CN115040450B

CN115040450B - Female private wet tissue and preparation method thereof

Info

Publication number: CN115040450B
Application number: CN202210849703.6A
Authority: CN
Inventors: 王金都
Original assignee: Orange Fujian Sanitary Products Co ltd
Current assignee: Orange Fujian Sanitary Products Co ltd
Priority date: 2022-07-19
Filing date: 2022-07-19
Publication date: 2023-05-16
Anticipated expiration: 2042-07-19
Also published as: CN115040450A

Abstract

The invention relates to the field of wet tissues, and provides a female private wet tissue and a preparation method thereof, wherein the wet tissue comprises a base material and a wet tissue compound liquid, and the wet tissue compound liquid comprises the following components in parts by weight: 0.04-0.08 part of benzalkonium chloride, 0.2-0.5 part of propylene glycol, 0.3-0.8 part of PEG-40 hydrogenated castor oil, 0.1-0.3 part of polyhexamethylene guanidine hydrochloride, 0.008-0.016 part of fructus cnidii extract, 0.015-0.03 part of motherwort extract, 0.03-0.08 part of honeysuckle extract, 0.02-0.04 part of raspberry extract, 0.01-0.03 part of polygonum multiflorum extract, 0.012-0.024 part of rosemary extract, 0.08-0.15 part of ethylhexyl glycerol, 0.06-0.12 part of phenoxyethanol and 85-95 parts of deionized water. The wet tissue solves the problems that the existing wet tissue is single in function and even stimulates female private parts.

Description

Female private wet tissue and preparation method thereof

Technical Field

The invention relates to the technical field of wet tissues, in particular to a female private wet tissue and a preparation method thereof.

Background

The wet towel is a disposable sanitary article which is made by selecting a wet-strength soft fiber high-permeability base material, folding, humidifying and packaging, and has the basic functions of cleaning, sterilizing, moisturizing skin, and is convenient to carry, etc., thus becoming an indispensable cleaning article in daily life of people.

The female private parts are important organs for metabolism and secretion, the female private parts are relatively complex in environment influenced by internal and external factors, are extremely easy to be infected by various germs and cause diseases, not only influence the physical and psychological health and the quality of life of females, but also can cause infertility; meanwhile, the skin at the private part is sensitive, various inflammations or simple skin itch are easy to occur, and special nourishing and nursing are needed. Most of the existing wet tissues have the simple and clean effect, have general antibacterial property and even can irritate the skin of female private parts, and can not well meet the requirements of female consumers. Therefore, developing a specialized wet wipe suitable for caring for the private parts of women is a highly desirable problem for those skilled in the art.

At present, various wet towel products special for female care have been developed successfully, for example, patent application number CN201310316640.9 discloses a wet towel special for female private care, and the wet towel is prepared by preparing a wet towel stock solution from nano silver solution, water-soluble vitamin E, hyaluronic acid, lauric acid modified superoxide dismutase, chamomile hydrosol, pearl hydrolysate, saponin extract, 1, 2-propylene glycol, isothiazolinone and deionized water according to a certain proportion, uniformly dripping the wet towel stock solution on a spun-laced non-woven fabric film, and sealing and packaging. The product of the invention is used, and the wet towel is only required to be covered on the private parts of women smoothly, and the private parts of women are wiped back and forth for a plurality of times after a moment. The product of the invention can sterilize and disinfect female private parts, moisten and clean skin of the private parts, and has no side effect and no irritation. For example, patent application number CN201410265378.4 discloses a functional female care wet tissue and a preparation method, wherein the functional female care wet tissue is prepared by injecting functional probiotics, propylene glycol, polyhexamethylene biguanide, a moisturizing curing agent, essential oil and purified water into a spun-laced non-woven fabric. The female care wet tissue provided by the invention is used for cleaning female pudendum, functional probiotics are introduced according to a specific formula proportion, long-term activity of the probiotics is maintained, growth and reproduction of female pudendum escherichia coli, staphylococcus aureus and candida albicans are effectively inhibited, and the micro-ecological environment of the pudendum is rebuilt. The sanitary towel has the effects of mildly cleaning, tendering and maintaining, can inhibit harmful bacteria infection of female pudendum, can endow the female care wet towel with good inhibition of harmful bacteria growth, reduces the conditions of itch, inflammation and the like caused by harmful bacteria infection of female private parts, effectively protects the health of female pudendum and genital tract, has no irritation and sensitization, and is safe and effective.

Disclosure of Invention

Therefore, aiming at the above, the invention provides the female private wet tissue and the preparation method thereof, which solve the problems that the existing wet tissue has single function, most of the wet tissue only has a cleaning function, has general antibacterial and antibacterial properties, even has irritation to the skin of the female private part and cannot well meet the requirements of female consumers.

In order to achieve the above purpose, the invention is realized by the following technical scheme:

the private wet tissue for women comprises a base material and a wet tissue compound liquid infiltrated on the base material, wherein the wet tissue compound liquid comprises the following components in parts by weight: 0.04-0.08 part of benzalkonium chloride, 0.2-0.5 part of propylene glycol, 0.008-0.016 part of fructus cnidii extract, 0.015-0.03 part of motherwort extract, 0.03-0.08 part of honeysuckle extract, 0.02-0.04 part of raspberry extract, 0.01-0.03 part of polygonum multiflorum extract, 0.012-0.024 part of rosemary extract, 0.3-0.8 part of PEG-40 hydrogenated castor oil, 0.1-0.3 part of polyhexamethylene guanidine hydrochloride, 0.08-0.15 part of ethylhexyl glycerol, 0.06-0.12 part of phenoxyethanol and 85-95 parts of deionized water.

The further improvement is that: the base material is a spunlaced non-woven fabric.

The further improvement is that: the mass ratio of the base material to the wet tissue compound liquid is 1:2-4.

