CN108578310A - A kind of nano peptide answers face exquisiteness essence and preparation method thereof - Google Patents
A kind of nano peptide answers face exquisiteness essence and preparation method thereof Download PDFInfo
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- CN108578310A CN108578310A CN201810258530.4A CN201810258530A CN108578310A CN 108578310 A CN108578310 A CN 108578310A CN 201810258530 A CN201810258530 A CN 201810258530A CN 108578310 A CN108578310 A CN 108578310A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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Abstract
The present invention relates to a kind of nano peptides to answer face exquisiteness essence and preparation method thereof, and it includes following component that nano peptide, which answers face exquisiteness essence,：Deionized water；Propylene glycol；Glycine betaine；Trehalose；Hyaluronic acid；Herba Saxifragae extract；Soluble collagen；Astragatus complanatus extract；Black bearberry leaf extract；Grape fruit extract；Ginger extract；Flos Chrysanthemi extract；Wolfberry fruit extract；Dipotassium glycyrrhizinate；Oligopeptides 1；Oligopeptides 2；Tripeptides 1；Phenoxyethanol；EDTA disodiums, formula is reasonable, does not add violated hormone, or easily decomposes and have the removing wrinkle and resisting aging substance of security risk；And removing wrinkle and resisting aging effect is good, and safety is without side-effects.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of nano peptide answers face exquisiteness essence, further relates to one kind and receives
Rice peptide answers the preparation method of face exquisiteness essence.
Background technology
Removing wrinkle and resisting aging product at present on the market is a variety of.But the removing wrinkle and resisting aging product anti-wrinkle period on the market is long, effect
Fruit unobvious, they are by hyaluronic acid in fact, and the synthesis such as collagen and semi-synthetic raw material reach anti-wrinkle effect, such original
Expect that molecular weight is big, grain size is also larger, is not easy percutaneously receipts and participates in fission process, to cause removing wrinkle and resisting aging effect not
Obviously, and safety is low, for a long time using easily bringing injury to human body.
Therefore, it is badly in need of a kind of nano peptide and answers face exquisiteness essence, is not adding labile security risk substance, reaching
To good removing wrinkle and resisting aging effect.
Invention content
In view of this, one of the objects of the present invention is to provide a kind of nano peptides to answer face exquisiteness essence；The purpose of the present invention
Two be to provide the preparation method that a kind of nano peptide answers face exquisiteness essence.
In order to achieve the above objectives, the present invention provides the following technical solutions：
A kind of nano peptide answers face exquisiteness essence, includes following component by weight：58.904 ~ 75.95 parts of deionized water；The third two
4 ~ 8 parts of alcohol；4 ~ 6 parts of glycine betaine；3 ~ 5 parts of trehalose；0.1 ~ 0.2 part of hyaluronic acid；2 ~ 3 parts of Herba Saxifragae extract；Soluble glue
It is 0.1 ~ 0.2 part former；1 ~ 2 part of astragatus complanatus extract；1 ~ 2 part of black bearberry leaf extract；2 ~ 3 parts of grape fruit extract；Ginger is extracted
1 ~ 2 part of object；2 ~ 3 parts of Flos Chrysanthemi extract；2 ~ 3 parts of wolfberry fruit extract；0.1 ~ 0.2 part of dipotassium glycyrrhizinate；0.5 ~ 1 part of oligopeptides -1；
0.5 ~ 1 part of oligopeptides -2；0.5 ~ 1 part of tripeptides -1；0.2 ~ 0.396 part of Phenoxyethanol；0.05 ~ 0.1 part of EDTA- disodiums.
Preferably, by weight include following component：74.654 parts of deionized water；5 parts of propylene glycol；4 parts of glycine betaine；Sea
3 parts of algae sugar；0.1 part of hyaluronic acid；2 parts of Herba Saxifragae extract；0.2 part of soluble collagen；1 part of astragatus complanatus extract；Bear
1 part of fruit leaf extract；2 parts of grape fruit extract；1 part of ginger extract；2 parts of Flos Chrysanthemi extract；2 parts of wolfberry fruit extract；Glycyrrhizic acid
0.1 part of dipotassium；0.5 part of oligopeptides -1；0.5 part of oligopeptides -2；0.5 part of tripeptides -1；0.396 part of Phenoxyethanol；EDTA- disodiums
0.05 part.
