酚、氧化汞、氯化亞汞、過氧化氫水、過氧化鋅、對苯二酚或其衍生物(對苯二酚苄基醚)等。(21) Melanin pigment reduction/decomposition substance phenylmercury hexachlorophenol, oxidized mercury, mercurous chloride, hydrogen peroxide water, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether) Wait.
(22)代謝回轉之促進作用/細胞活化物質 對苯二酚、乳酸菌萃取物、胎盤萃取物、靈芝萃取物、維生素A、維生素E、尿囊素、脾臟萃取物、胸腺萃取物、酵母萃取物、醱酵乳萃取物、植物萃取物(蘆薈、黃芩、木賊、龍膽、牛蒡、紫根、人參、金縷梅、忽布、薏苡仁、野芝麻、當藥、當歸、金盞花、甘茶、小連翹、黃瓜、百里香、迷迭香、洋芫荽)等。(22) Promotion of metabolic turnover / cell activating substance hydroquinone, lactic acid bacteria extract, placental extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract , fermented milk extract, plant extracts (aloe, scutellaria, squid, gentian, burdock, purple root, ginseng, witch hazel, bud, hazelnut, wild sesame, medicine, angelica, calendula, sweet tea, small forsythia, Cucumber, thyme, rosemary, artichoke, etc.
(23)收斂劑 琥珀酸、尿囊素、氯化鋅、硫酸鋅、氧化鋅、異極礦、對苯酚磺酸鋅、硫酸鋁鉀、間苯二酚、氯化鐵、鞣酸(含有兒茶素化合物)等。(23) astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, heteropolar ore, zinc phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, citric acid (including children) Tea compound) and the like.
(24)活性氧消除劑 SOD(Superoxide Dismutase,超氧化物歧化酶)、觸酶、麩胱甘肽過氧化酶等。(24) Active oxygen scavenger SOD (Superoxide Dismutase), contact enzyme, glutathione peroxidase and the like.
(25)抗氧化劑 維生素C或其鹽、硬脂酸酯、維生素E或其衍生物、正二氫癒創酸、丁基羥基甲苯(BHT)、丁基羥基苯甲醚(BHA)、羥基酪醇、對羥基苯甲醚、沒食子酸丙酯、芝麻酚、芝麻林素、棉籽酚、蜂膠等。(25) Antioxidant Vitamin C or its salt, stearate, vitamin E or its derivative, n-dihydroguaiac acid, butyl hydroxytoluene (BHT), butyl hydroxyanisole (BHA), hydroxytyrosol , p-hydroxyanisole, propyl gallate, sesame phenol, sesame seed, cottonseed phenol, propolis and the like.
(26)過氧化脂質生成抑制劑 β-胡蘿蔔素、植物萃取物(胡麻培養細胞、甘茶、小連翹、金縷梅、丁香、蜜蜂花、延命草、白樺、鼠尾草、迷迭香、南天實、營實、銀杏、綠茶)等。(26) Peroxidative lipid production inhibitor β-carotene, plant extract (flax cultured cells, sweet tea, small forsythia, witch hazel, clove, melissa, marigold, birch, sage, rosemary, southern Real, camp, ginkgo, green tea, etc.
(27)抗炎症劑 魚石脂、吲哚美辛、高嶺土、水楊酸、水楊酸鈉、水楊酸甲酯、乙醯水楊酸、鹽酸苯海拉明、d-樟腦、dl-樟腦、氫化可體松、癒創薁、母菊薁(Chamazulene)、馬來酸氯苯那敏、甘草酸或其鹽、甘草次酸或其鹽、甘草萃取物、紫根萃取物、營實萃取物、蜂膠等。(27) Anti-inflammatory agents fish fat, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetamidine salicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, Hydrocortisone, guaiac, Chamazulene, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, purple root extract, commercial extract, Propolis and so on.
(28)抗菌、殺菌、消毒藥 利凡諾、硫、葡萄糖酸鈣、葡萄糖酸雙氯苯雙胍己啶、胺基磺酸、汞溴紅、乳鐵蛋白或其水解物、氯化烷基二胺基乙基甘胺酸液、三氯生、次氯酸鈉、氯胺T、漂白粉、碘化合物、碘仿、己二烯酸或其鹽、丙酸或其鹽、水楊酸、脫氫乙酸、對羥基苯甲酸酯類、十一碳烯酸、硫胺素月桂基硫酸鹽、硫胺素月桂基硝酸鹽、苯酚、甲酚、對氯酚、對氯間二甲苯酚、對氯間甲酚、瑞香草酚、苯乙醇、鄰苯基苯酚、Irgasan CH3565、鹵卡班、六氯酚、雙氯苯雙胍己啶、乙醇、甲醇、異丙醇、苄醇、乙二醇、丙二醇、2-苯氧基乙醇、1,2-戊二醇、吡啶硫酮鋅、氯丁醇、異丙基甲基苯酚、非離子界面活性劑(聚氧乙烯月桂醚、聚氧乙烯壬基苯醚、聚氧乙烯辛基苯醚等)、兩性界面活性劑、陰離子界面活性劑(月桂基硫酸鈉、月桂醯肌胺酸鉀等)、陽離子界面活性劑(溴化鯨蠟基三甲基銨、氯化苄烷銨、苄索氯銨、氯化甲基玫瑰苯胺)、甲醛、六亞甲基四胺、煌綠、孔雀綠、結晶紫、Germal、感光素101號、感光素201號、感光素401號、N-長鏈醯基鹼性胺基酸衍生物及其酸加成鹽、氧化鋅、檜木醇、苦參、蜂膠等。(28) antibacterial, bactericidal, disinfectant rivanol, sulfur, calcium gluconate, glucopicic acid dichlorobenzidine, amino sulfonic acid, mercury bromine red, lactoferrin or its hydrolyzate, alkyl chloride Aminoethylglycine, triclosan, sodium hypochlorite, chloramine T, bleaching powder, iodine compound, iodoform, hexadienoic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, p-hydroxybenzoic acid Ester, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-xylenol, p-chloro-m-cresol, resveratrol , phenylethyl alcohol, o-phenylphenol, Irgasan CH3565, haloban, hexachlorophenol, chlorhexidine, ethanol, methanol, isopropanol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol 1,2-pentanediol, zinc pyrithione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octyl) Phenyl ether, etc., amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, potassium lauric acid, etc.), cation Surfactant (bromo cetyltrimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methyl rosyl chloride), formaldehyde, hexamethylenetetramine, brilliant green, malachite green, crystal violet , Germal, photoreceptor No. 101, photoreceptor No. 201, photoreceptor No. 401, N-long-chain mercapto basic amino acid derivatives and acid addition salts thereof, zinc oxide, eucalyptus, matrine, propolis and the like.
(29)保濕劑 甘油、丙二醇、1,3-丁二醇、玻尿酸或其鹽、聚乙二醇、軟骨素硫酸或其鹽、水溶性甲殼素衍生物、水溶性殼聚糖衍生物、吡咯啶酮羧酸或其鹽、乳酸鈉、小笹錦米(Mini Sasanishiki)萃取物、納豆菌代謝物、納豆萃取物、絲瓜水、白樺或赤松之樹液(29) humectant glycerin, propylene glycol, 1,3-butanediol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin derivative, water-soluble chitosan derivative, pyrrole Pyridonecarboxylic acid or its salt, sodium lactate, Mini Sasanishiki extract, natto metabolite, natto extract, loofah water, white birch or red pine sap
(30)彈性蛋白酶活性抑制劑 氟磷酸二異丙酯、植物萃取物(黃芩、小連翹、苦參、桑葉、桂皮、牻牛兒苗、康富力、鼠尾草、歐洲接骨木、菩提樹、牡丹皮)、海藻萃取物等。(30) Elastase activity inhibitor Diisopropyl fluorophosphate, plant extracts (Astragalus, Small forsythia, Sophora flavescens, Mulberry leaves, Cinnamon, Yak seedlings, Confucius, Sage, European elderberry, Linden, Mudan peel), seaweed extract, etc.