The further improvement is that: the fructus cnidii extract is prepared by the following steps: pulverizing dried fructus Cnidii to 40-60 meshes, adding 12-16 times of first solvent of fructus Cnidii, performing ultrasonic extraction for 20-40min at 56-64deg.C, reflux-extracting at constant temperature for 2-4 hr, concentrating the filtered filtrate under reduced pressure to obtain fructus Cnidii extractive solution, wherein the first solvent is prepared by compounding isopropanol and ethylene glycol dimethyl ether at a mass ratio of 1:1.

The further improvement is that: the motherwort extracting solution is prepared by the following steps:

pulverizing dried herba Leonuri leaves to 30-50 mesh, adding 14-18 times of second solvent of herba Leonuri, ultrasonic extracting for 20-40min at 45-55deg.C, reflux extracting at constant temperature for 3.5-5.5 hr, filtering, concentrating under reduced pressure to obtain herba Leonuri extractive solution, wherein the second solvent is prepared by compounding isopropanol and ethylene glycol dimethyl ether at mass ratio of 3:2.

The further improvement is that: the honeysuckle extract is prepared by the following steps:

pulverizing dried honeysuckle to 40-60 meshes, adding a third solvent 15-20 times of the honeysuckle, performing ultrasonic extraction for 25-45min at the ultrasonic extraction temperature of 42-48 ℃, performing constant-temperature reflux extraction for 2.5-4.5h, and concentrating the filtered filtrate under reduced pressure to obtain honeysuckle extract, wherein the third solvent is prepared by compounding ethyl acetate and acetone according to the mass ratio of 1:2.

The further improvement is that: the raspberry extract is prepared by the following steps:

pulverizing dried Rubi fructus to 60-80 mesh, adding 10-15 times of 85wt% ethanol solution of Rubi fructus, soaking for 1-2 hr, ultrasonic extracting for 30-50min at 35-45deg.C, and filtering to obtain first filtrate and first residue; adding 9-13 times of 85wt% ethanol solution into the first filter residue, reflux extracting for 1.5-3h, and filtering to obtain second filtrate and second filter residue; adding 6-9 times of 85wt% ethanol solution into the second filter residue, reflux extracting for 1-2h, and filtering to obtain a third filtrate; mixing the filtrates, and concentrating under reduced pressure to obtain Rubi fructus extract.

The further improvement is that: the polygonum multiflorum extracting solution is prepared by the following steps:

pulverizing dried Polygoni Multiflori radix to 60-80 mesh, adding 14-18 times of fourth solvent, ultrasonic extracting at room temperature for 20-40min, reflux extracting at constant temperature for 3-5 hr, filtering, concentrating under reduced pressure to obtain Polygoni Multiflori radix extractive solution, and mixing ethanol and diethyl ether at a mass ratio of 4:1 to obtain the final product.

The further improvement is that: the rosemary extract is prepared by the following steps:

pulverizing dried herba Rosmarini officinalis to 20-40 mesh, adding 15-20 times of 85wt% ethanol solution of herba Rosmarini officinalis, soaking for 0.5-1.5 hr, ultrasonic extracting for 40-60min at 35-45deg.C, and filtering to obtain fourth filtrate and fourth residue; adding 12-16 times of 85wt% ethanol solution into the fourth filter residue, reflux extracting for 2-4h, and filtering to obtain fifth filtrate and fifth filter residue; adding 9-13 times of 85wt% ethanol solution into the fifth filter residue, reflux extracting for 1-3h, and filtering to obtain sixth filtrate; mixing the filtrates, and concentrating under reduced pressure to obtain herba Rosmarini officinalis extractive solution.

The invention also provides a preparation method of the female private wet tissue, which comprises the following steps:

s1, uniformly stirring and mixing an cnidium fruit extract, a motherwort extract, a honeysuckle extract, a raspberry extract, a polygonum multiflorum extract, a rosemary extract, propylene glycol, PEG-40 hydrogenated castor oil, ethylhexyl glycerol and phenoxyethanol to obtain an oil phase solution;

s2, adding benzalkonium chloride and polyhexamethylene biguanide hydrochloride into deionized water, and uniformly stirring and mixing to obtain a water phase solution;

s3, adding the aqueous phase solution into the oil phase solution, and uniformly stirring and mixing to obtain wet tissue compound liquid;

s4, soaking the sterilized base material in the wet tissue compound liquid, and finally folding, sealing and packaging to obtain the female private wet tissue.

The polyhexamethylene biguanide hydrochloride is a cationic polymer, is an environment-friendly high-molecular polymer bactericide, has the advantages of no color, no smell, no irritation to skin, no toxicity and the like, has broad-spectrum antibacterial property, high action speed, stable property, low effective concentration and the like, and is easy to be adsorbed by microorganisms, so that the splitting function of the microorganisms such as bacteria and the like is inhibited, the microorganisms lose reproductive capacity, and the polymer blocks the respiratory passage of the microorganisms, so that the microorganisms are choked.

The benzalkonium chloride solution is a quaternary ammonium salt cationic surfactant, is a broad-spectrum bactericide, can change the permeability of bacterial cytoplasmic membrane, and can make bacterial cytoplasmic substances extravasate to block metabolism and play a role in killing. The water-soluble modified starch has the advantages of low toxicity, small irritation, good water solubility, convenient use and storage, certain dispersive permeation effect and capability of removing peculiar smell.

Polygonum multiflorum is bitter, sweet and astringent in taste, warm in nature, and enters liver and kidney meridians. Is used for nourishing blood, nourishing yin, loosening bowel to relieve constipation, stopping malaria, dispelling pathogenic wind, and removing toxic substances. Is used for treating dizziness due to blood deficiency, palpitation, insomnia, soreness of waist and knees due to yin deficiency of liver and kidney, premature gray hair, tinnitus, spermatorrhea, constipation due to intestinal dryness, weakness due to malaria, rubella, pruritus, sore, carbuncle, scrofula, and hemorrhoid.