Preferably, by weight include following component：75.95 parts of deionized water；4 parts of propylene glycol；4 parts of glycine betaine；Sea
3 parts of algae sugar；0.1 part of hyaluronic acid；2 parts of Herba Saxifragae extract；0.1 part of soluble collagen；1 part of astragatus complanatus extract；Bear
1 part of fruit leaf extract；2 parts of grape fruit extract；1 part of ginger extract；2 parts of Flos Chrysanthemi extract；2 parts of wolfberry fruit extract；Glycyrrhizic acid
0.1 part of dipotassium；0.5 part of oligopeptides -1；0.5 part of oligopeptides -2；0.5 part of tripeptides -1；0.2 part of Phenoxyethanol；EDTA- disodiums 0.05
Part.
Preferably, by weight include following component：58.904 parts of deionized water；8 parts of propylene glycol；6 parts of glycine betaine；Sea
5 parts of algae sugar；0.2 part of hyaluronic acid；3 parts of Herba Saxifragae extract；0.2 part of soluble collagen；2 parts of astragatus complanatus extract；Bear
2 parts of fruit leaf extract；3 parts of grape fruit extract；2 parts of ginger extract；3 parts of Flos Chrysanthemi extract；3 parts of wolfberry fruit extract；Glycyrrhizic acid
0.2 part of dipotassium；1 part of oligopeptides -1；1 part of oligopeptides -2；1 part of tripeptides -1；0.396 part of Phenoxyethanol；0.1 part of EDTA- disodiums.
Preferably, the weight ratio of the material is：67.22 parts of deionized water；6 parts of propylene glycol；5 parts of glycine betaine；Trehalose 4
Part；0.15 part of hyaluronic acid；2.5 parts of Herba Saxifragae extract；0.2 part of soluble collagen；1.5 parts of astragatus complanatus extract；Black bearberry
1.5 parts of leaf extract；2.5 parts of grape fruit extract；1.5% part of ginger extract；2.5 parts of Flos Chrysanthemi extract；Wolfberry fruit extract 2.5
Part；0.15 part of dipotassium glycyrrhizinate；0.8 part of oligopeptides -1；0.8 part of oligopeptides -2；0.8 part of tripeptides -1；0.3 part of Phenoxyethanol；
0.08 part of EDTA- disodiums.
, described nano peptide answer the preparation method of face exquisiteness essence, include the following steps：
（1）According to formula, appropriate raw material is weighed；
（2）Deionized water, propylene glycol, glycine betaine, trehalose, hyaluronic acid, EDTA- disodiums are added in emulsifying pot, is warming up to
80 DEG C ~ 85 DEG C are stirred material to uniform solution；
（3）By step（2）In uniform solution keep the temperature 30min, stirring be cooled to 45 DEG C ~ 50 DEG C；
（4）Wait for temperature be down to 45 DEG C ~ 50 DEG C dipotassium glycyrrhizinates are added, soluble collagens stir 25 ~ 30min, temperature is down to 35 ~
40℃；
（5）Wait for that temperature is down to 35 ~ 40 DEG C or so and Herba Saxifragae extract, astragatus complanatus extract, black bearberry leaf extract, grape is added
Shaddock extract, ginger extract, Flos Chrysanthemi extract, wolfberry fruit extract, oligopeptides -1, oligopeptides -2, tripeptides -1, Phenoxyethanol stirring 30 ~
45min is to uniform solution；
（6）It after stirring, is cooled to room temperature, finished product filtering is sealed.
Preferably, step（2）In be warming up to 85 DEG C.
Preferably, step（3）Middle stirring is cooled to 45 DEG C.
Preferably, step（4）In, mixing time 28min.