(31)頭髮用劑 二硫化硒、溴化烷基異喹啉鎓液、硫代嘧啶氧鋅、珍尼柳酯、二甲硫蒽、海狸酊、薑酊、辣椒酊、鹽酸奎寧、強氨水、溴酸鉀、溴酸鈉、硫代乙醇酸等。(31) hair agent selenium disulfide, alkyl bromide alkyl isoquinolinium sulfonate, thiopyrimidine zinc oxide, jinniuol ester, dimethyl sulfonium, beaver, ginger, capsicum, quinine hydrochloride, strong Ammonia water, potassium bromate, sodium bromate, thioglycolic acid, and the like.
(32)抗雄激素劑 卵胞激素(雌酮、雌二醇、乙炔雌二醇等)、異黃酮、異乙諾酮等。(32) Antiandrogen Egg hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, isoethenone, and the like.
(33)末梢血管促進血流劑 維生素E或其衍生物、當藥萃取物、蒜萃取物、人參萃取物、蘆薈萃取物、龍膽萃取物、當歸萃取物、頭花千金藤鹼、卡普氯胺、敏樂定等。(33) peripheral blood vessels promote blood flow agent vitamin E or its derivatives, drug extract, garlic extract, ginseng extract, aloe extract, gentian extract, angelica extract, head flower ginseng, cape Chloramine, Minidine, etc.
(34)刺激劑 辣椒酊、壬酸香草基醯胺、斑蝥酊、薑酊、薄荷油、l-薄荷腦、樟腦、煙鹼酸苄酯等。(34) Stimulators Capsicum anthraquinone, vanillyl citrate, cantharidin, ginger, peppermint oil, l-menthol, camphor, benzyl nicotinic acid, and the like.
(35)代謝活性劑 感光素301號、檜木醇、泛酸或其衍生物、尿囊素、胎盤萃取物、生物素、甘油十五烷酸酯等。(35) Metabolic active agent Photosensitive No. 301, eucalyptus, pantothenic acid or a derivative thereof, allantoin, placental extract, biotin, glycerol pentadecanoate, and the like.
(36)抗脂溢劑 吡哆醇或其衍生物、硫、維生素B6等。(36) Anti-lipids Pyridoxine or its derivatives, sulfur, vitamin B6, and the like.
(37)角質溶解劑 間苯二酚、水楊酸、乳酸、脲等。(37) Keratinolytic agents Resorcinol, salicylic acid, lactic acid, urea, and the like.
(38)氧化劑 過氧化氫水、過硫酸鈉、過硫酸銨、過硼酸鈉、過氧化脲、過碳酸鈉、過氧化三聚磷酸鈉、溴酸鈉、溴酸鉀、過氧化焦磷酸鈉、過氧化正磷酸鈉、矽酸鈉過氧化氫加成物、硫酸鈉過氧化氫加成物、氯化鈉過氧化氫加成物、β-酪胺酸酶酵素液、蘑菇萃取液等。(38) oxidant hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, peroxidation Sodium orthophosphate, sodium citrate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, and the like.
(39)除毛劑 硫酸鍶、硫化鈉、硫化鋇、硫化鈣等無機系還原劑;硫代乙醇酸或其鹽類(硫代乙醇酸鈣、硫代乙醇酸鈉、硫代乙醇酸鋰、硫代乙醇酸鎂、硫代乙醇酸鍶)等。(39) Inorganic reducing agents such as barium sulfate, sodium sulfide, barium sulfide and calcium sulfide; thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, Magnesium thioglycolate, bismuth thioglycolate, and the like.
(40)毛髮膨潤劑 乙醇胺、脲、胍等。(40) Hair swelling agent Ethanolamine, urea, hydrazine, and the like.
(41)染料劑 5-胺基鄰甲酚、2-胺基-4-硝基苯酚、2-胺基-5-硝基苯酚、1-胺基-4-甲基胺基蒽醌、3,3'-亞胺基二苯酚、鹽酸2,4-二胺基苯氧基乙醇、鹽酸2,4-二胺基苯酚、鹽酸甲苯-2,5-二胺、鹽酸硝基對苯二胺、鹽酸對苯二胺、鹽酸N-苯基對苯二胺、鹽酸間苯二胺、鄰胺基苯酚、乙酸N-苯基對苯二胺、1,4-二胺基蒽醌、2,6-二胺基吡啶、1,5-二羥基萘、甲苯-2,5-二胺、甲苯-3,4-二胺、硝基對苯二胺、對胺基苯酚、對硝基鄰苯二胺、對苯二胺、對甲基胺基苯酚、苦胺酸、苦胺酸鈉、N,N'-雙(4-胺基苯基)-2,5-二胺基-1,4-醌二亞胺、5-(2-羥基乙基胺基)-2-甲基苯酚、N-苯基對苯二胺、間胺基苯酚、間苯二胺、硫酸5-胺基鄰甲酚、硫酸2-胺基-5-硝基苯酚、硫酸鄰胺基苯酚、硫酸鄰氯對苯二胺、硫酸4,4'-二胺基二苯基胺、硫酸2,4-二胺基苯酚、硫酸甲苯-2,5-二胺、硫酸硝基對苯二胺、硫酸對胺基苯酚、硫酸對硝基鄰苯二胺、硫酸對硝基間苯二胺、硫酸對苯二胺、硫酸對甲基胺基苯酚、硫酸間胺基苯酚、硫酸間苯二胺、兒茶酚、二苯基胺、α-萘酚、氫醌、鄰苯三酚、間苯三酚、沒食子酸、間苯二酚、鞣酸、2-羥基-5-硝基-2',4'-二胺基偶氮苯-5'-磺酸鈉、蘇木紅等。(41) Dyeing agent 5-amino o-cresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylamino hydrazine, 3 , 3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitro-p-phenylenediamine hydrochloride , p-phenylenediamine hydrochloride, N-phenyl p-phenylenediamine hydrochloride, m-phenylenediamine hydrochloride, o-aminophenol, N-phenyl-p-phenylenediamine acetate, 1,4-diaminopurine, 2, 6-Diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitro-p-phenylenediamine, p-aminophenol, p-nitroorthobenzene Diamine, p-phenylenediamine, p-methylaminophenol, picrylic acid, sodium picrate, N,N'-bis(4-aminophenyl)-2,5-diamino-1,4 - quinone diimine, 5-(2-hydroxyethylamino)-2-methylphenol, N-phenyl-p-phenylenediamine, m-aminophenol, m-phenylenediamine, 5-amino-based phthalate Phenol, 2-amino-5-nitrophenol sulfate, o-aminophenol sulfate, o-chloro-p-phenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diamine sulfate Phenol, toluene-2,5-diamine sulfate, nitro-p-phenylenediamine sulfate, sulfuric acid Aminophenol, p-nitrophthalic acid sulfate, p-nitrom-phenylenediamine sulfate, p-phenylenediamine sulfate, p-methylaminophenol sulfate, m-aminophenol sulfate, m-phenylenediamine sulfate, catechu Phenol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucinol, gallic acid, resorcinol, citric acid, 2-hydroxy-5-nitro-2', 4'-Diaminoazobenzene-5'-sulfonic acid sodium, hematoxylin and the like.