Herba Rosmarini officinalis has warm nature, pungent taste, and effects of tranquilizing, sterilizing, refreshing, and promoting urination, and can be used for treating dyspepsia, gastralgia, insomnia, headache, and palpitation. The extract of Rosmarinus officinalis also has effects of promoting blood circulation, promoting metabolism, lowering blood sugar, preventing and treating atherosclerosis, improving memory, caring skin, reducing cholesterol, reducing weight, improving attention, strengthening liver function, and improving alopecia, and can be used for adjuvant treatment of arthritis, trauma, rheumatism, etc. The rosemary extract gives off a sweet aroma and has a unique flavor.

Di Huang Zi is pungent, bitter and warm in nature, and has little toxicity, and enters kidney meridian. The fructus Cnidii extract has effects of eliminating dampness, dispelling pathogenic wind, killing parasite and relieving itching. Can be used for treating cold womb, cold-dampness leukorrhagia, damp arthralgia, lumbago, eczema of yin, trichomonas vaginitis, etc. The essential drugs for treating damp itch, female leukorrhagia and pruritus vulvae, scabies and tinea damp sore are mainly carried in Shennong Ben Cao Jing, which is "swelling and pain in the middle-jiao of main women", and the volatile oil contained in the essential drugs has stronger effects of resisting trichomonas, fungi and the like.

Leonurus herb is pungent and bitter in flavor and slightly cold in nature, enters liver, kidney and pericardium meridians. The herba Leonuri extract has effects of promoting blood circulation, regulating menstruation, removing blood stasis, promoting tissue regeneration, promoting urination, relieving swelling, and clearing heat and toxic substances, and can be used for treating menoxenia, miscarriage, dystocia, and puerperal retention, puerperal blood dizziness, abdominal pain due to blood stasis, metrorrhagia, hematuria, blood diarrhea, carbuncle, swelling and skin infection.

Honeysuckle is sweet and cold in nature and enters lung and stomach meridians. Shennong Ben Cao Jing (Shennong's herbal medicine book): honeysuckle flower has cold nature and sweet taste, has the effects of clearing heat and detoxicating, cooling blood and removing blood stasis, and is mainly used for treating exogenous wind-heat, initial pestilence, sore and ulcer furuncle, red swelling and pain, purulent stool, blood stasis and the like. The flos Lonicerae extract has antibacterial and antiinflammatory effects, and has strong skin penetration effect, and can reach deep skin.

The raspberry temperature; sweet and sour; enter kidney and bladder meridians. The raspberry extract contains a large amount of flavonoid substances, has the effects of resisting bacteria, diminishing inflammation and resisting allergy, is also used for protecting skin, improving the blood circulation of skin, enhancing the elasticity of skin capillaries, and further regenerating skin cells to obtain the effects of maintaining beauty, keeping young and resisting aging.

By adopting the technical scheme, the invention has the beneficial effects that:

the formula of the wet tissue compound liquid is adjusted and optimized, the raw materials are reasonably proportioned, and the prepared wet tissue can effectively moisten and clean female private parts, is safe and non-irritating, and does not damage vaginal mucosa. The raw material components of the wet tissue compound liquid play roles of the raw material components, and simultaneously cooperate with each other to promote the effects of the raw material components, so that the wet tissue compound liquid has an excellent antibacterial effect, can reduce the conditions of peculiar smell, itching, inflammation and the like of female private parts caused by harmful bacteria infection, regulate and maintain the ecological balance of flora of the female private parts, and effectively protect the health of female private parts and genital tracts.

The invention selects natural plants of fructus cnidii, motherwort, honeysuckle, raspberry, polygonum multiflorum and rosemary as raw materials, determines a targeted extraction process based on the full research of various natural plants, selects specific two solvents as an extracting agent, combines ultrasonic auxiliary extraction, and has high active ingredient content in the obtained extracting solution, and the extraction rate is superior to that of the single solvent extraction method in the prior art. The six natural plant extracts are scientifically combined, so that the six natural plant extracts can quickly permeate into the skin, and the respective effects are exerted. The strong permeability of the honeysuckle can promote the rapid permeation and absorption of other natural plant components, the time for generating the effect is faster, and the effect is more obvious. The rosemary and the raspberry have the effects of promoting blood circulation, improving the state of skin at the private part of female skin, increasing the permeability of the skin and promoting the permeation and absorption of active ingredients. The polygonum multiflorum contains rich lecithin, and the compound system of the ethanol and the diethyl ether is used as an extracting agent, so that the extraction rate of the lecithin can be improved, the lecithin not only can soften and relieve the skin, but also can serve as a permeation promoter, and the permeation of other active ingredients is enhanced to reach deep skin.

The preparation method comprises pulverizing and sieving various natural plants before extraction, and can promote release of active ingredients, increase dissolution amount in extractant, increase active ingredient content in extractive solution, and improve extraction efficiency. Each natural plant has an optimal particle size range, the extraction efficiency is reduced when the particle size is too large, the particle size is too small and is easy to float above the solution, and the extraction effect is affected. Based on the quality of natural plant powder, the active ingredients can be fully released and dissolved by adopting an extracting agent with proper quality, so that the extraction rate of the active ingredients is improved; on the premise of ensuring the extraction rate, the use amount of the extractant can be reduced, and the cost is saved.

Detailed Description

The following describes embodiments of the present invention in detail with reference to specific examples, so as to solve the technical problem by applying the technical means to the present invention, and the implementation process for achieving the technical effect can be fully understood and implemented accordingly.

Unless otherwise indicated, the technical means employed in the examples are conventional means well known to those skilled in the art, and the reagents and products employed are also commercially available. The sources of the reagents used, the trade names and the members of the list of constituents which are necessary are all indicated at the first occurrence.