Preferably, step（6）In, finished product is qualified products after detection.
The beneficial effects of the present invention are：The invention discloses a kind of nano peptides to answer face exquisiteness essence, and formula is reasonable, and not
Violated hormone is added, or easily decomposes and have the removing wrinkle and resisting aging substance of security risk；Removing wrinkle and resisting aging effect, and safe nothing can be reached
Side effect.
Specific implementation mode
The preferred embodiment of the present invention will be described in detail below.The present embodiment is being with technical solution of the present invention
Under the premise of implemented, give detailed embodiment and specific operating process, but protection scope of the present invention is not limited to
Following embodiments.In the following examples, the experimental methods for specific conditions are not specified, usually according to normal condition or according to manufacture
Condition proposed by manufacturer.
A kind of nano peptide of present invention offer answers face exquisiteness essence formula, including deionized water, propylene glycol, glycine betaine, seaweed
Sugar, hyaluronic acid, Herba Saxifragae extract, soluble collagen, astragatus complanatus extract, black bearberry leaf extract, grape fruit extract,
Ginger extract, Flos Chrysanthemi extract, wolfberry fruit extract, dipotassium glycyrrhizinate, oligopeptides -1, oligopeptides -2, tripeptides -1, Phenoxyethanol, EDTA-
Disodium；The weight ratio of the material is：Deionized water 58.904% ~ 75.95%；Propylene glycol 4% ~ 8%；Glycine betaine 4% ~ 6%；
Trehalose 3% ~ 5%；Hyaluronic acid 0.1% ~ 0.2%；Herba Saxifragae extract 2% ~ 3%；Soluble collagen 0.1% ~ 0.2%；
Astragatus complanatus extract 1% ~ 2%；Black bearberry leaf extract 1% ~ 2%；Grape fruit extract 2% ~ 3%；Ginger extract 1% ~
2%；Flos Chrysanthemi extract 2% ~ 3%；Wolfberry fruit extract 2% ~ 3%；Dipotassium glycyrrhizinate 0.1% ~ 0.2%；Oligopeptides -1 0.5% ~
1%；Oligopeptides -2 0.5% ~ 1%；Tripeptides -1 0.5% ~ 1%；Phenoxyethanol 0.2% ~ 0.396%；EDTA- disodiums 0.05% ~
0.1%；
Embodiment 1
A kind of nano peptide answers face exquisiteness essence processing technology, includes the following steps：
（1）Deionized water 74.654% is weighed by weight percentage；Propylene glycol 5%；Glycine betaine 4%；Trehalose 3%；Hyalomitome
Acid 0.1%；Herba Saxifragae extract 2%；Soluble collagen 0.2%；Astragatus complanatus extract 1%；Black bearberry leaf extract 1%；
Grape fruit extract 2%；Ginger extract 1%；Flos Chrysanthemi extract 2%；Wolfberry fruit extract 2%；Dipotassium glycyrrhizinate 0.1%；It is few
Peptide -1 0.5%；Oligopeptides -2 0.5%；Tripeptides -1 0.5%；Phenoxyethanol 0.396%；EDTA- disodiums 0.05%；
（2）Deionized water, propylene glycol, glycine betaine, trehalose, hyaluronic acid, EDTA- disodiums are added in emulsifying pot, is warming up to
80 DEG C ~ 85 DEG C are stirred material to uniform solution；
（3）By step（2）In uniform solution keep the temperature 30min, stirring be cooled to 45 DEG C ~ 50 DEG C；
（4）Wait for temperature be down to 45 DEG C ~ 50 DEG C dipotassium glycyrrhizinates are added, soluble collagens stir 25 ~ 30min, temperature is down to 35 ~
40 DEG C or so；
（5）Wait for that temperature is down to 35 ~ 40 DEG C or so and Herba Saxifragae extract, astragatus complanatus extract, black bearberry leaf extract, grape is added
Shaddock extract, ginger extract, Flos Chrysanthemi extract, wolfberry fruit extract, oligopeptides -1, oligopeptides -2, tripeptides -1, Phenoxyethanol stirring 30 ~
45min is to uniform solution；
（6）It after stirring, is cooled to room temperature, finished product filtering is sealed.