(42)香料 麝香、靈貓香、海狸香、龍涎香等天然動物性香料;大茴香精油、白芷精油、依蘭精油、鳶尾精油、茴香精油、橙精油、香水樹精油、葛縷子精油、小豆蔻精油、癒創木精油、小茴香精油、釣樟精油、桂皮精油、錫蘭肉桂精油、老鸛草精油、古巴香脂精油、芫荽精油、紫蘇精油、香柏精油、香茅精油、茉莉精油、薑草精油、杉木精油、綠薄荷精油、胡椒薄荷精油、大茴香精油、晚香玉精油、丁香精油、橙花精油、冬青精油、吐魯香膠精油、虎尾草精油、薔薇精油、玫瑰草精油、檜木精油、羅漢柏木精油、白檀精油、卑檸精油、香葉精油、岩蘭草精油、香柑精油、秘魯香膠精油、玫瑰木精油、芳樟精油、柑橘精油、桉樹精油、酸橙精油、薰衣草精油、沈香精油、檸檬草精油、檸檬精油、迷迭香精油、日本薄荷精油等植物性香料;其他合成香料等。(42) Natural animal flavors such as musk, civet, beaver, and ambergris; anise essential oil, white peony oil, ylang-ylang oil, iris oil, fennel oil, orange essential oil, perfume tree oil, caraway essential oil, Cardamom essential oil, guaiac essential oil, cumin essential oil, fishing rod essential oil, cinnamon oil, Ceylon cinnamon oil, geranium essential oil, Cuba balsam essential oil, alfalfa essential oil, perilla essential oil, cedar essential oil, citronella essential oil, jasmine essential oil , Ginger Essential Oil, Chinese Fir Essential Oil, Spearmint Essential Oil, Peppermint Essential Oil, Anise Essential Oil, Tuberose Oil, Clove Essential Oil, Neroli Essential Oil, Holly Essential Oil, Turul gum Essential Oil, Chloris Essential Oil, Rose Essential Oil, Rose Grass Essential oil, eucalyptus essential oil, arborvitae essential oil, white sandalwood essential oil, lime essential oil, geranium essential oil, ylang ylang essential oil, citrus essential oil, Peruvian scented essential oil, rosewood essential oil, eucalyptus essential oil, citrus essential oil, eucalyptus essential oil, lime essential oil , botanical oils such as lavender essential oil, agarwood essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese mint essential oil; other synthetic fragrance Wait.
(43)色素、著色劑 紅甘藍色素、紅米色素、茜草色素、胭脂樹紅色素、烏賊黑色素、薑黃色素、槐米色素、磷蝦色素、柿色素、焦糖、金、銀、梔子色素、玉米色素、洋蔥色素、羅望子色素、螺旋藻色素、蕎麥全草色素、櫻桃色素、海苔色素、木槿色素、葡萄果汁色素、金盞花色素、紫番薯色素、紫薯蕷色素、蟲膠色素、芸香苷等。(43) Pigment, coloring agent red cabbage pigment, red rice pigment, valerian pigment, annatto red pigment, squid melanin, curcumin, glutinous rice pigment, krill pigment, persimmon pigment, caramel, gold, silver, hazelnut pigment , corn pigment, onion pigment, tamarind pigment, spirulina pigment, buckwheat whole grass pigment, cherry pigment, seaweed pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple sweet potato pigment, purple sweet potato pigment, shellac pigment, rutin Wait.
(44)其他 可列舉激素類、金屬離子封阻劑、pH值調節劑、螯合劑、防腐/防黴劑、清涼劑、穩定劑、乳化劑、動/植物性蛋白質及其分解物、動/植物性多糖類及其分解物、動/植物性糖蛋白質及其分解物、促進血流劑、抗炎症劑/消炎劑/抗過敏劑、創傷治療劑、增泡劑、增黏劑、酵素、純化水(包括電子水、小簇化等)、口腔用劑、消臭/除臭劑、苦味料、調味料等,藉由與該等併用,可期待本發明效果或其他美容效果之累加或協同之提昇。 實施例(44) Other examples include hormones, metal ion blockers, pH adjusters, chelating agents, antiseptic/mold inhibitors, cooling agents, stabilizers, emulsifiers, animal/plant proteins and their decomposition products, and Plant polysaccharides and their decomposition products, animal/plant glycoproteins and their decomposition products, blood flow promoting agents, anti-inflammatory agents/anti-inflammatory agents/anti-allergic agents, wound healing agents, foam boosters, tackifiers, enzymes, Purified water (including electronic water, small clustering, etc.), oral preparation, deodorizing/deodorizing agent, bittering material, seasoning, etc., in combination with these, it is expected that the effect of the present invention or other cosmetic effects may be accumulated or Collaborative improvement. Example
例示以本發明之目標效果中最顯著之糞腸球菌EC-12作為腸球菌屬乳酸球菌之實施例,但本發明並不限定於該等實施例等。The example of Enterococcus faecalis EC-12 which is the most prominent of the target effects of the present invention is exemplified as the Enterococcus genus Lactococcus, but the present invention is not limited to the examples and the like.
(微生物之寄存) 於2005年2月25日(原寄存日)將糞腸球菌EC-12(糞腸球菌EC-12)寄存於獨立行政法人產業技術綜合研究所 專利生物寄存中心(茨城縣築波市東1丁目1番地1 中央第6)。寄存編號為FERM BP-10284。(The storage of the micro-organisms) On February 25, 2005 (the original storage day), the Enterococcus faecalis EC-12 (E. faecalis EC-12) was deposited in the Patent Bio-Reservation Center of the Industrial and Technological Research Institute of the Independent Administrative Corporation (Ibaraki Prefecture) It is the sixth in the central part of the city. The deposit number is FERM BP-10284.
根據本發明之較佳之態樣,用作有效成分之細菌為屬於腸球菌屬之菌。更佳為該細菌為糞腸球菌(Enterococcus faecalis)。According to a preferred aspect of the present invention, the bacterium used as an active ingredient is a bacterium belonging to the genus Enterococcus. More preferably, the bacterium is Enterococcus faecalis.
作為糞腸球菌,例如可例示糞腸球菌EC-12(寄存編號FERM BP-10284)、ATCC 19433、ATCC 14508、ATCC 23655、IFO 16803、IFO 16804等菌株或其變異株。作為用作有效成分之細菌,其中最佳為上述EC-12。 再者,此處所謂「變異株」意指包含對於特定之菌株,業者藉由業者所周知之方法於不會使其性質發生變化之範圍內使其變異而成者、或業者可確認與其同等者。Examples of the Enterococcus faecalis include strains of Enterococcus faecalis EC-12 (Accession No. FERM BP-10284), ATCC 19433, ATCC 14508, ATCC 23655, IFO 16803, IFO 16804, or variants thereof. As the bacteria to be used as an active ingredient, the above-mentioned EC-12 is most preferable. In addition, the term "mutant strain" as used herein means that a particular strain is mutated by a manufacturer in a manner that does not change its properties by a method known to the manufacturer, or the operator can confirm that it is equivalent. By.
(腸球菌屬乳酸球菌及其加熱處理死菌體之獲得) 糞腸球菌EC-12(寄存編號FERM BP-10284)係使用自Combi股份有限公司購買者。(Adduction of Enterococcus genus Lactococcus and its heat-treated dead cells) Enterococcus faecalis EC-12 (registered number FERM BP-10284) was purchased from Combi Co., Ltd.
(植物性多糖類之製造) 製造真蘆薈多糖類作為植物性多糖類。將真蘆薈之葉100g粉碎後,進行壓榨萃取、過濾,於所獲得之濾液中添加乙醇或異丙醇並進行攪拌後,將產生之沈澱物回收,再次添加乙醇或異丙醇並洗淨後,將所獲得之洗淨物加以乾燥,而獲得真蘆薈多糖類粉末。(Production of Plant Polysaccharides) True aloe polysaccharides are produced as plant polysaccharides. After pulverizing 100 g of true aloe leaves, press extraction and filtration, adding ethanol or isopropyl alcohol to the obtained filtrate and stirring, recovering the precipitate, and adding ethanol or isopropanol again and washing The obtained washing material is dried to obtain a true aloe polysaccharide powder.