Example 1

The utility model provides a private wet wipe for women, includes substrate and wet wipe compound liquid that soaks on the substrate, the substrate is water thorn non-woven fabrics, substrate and wet wipe compound liquid's mass ratio is 1:2, wet wipe compound liquid includes the component of following parts by weight: 0.04 part of benzalkonium chloride, 0.2 part of propylene glycol, 0.008 part of fructus cnidii extract, 0.024 part of motherwort extract, 0.08 part of honeysuckle extract, 0.02 part of raspberry extract, 0.01 part of polygonum multiflorum extract, 0.018 part of rosemary extract, 0.3 part of PEG-40 hydrogenated castor oil, 0.1 part of polyhexamethylene guanidine hydrochloride, 0.08 part of ethylhexyl glycerol, 0.06 part of phenoxyethanol and 85 parts of deionized water.

The fructus cnidii extract is prepared by the following steps: pulverizing dried fructus Cnidii to 40 meshes, adding 12 times of first solvent of fructus Cnidii, performing ultrasonic extraction for 40min at a temperature of 56 ℃, performing constant-temperature reflux extraction for 2h, and concentrating the filtered filtrate under reduced pressure to obtain fructus Cnidii extract, wherein the first solvent is prepared by compounding isopropanol and ethylene glycol dimethyl ether according to a mass ratio of 1:1.

The motherwort extracting solution is prepared by the following steps: pulverizing dried herba Leonuri leaves to 30 mesh, adding 14 times of second solvent of herba Leonuri, ultrasonic extracting for 40min at 45deg.C, reflux extracting at constant temperature for 3.5 hr, concentrating the filtrate under reduced pressure to obtain herba Leonuri extractive solution, and mixing isopropanol and ethylene glycol dimethyl ether at a mass ratio of 3:2.

The honeysuckle extract is prepared by the following steps: pulverizing dried honeysuckle to 40 meshes, adding a third solvent 15 times of the honeysuckle, performing ultrasonic extraction for 45min, performing constant-temperature reflux extraction for 2.5h at the ultrasonic extraction temperature of 42 ℃, and concentrating the filtered filtrate under reduced pressure to obtain honeysuckle extract, wherein the third solvent is prepared by compounding ethyl acetate and acetone according to the mass ratio of 1:2.

The raspberry extract is prepared by the following steps: pulverizing dried Rubi fructus to 60 mesh, adding 10 times of 85wt% ethanol solution of Rubi fructus, soaking for 1 hr, ultrasonic extracting for 50min at 35deg.C, and filtering to obtain first filtrate and first residue; adding 9 times of 85wt% ethanol solution into the first filter residue, reflux extracting for 1.5h, and filtering to obtain a second filtrate and a second filter residue; adding 6 times of 85wt% ethanol solution into the second filter residue, reflux-extracting for 1h, and filtering to obtain a third filtrate; mixing the filtrates, and concentrating under reduced pressure to obtain Rubi fructus extract.

The polygonum multiflorum extracting solution is prepared by the following steps: pulverizing dried Polygoni Multiflori radix to 60 mesh, adding 14 times of fourth solvent, ultrasonic extracting at room temperature for 40min, reflux extracting at constant temperature for 3 hr, and concentrating the filtrate under reduced pressure to obtain Polygoni Multiflori radix extractive solution, wherein the fourth solvent is prepared by compounding ethanol and diethyl ether at a mass ratio of 4:1.

The rosemary extract is prepared by the following steps: pulverizing dried herba Rosmarini officinalis to 20 mesh, adding 15 times of 85wt% ethanol solution of herba Rosmarini officinalis, soaking for 0.5 hr, ultrasonic extracting for 60min at 35deg.C, and filtering to obtain fourth filtrate and fourth residue; adding 12 times of 85wt% ethanol solution into the fourth filter residue, reflux-extracting for 2h, and filtering to obtain a fifth filtrate and a fifth filter residue; adding 9 times of 85wt% ethanol solution into the fifth filter residue, reflux-extracting for 1h, and filtering to obtain a sixth filtrate; mixing the filtrates, and concentrating under reduced pressure to obtain herba Rosmarini officinalis extractive solution.

The preparation method of the female private wet tissue comprises the following steps:

According to GB15979-2002 "sanitary Standard for Disposable sanitary articles", the female private wet towel prepared in this example is subjected to an antibacterial test for 5min, the test strains are staphylococcus aureus ATCC6538, escherichia coli ATCC 25922 and candida albicans ATCC10231, and the test results are as follows: the antibacterial rate of staphylococcus aureus is 99.42%, the antibacterial rate of escherichia coli is 99.34%, and the antibacterial rate of candida albicans is 98.95%.

Comparative example 1

A female private wet tissue and a preparation method thereof are different from example 1 in that: the benzalkonium chloride is proportionally replaced by polyhexamethylene guanidine hydrochloride and six extracting solutions, and the total mass is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 84.63%, the bacteriostasis rate of escherichia coli is 79.55%, and the bacteriostasis rate of candida albicans is 75.81%.

Comparative example 2

A female private wet tissue and a preparation method thereof are different from example 1 in that: the polyhexamethylene guanidine hydrochloride is proportionally replaced by benzalkonium chloride and six extracting solutions, and the total mass is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 81.26%, the bacteriostasis rate of escherichia coli is 78.34%, and the bacteriostasis rate of candida albicans is 73.72%.

Comparative example 3

A female private wet tissue and a preparation method thereof are different from example 1 in that: the six extracting solutions are replaced by cinnamon extracting solution with equal mass, and the total mass is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 82.85%, the bacteriostasis rate of escherichia coli is 76.48%, and the bacteriostasis rate of candida albicans is 74.09%.