In the present embodiment, step（2）In most preferably 85 DEG C of raised temperature；Step（3）The temperature of middle reduction is 45 recently
℃；Step（4）In, the Best Times of stirring are 28min；Step（6）In, finished product is qualified products after detection.
Embodiment 2
A kind of nano peptide answers face exquisiteness essence processing technology, includes the following steps：
（1）Deionized water 75.95% is weighed by weight percentage；Propylene glycol 4%；Glycine betaine 4%；Trehalose 3%；Hyaluronic acid
0.1%；Herba Saxifragae extract 2%；Soluble collagen 0.1%；Astragatus complanatus extract 1%；Black bearberry leaf extract 1%；Portugal
Grape shaddock extract 2%；Ginger extract 1%；Flos Chrysanthemi extract 2%；Wolfberry fruit extract 2%；Dipotassium glycyrrhizinate 0.1%；Oligopeptides -1
0.5%；Oligopeptides -2 0.5%；Tripeptides -1 0.5%；Phenoxyethanol 0.2%；EDTA- disodiums 0.05%；
（2）Deionized water, propylene glycol, glycine betaine, trehalose, hyaluronic acid, EDTA- disodiums are added in emulsifying pot, is warming up to
80 DEG C ~ 85 DEG C are stirred material to uniform solution；
（3）By step（2）In uniform solution keep the temperature 30min, stirring be cooled to 45 DEG C ~ 50 DEG C；
（4）Wait for temperature be down to 45 DEG C ~ 50 DEG C dipotassium glycyrrhizinates are added, soluble collagens stir 25 ~ 30min, temperature is down to 35 ~
40℃；
（5）Wait for that temperature is down to 35 ~ 40 DEG C or so and Herba Saxifragae extract, astragatus complanatus extract, black bearberry leaf extract, grape is added
Shaddock extract, ginger extract, Flos Chrysanthemi extract, wolfberry fruit extract, oligopeptides -1, oligopeptides -2, tripeptides -1, Phenoxyethanol stirring 30 ~
45min is to uniform solution；
（6）It after stirring, is cooled to room temperature, finished product filtering is sealed.
In the present embodiment, the step（2）In most preferably 85 DEG C of raised temperature；Step（3）The temperature of middle reduction is 45
℃；Step（4）In, the Best Times of stirring are 28min；Step（6）In, finished product is qualified products after detection.
Embodiment 3
A kind of nano peptide answers face exquisiteness essence processing technology, includes the following steps：
（1）Deionized water 58.904% is weighed by weight percentage；Propylene glycol 8%；Glycine betaine 6%；Trehalose 5%；Hyalomitome
Acid 0.2%；Herba Saxifragae extract 3%；Soluble collagen 0.2%；Astragatus complanatus extract 2%；Black bearberry leaf extract 2%；
Grape fruit extract 3%；Ginger extract 2%；Flos Chrysanthemi extract 3%；Wolfberry fruit extract 3%；Dipotassium glycyrrhizinate 0.2%；It is few
Peptide -1 1%；Oligopeptides -2 1%；Tripeptides -1 1%；Phenoxyethanol 0.396%；EDTA- disodiums 0.1%
（2）Deionized water, propylene glycol, glycine betaine, trehalose, hyaluronic acid, EDTA- disodiums are added in emulsifying pot, is warming up to
75 DEG C ~ 85 DEG C are stirred material to uniform solution；
（3）By step（2）In uniform solution keep the temperature 30min, stirring be cooled to 45 DEG C ~ 50 DEG C；
（4）Wait for temperature be down to 45 DEG C ~ 50 DEG C dipotassium glycyrrhizinates are added, soluble collagens stir 25 ~ 30min, temperature is down to 35 ~
40℃；
（5）Wait for that temperature is down to 35 ~ 40 DEG C of addition Herba Saxifragae extracts, astragatus complanatus extract, black bearberry leaf extract, grape fruits and is carried
Object, ginger extract, Flos Chrysanthemi extract, wolfberry fruit extract, oligopeptides -1, oligopeptides -2, tripeptides -1, Phenoxyethanol is taken to stir 30 ~ 45min
To uniform solution；
（6）It after stirring, is cooled to room temperature, finished product filtering is sealed.