(樣品之製備) 將上述所製造之腸球菌屬乳酸球菌加熱處理死菌體與真蘆薈多糖類加以混合,而製備表1所示之樣品1~4(添加培養基之最終濃度)。 [表1]
(表皮葡萄球菌標準菌之培養) 使用營養肉湯No.2(日水製藥股份有限公司)作為培養基。於該培養基中添加樣品1~4(表中值:培養基最終濃度%)。繼而,以成為1~5×103 CFU/μL之方式於培養基中接種表皮葡萄球菌(Staphylococcus epidermidis)標準菌(ATCC12228),於37℃下將該等培養24小時。再者,對照組設為未添加腸球菌屬乳酸球菌加熱處理死菌體(樣品1)。(Cultivation of Staphylococcus epidermidis standard bacteria) Nutrient broth No. 2 (Nissui Pharmaceutical Co., Ltd.) was used as a medium. Samples 1 to 4 (value in the table: % final concentration of the medium) were added to the medium. Then, Staphylococcus epidermidis standard strain (ATCC12228) was inoculated into the medium in a manner of 1 to 5 × 10 3 CFU/μL, and the cells were cultured at 37 ° C for 24 hours. Further, the control group was set to heat-treated dead cells (sample 1) without adding Enterococcus genus.
(人類皮膚常駐菌之收集方法) 利用殺菌棉棒按照縱向3次、橫向3次之方式擦拭3cm見方之眉間,採集皮膚常駐菌。繼而,將棉棒於磷酸緩衝生理食鹽水10mL中清洗而收集細菌。(Collection method of human skin resident bacteria) Using a sterilizing cotton swab, wipe the 3 cm square eyebrows in the longitudinal direction 3 times and the horizontal direction 3 times, and collect the skin resident bacteria. Then, the cotton swab was washed in 10 mL of phosphate buffered physiological saline to collect bacteria.
(人類皮膚常駐菌之培養) 使用營養肉湯No.2(日水製藥股份有限公司)作為培養基。以最終濃度成為0.25、0.5、1.0w/w%之方式於該培養基中添加腸球菌屬乳酸球菌加熱處理死菌體。繼而,於100 μL培養基中接種藉由上述方法收集之皮膚常駐菌。於37℃下將該等培養24小時。再者,對照組設為未添加加熱處理死菌體(0w/w%)。(Cultivation of human skin resident bacteria) Nutrient broth No. 2 (Nissui Pharmaceutical Co., Ltd.) was used as a medium. The Enterococcus genus Lactococcus was added to the medium to heat-treat the dead cells in such a manner that the final concentration became 0.25, 0.5, 1.0 w/w%. Then, the resident bacteria of the skin collected by the above method were inoculated in 100 μL of the medium. The cells were incubated at 37 ° C for 24 hours. Further, the control group was set to have no heat-treated dead cells (0 w/w%).
(甘油量之測定) 分取上述表皮葡萄球菌標準菌(ATCC12228)及人類皮膚常駐菌各自之培養液。利用漩渦攪拌器攪拌該等培養液,利用甘油檢測套組(Cayman Chemical),依照常規方法對甘油量進行測定。(Measurement of Amount of Glycerin) The culture solution of each of the above-mentioned Staphylococcus epidermidis standard bacteria (ATCC12228) and human skin resident bacteria was fractionated. The culture solution was stirred with a vortex mixer, and the amount of glycerin was measured in accordance with a conventional method using a glycerol detection kit (Cayman Chemical).
(甘油量之測定結果) 將結果示於圖1~圖2。藉由腸球菌屬乳酸球菌加熱處理死菌體,源自表皮葡萄球菌標準菌(ATCC12228)之甘油產生顯著增加(圖1)。於向培養基中之最終添加濃度1.0w/w%(樣品2)下觀察到大致10倍之甘油產生促進效果。又,於與真蘆薈多糖類(0.1w/w%)之組合(樣品4)中,源自表皮葡萄球菌標準菌之甘油產生協同地增加。藉由添加腸球菌屬乳酸球菌加熱處理死菌體,人類皮膚常駐菌培養液中亦觀察到甘油產生量之上升(圖2)。(Results of measurement of glycerin amount) The results are shown in Fig. 1 to Fig. 2 . The dead cells were heat-treated by Enterococcus genus, and the glycerol production from the Staphylococcus epidermidis standard strain (ATCC 12228) was significantly increased (Fig. 1). Approximately 10 times the glycerol production-promoting effect was observed at a final concentration of 1.0 w/w% (sample 2) in the medium. Further, in the combination with the true aloe polysaccharide (0.1 w/w%) (sample 4), the glycerol production derived from the Staphylococcus epidermidis standard bacteria was synergistically increased. The dead cells were heat-treated by the addition of Enterococcus genus, and an increase in the amount of glycerol production was observed in the human skin resident culture medium (Fig. 2).
(人觀察試驗) 男女官能檢查員(受驗者:總共18名)於每天就寢前洗臉後,對右頰使用添加有腸球菌屬乳酸球菌加熱處理死菌體之柔軟化妝水(化妝水A),對左頰使用成為對照之未添加腸球菌屬乳酸球菌加熱處理死菌體之安慰劑柔軟化妝水(化妝水B),連續使用7天(配方為下述柔軟化妝水),第8天起床後,利用殺菌棉棒按照縱向3次、橫向3次之方式擦拭3cm見方之各頰,而將皮膚表面之甘油回收。繼而,於磷酸緩衝生理食鹽水200μL中清洗棉棒,將代謝物分散。(personal observation test) Male and female functional inspectors (subjects: 18 in total) wash their faces before going to bed every day, and apply a soft lotion (lotion A) to the right cheek with heat-treated dead bacteria added with Enterococcus genus For the left cheek, use a placebo soft lotion (make lotion B) that is not added with Enterococcus genus Lactococcus to heat the dead cells. It is used continuously for 7 days (formula is the soft lotion described below), and gets up on the 8th day. Thereafter, each of the cheeks of 3 cm square was wiped by a sterilizing cotton swab in the longitudinal direction three times and three times in the transverse direction, and the glycerin on the skin surface was recovered. Then, the cotton swab was washed in 200 μL of phosphate buffered physiological saline to disperse the metabolite.
(柔軟化妝水) 腸球菌屬乳酸球菌加熱處理死菌體 0或0.1w/v% 乙醇 5.0% 1,3-丁二醇 8.0% PEG-60氫化蓖麻油 0.2% 香料 0.01% 對羥基苯甲酸甲酯 0.15% 檸檬酸 0.02% 檸檬酸三鈉 0.08% EDTA二鈉 0.03% 水 設為100之剩餘量 依照常規方法將上述均勻混合,而獲得柔軟化妝水(化妝水A、化妝水B)。(Soft lotion) Enterococcus genus Lactococcus heat treatment Dead bacteria 0 or 0.1w/v% Ethanol 5.0% 1,3-Butane diol 8.0% PEG-60 hydrogenated castor oil 0.2% Perfume 0.01% Hydroxybenzoic acid Ester 0.15% Citric acid 0.02% Trisodium citrate 0.08% EDTA disodium 0.03% The remaining amount of water was set to 100. The above was uniformly mixed according to a conventional method to obtain a soft lotion (molder A, lotion B).
(甘油量之測定) 利用漩渦攪拌器攪拌上述分散液,利用甘油檢測套組(Cayman Chemical),依照常規方法對甘油量進行測定。(Measurement of Amount of Glycerin) The above dispersion was stirred by a vortex mixer, and a glycerin test kit (Cayman Chemical) was used, and the amount of glycerin was measured in accordance with a conventional method.
(甘油量之測定結果) 將結果示於圖3。於使用添加有腸球菌屬乳酸球菌加熱處理死菌體之柔軟化妝水之情形時,與對照組之柔軟化妝水相比觀察組人員皮膚表面之甘油顯著增加。(Results of measurement of glycerin amount) The results are shown in Fig. 3 . In the case of using a soft lotion to which the dead bacteria were heat-treated with Enterococcus genus, the glycerin on the skin surface of the group was observed to be significantly increased as compared with the soft lotion of the control group.