As is clear from comparison of example 1 and comparative examples 1 to 3, benzalkonium chloride, polyhexamethylene guanidine hydrochloride and plant extract all have antibacterial properties, and after compounding, a synergistic antibacterial effect is generated, the antibacterial effect is remarkably enhanced, and under the same total addition amount, any antibacterial component in the mixture is absent, and the antibacterial effect is reduced. The common antibacterial component cinnamon extract is replaced by the composite plant extract, so that the antibacterial effect is weakened, and the fact that the cinnamon extract is combined with benzalkonium chloride and polyhexamethylene guanidine hydrochloride does not have or has relatively weak synergistic antibacterial effect is indicated.

Comparative example 4

A female private wet tissue and a preparation method thereof are different from example 1 in that: the cnidium fruit extract is replaced by other five extracts in proportion, and the total mass is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 92.18%, the bacteriostasis rate of escherichia coli is 88.92%, and the bacteriostasis rate of candida albicans is 82.73%.

Comparative example 5

A female private wet tissue and a preparation method thereof are different from example 1 in that: the motherwort extracting solution is replaced by other five extracting solutions according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 90.65%, the bacteriostasis rate of escherichia coli is 90.26%, and the bacteriostasis rate of candida albicans is 80.49%.

Comparative example 6

A female private wet tissue and a preparation method thereof are different from example 1 in that: the honeysuckle extracting solution is replaced by other five extracting solutions according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 92.66%, the bacteriostasis rate of escherichia coli is 86.37%, and the bacteriostasis rate of candida albicans is 77.52%.

Comparative example 7

A female private wet tissue and a preparation method thereof are different from example 1 in that: the raspberry extract is replaced by other five extracts according to a certain proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 89.41%, the bacteriostasis rate of escherichia coli is 86.03%, and the bacteriostasis rate of candida albicans is 80.29%.

Comparative example 8

A female private wet tissue and a preparation method thereof are different from example 1 in that: the polygonum multiflorum extracting solution is replaced by other five extracting solutions according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 90.97%, the bacteriostasis rate of escherichia coli is 91.20%, and the bacteriostasis rate of candida albicans is 82.36%.

Comparative example 9

A female private wet tissue and a preparation method thereof are different from example 1 in that: the rosemary extract is replaced by other five extracts according to a certain proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 91.58%, the bacteriostasis rate of escherichia coli is 91.09%, and the bacteriostasis rate of candida albicans is 81.43%.

Comparative example 10

A female private wet tissue and a preparation method thereof are different from example 1 in that: the fructus cnidii extract and the motherwort extract are replaced by other four extracts according to the proportion, and the total mass is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 88.13%, the bacteriostasis rate of escherichia coli is 86.75%, and the bacteriostasis rate of candida albicans is 78.64%.

Comparative example 11

A female private wet tissue and a preparation method thereof are different from example 1 in that: the fructus cnidii extract and the honeysuckle extract are replaced by other four extracts according to the proportion, and the total mass is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 88.76%, the bacteriostasis rate of escherichia coli is 86.10%, and the bacteriostasis rate of candida albicans is 77.54%.

Comparative example 12

A female private wet tissue and a preparation method thereof are different from example 1 in that: the fructus cnidii extract and the raspberry extract are replaced by other four extracts according to the proportion, and the total mass is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 86.29%, the bacteriostasis rate of escherichia coli is 82.03%, and the bacteriostasis rate of candida albicans is 75.84%.

Comparative example 13

A female private wet tissue and a preparation method thereof are different from example 1 in that: the cnidium fruit extract and the polygonum multiflorum extract are replaced by other four extracts according to a proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 88.36%, the bacteriostasis rate of escherichia coli is 87.95%, and the bacteriostasis rate of candida albicans is 80.41%.

Comparative example 14

A female private wet tissue and a preparation method thereof are different from example 1 in that: the fructus cnidii extract and the rosemary extract are replaced by other four extracts according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 89.24%, the bacteriostasis rate of escherichia coli is 87.48%, and the bacteriostasis rate of candida albicans is 79.55%.

Comparative example 15

A female private wet tissue and a preparation method thereof are different from example 1 in that: the motherwort extracting solution and the honeysuckle extracting solution are replaced by other four extracting solutions according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 87.58%, the bacteriostasis rate of escherichia coli is 85.26%, and the bacteriostasis rate of candida albicans is 76.39%.

Comparative example 16

A female private wet tissue and a preparation method thereof are different from example 1 in that: the motherwort extracting solution and the raspberry extracting solution are replaced by other four extracting solutions according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 84.61%, the bacteriostasis rate of escherichia coli is 82.35%, and the bacteriostasis rate of candida albicans is 75.40%.

Comparative example 17

A female private wet tissue and a preparation method thereof are different from example 1 in that: the motherwort extract and the polygonum multiflorum extract are replaced by other four extracts according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 87.09%, the bacteriostasis rate of escherichia coli is 86.17%, and the bacteriostasis rate of candida albicans is 78.35%.

Comparative example 18

A female private wet tissue and a preparation method thereof are different from example 1 in that: the motherwort extracting solution and the rosemary extracting solution are replaced by other four extracting solutions according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 86.53%, the bacteriostasis rate of escherichia coli is 86.87%, and the bacteriostasis rate of candida albicans is 76.05%.

Comparative example 19

A female private wet tissue and a preparation method thereof are different from example 1 in that: the honeysuckle extracting solution and the raspberry extracting solution are replaced by other four extracting solutions according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 84.42%, the bacteriostasis rate of escherichia coli is 82.91%, and the bacteriostasis rate of candida albicans is 75.73%.

Comparative example 20

A female private wet tissue and a preparation method thereof are different from example 1 in that: the honeysuckle extract and the polygonum multiflorum extract are replaced by other four extracts according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 89.11%, the bacteriostasis rate of escherichia coli is 87.64%, and the bacteriostasis rate of candida albicans is 80.25%.

Comparative example 21

A female private wet tissue and a preparation method thereof are different from example 1 in that: the honeysuckle extract and the rosemary extract are replaced by other four extracts according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 87.83%, the bacteriostasis rate of escherichia coli is 88.05%, and the bacteriostasis rate of candida albicans is 78.17%.