In the present embodiment, step（2）In most preferably 85 DEG C of raised temperature；Step（3）In, the temperature most preferably 45 of reduction
℃；Step（4）In, the Best Times of stirring are 28min；Step（6）In, finished product is qualified products after detection.
Embodiment 4
A kind of nano peptide answers face exquisiteness essence processing technology, includes the following steps：
（1）Deionized water 67.22% is weighed by weight percentage；Propylene glycol 6%；Glycine betaine 5%；Trehalose 4%；Hyaluronic acid
0.15%；Herba Saxifragae extract 2.5%；Soluble collagen 0.2%；Astragatus complanatus extract 1.5%；Black bearberry leaf extract
1.5%；Grape fruit extract 2.5%；Ginger extract 1.5%；Flos Chrysanthemi extract 2.5%；Wolfberry fruit extract 2.5%；Glycyrrhizic acid
Dipotassium 0.15%；Oligopeptides -1 0.8%；Oligopeptides -2 0.8%；Tripeptides -1 0.8%；Phenoxyethanol 0.3%；EDTA- disodiums
0.08%；
（2）Deionized water, propylene glycol, glycine betaine, trehalose, hyaluronic acid, EDTA- disodiums are added in emulsifying pot, is warming up to
80 DEG C ~ 85 DEG C are stirred material to uniform solution；
（3）By step（2）In uniform solution keep the temperature 30min, stirring be cooled to 45 DEG C ~ 50 DEG C；
（4）Wait for temperature be down to 45 DEG C ~ 50 DEG C dipotassium glycyrrhizinates are added, soluble collagens stir 25 ~ 30min, temperature is down to 35 ~
40 DEG C or so；
（5）Wait for that temperature is down to 35 ~ 40 DEG C or so and Herba Saxifragae extract, astragatus complanatus extract, black bearberry leaf extract, grape is added
Shaddock extract, ginger extract, Flos Chrysanthemi extract, wolfberry fruit extract, oligopeptides -1, oligopeptides -2, tripeptides -1, Phenoxyethanol stirring 30 ~
45min is to uniform solution；
（6）It after stirring, is cooled to room temperature, finished product filtering is sealed.
In the present embodiment, step（2）In most preferably 85 DEG C of raised temperature；Step（3）The temperature of middle reduction most preferably 45
℃；Step（4）In, the Best Times of stirring are 28min；Step（6）In, finished product is qualified products after detection.
Embodiment 5
A kind of nano peptide answers face exquisiteness essence processing technology, includes the following steps：
（1）Deionized water 70.65% is weighed by weight percentage；Propylene glycol 7%；Glycine betaine 3.5%；Trehalose 3.5%；
Hyaluronic acid 0.12%；Herba Saxifragae extract 2.3%；Soluble collagen 0.2%；Astragatus complanatus extract 1.8%；Uva ursi
Extract 1.8%；Grape fruit extract 2%；Ginger extract 1.8%；Flos Chrysanthemi extract 2%；Wolfberry fruit extract 1.8%；Radix Glycyrrhizae
Sour dipotassium 0.12%；Oligopeptides -1 0.6%；Oligopeptides -2 0.6%；Tripeptides -1 0.6%；Phenoxyethanol 0.35%；EDTA- disodiums
0.06%；
（2）Deionized water, propylene glycol, glycine betaine, trehalose, hyaluronic acid, EDTA- disodiums are added in emulsifying pot, is warming up to
80 DEG C ~ 85 DEG C are stirred material to uniform solution；
（3）By step（2）In uniform solution keep the temperature 30min, stirring be cooled to 45 DEG C ~ 50 DEG C；
（4）Wait for temperature be down to 45 DEG C ~ 50 DEG C dipotassium glycyrrhizinates are added, soluble collagens stir 25 ~ 30min, temperature is down to 35 ~
40℃；
（5）Wait for that temperature is down to 35 ~ 40 DEG C or so and Herba Saxifragae extract, astragatus complanatus extract, black bearberry leaf extract, grape is added
Shaddock extract, ginger extract, Flos Chrysanthemi extract, wolfberry fruit extract, oligopeptides -1, oligopeptides -2, tripeptides -1, Phenoxyethanol stirring 30 ~
45min is to uniform solution；
（6）It after stirring, is cooled to room temperature, finished product filtering is sealed.