(人觀察試驗官能評價) 針對進行人觀察試驗之男女官能檢查員(受驗者:總共18名),對關於試驗所使用之柔軟化妝水之使用感、以及試驗前與試驗後皮膚之狀態進行問卷調查。將其回答結果示於表2。 [表2]
(人類β-防禦素-2(hBD2)、人類β-3(hBD3) mRNA之定量解析) 於24孔培養盤中,使用表皮細胞用培養基(Humedia KG2,Kurabo公司製造),將人類表皮角化細胞(Kurabo公司製造)培養至亞融合狀態。於向Humedia KG2中添加有鈣之分化誘導用培養基中進一步於37℃、5%CO2 存在下培養3天後,轉移至新培養基中。以最終濃度成為0.25、0.5、1.0w/w%之方式於該培養基中 添加腸球菌屬乳酸球菌加熱處理死菌體。以成為約1×104 個/mL之方式添加表皮葡萄球菌標準菌作為陽性對象。培養6小時後,使用RNeasy(Qiagen)自人類表皮角化細胞中提取總RNA。以所提取之各RNA作為模板,藉由常規方法使用SuperScriptVILO(Invitrogen)進行反轉錄反應,而製作cDNA。(Quantitative analysis of human β-defensin-2 (hBD2), human β-3 (hBD3) mRNA) Human epidermal keratinization using a culture medium for epidermal cells (Humedia KG2, manufactured by Kurabo Co., Ltd.) in a 24-well culture dish The cells (manufactured by Kurabo Co., Ltd.) were cultured to a sub-fusion state. The culture medium for inducing differentiation of calcium to Humedia KG2 was further cultured in the presence of 5% CO 2 at 37 ° C for 3 days, and then transferred to a new medium. The Enterococcus genus Lactococcus was added to the culture medium to heat-treat the dead cells in such a manner that the final concentration became 0.25, 0.5, 1.0 w/w%. The Staphylococcus epidermidis standard strain was added as a positive object so as to be about 1 × 10 4 /mL. After 6 hours of culture, total RNA was extracted from human epidermal keratinocytes using RNeasy (Qiagen). Using the extracted RNA as a template, a reverse transcription reaction was carried out by a conventional method using SuperScript VILO (Invitrogen) to prepare cDNA.
使用上述cDNA進行PCR。PCR之條件係基於人類β-防禦素-2之cDNA之序列(Accession No. NG_023301)、人類-β防禦素-3之cDNA序列(Accession No. NC_000008),製作表3所示之引子。使用TAKARA Human Housekeeping Gene Primer Set Human ACTB Primer作為針對用作內部標準之β-肌動蛋白的引子。PCR was carried out using the above cDNA. The conditions of PCR were based on the sequence of human β-defensin-2 cDNA (Accession No. NG_023301) and the cDNA sequence of human-β defensin-3 (Accession No. NC_000008), and the primers shown in Table 3 were prepared. The TAKARA Human Housekeeping Gene Primer Set Human ACTB Primer was used as an primer for β-actin used as an internal standard.
[表3]
使用One Step SYBRR PrimeScriptTM RT-PCR Kit(TAKARA)進行PCR反應,並使用TaKaRa PCR Thermal Cycler Dice,藉由常規方法進行即時PCR解析。根據上述即時PCR解析,對人類β-防禦素-2及人類β-防禦素-3與β-肌動蛋白之mRNA量進行相對定量。Using One Step SYBRR PrimeScript TM RT-PCR Kit (TAKARA) PCR reaction was performed using TaKaRa PCR Thermal Cycler Dice, real time PCR performed by conventional analytical methods. The amount of mRNA of human β-defensin-2 and human β-defensin-3 and β-actin was relatively quantified according to the above-described real-time PCR analysis.
(人類β-防禦素-2及人類β-防禦素-3與β-肌動蛋白之mRNA量之評價方法) 以百分率對相對於作為內部標準之β肌動蛋白之mRNA量的人類β-防禦素-2及人類β-防禦素-3與β-肌動蛋白之mRNA量進行評價。 人類β-防禦素-2及人類β-防禦素-3mRNA之相對表現量(相對於對照組之%)=(人類β-防禦素-2及人類β-防禦素-3mRNA量)/(β-肌動蛋白之mRNA量)×100(Method for evaluating the amount of mRNA of human β-defensin-2 and human β-defensin-3 and β-actin) Percentage of human β-defense against the amount of mRNA as β-actin as an internal standard The mRNA levels of cytokinin-2 and human β-defensin-3 and β-actin were evaluated. Relative expression of human β-defensin-2 and human β-defensin-3 mRNA (% relative to control group) = (human β-defensin-2 and human β-defensin-3 mRNA amount) / (β- Actin mRNA amount) × 100
(人類β-防禦素-2及人類β-防禦素-3mRNA之定量解析結果) 將結果示於圖4。藉由腸球菌屬乳酸球菌加熱處理死菌體,源自人類表皮角化細胞之β-防禦素-2及β-防禦素-3 mRNA之表現量亦有所增加(圖4)。(Quantitative analysis results of human β-defensin-2 and human β-defensin-3 mRNA) The results are shown in Fig. 4 . The amount of β-defensin-2 and β-defensin-3 mRNA derived from human epidermal keratinocytes was also increased by heat treatment of the dead cells by Enterococcus genus Lactococcus (Fig. 4).
(各種皮膚保護用外用劑之製造例) 1.防曬乳霜(O/W乳霜型) (油相部) 對甲氧基肉桂酸2-乙基己酯 5.0% 4-第三丁基-4'-甲氧基二苯甲醯丁烷 1.0% 角鯊烷 10.0% 凡士林 5.0% 硬脂醇 3.0% 硬脂酸 3.0% 甘油單硬脂酸酯 3.0% 聚丙烯酸 1.0% 抗氧化劑 適量 防腐劑 適量 香料 適量 腸球菌屬乳酸球菌加熱處理死菌體 0.01~1%(適量) (水相部) 純化水 設為100之剩餘量 二丙二醇 7.0% 二氧化鈦(氧化鋁表面處理品) 5.0% 乙二胺四乙酸二鈉 0.05% 三乙醇胺 1.0% (製造方法) 將油相部與水相部分別加熱至70℃而使其溶解,將水相部充分進行二氧化鈦之分散,添加油相部,使用均質攪拌機使乳化粒子變得均勻後,進行脫氣、過濾、冷卻而收容。作為冷卻方法,藉由在向製造釜之套管中注入冷媒之狀態下一面攪拌一面緩慢冷卻之方法與使用熱交換器進行冷卻之方法等而進行。(Examples of various external preparations for skin protection) 1. Sunscreen cream (O/W cream type) (oil phase) 2-methoxyhexyl methoxycinnamate 5.0% 4-tert-butyl- 4'-Methoxydibenzopyrene 1.0% squalane 10.0% Vaseline 5.0% Stearyl alcohol 3.0% Stearic acid 3.0% Glycerol monostearate 3.0% Polyacrylic acid 1.0% Antioxidant Appropriate amount of preservative Proper amount of Enterococcus genus Lactococcus is heated to treat dead cells 0.01-1% (appropriate amount) (Water phase) Purified water The remaining amount of 100 is dipropylene glycol 7.0% titanium dioxide (alumina surface treatment) 5.0% disodium edetate 0.05% triethanolamine 1.0% (manufacturing method) The oil phase and the water phase are separately heated to 70 ° C Further, the aqueous phase portion was sufficiently dispersed in titanium dioxide, and the oil phase portion was added. The emulsified particles were homogenized using a homomixer, and then degassed, filtered, and cooled to be stored. The cooling method is carried out by a method of slowly cooling while stirring a tank into a casing for producing a kettle, a method of cooling by using a heat exchanger, and the like.