Comparative example 22

A female private wet tissue and a preparation method thereof are different from example 1 in that: the raspberry extract and the rosemary extract are replaced by other four extracts according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 86.38%, the bacteriostasis rate of escherichia coli is 83.22%, and the bacteriostasis rate of candida albicans is 76.49%.

Comparative example 23

A female private wet tissue and a preparation method thereof are different from example 1 in that: the raspberry extract and the polygonum multiflorum extract are replaced by other four extracts according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 87.41%, the bacteriostasis rate of escherichia coli is 87.50%, and the bacteriostasis rate of candida albicans is 80.06%.

Comparative example 24

A female private wet tissue and a preparation method thereof are different from example 1 in that: the rosemary extract and the polygonum multiflorum extract are replaced by other four extracts according to the proportion, and the total quality is kept unchanged. The bacteriostasis rate of the finally prepared wet tissue on staphylococcus aureus is 88.95%, the bacteriostasis rate of escherichia coli is 88.30%, and the bacteriostasis rate of candida albicans is 80.52%.

As can be seen from a comparison of example 1 with comparative examples 4-24, the six plant extracts are synergistic, the antibacterial properties of the wet tissues are improved, and the antibacterial rate of the wet tissues is reduced to a certain extent when any one or more of the six plant extracts are absent.

Example 2

The utility model provides a private wet wipe for women, includes substrate and wet wipe compound liquid that soaks on the substrate, the substrate is water thorn non-woven fabrics, substrate and wet wipe compound liquid's mass ratio is 1:3, wet wipe compound liquid includes the component of following parts by weight: 0.06 part of benzalkonium chloride, 0.4 part of propylene glycol, 0.012 part of fructus cnidii extract, 0.03 part of motherwort extract, 0.03 part of honeysuckle extract, 0.03 part of raspberry extract, 0.03 part of polygonum multiflorum extract, 0.012 part of rosemary extract, 0.5 part of PEG-40 hydrogenated castor oil, 0.2 part of polyhexamethylene guanidine hydrochloride, 0.12 part of ethylhexyl glycerol, 0.09 part of phenoxyethanol and 90 parts of deionized water.

The fructus cnidii extract is prepared by the following steps: pulverizing dried fructus Cnidii to 50 meshes, adding 14 times of first solvent of fructus Cnidii, performing ultrasonic extraction for 30min at 60deg.C, performing constant temperature reflux extraction for 3 hr, and concentrating the filtrate under reduced pressure to obtain fructus Cnidii extractive solution, wherein the first solvent is prepared by compounding isopropanol and ethylene glycol dimethyl ether at a mass ratio of 1:1.

The motherwort extracting solution is prepared by the following steps: pulverizing dried herba Leonuri leaves to 40 mesh, adding 16 times of second solvent of herba Leonuri, ultrasonic extracting for 30min at 50deg.C, reflux extracting at constant temperature for 4.5 hr, filtering, concentrating under reduced pressure to obtain herba Leonuri extractive solution, and mixing isopropanol and ethylene glycol dimethyl ether at a mass ratio of 3:2.

The honeysuckle extract is prepared by the following steps: pulverizing dried honeysuckle to 50 meshes, adding a third solvent which is 18 times of the honeysuckle, carrying out ultrasonic extraction for 35min, carrying out constant-temperature reflux extraction for 3.5h at the ultrasonic extraction temperature of 45 ℃, and carrying out reduced pressure concentration on the filtered filtrate to obtain honeysuckle extract, wherein the third solvent is prepared by compounding ethyl acetate and acetone according to the mass ratio of 1:2.

The raspberry extract is prepared by the following steps: pulverizing dried Rubi fructus to 70 mesh, adding 12 times of 85wt% ethanol solution of Rubi fructus, soaking for 1.5 hr, ultrasonic extracting for 40min at 40deg.C, and filtering to obtain first filtrate and first residue; adding 11 times of 85wt% ethanol solution into the first filter residue, reflux-extracting for 2h, and filtering to obtain a second filtrate and a second filter residue; adding 8 times of 85wt% ethanol solution into the second filter residue, reflux-extracting for 1.5h, and filtering to obtain a third filtrate; mixing the filtrates, and concentrating under reduced pressure to obtain Rubi fructus extract.

The polygonum multiflorum extracting solution is prepared by the following steps: pulverizing dried Polygoni Multiflori radix to 70 mesh, adding 16 times of fourth solvent, ultrasonic extracting at room temperature for 30min, reflux extracting at constant temperature for 4 hr, and concentrating the filtrate under reduced pressure to obtain Polygoni Multiflori radix extractive solution, wherein the fourth solvent is prepared by compounding ethanol and diethyl ether at a mass ratio of 4:1.

The rosemary extract is prepared by the following steps: pulverizing dried herba Rosmarini officinalis to 30 mesh, adding 18 times of 85wt% ethanol solution of herba Rosmarini officinalis, soaking for 1 hr, ultrasonic extracting for 50min at 40deg.C, and filtering to obtain fourth filtrate and fourth residue; adding a 14-fold amount of 85wt% ethanol solution into the fourth filter residue, carrying out reflux extraction for 3h, and filtering to obtain a fifth filtrate and a fifth filter residue; adding 11 times of 85wt% ethanol solution into the fifth filter residue, reflux-extracting for 2h, and filtering to obtain a sixth filtrate; mixing the filtrates, and concentrating under reduced pressure to obtain herba Rosmarini officinalis extractive solution.

The wet tissue prepared in the embodiment has a bacteriostasis rate of 99.79% on staphylococcus aureus, 99.81% on escherichia coli and 99.25% on candida albicans.