In the present embodiment, the step（2）In most preferably 85 DEG C of raised temperature；Step（3）The temperature of middle reduction is nearest
It is 45 DEG C；Step（4）In, the Best Times of stirring are 28min；Step（6）In, finished product is qualified products after detection.
Oligopeptides -1, oligopeptides -2, tripeptides -1 and soluble collagen, after nano-encapsulated technical finesse, product cut size≤
5nm absorbs so as to effective transdermal penetration, to achieve the effect that preferable removing wrinkle and resisting aging.
Herba Saxifragae extract, astragatus complanatus extract, black bearberry leaf extract, grape fruit extract, ginger extraction in embodiment
Object, Flos Chrysanthemi extract, the extracting method of wolfberry fruit extract are as shown in table 1.
The extracting method of 1. extract of table
| Kiss-me carries Take object | Astragatus complanatus carries Take object | Uva ursi extracts Object | Grape fruit extracts Object | Ginger extract | Flos Chrysanthemi extract | Matrimony vine is extracted Object | |
| Extracting method | Supercritical CO 2 Extraction | Steam distillation Method | Supercritical CO 2 Extraction | Acetic acid extraction method | Supercritical CO 2 Extraction | Steam distillation Method | Water vapour steams Evaporate method |
| Solvent | CO2 | Water | CO2 | Ethyl alcohol | CO2 | Water | Water |
| Extraction temperature | 35~40℃ | 100℃ | 35~40℃ | 25~35℃ | 35~40℃ | 100℃ | 100℃ |
| Extraction time | ≤30min | 2~8h | ≤30min | 12h | ≤30min | 2~8h | 2~8h |
| Overcome disclosure Insufficient Defect | It is solvent-free residual It stays, low temperature extraction It takes, effectively Ensure brave ear The work of careless element Property | Without hazardous solvent Residual, effectively Ensure that flat stem is yellow Stilbene extract Purity | It is solvent-free residual It stays, low temperature extraction It takes, effectively Ensure uva ursi The activity of element | It is effective to ensure Grape fruit extracts The purity of object and Activity | It is effective to protect Demonstrate,prove ginger extraction The work of object element Property | It is effective to ensure Flos Chrysanthemi extract It is active and pure Degree | It is effective to protect Card matrimony vine carries Take the work of object Property and purity |
Oligopeptides -1, oligopeptides -2, tripeptides -1 amino acid sequence and overcome the defect of insufficient disclosure.
| Ingredient | Effect | |
| Oligopeptides -1 | Ala-Glu-Glu-Met-Gln-Arg-Arg | Pore refining, it is crease-resistant, human skin can be promoted quickly to update |
| Oligopeptides -2 | His-Ala-Pro | Anti-carbonation promotes collagenocyte growth, adjusts immune, antibacterial |
| Tripeptides -1 | Gly-His-Lys | Promote collagen IV and laminin V synthesis |
Nano peptide obtained is answered into face exquisiteness essence and carries out human test, human test continues 56 days, and female volunteers' group smooths
The effect of wrinkle, is it is clear that the results are shown in Table 2.