2.防曬乳液(W/O型乳液) (油相部) 對甲氧基肉桂酸2-乙基己酯 5.0% 二氧化鈦(疏水化處理品) 5.0% 氧化鋅(疏水化處理品) 9.0% 角鯊烷 20.0% 聚矽氧油 23.0% 聚矽氧樹脂 2.0% 甘油二異硬脂酸酯 2.0% 有機改質蒙脫石 0.5% 防腐劑 適量 香料 適量 腸球菌屬乳酸球菌 0.01~1%(適量) (水相部) 純化水 設為100之剩餘量 1,3-丁二醇 5.0% (製造方法) 將油相部與水相部分別加熱至60℃而使其溶解,將油相部充分進行二氧化鈦、氧化鋅之分散,添加水相部,使用均質攪拌機使乳化粒子變得均勻後,進行脫氣、過濾、冷卻而收容。2. Sunscreen lotion (W/O type emulsion) (oil phase part) 2-ethylhexyl methoxycinnamate 5.0% Titanium dioxide (hydrophobic treatment) 5.0% Zinc oxide (hydrophobic treatment) 9.0% Angle Squalane 20.0% Polyoxyl 23.0% Polyoxyl 2.0% Glyceryl diisostearate 2.0% Organically modified montmorillonite 0.5% Preservatives Proper amount of appropriate amount of Enterococcus genus Lactococcus 0.01 to 1% (appropriate amount) (Water phase part) The remaining amount of purified water is set to 100% of 1,3-butanediol 5.0% (manufacturing method) The portion and the water phase portion are separately heated to 60 ° C to be dissolved, and the oil phase portion is sufficiently dispersed in titanium dioxide or zinc oxide, and the aqueous phase portion is added, and the emulsified particles are uniformly homogenized using a homomixer, and then degassed and filtered. Cool and store.
3.防曬油 對甲氧基肉桂酸2-乙基己酯 2.0% 液態石蠟 56.0% 肉豆蔻酸異丙酯 10.0% 聚矽氧油 30.0% 聚矽氧樹脂 2.0% 抗氧化劑 適量 香料 適量 腸球菌屬乳酸球菌加熱處理死菌體 0.01~1%(適量) (製造方法) 將聚矽氧樹脂添加至聚矽氧油中使其溶解,繼而添加肉豆蔻酸異丙酯並充分攪拌混合後,添加其餘成分並加以攪拌。3. sunscreen oil p-methoxycinnamic acid 2-ethylhexyl ester 2.0% liquid paraffin 56.0% isopropyl myristate 10.0% polyxanthene oil 30.0% polyoxyl resin 2.0% antioxidant appropriate amount of flavor appropriate enterococci Lactobacillus heat treatment of dead cells 0.01 to 1% (appropriate amount) (Manufacturing method) Add polyoxyxylene resin to polysulfonate to dissolve it, then add isopropyl myristate and stir well, then add the rest. Ingredients and stir.
4.粉末型粉底 (粉體) 肉豆蔻酸鋅處理滑石 20.0% 絹雲母 34.6% 氧化鈦 10.0% 鐵丹 1.0% 氧化鐵黃 4.0% 氧化鐵黑 0.4% 氧化鈦/氧化鋁表面處理雲母 15.0% 尼龍粉末 5.0% 腸球菌屬乳酸球菌 0.01~1%(適量) (基材) 角鯊烷 3.0% 肉豆蔻酸辛基十二烷基酯 3.5% 凡士林 2.5% (其他) 防腐劑 適量 香料 適量 (製造方法) 使用高速流動型攪拌機等混合機將粉體成分混合,進一步藉由粉碎機製造細小之粒子,繼而添加基材,使用立式螺旋型攪拌機等進行充分混合。進一步使用錘磨機等進行粉碎、制粒後,進行壓縮成型。4. Powder type foundation (powder) Zinc myristate treated talc 20.0% sericin 34.6% titanium oxide 10.0% iron oxide 1.0% iron oxide yellow 4.0% iron oxide black 0.4% titanium oxide/alumina surface treatment mica 15.0% nylon Powder 5.0% Enterococcus genus Lactococcus 0.01 to 1% (appropriate amount) (substrate) Squalane 3.0% Octyl lauryl myristate 3.5% Vaseline 2.5% (Other) Preservatives Appropriate amount (Manufacturing method) The powder components are mixed by a mixer such as a high-speed flow type mixer, and fine particles are further produced by a pulverizer, and then the base material is added, and the mixture is sufficiently mixed using a vertical screw type mixer or the like. Further, after pulverization and granulation using a hammer mill or the like, compression molding is performed.
5.兩用型粉底 (粉體) 矽處理氧化鈦 10.0% 滑石 30.0% 絹雲母 39.6% 鐵丹 1.5% 氧化鐵黃 5.5% 氧化鐵黑 0.4% 甲基丙烯酸甲酯粉末 3.0% 腸球菌屬乳酸球菌加熱處理死菌體 0.01~1(適量) (基材) 角鯊烷 3.0% 聚二甲基矽氧烷 2.0% 三異辛酸甘油酯 3.0% 對胺基苯甲酸乙酯 2.0% (其他) 防腐劑 適量 香料 適量5. Dual-purpose foundation (powder) 矽 treatment of titanium oxide 10.0% talc 30.0% sericite 39.6% iron oxide 1.5% iron oxide yellow 5.5% iron oxide black 0.4% methyl methacrylate powder 3.0% Enterococcus genus Heat treatment of dead cells 0.01 to 1 (appropriate amount) (substrate) Squalane 3.0% Polydimethyl methoxy oxide 2.0% Triisooctanoic acid glyceride 3.0% Ethyl benzoic acid ethyl ester 2.0% (Other) Preservative Moderate amount of spices Moderate amount
6.乳霜(W/O型) (A相) 第三丁基甲氧基二苯甲醯甲烷 3.0% 二乙胺基羥基苯甲醯苯甲酸己酯 2.0% 聚二甲基矽氧烷、辛基聚二甲基矽氧烷乙氧基葡糖苷 20.0% 甘油三(山萮酸/異硬脂酸/二十烷二酸)酯 1.0% 硬脂基聚二甲基矽氧烷 1.0% 乙酸維生素E酯 0.05% 苯甲酸 0.3% 癸二酸二異丙酯 7.0% 氰雙苯丙烯酸辛酯 8.0% 滑石、氧化鐵黃、硬脂酸鎂、二氧化鈦、雲母、氫氧化鋁、硬脂酸 1.4% (B相) 二氧化鈦、硬脂酸鎂、滑石、氧化鐵黑、氫氧化鋁、雲母、硬脂酸 1.13% 紅色及褐色氧化鐵、硬脂酸鎂、二氧化鈦、雲母、水、氧化鋁、硬脂酸 0.85% 二氧化鈦、滑石、硬脂酸鎂、氫氧化鋁、雲母、硬脂酸 3.9% (C相) 水 設為100之剩餘量 硫酸鎂 0.7% 甜菜鹼 1.0% 玻尿酸鈉 0.1% 甘油 1.0% (D相) 苯氧基乙醇 0.4% (E相) 二氧化鈦、甘油、氧化鋁 3.5% (F相) 二甲基矽烷基化二氧化矽 1.0% (G相) 環戊矽氧烷、(聚二甲基矽氧烷/乙烯基三甲基矽烷氧基矽酸)交聯聚合物 1.0% 腸球菌屬乳酸球菌加熱處理死菌體 0.01~1(適量) (H相) 香料 0.3% (製造方法) 於攪拌下將A相之原料混合,升溫至70~75℃,一面攪拌一面將B相添加至A相中,攪拌至均勻。於另一容器中一面攪拌C相之原料一面加以混合,升溫至70~75℃,將C相添加至AB混合相中,一面攪拌一面緩慢添加(5分鐘左右),添加C相後攪拌3分鐘,其後自然冷卻。於溫度達到40℃以下時,添加D相並攪拌1分鐘,添加E相並攪拌5分鐘,繼而添加F相並攪拌1分鐘,添加G相並攪拌1分鐘。最後添加H相並攪拌2分鐘,其後自然冷卻至室溫。6. Cream (W/O type) (A phase) Third butyl methoxybenzhydryl methane 3.0% Diethylamino hydroxybenzimidium benzoate 2.0% Polydimethyl oxa oxide, octyl Polydimethyloxane ethoxy glucoside 20.0% glycerol tris(behenic acid/isostearic acid/eicosanedioic acid) 1.0% stearyl polydimethyl methoxy alkane 1.0% acetic acid vitamin E Ester 0.05% Benzoic acid 0.3% Diisopropyl sebacate 7.0% Octyl cyanoacrylate 8.0% Talc, iron oxide yellow, magnesium stearate, titanium dioxide, mica, aluminum hydroxide, stearic acid 1.4% (B Phase) Titanium Dioxide, Magnesium Stearate, Talc, Iron Oxide Black, Aluminum Hydroxide, Mica, Stearic Acid 1.13% Red and Brown Iron Oxide, Hard Fat Magnesium, titanium dioxide, mica, water, alumina, stearic acid 0.85% titanium dioxide, talc, magnesium stearate, aluminum hydroxide, mica, stearic