Example 3

The utility model provides a private wet wipe for women, includes substrate and wet wipe compound liquid that soaks on the substrate, the substrate is the water thorn non-woven fabrics, substrate and wet wipe compound liquid's mass ratio is 1:4, wet wipe compound liquid includes the component of following parts by weight: 0.08 part of benzalkonium chloride, 0.5 part of propylene glycol, 0.016 part of fructus cnidii extract, 0.015 part of motherwort extract, 0.06 part of honeysuckle extract, 0.04 part of raspberry extract, 0.02 part of polygonum multiflorum extract, 0.024 part of rosemary extract, 0.8 part of PEG-40 hydrogenated castor oil, 0.3 part of polyhexamethylene guanidine hydrochloride, 0.15 part of ethylhexyl glycerol, 0.12 part of phenoxyethanol and 95 parts of deionized water.

The fructus cnidii extract is prepared by the following steps: pulverizing dried fructus Cnidii to 60 meshes, adding 16 times of first solvent of fructus Cnidii, performing ultrasonic extraction for 20min at the ultrasonic extraction temperature of 64 ℃, performing constant-temperature reflux extraction for 4h, and concentrating the filtered filtrate under reduced pressure to obtain fructus Cnidii extract, wherein the first solvent is prepared by compounding isopropanol and ethylene glycol dimethyl ether according to the mass ratio of 1:1.

The motherwort extracting solution is prepared by the following steps: pulverizing dried herba Leonuri leaves to 50 mesh, adding 18 times of second solvent of herba Leonuri, ultrasonic extracting for 20min at 55deg.C, reflux extracting at constant temperature for 5.5 hr, filtering, concentrating under reduced pressure to obtain herba Leonuri extractive solution, and mixing isopropanol and ethylene glycol dimethyl ether at mass ratio of 3:2.

The honeysuckle extract is prepared by the following steps: pulverizing dried honeysuckle to 60 meshes, adding a third solvent which is 20 times of the honeysuckle, carrying out ultrasonic extraction for 25min, carrying out constant-temperature reflux extraction for 4.5h at the ultrasonic extraction temperature of 48 ℃, and concentrating the filtered filtrate under reduced pressure to obtain honeysuckle extract, wherein the third solvent is prepared by compounding ethyl acetate and acetone according to the mass ratio of 1:2.

The raspberry extract is prepared by the following steps: pulverizing dried Rubi fructus to 80 mesh, adding 15 times of 85wt% ethanol solution of Rubi fructus, soaking for 2 hr, ultrasonic extracting for 30min at 45deg.C, and filtering to obtain first filtrate and first residue; adding 13 times of 85wt% ethanol solution into the first filter residue, reflux-extracting for 3h, and filtering to obtain a second filtrate and a second filter residue; adding 9 times of 85wt% ethanol solution into the second filter residue, reflux-extracting for 2h, and filtering to obtain a third filtrate; mixing the filtrates, and concentrating under reduced pressure to obtain Rubi fructus extract.

The polygonum multiflorum extracting solution is prepared by the following steps: pulverizing dried Polygoni Multiflori radix to 80 mesh, adding 18 times of fourth solvent, ultrasonic extracting at room temperature for 20min, reflux extracting at constant temperature for 5 hr, and concentrating the filtrate under reduced pressure to obtain Polygoni Multiflori radix extractive solution, wherein the fourth solvent is prepared by compounding ethanol and diethyl ether at a mass ratio of 4:1.

The rosemary extract is prepared by the following steps: pulverizing dried herba Rosmarini officinalis to 40 mesh, adding 20 times of 85wt% ethanol solution of herba Rosmarini officinalis, soaking for 1.5 hr, ultrasonic extracting for 40min at 45deg.C, and filtering to obtain fourth filtrate and fourth residue; adding a 16-fold amount of 85wt% ethanol solution into the fourth filter residue, carrying out reflux extraction for 4 hours, and filtering to obtain a fifth filtrate and a fifth filter residue; adding 13 times of 85wt% ethanol solution into the fifth filter residue, reflux-extracting for 3h, and filtering to obtain a sixth filtrate; mixing the filtrates, and concentrating under reduced pressure to obtain herba Rosmarini officinalis extractive solution.

The wet tissue prepared in the embodiment has a bacteriostasis rate of 99.99% on staphylococcus aureus, 99.99% on escherichia coli and 99.99% on candida albicans.

Skin irritation test

15 healthy, skin-friendly white rabbits were taken as test animals and divided into 3 groups of 5 animals each. 24 hours prior to testing, the hairs on both sides of the back spine of each group of test animals were cut off, exposing a 3cm x3cm area of skin. In the test, wet tissues prepared in examples one to three were respectively cut into pieces of 2.5cm×2.5cm and applied to the exposed skin on one side of the back of the rabbit, and the skin on the other side was used as a control. After application for 4 hours, the application was removed, and skin reactions at the application site were observed and recorded at lh, 24 hours, and 48 hours, respectively. The scoring criteria are as follows: (1) erythema formation: 0 is none; 1 is barely visible; 2 is obvious; 3 is severe; 4 is purplish red erythema with eschar. (2) edema formation: 0 is none; 1 is barely visible; 2 is skin bulge, the outline is clear; 3 is edema bulge about 1mm;4 is edema with a bulge exceeding 1mm. The test results are shown in Table 1.

TABLE 1

As can be seen from Table 1, the skin of each group of test animals did not develop erythema or edema within 48 hours, indicating that the wet tissues prepared in examples 1-3 were not irritating to the skin.

Vaginal mucosa irritation test

9 healthy, primary adult female white rabbits of the same strain are taken as test animals and are divided into 3 groups of 3 animals, and the weight of the animals is 2.0-2.5kg. The subject's vaginal orifice is free of secretions, congestion, oedema and other damage. According to the 'disinfection technical Specification', vaginal mucosa irritation test is carried out, the liquid in the wet tissues prepared in the examples 1-3 is extruded to be used as a test liquid, after the wet tissues are soaked by a sterilized cotton sliver, the sterilized cotton sliver is inserted into the vagina (4-5 cm), a control group is soaked by normal saline, the sterilized cotton sliver is inserted into the vagina of a test subject, after 24 hours, the animal is killed by an air embolism method, the vagina is taken out after the abdomen is opened, and whether congestion, edema and other phenomena exist or not is observed visually. The vaginal mucosa irritation response was scored according to the rules of the disinfection technical Specification, and the results are shown in Table 2.