2. nano peptide of table answers face exquisiteness essence test result
| The variation of different parameters before comparison nursing（%） | Nano peptide answers face exquisiteness essence | Youth shining color essence |
| By deep wrinkle（200 μm of ＞）The surface area of covering | -44.9** | -27.7** |
| The density of main wrinkle | -37* | -27.3* |
| The mean depth of main wrinkle | -15.1** | -9.8* |
| Main wrinkle recess refers to | -18.5** | -14.7** |
| Roughness | -14.4** | -10.8** |
| Complexity（Lifting effect） | -16.6** | -12.7** |
Then by confocal laser microscope, the removing of fibre debris is measured, the results are shown in Table 3.
The improvement result of table 3, corium fabric framework
Finally illustrate, preferred embodiment above is merely illustrative of the technical solution of the present invention and unrestricted, although by upper
It states preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be in form
Various changes are made to it in upper and details, without departing from claims of the present invention limited range.
Claims (10)
1. a kind of nano peptide answers face exquisiteness essence, which is characterized in that include following component by weight：Deionized water 58.904
~ 75.95 parts；4 ~ 8 parts of propylene glycol；4 ~ 6 parts of glycine betaine；3 ~ 5 parts of trehalose；0.1 ~ 0.2 part of hyaluronic acid；Herba Saxifragae extract 2 ~
3 parts；0.1 ~ 0.2 part of soluble collagen；1 ~ 2 part of astragatus complanatus extract；1 ~ 2 part of black bearberry leaf extract；Grape fruit extract 2
~ 3 parts；1 ~ 2 part of ginger extract；2 ~ 3 parts of Flos Chrysanthemi extract；2 ~ 3 parts of wolfberry fruit extract；0.1 ~ 0.2 part of dipotassium glycyrrhizinate；Oligopeptides-
1 0.5 ~ 1 part；0.5 ~ 1 part of oligopeptides -2；0.5 ~ 1 part of tripeptides -1；0.2 ~ 0.396 part of Phenoxyethanol；EDTA- disodiums 0.05 ~
0.1 part；- 1 amino acid sequence of the oligopeptides is as follows：Ala Glu Glu Met Gln Arg Arg；- 2 amino acid sequence of the oligopeptides
Row are as follows：His Ala Pro；The tripeptide amino acid sequence is as follows：Gly His Lys.
2. a kind of nano peptide according to claim 1 answers face exquisiteness essence, which is characterized in that include as follows by weight
Component：74.654 parts of deionized water；5 parts of propylene glycol；4 parts of glycine betaine；3 parts of trehalose；0.1 part of hyaluronic acid；Kiss-me is extracted
2 parts of object；0.2 part of soluble collagen；1 part of astragatus complanatus extract；1 part of black bearberry leaf extract；2 parts of grape fruit extract；Ginger
1 part of extract；2 parts of Flos Chrysanthemi extract；2 parts of wolfberry fruit extract；0.1 part of dipotassium glycyrrhizinate；0.5 part of oligopeptides -1；Oligopeptides -2
0.5 part；0.5 part of tripeptides -1；0.396 part of Phenoxyethanol；0.05 part of EDTA- disodiums.
3. a kind of nano peptide according to claim 1 answers face exquisiteness essence, which is characterized in that include as follows by weight
Component：75.95 parts of deionized water；4 parts of propylene glycol；4 parts of glycine betaine；3 parts of trehalose；0.1 part of hyaluronic acid；Herba Saxifragae extract
2 parts；0.1 part of soluble collagen；1 part of astragatus complanatus extract；1 part of black bearberry leaf extract；2 parts of grape fruit extract；Ginger carries
Take 1 part of object；2 parts of Flos Chrysanthemi extract；2 parts of wolfberry fruit extract；0.1 part of dipotassium glycyrrhizinate；0.5 part of oligopeptides -1；Oligopeptides -2 0.5
Part；0.5 part of tripeptides -1；0.2 part of Phenoxyethanol；0.05 part of EDTA- disodiums.
4. a kind of nano peptide according to claim 1 answers face exquisiteness essence, which is characterized in that include as follows by weight
Component：58.904 parts of deionized water；8 parts of propylene glycol；6 parts of glycine betaine；5 parts of trehalose；0.2 part of hyaluronic acid；Kiss-me is extracted
3 parts of object；0.2 part of soluble collagen；2 parts of astragatus complanatus extract；2 parts of black bearberry leaf extract；3 parts of grape fruit extract；Ginger
2 parts of extract；3 parts of Flos Chrysanthemi extract；3 parts of wolfberry fruit extract；0.2 part of dipotassium glycyrrhizinate；1 part of oligopeptides -1；1 part of oligopeptides -2；
1 part of tripeptides -1；0.396 part of Phenoxyethanol；0.1 part of EDTA- disodiums.
5. a kind of nano peptide according to claim 1 answers face exquisiteness essence, it is characterised in that：The weight ratio of the material
For：67.22 parts of deionized water；6 parts of propylene glycol；5 parts of glycine betaine；4 parts of trehalose；0.15 part of hyaluronic acid；Herba Saxifragae extract
2.5 part；0.2 part of soluble collagen；1.5 parts of astragatus complanatus extract；1.5 parts of black bearberry leaf extract；Grape fruit extract 2.5
Part；1.5% part of ginger extract；2.5 parts of Flos Chrysanthemi extract；2.5 parts of wolfberry fruit extract；0.15 part of dipotassium glycyrrhizinate；Oligopeptides -1
0.8 part；0.8 part of oligopeptides -2；0.8 part of tripeptides -1；0.3 part of Phenoxyethanol；0.08 part of EDTA- disodiums.
6. claim 1 ~ 5 any one of them nano peptide answers the preparation method of face exquisiteness essence, which is characterized in that including following
Step：（1）According to formula, appropriate raw material is weighed；
（2）Deionized water, propylene glycol, glycine betaine, trehalose, hyaluronic acid, EDTA- disodiums are added in emulsifying pot, is warming up to
80 DEG C ~ 85 DEG C are stirred material to uniform solution；
（3）By step（2）In uniform solution keep the temperature 30min, stirring be cooled to 45 DEG C ~ 50 DEG C；
（4）Wait for temperature be down to 45 DEG C ~ 50 DEG C dipotassium glycyrrhizinates are added, soluble collagens stir 25 ~ 30min, temperature is down to 35 ~
40℃；
（5）Wait for that temperature is down to 35 ~ 40 DEG C or so and Herba Saxifragae extract, astragatus complanatus extract, black bearberry leaf extract, grape is added
Shaddock extract, ginger extract, Flos Chrysanthemi extract, wolfberry fruit extract, oligopeptides -1, oligopeptides -2, tripeptides -1, Phenoxyethanol stirring 30 ~
45min is to uniform solution；
（6）It after stirring, is cooled to room temperature, finished product filtering is sealed.
7. a kind of nano peptide according to claim 6 answers the preparation method of face exquisiteness essence, it is characterised in that：Step（2）
In be warming up to 85 DEG C.
8. a kind of nano peptide according to claim 6 answers the preparation method of face exquisiteness essence, it is characterised in that：Step（3）
Middle stirring is cooled to 45 DEG C.
9. a kind of nano peptide according to claim 6 answers the preparation method of face exquisiteness essence, it is characterised in that：Step（4）
In, mixing time 28min.
10. a kind of nano peptide according to claim 6 answers the preparation method of face exquisiteness essence, it is characterised in that：Step（6）
In, finished product is qualified products after detection.
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| CN111228176A (en) * | 2020-02-28 | 2020-06-05 | 广东鑫美鑫化妆品有限公司 | Composition with pore shrinking effect, essence water, preparation method and application |
| CN112076340A (en) * | 2020-09-21 | 2020-12-15 | 海南鸿翼医疗器械有限公司 | Skin barrier repairing dressing mask and preparation method thereof |
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| CN112076340A (en) * | 2020-09-21 | 2020-12-15 | 海南鸿翼医疗器械有限公司 | Skin barrier repairing dressing mask and preparation method thereof |
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Application publication date: 20180928 |