acid 3.9% (phase C) water is set to 100 residual magnesium sulfate 0.7% betaine 1.0% sodium hyaluronate 0.1% glycerol 1.0% (D phase) phenoxyethanol 0.4% (E phase) Titanium dioxide, glycerin, alumina 3.5% (F phase) Dimethyl hydrazine alkylation cerium oxide 1.0% (G phase) cyclopentaoxane, (polydimethyl methoxy oxane / vinyl trimethyl decyloxy decanoic acid) crosslinked polymer 1.0% Enterococcus genus Lactococcus heat treatment of dead cells 0.01 to 1 (appropriate amount) (H phase) Flavor 0.3% (Manufacturing method) Mix the raw materials of phase A with stirring, and raise the temperature to 70 to 75 ° C while stirring Add phase B to phase A and stir until homogeneous. While stirring the raw material of the C phase in another container, the mixture was heated to 70 to 75 ° C, and the phase C was added to the AB mixed phase, and the mixture was slowly added while stirring (about 5 minutes), and the phase C was added and stirred for 3 minutes. Then it cools naturally. When the temperature reached 40 ° C or lower, the phase D was added and stirred for 1 minute, the phase E was added and stirred for 5 minutes, then the phase F was added and stirred for 1 minute, and the phase G was added and stirred for 1 minute. Finally, the H phase was added and stirred for 2 minutes, after which it was naturally cooled to room temperature.
7.保濕凝膠(美容液) (A相) 橄欖油脂肪酸硬脂酯+山梨醇酐橄欖油脂肪酸酯 3.5% 橄欖油不皂化物 0.5% 碳酸二正辛酯 3.0% 牛油樹油脂 0.5% 小麥胚芽油 0.5% 環甲矽酯 6.0% 聚二甲基矽氧烷 1.0% (B相) 水 設為100之剩餘量 甘油 1.5% 丙二醇 1.5% 聚丙烯酸鈉 0.7% 三仙膠 0.1% (C相) 防腐劑 適量 香料 適量 薄荷腦 0.3% 乙醇 3.0% 腸球菌屬乳酸球菌加熱處理死菌體 0.01~1(適量) (製造方法) 分別將A相與B相混合而準備。藉由使用批次型分散機等使三仙膠、聚丙烯酸鈉分散,於75℃下將A相添加至B相中,均質化數分鐘後一面緩慢攪拌一面加以冷卻,達到40℃後添加C相(薄荷腦預先溶解於乙醇中)。7. Moisturizing gel (cosmetic liquid) (A phase) Olive oil fatty acid stearyl ester + sorbitan olive oil fatty acid ester 3.5% olive oil unsaponifiable 0.5% di-n-octyl carbonate 3.0% avocado oil 0.5% Wheat Germ Oil 0.5% Cyclodecyl Ester 6.0% Polydimethyloxane 1.0% (Grade B) Water is 100% Residual Glycerin 1.5% Propylene Glycol 1.5% Sodium Polyacrylate 0.7% Trister Gum 0.1% (C Phase Preservatives Menthol amount 3.0% 0.3% ethanol, 0.01 to 1 Enterococcus (qs) (Production Method) Lactococcus lactis heat treated dead cells were prepared the A phase and B are mixed. By dispersing the Sanxian gum and sodium polyacrylate by using a batch type disperser or the like, the phase A is added to the phase B at 75 ° C, and after a few minutes of homogenization, the mixture is slowly stirred while being cooled, and after adding 40 ° C, C is added. Phase (mentholm pre-dissolved in ethanol).
8.唇膏 (A相) 礦物油 8.0% 紅色顏料 1.0% 黃色顏料 0.3% 腸球菌屬乳酸球菌 0.01~1%(適量) (B相) 甘油三(辛酸/癸酸)酯 設為100之剩餘量 甲氧基桂皮酸乙基己酯 3.0% 肉豆蔻酸異丙酯 10.0% (C相) 烷基(C26-28)聚甲基矽氧烷 9.0% 鯨蠟醇 1.6% (D相) PEG-8、維生素E、抗壞血酸棕櫚酸酯、抗壞血酸、檸檬酸混合物 0.1% 對羥基苯甲酸丙酯 0.1% (E相) 香料 0.2% 雲母、氧化鈦混合物 18.4% 雲母、氧化鈦、氧化鐵混合物 7.0% 二氧化矽 0.5% (製造方法) 將A相均勻地預混,添加至B相中並均勻混合,進一步添加C相,一面緩慢攪拌一面加熱至78~80℃後,逐量添加D相、E相,攪拌均勻後流入至模具中,使其自然冷卻至常溫。8. Lipstick (A phase) Mineral oil 8.0% Red pigment 1.0% Yellow pigment 0.3% Enterococcus genus Lactococcus 0.01 to 1% (appropriate amount) (B phase) Triglyceride (octanoic acid/capric acid) ester is set to 100 residual amount Ethylhexyl methoxycinnamate 3.0% Isopropyl myristate 10.0% (C phase) Alkyl (C26-28) polymethyloxane 9.0% Cetyl alcohol 1.6% (D phase) PEG-8 , vitamin E, ascorbyl palmitate, ascorbic acid, citric acid mixture 0.1% propylparaben 0.1% (E phase) perfume 0.2% mica, titanium oxide mixture 18.4% mica, titanium oxide, iron oxide mixture 7.0% cerium oxide 0.5% (manufacturing method) The phase A is uniformly premixed, added to the phase B and uniformly mixed, and the phase C is further added, and the mixture is heated to 78 while stirring slowly. After the temperature was changed to 80 ° C, the D phase and the E phase were added in portions, and the mixture was uniformly stirred, and then poured into a mold to be naturally cooled to normal temperature.
9.粉底液(O/W型) (油相) 硬脂酸 2.4% 丙二醇單硬脂酸酯 2.0% 鯨蠟硬脂醇 0.2% 液狀羊毛脂 2.0% 液態石蠟 3.0% 肉豆蔻酸異丙酯 8.5% 油溶性防腐劑 適量 (水相) 純化水 設為100之剩餘量 羧甲基纖維素鈉 0.2% 膨潤土 0.5% 二丙二醇 4.0% 三乙醇胺 1.1% 水溶性防腐劑 適量 (粉體) 氧化鈦 8.0% 滑石 4.0% 著色顏料 適量 腸球菌屬乳酸球菌加熱處理死菌體 0.01~1(適量) (其他) 香料 適量 (製造方法) 將粉體粉碎後,添加水相並加以混合,一面攪拌一面向其中添加油相、香料,藉由均質攪拌機將其乳化分散後,冷卻至室溫。9. Foundation (O/W type) (oil phase) Stearic acid 2.4% Propylene glycol monostearate 2.0% Cetearyl alcohol 0.2% Liquid lanolin 2.0% Liquid paraffin 3.0% Isopropyl myristate 8.5% oil-soluble preservative proper amount (aqueous phase) Purified water set to 100 remaining amount of sodium carboxymethylcellulose 0.2% bentonite 0.5% dipropylene glycol 4.0% triethanolamine 1.1% water-soluble preservative proper amount (powder) Titanium 8.0% Talc 4.0% Coloring pigment Appropriate amount of Enterococcus genus Lactococcus heat treatment Dead bacteria 0.01 to 1 (appropriate amount) (Others) Flavor amount (manufacturing method) After pulverizing the powder, add the water phase and mix it while stirring The oil phase and the fragrance were added thereto, and the mixture was emulsified and dispersed by a homomixer, and then cooled to room temperature.
10.乳霜粉底(W/O型) (油相) 十甲基環戊矽氧烷 15.0% 液態石蠟 5.0% 對甲氧基肉桂酸酯 3.0% 聚醚改質二甲基矽氧烷 2.0% (水相) 純化水 設為100之剩餘量 甘油 5.0% 水溶性防腐劑 適量 (粉體) 氧化鈦 10.0% 滑石 3.8% 著色顏料 適量 腸球菌屬乳酸球菌 0.01~1%(適量) (其他) 香料 適量10. Cream foundation (W/O type) (oil phase) Decamethylcyclopentaoxane 15.0% Liquid paraffin 5.0% p-methoxycinnamate 3.0% Polyether modified dimethyloxane 2.0% (Aqueous phase) Purified water set to 100 Residual amount of glycerin 5.0% Water-soluble preservative appropriate amount (powder) Titanium oxide 10.0% Talc 3.8% Coloring pigment appropriate amount Enterococcus genus Lactococcus 0.01 to 1% (proper) (Other) Spice Moderate amount
11.保濕乳霜(O/W型) (A相) 牛油樹油脂 1.5% 苯甲酸烷基(C12-15)酯 1.3% 烷基(C26-28)聚二甲基矽氧烷 6.5% 硬脂酸甘油酯 1.5% 硬脂酸甘油酯、硬脂酸PEG-100混合物 3.0% 月桂酸己酯 1.3% 異十二烷 1.3% 異十六烷 1.3% 棕櫚酸異丙酯 1.3% 乙酸維生素E酯 0.5% 腸球菌屬乳酸球菌加熱處理死菌體 0.01~1(適量) (B相) 純化水 設為100之剩餘量 卡波姆 0.3% 甘油 2.0% 丙二醇 2.0% (C相) 香料 0.5% 苯氧基乙醇、對羥基苯甲酸甲酯、對羥基苯甲酸乙酯、對羥基苯甲酸丁酯、對羥基苯甲酸丙酯、對羥基苯甲酸異丁酯混合物 0.5% 四羥基丙基乙二胺 0.7% (製造方法) 於不同之容器中將A相與B相加熱至70℃後,將A相添加至B相中,使用批次型分散機等進行均質化,一面攪拌一面自然冷卻至40℃。繼而,於其中添加C相,進一步進行均質化,並冷卻至室溫。 [產業上之可利用性]11. Moisturizing cream (O/W type) (A phase) Shea butter 1.5% alkyl benzoate (C12-15) ester 1.3% alkyl (C26-28) polydimethyl oxirane 6.5% Hard Glycerylglycerol 1.5% Stearic acid glyceride, stearic acid PEG-100 mixture 3.0% hexyl laurate 1.3% isododecane 1.3% isohexadecane 1.3% isopropyl palmitate 1.3% Vitamin E ester 0.5% Enterococcus genus Lactococcus heat treatment of dead cells 0.01 ~ 1 (appropriate amount) (B phase) Purified water set to 100 residual amount of carbomer 0.3% glycerol 2.0% propylene glycol 2.0% (C phase) Perfume 0.5% Phenoxyethanol, methyl paraben, ethyl p-hydroxybenzoate, butyl p-hydroxybenzoate, propyl p-hydroxybenzoate, p-hydroxybenzoic acid Butyl ester mixture 0.5% tetrahydroxypropyl ethylenediamine 0.7% (Manufacturing method) After heating phase A and phase B to 70 ° C in different vessels, phase A is added to phase B, using batch type disperser After homogenization, it was naturally cooled to 40 ° C while stirring. Then, the phase C was added thereto, further homogenized, and cooled to room temperature. [Industrial availability]
本發明之腸球菌屬乳酸球菌可促進源自作為對於皮膚有益之皮膚常駐菌之表皮葡萄球菌的甘油之產生與源自皮膚表皮角化細胞之抗菌胜肽之產生。又,於應用於皮膚時,乾爽而觸感性非常優異,對於水性系、油性系、乳液系、粉末系之任一類型之外用劑均可賦予良好觸感性。因此,於使皮膚狀態正常化或保護維持正常性之皮膚的藥劑與皮膚保護用外用劑中之利用性極高。The Enterococcus genus Lactococcus of the present invention can promote the production of glycerol derived from Staphylococcus epidermidis which is a resident skin-preserving skin and the production of an antibacterial peptide derived from cutaneous keratinocytes of the skin. Moreover, when applied to the skin, it is very dry and very excellent in touch, and it can provide good sensibility to any of the aqueous, oily, emulsion, and powder-based external preparations. Therefore, the use of the agent for normalizing the skin condition or protecting the skin which maintains normalness and the external preparation for skin protection are extremely high.
圖1表示將糞腸球菌EC-12之加熱處理死菌體、與作為植物性多糖類之真蘆薈多糖類添加至表皮葡萄球菌(Staphylococcus epidermidis)標準菌(ATCC12228)之培養液中,並對甘油產生量進行定量而獲得之結果。 圖2表示將糞腸球菌EC-12之加熱處理死菌體添加至自人類眉間採集之皮膚常駐菌之培養液中,並對甘油產生量進行定量而獲得之結果。 圖3表示對使用含有糞腸球菌EC-12之加熱處理死菌體之柔軟化妝水的人觀察試驗中之自人類面頰採集之甘油量進行定量而獲得之結果。 圖4表示於含有糞腸球菌EC-12之加熱處理死菌體之培養基中培養人類正常角化細胞培養株,自人類正常角化細胞株中提取RNA,並藉由即時PCR測定人類β-防禦素-2(hBD2)、人類β-防禦素-3(hBD3) mRNA之表現量而獲得之結果。Fig. 1 shows a heat-treated dead cell of Enterococcus faecalis EC-12 and a true aloe polysaccharide as a plant polysaccharide added to a culture solution of Staphylococcus epidermidis standard strain (ATCC 12228), and glycerin The amount produced is quantified to obtain the result. Fig. 2 shows the results obtained by adding the heat-treated dead cells of Enterococcus faecalis EC-12 to the culture solution of the skin resident bacteria collected from the human eyebrows, and quantifying the amount of glycerol production. Fig. 3 shows the results obtained by quantifying the amount of glycerol collected from human cheeks in a human observation test using a soft lotion containing heat-treating dead cells of Enterococcus faecalis EC-12. Figure 4 shows the culture of a human normal keratinocyte culture medium in a medium containing heat-treated dead cells containing Enterococcus faecalis EC-12, extracting RNA from a human normal keratinocyte cell line, and measuring human β-defense by real-time PCR. The results obtained by expressing the amount of ubiquitin-2 (hBD2) and human β-defensin-3 (hBD3) mRNA.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111763630A (en) * | 2019-03-27 | 2020-10-13 | 深圳微健康基因科技有限公司 | Staphylococcus epidermidis and application thereof |
Also Published As
Publication number | Publication date |
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HK1252774A1 (en) | 2019-05-31 |
WO2017094916A1 (en) | 2017-06-08 |
TWI746492B (en) | 2021-11-21 |
JP6185041B2 (en) | 2017-08-23 |
JP2017101006A (en) | 2017-06-08 |
KR20180084729A (en) | 2018-07-25 |
CN107922956A (en) | 2018-04-17 |
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