TABLE 2

As can be seen from Table 2, the wet tissues prepared in the examples of the present invention have a score of less than 1 in the irritation response to vaginal mucosa, indicating that the product has no irritation to vaginal mucosa.

The above description is illustrative of the embodiments using the present teachings, and is not intended to limit the scope of the present teachings to any particular modification or variation of the present teachings by those skilled in the art.

Claims

1. A female private wet tissue, which is characterized in that: the wet tissue compound liquid comprises a base material and wet tissue compound liquid infiltrated on the base material, wherein the wet tissue compound liquid comprises the following components in parts by weight: 0.04-0.08 part of benzalkonium chloride, 0.2-0.5 part of propylene glycol, 0.3-0.8 part of PEG-40 hydrogenated castor oil, 0.1-0.3 part of polyhexamethylene guanidine hydrochloride, 0.008-0.016 part of fructus cnidii extract, 0.015-0.03 part of motherwort extract, 0.03-0.08 part of honeysuckle extract, 0.02-0.04 part of raspberry extract, 0.01-0.03 part of polygonum multiflorum extract, 0.012-0.024 part of rosemary extract, 0.08-0.15 part of ethylhexyl glycerol, 0.06-0.12 part of phenoxyethanol and 85-95 parts of deionized water.

2. A feminine private wet wipe as set forth in claim 1 wherein: the base material is a spunlaced non-woven fabric.

3. A feminine private wet wipe as set forth in claim 1 wherein: the mass ratio of the base material to the wet tissue compound liquid is 1:2-4.

4. A feminine private wet wipe as set forth in claim 1 wherein: the fructus cnidii extract is prepared by the following steps: pulverizing dried fructus Cnidii to 40-60 meshes, adding 12-16 times of first solvent of fructus Cnidii, extracting with ultrasound for 20-40min, reflux extracting at constant temperature for 2-4 hr, concentrating the filtrate under reduced pressure to obtain fructus Cnidii extractive solution, wherein the first solvent is prepared by compounding isopropanol and ethylene glycol dimethyl ether at a mass ratio of 1:1.

5. A feminine private wet wipe as set forth in claim 1 wherein: the motherwort extracting solution is prepared by the following steps: pulverizing dried herba Leonuri leaves to 30-50 mesh, adding 14-18 times of second solvent of herba Leonuri, ultrasonic extracting for 20-40min, reflux extracting at constant temperature for 3.5-5.5 hr, concentrating the filtrate under reduced pressure to obtain herba Leonuri extractive solution, wherein the second solvent is prepared by compounding isopropanol and ethylene glycol dimethyl ether at a mass ratio of 3:2.

6. A feminine private wet wipe as set forth in claim 1 wherein: the honeysuckle extract is prepared by the following steps: pulverizing dried honeysuckle to 40-60 meshes, adding a third solvent 15-20 times of the honeysuckle, performing ultrasonic extraction for 25-45min, performing constant-temperature reflux extraction for 2.5-4.5h, and concentrating the filtered filtrate under reduced pressure to obtain honeysuckle extract, wherein the third solvent is prepared by compounding ethyl acetate and acetone according to a mass ratio of 1:2.

7. A feminine private wet wipe as set forth in claim 1 wherein: the raspberry extract is prepared by the following steps: pulverizing dried Rubi fructus to 60-80 mesh, adding 10-15 times of 85wt% ethanol solution of Rubi fructus, soaking for 1-2 hr, ultrasonic extracting for 30-50min at 35-45deg.C, and filtering to obtain first filtrate and first residue; adding 9-13 times of 85wt% ethanol solution into the first filter residue, reflux extracting for 1.5-3h, and filtering to obtain second filtrate and second filter residue; adding 6-9 times of 85wt% ethanol solution into the second filter residue, reflux extracting for 1-2h, and filtering to obtain a third filtrate; mixing the filtrates, and concentrating under reduced pressure to obtain Rubi fructus extract.

8. A feminine private wet wipe as set forth in claim 1 wherein: the polygonum multiflorum extracting solution is prepared by the following steps: pulverizing dried Polygoni Multiflori radix to 60-80 mesh, adding fourth solvent 14-18 times of Polygoni Multiflori radix, ultrasonic extracting for 20-40min, reflux extracting at constant temperature for 3-5 hr, concentrating the filtrate under reduced pressure to obtain Polygoni Multiflori radix extractive solution, and mixing ethanol and diethyl ether at a mass ratio of 4:1 to obtain the final product.

9. A feminine private wet wipe as set forth in claim 1 wherein: the rosemary extract is prepared by the following steps: pulverizing dried herba Rosmarini officinalis to 20-40 mesh, adding 15-20 times of 85wt% ethanol solution of herba Rosmarini officinalis, soaking for 0.5-1.5 hr, ultrasonic extracting for 40-60min at 35-45deg.C, and filtering to obtain fourth filtrate and fourth residue; adding 12-16 times of 85wt% ethanol solution into the fourth filter residue, reflux extracting for 2-4h, and filtering to obtain fifth filtrate and fifth filter residue; adding 9-13 times of 85wt% ethanol solution into the fifth filter residue, reflux extracting for 1-3h, and filtering to obtain sixth filtrate; mixing the filtrates, and concentrating under reduced pressure to obtain herba Rosmarini officinalis extractive solution.

10. A method of making a feminine private wet wipe according to any of claims 1-9, wherein: the method comprises the following steps: