KR20150016025A - Preparation method for fermented ginseng berry extract, nutraceutical composition and cosmetic compostion using the same - Google Patents

Preparation method for fermented ginseng berry extract, nutraceutical composition and cosmetic compostion using the same Download PDF

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KR20150016025A
KR20150016025A KR1020130092228A KR20130092228A KR20150016025A KR 20150016025 A KR20150016025 A KR 20150016025A KR 1020130092228 A KR1020130092228 A KR 1020130092228A KR 20130092228 A KR20130092228 A KR 20130092228A KR 20150016025 A KR20150016025 A KR 20150016025A
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ginseng
ginseng fruit
ginsenoside
drying
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박명애
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주식회사 한국지네틱팜
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00Food ingredients
    • A23V2250/20Natural extracts
    • A23V2250/21Plant extracts
    • A23V2250/2124Ginseng

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Abstract

The present invention relates to a manufacturing method of fermented extracts of steamed and dried ginseng and a health promoting functional food composition and a cosmetic composition using the same. The manufacturing method of fermented extracts of steamed and dried ginseng comprises the steps of steaming and drying washed ginseng berries; fermenting the dried ginseng berries by using lactic acid bacterium; naturally drying the fermented ginseng berries; and extracting the naturally dried ginseng berries. According to the present invention, processed ginseng products with a large amount of ginsenoside are obtained by using ginseng berries wasted in farms raising ginseng. In addition, the content of ginsenoside Re can be increased among obtained extracts wherein the ginsenoside Re has greater antidiabetic effects, anti-oxidant effects, and an effect of protecting liver compared to other ginsenoside derivatives.

Description

증포인삼열매의 발효 추출물 제조방법, 이를 이용한 건강기능식품 조성물 및 화장료 조성물{PREPARATION METHOD FOR FERMENTED GINSENG BERRY EXTRACT, NUTRACEUTICAL COMPOSITION AND COSMETIC COMPOSTION USING THE SAME}FIELD OF THE INVENTION [0001] The present invention relates to a method for producing a fermented extract of ginseng fruit, a health functional food composition using the same and a cosmetic composition,

본 발명은 인삼열매의 진세노사이드 Re와 같은 유용성분들의 추출효율을 증대시킨 증포인삼열매의 발효 추출물의 제조방법, 이를 이용한 건강기능식품 조성물 및 화장료 조성물에 관한 것이다. The present invention relates to a method for producing a fermented extract of a ginseng fruit having enhanced extractability of useful components such as ginsenoside Re of ginseng fruit, a health functional food composition using the same, and a cosmetic composition.

인삼은 다년생 반음지성 식물로 오가피과에 속하는 것으로서 중국, 한국의 다양한 의서에서 그 효능이 널리 알려져 있어 예로부터 많은 분야의 한약재로 사용하고 있다.Ginseng is a perennial semisynthetic oily plant belonging to the acanthomaceae family. Its efficacy is widely known in various fields of China and Korea.

현대에 와서 인삼에 대해 널리 연구한바, 인삼에는 다량의 진세노사이드(Ginsenoside)가 함유되어 있는 것으로 알려져 예로부터 사용되는 약재 이외에도 근래에는 식품에 적용하여 건강식품의 재료로 많이 사용하고 있다.It is widely known that ginseng contains a large amount of ginsenoside, and it has recently been used as a food for health food by applying it to foods in recent years.

인삼은 보통 재배기간이 4년 이상 소요되며, 또한 최고 품질의 인삼을 얻기 위해서는 6년간 재배하여야 하는데 재배기간이 오래 걸리고, 또한 재배하는 동안 각종 병충해, 자연재해 등 여러 가지 이유로 인해 최초 재배량보다 수확량이 적게 되어 가격이 비싸며, 인삼을 얻기까지 많은 시간이 소요되는 단점이 있다.Ginseng usually takes more than 4 years to grow, and in order to obtain the highest quality ginseng, it has to be cultivated for 6 years. It takes a long time to grow, and during the cultivation, yields are higher than the original cultivation for various reasons such as various diseases and natural disasters. There is a disadvantage that it takes a lot of time to obtain ginseng.

인삼은 땅 밑에 뿌리와 뇌두가 있으며, 땅 위에는 줄기, 잎, 열매로 이루어져 있다. 더욱 상세하게는 땅 밑의 세근, 지근 및 주근의 뿌리와 뇌두, 뇌두에서 연결된 줄기(경), 줄기로부터 뻗은 잎, 줄기 끝의 열매(화, 과실) 및 상기 줄기와 열매 사이를 이어주는 부분으로 작은 가지인 화병이 있다.Ginseng has roots and spines under the ground, and it consists of stems, leaves, and fruits on the ground. More particularly, the present invention relates to a plant having a root, root and main root and a stem connected to the root of the root, a root extending from the root of the root, a stem extending from the root, There is a vase of branches.

인삼은 3년차 이상에서 인삼의 꽃이 피기 시작하며, 5월경에는 초록빛 색깔의 열매가 생기게 된다. 7월 중순이 되면 인삼의 초록빛 열매가 무르익으면서 붉게 변하면서 결실하게 된다.Ginseng begins to bloom with ginseng in its third year or more, and greenish-colored fruit is produced in May. In the middle of July, the green fruits of ginseng ripen while ripening, and become fruitless.

인삼재배 농가에서는 인삼의 뿌리를 주로 활용하기 때문에 생식 성장보다는 뿌리의 성장을 촉진하기 위해 인삼 열매가 생기기 시작하면 인삼열매를 따서 버리고 있는 실정이다. 이때 현장에서는 화경의 일부를 잘라서 화경과 인삼열매를 같이 한덩어리 상태로 따서 버리고 있다.Ginseng cultivation farms use ginseng roots mainly. Therefore, in order to promote root growth rather than reproductive growth, when ginseng fruit starts to be produced, ginseng fruit is picked up. At this time, in the field, a part of the flower is cut, and the flower and the ginseng fruit are taken together in a lump state.

진세노사이드(Ginsenoside)는 인삼에 함유된 사포닌(Saponin)을 의미하며, 인삼에는 다양한 종류의 진세노사이드 성분이 함유되어 있다. 인삼의 진세노사이드는 파낙사디올(Panaxadiol, PD)계, 파낙사트리올(Panaxatriol, PT)계, 올레안(Oleanane)계 등이 있다. 또한, 인삼에는 상기 진세노사이드 성분 이외에도 비진세노사이드 물질로서 전분 등의 탄수화물, 폴리아세틸렌의 항산화성방향족 화합물, 간장을 보호하는 고미신(Gomisin N-A), 유사인슐린 작용을 하는 산성 펩티드 등이 있다. Ginsenoside refers to saponin contained in ginseng, and ginseng contains various kinds of ginsenosides. The ginsenosides of ginseng include Panaxadiol (PD), Panaxatriol (PT), and Oleanane. In addition to the above ginsenoside components, ginsenosides include carbohydrates such as starch as antidiaminoside materials, antioxidative aromatic compounds of polyacetylene, gomisin N-A to protect liver, and acidic peptides that act like insulin.

진세노사이드의 주요 약리작용은 중추신경계를 비롯하여, 내분비계, 면역계, 대사계등에 영향을 미쳐 신체조절 기능에 다양한 효과를 발휘한다. 그 이외에도 진세노사이드(ginsenoside)는 지방분해력이 크고, 영양분흡수와 소화를 촉진시키며, 세포내의 효소활성화로 신진대사촉진, 에너지를 증가시켜 원기회복, 피로, 무력감, 식욕부진 개선, 혈청단백질 합성을 촉진 등의 효과가 있다고 알려져 있다.The main pharmacological actions of ginsenoside affect the central nervous system, the endocrine system, the immune system, the metabolic system, etc., and exert various effects on the body regulating function. In addition, ginsenoside has a high ability to decompose fat, promoting nutrient absorption and digestion, promoting metabolism through activation of intracellular enzymes, increasing energy, restoring fatigue, feeling helpless, improving appetite, It is known that there is an effect such as acceleration.

인삼뿌리보다 인삼열매에 월등히 많은 진세노사이드 Re는 항당뇨작용, 간보호작용, 항산화작용, 중추신경억제 작용, DNA 및 RNA 촉진작용, 프라스민 활성화 작용, 부신피질자극호르몬 분비 촉진작용을 하는 것으로 알려져 있고, Rd는 부신피질 호르몬 분비촉진 작용을 하며, Rb2는 중추신경억제 작용, DNA 및 RNA 합성 촉진 작용, 프라스민 활성화 작용, 부신피질자극호르몬 분비촉진작용, 항당뇨 작용을 하는 것으로 알려져 있다.Ginsenoside Re, which is much higher in ginseng root than ginseng root, has anti-diabetic effect, liver protective effect, antioxidant effect, central nervous suppression effect, DNA and RNA promoting action, prasmin activating action and promoting adrenocorticotropic hormone secretion Rd is known to promote adrenocortical hormone secretion, Rb 2 is known to have central nerve inhibitory action, promoting DNA and RNA synthesis, plasmin activating action, promoting adrenocortical stimulating hormone secretion, and antidiabetic action .

그러나 상기 인삼열매 및 인삼화경은 인삼뿌리의 성장을 위해 인삼에서 제거된 후 그냥 버려지고 있어 인삼열매, 인삼화경에 함유된 진세노사이드의 이용이 부족한 실정이다.However, since the ginseng fruit and ginseng root are removed from the ginseng for the growth of ginseng roots, the ginsenoside is not used in the ginseng fruit and ginseng root.

이에 인삼 열매를 건강보조식품, 음료 등으로 활용하고자 다양한 추출방법이 제안된 바 있다. Therefore, various extraction methods have been proposed to utilize the fruits of ginseng as a health supplement food, beverage, and the like.

일예로 대한민국 공개특허 제10-2008-0093266호는 인삼열매농축액, 이의 제조방법 및 인삼열매농축액을 포함하는 건강기능식품에 관한 것으로, 볶음처리한 인삼열매를 추출하고, 추출된 추출물을 농축하는 인삼열매농축액의 제조방법을 개시하고 있다. Korean Patent Laid-Open No. 10-2008-0093266, for example, relates to a health functional food containing a concentrated ginseng fruit concentrate, a method for producing the same, and a concentrated ginseng fruit concentrate, which comprises extracting the roasted ginseng fruit and extracting ginseng Discloses a method for producing a fruit concentrate.

또한 대한민국 특허등록 제10-0852139호는 팽화 및 발효 처리된 인삼열매와 인삼화병 추출물의제조방법에 관한 것으로, 인삼열매와 인삼화병의 추출물 제조에 있어서, (1) 빛을 조사 처리한 인삼열매와 인삼화병을 증숙 후 건조하는 단계, (2)상기 건조한 인삼열매와 인삼화병을 팽화처리하는 단계, (3) 상기 팽화처리한 인삼열매와 인삼화병을 발효시키는 단계, (4) 상기 발효된 인삼열매와 인삼화병을 추출하는 단계를 포함하는 팽화 및 발효 처리된 인삼열매와 인삼화병 추출물의 제조방법을 개시하고 있다.In addition, Korean Patent Registration No. 10-0852139 relates to a method for producing a ginseng fruit and a ginseng vase extract, which comprises expanding and fermenting the ginseng fruit and extracting the ginseng vase, comprising the steps of: (1) (2) a step of expanding the dried ginseng fruit and the ginseng vase, (3) fermenting the expanded ginseng fruit and the ginseng vase, (4) the step of fermenting the fermented ginseng fruit And a step of extracting the ginseng vase, and a method of producing the ginseng vase extract and the expanded and fermented ginseng fruit.

대한민국 공개특허 제10-2008-0093266호Korean Patent Publication No. 10-2008-0093266 대한민국 특허등록 제10-0852139호Korean Patent Registration No. 10-0852139

본 발명은 인삼 열매에 많이 포함된 진세노사이드 Re를 포함하는 다양한 유용성분이 다량 함유된 증포인삼열매 발효추출물의 제조방법, 이를 이용한 건강기능식품 조성물 및 화장료 조성물을 제공하는 것을 그 목적으로 한다. It is an object of the present invention to provide a method for producing a fermented extract of ginseng fruit which contains a large amount of various components including ginsenoside Re, which is contained in ginseng fruit, and a health functional food composition and a cosmetic composition using the same.

이를 위해 본 발명은,To this end,

세척된 인삼 열매를 증숙한 후 건조하는 단계와,Washing and drying the washed ginseng fruit,

건조된 인삼 열매를 유산균으로 발효하는 단계와,Fermenting the dried ginseng fruit with lactic acid bacteria,

발효된 인삼 열매를 자연 건조하는 단계와,Naturally drying the fermented ginseng fruit,

자연 건조된 인삼 열매를 추출하는 단계Step of extracting naturally dried ginseng fruit

를 포함하는 인삼 열매 발효추출물의 제조방법을 제공한다.And a method for producing the fermented ginseng extract.

본 발명에 따르면, 종래 인삼재배 농가에서 그냥 버려지는 인삼열매를 이용하여 진세노사이드 함량이 많은 인삼 가공품을 얻을 수 있다. 또한, 얻어지는 추출물 중에 다른 진세노사이드 유도체에 비하여 항당뇨 효과, 항산화 작용, 간보호 작용이 우수한 것으로 알려져 있는 진세노사이드 Re의 함량을 높일 수 있다.According to the present invention, ginseng processed products having a high ginsenoside content can be obtained using the ginseng fruit which is just discarded in the conventional ginseng cultivation farmhouse. In addition, the content of ginsenoside Re, which is known to be superior to other ginsenoside derivatives in antidiabetic effect, antioxidative action, and liver protective action, can be increased in the obtained extract.

본 발명에서는 수회에 걸쳐 인삼 열매를 증숙한 후 건조한 다음 자연 건조를 실시함으로써 인삼 열매에 함유된 진세노사이드 Re의 함량을 특히 증대시킨 인삼 추출물 제조방법을 제시한다. In the present invention, a method for preparing ginseng extract, in which the content of ginsenoside Re contained in the ginseng fruit is specifically increased by drying the ginseng fruit after boiling the ginseng fruit several times, followed by natural drying, is presented.

이하 각 단계별로 더욱 상세히 설명한다.Each step will be described in more detail below.

먼저, 세척된 인삼열매를 증숙한 후 건조한다. First, the washed ginseng fruit is boiled and then dried.

본 단계는 인삼 열매에 함유되는 진세노사이드의 함량을 증대시키거나 다양한 진세노사이드가 생성되도록 하기 위한 것이다.This step is intended to increase the content of ginsenosides contained in the ginseng fruit or to produce various ginsenosides.

이때 증숙은 상기한 목적을 고려할 때 80 내지 90 ℃에서 1 내지 2시간 동안 실시하는 것이 바람직하며, 시판되는 증자기, 증숙기를 이용하여 증숙할 수 있다. At this time, considering the above-mentioned purpose, it is preferable to perform the steaming at 80 to 90 ° C for 1 to 2 hours, and the steaming may be carried out using a commercially available steamer and a tiller.

증숙한 인삼 열매에서 물기 및/또는 수증기를 제거하기 위해 건조를 실시한다. 상기 인삼열매의 증숙 후 건조는 인삼열매의 수분함량이 12±15%가 되도록 하는 것이 좋으며, 70 내지 80 ℃에서 5 내지 12시간 동안 실시한다.The dried ginseng fruit is dried to remove water and / or water vapor. It is preferable that the ginseng fruit is dried after steaming at a temperature of 70 to 80 ° C for 5 to 12 hours so that the water content of the ginseng fruit is 12 ± 15%.

이러한 증숙 후 건조단계는 3회 반복하여 실시하는 경우, 인삼 열매에 함유되는 진세노사이드 성분의 함량을 최대로 증대시킬 수 있을 뿐만 아니라 소비자의 관능적 선호도를 향상시킬 수 있다.
When the drying step after the boiling is repeated three times, the content of the ginsenoside ingredient contained in the ginseng fruit can be maximized and the sensory preference of the consumer can be improved.

다음으로, 건조된 인삼 열매에 소량의 수분을 분사한 후 유산균을 접종하여 35~ 40℃에서 7일 이상 발효한다.
Next, a small amount of water is sprayed onto the dried ginseng fruit, and lactic acid bacteria are inoculated and fermented at 35 to 40 ° C for more than 7 days.

이어서, 발효된 인삼 열매를 12시간 이상 자연 건조한다. Then, the fermented ginseng fruit is naturally dried for 12 hours or more.

수회에 걸쳐 반복된 증숙 후 건조 과정 이후 추가적으로 인삼 열매를 미생물 발효와 자연 건조를 함으로써 인삼 열매 내에 함유된 진세노사이드 Re의 함량을 최대화한다. 특히 자연 건조과정을 통해 열풍건조, 동결건조 등의 건조공정을 통해 얻을 수 없었던 진세노사이드 Re의 함량 증가 효과를 확보할 수 있다. After several times of repeated drying, the ginseng fruit is further subjected to microbial fermentation and natural drying to maximize the content of ginsenoside Re contained in the ginseng fruit. Especially, it is possible to secure the effect of increasing the content of ginsenoside Re, which could not be obtained through a drying process such as hot air drying or freeze drying, through a natural drying process.

이때 건조는 인삼 열매 내의 수분 함량이 10 % 이하가 되도록 하기 위해 12 시간 이상 이루어지는 것이 바람직한데, 수분 함량이 상기 상한치를 초과하는 경우에는 과도한 수분함량으로 인하여 이후 수행될 추출 과정의 효율이 저하될 우려가 있어 바람직하지 않다.
In this case, it is preferable that the drying is performed for 12 hours or more in order to make the moisture content of the ginseng fruit 10% or less. If the water content exceeds the upper limit value, the efficiency of the extraction process to be performed subsequently may be deteriorated due to excessive moisture content Which is undesirable.

다음으로, 자연 건조된 인삼 열매를 추출한다. Next, the naturally dried ginseng fruit is extracted.

본 발명의 인삼 열매 추출물은, 당업계에 공지된 통상의 방법에 따라, 즉, 통상적인 용매를 사용하여, 통상적으로 이용되는 열수추출, 실온추출, 가온추출, 초음파추출, 초임계추출 등의 방법으로 제조될 수 있다. The ginseng fruit extract of the present invention can be produced by a conventional method known in the art, that is, a method such as hot water extraction, room temperature extraction, warming extraction, ultrasonic extraction, supercritical extraction ≪ / RTI >

구체적으로는 물, 탄소수 1 내지 6의 글리콜, 탄소수 1 내지 4의 무수 또는 함수 알코올, 아세토니트릴, 디옥산, 디메틸설폭사이드, 1,3-부틸렌글리콜 및 이들의 혼합물로 이루어진 군으로부터 선택되는 용매를 사용하여 추출한다. Specific examples include water, a glycol having 1 to 6 carbon atoms, an anhydrous or hydrolyzed alcohol having 1 to 4 carbon atoms, a solvent selected from the group consisting of acetonitrile, dioxane, dimethyl sulfoxide, 1,3-butylene glycol, .

추출온도와 시간은 추출하고자 하는 시료의 양에 따라 달라질 수 있으며 바람직하게는 열수 추출시 정제수의 사용량은 원료 중량의 10 내지 30 배로 하여 80 내지 90 ℃에서 8 내지 36시간 동안 추출한다. 또는 유기 용매를 이용할 경우 바람직하게는 원료 중량의 5 내지 10 배의 사용량으로 70 내지 80 ℃에서 8 내지 24시간 동안 추출한다. The extraction temperature and time may vary depending on the amount of the sample to be extracted. Preferably, the amount of purified water to be used in the hot water extraction is 10 to 30 times the weight of the raw material and is extracted at 80 to 90 ° C for 8 to 36 hours. Or an organic solvent is preferably used at an amount of 5 to 10 times the weight of the raw material at 70 to 80 캜 for 8 to 24 hours.

또한 인삼 열매 내 존재하는 유효성분의 충분한 추출을 위하며, 상기 과정에 의해 1회 추출한 인삼 열매에 다시 한 번 용매를 가하여 1~2회 추가로 추출하는 과정을 부가할 수 있다. Also, in order to sufficiently extract the active ingredient present in the ginseng fruit, the process of extracting the once extracted ginseng fruit once more by adding the solvent once or twice may be added.

이후 추출결과물을 여과 또는 정제하는 과정을 거칠 수 있다.
The extraction result may then be subjected to filtration or purification.

이와 함께, 본 발명의 제조방법은 후 가공처리 단계를 더 포함할 수 있다. 상기 가공처리는 필요에 따라 공지의 방법에 의해 추출물을 농축시키거나 농축된 액을 감압 증류, 동결 건조 또는 분무 건조 등과 같은 추가적인 과정에 의해 분말 상태로 제조될 수 있다.
In addition, the manufacturing method of the present invention may further include a post-processing step. The processing may be carried out by concentrating the extract by a known method or by adding the concentrated liquid to the powder by an additional process such as vacuum distillation, freeze drying or spray drying.

이하, 본 발명을 바람직한 실시예를 들어 더욱 상세히 설명하기로 한다. 단, 하기의 실시예는 본 발명을 설명하기 위한 것일 뿐이며, 본 발명의 범위 안에서 얼마든지 변형 가능한 것이다.
Hereinafter, the present invention will be described in more detail with reference to preferred embodiments. It is to be understood, however, that the following examples are illustrative only and are not to be construed as limiting the scope of the present invention.

(실시예 1)(Example 1)

인삼 열매 10 kg을 정제수로 세척하여 이물질을 제거하였다. 세척된 인삼 열매를 채반에 정렬하여 증숙기 넣고, 가온하여 평균온도 85℃를 유지시키면서 2시간 동안 1차 증숙하였다. 증숙된 인삼 열매를 건조기에 넣고, 온도 70~80℃ 범위를 유지하도록 가열하면서 12시간 1차 건조하였다. 10 kg of ginseng fruit was washed with purified water to remove foreign matter. The washed ginseng fruits were placed in a vat, and the vat was placed in a boil and heated for 2 hours at an average temperature of 85 ° C. The cooked ginseng fruit was placed in a drier and dried for 12 hours while heating to maintain the temperature in the range of 70 to 80 ° C.

1차 건조가 완료된 인삼 열매를 다시 증숙기에 넣고 가온하여 평균온도 85℃를 유지시키면서 1시간 30분 동안 2차 증숙하였다. 증숙된 인삼 열매를 건조기에 넣고, 온도 70~80℃ 범위를 유지하도록 가열하면서 8시간 동안 2차 건조하였다. The first dried ginseng fruit was again put in a boil and warmed for 1 hour and 30 minutes while maintaining an average temperature of 85 ° C. The cooked ginseng fruit was put into a drier and dried for 8 hours while heating to maintain the temperature in the range of 70 to 80 ° C.

2차 건조가 완료된 인삼 열매를 다시 증숙기에 넣고 가온하여 평균온도 85℃를 유지시키면서 1시간 동안 3차 증숙하였다. 증숙된 인삼 열매를 건조기에 넣고, 온도 70~80℃ 범위를 유지하도록 가열하면서 5시간 동안 3차 건조하였다. After the second drying, the ginseng fruit was heated again in the boiler and heated at 85 ° C for 3 hours for 1 hour. The cooked ginseng fruit was placed in a drier and was dried for 5 hours while heating to maintain the temperature at 70 to 80 ° C.

3차 건조가 완료된 인삼 열매를 다시 증숙기에 넣고 가온하여 평균온도 85를 유지시키면서 1시간 동안 4차 증숙하였다. 증숙된 인삼 열매를 건조기에 넣고, 온도 70~80 범위를 유지하도록 가열하면서 5시간 동안 4차 건조하였다After the third drying, the ginseng fruit was again heated in a boiling water bath and maintained at an average temperature of 85 ° C for 4 hours. The cooked ginseng fruit was placed in a drier and dried for 4 hours while heating to maintain the temperature in the range of 70 to 80

4회 증포가 완료된 인삼열매에 소량의 수분을 분사 후 유산균을 접종하여 10일 동안 발효하였다.After spraying with a small amount of water, the lactic acid bacteria were inoculated into the ginseng fruit which had been frozen four times and fermented for 10 days.

4회 증숙과 건조 및 발효를 거친 인삼 열매에 정제수 10배 중량을 첨가하여 85 ℃에서 24시간 동안 추출하였다.
Four times of boiled, dried and fermented ginseng fruit was added with 10 times the weight of purified water and extracted at 85 ° C for 24 hours.

(실시예 2)(Example 2)

상기 실시예 1과 동일한 방법으로 4회 증숙과 건조를 반복된 인삼 열매에 95/5 v/v 에탄올 수용액 8배 중량을 첨가하여 85 ℃에서 24시간 동안 추출하였다.
In the same manner as in Example 1, eight times the weight of an aqueous 95/5 v / v ethanol solution was added to the ginseng fruit which had been subjected to four times of steam drying and drying, and then the mixture was extracted at 85 캜 for 24 hours.

(비교예 1)(Comparative Example 1)

상기 실시예 1에서 2회에 걸쳐 증숙과 건조 과정을 수행한 것을 제외하고 동일하게 실시하여 인삼 열매 추출물을 얻었다. The extracts of ginseng fruit were obtained in the same manner as in Example 1, except that the boiling and drying processes were carried out twice.

(비교예 2)(Comparative Example 2)

상기 실시예 1에서 4회에 걸쳐 증숙과 건조 과정을 수행한 것을 제외하고 동일하게 실시하여 인삼 열매 추출물을 얻었다.
The extracts of ginseng fruits were obtained in the same manner as in Example 1, except that the boiling and drying processes were carried out four times.

(비교예 3)(Comparative Example 3)

상기 실시예 1에서 자연 건조 대신 건조기 내에서 70 ℃에서 6시간 동안 건조과정을 수행한 것을 제외하고 동일하게 실시하여 인삼 열매 추출물을 얻었다. The same procedure as in Example 1 was repeated except for drying at 70 ° C for 6 hours in a drier instead of natural drying to obtain a ginseng fruit extract.

Claims (8)

세척된 인삼 열매를 증숙한 후 건조하는 단계와,
건조된 인삼 열매를 유산균으로 발효하는 단계와,
발효된 인삼 열매를 자연 건조하는 단계와,
자연 건조된 인삼 열매를 추출하는 단계
를 포함하는 인삼 열매 발효추출물의 제조방법.
Washing and drying the washed ginseng fruit,
Fermenting the dried ginseng fruit with lactic acid bacteria,
Naturally drying the fermented ginseng fruit,
Step of extracting naturally dried ginseng fruit
≪ / RTI >
제1항에 있어서, 상기 증숙한 후 건조하는 단계는
3회 반복실시되는 것을 특징으로 하는 제조방법.
2. The method of claim 1,
And repeating it three times.
제1항 또는 제2항에 있어서, 상기 증숙은
80 내지 90 ℃에서 1 내지 2시간 동안 실시하는 것을 특징으로 하는 제조방법.
The method according to claim 1 or 2,
At 80 to 90 占 폚 for 1 to 2 hours.
제1항 또는 제2항에 있어서, 상기 건조는
70 내지 80 ℃에서 5 내지 12시간 동안 실시하는 것을 특징으로 하는 제조방법.
3. The process according to claim 1 or 2,
RTI ID = 0.0 > 80 C < / RTI > for 5 to 12 hours.
제1항에 있어서, 상기 자연 건조는
인삼 열매의 수분 함량이 10 % 이하가 되도록 12 시간 이상 실시하는 것을 특징으로 하는 제조방법.
The method according to claim 1, wherein the natural drying
Wherein the water content of the ginseng fruit is at least 10% for at least 12 hours.
제1항에 있어서, 상기 추출은
열수 또는 탄소수 1 내지 6의 글리콜, 탄소수 1 내지 4의 무수 또는 함수 알코올, 아세토니트릴, 디옥산, 디메틸설폭사이드, 1,3-부틸렌글리콜 및 이들의 혼합물로 이루어진 군에서 선택된 1종의 유기용매를 사용하여 실시하는 것을 특징으로 하는 제조방법.
The method of claim 1,
An organic solvent selected from the group consisting of hot water or a glycol having 1 to 6 carbon atoms, anhydrous or hydrous alcohol having 1 to 4 carbon atoms, acetonitrile, dioxane, dimethylsulfoxide, 1,3-butylene glycol, Is carried out by using the above method.
제1항의 제조방법에 따라 제조된 인삼 열매 발효추출물을 유효성분으로 함유하는 건강기능식품 조성물. A health functional food composition comprising the fermented extract of ginseng fruit according to claim 1 as an active ingredient. 제1항의 제조방법에 따라 제조된 인삼 열매 발효추출물을 유효성분으로 함유하는 화장료 조성물. A cosmetic composition comprising a fermented extract of ginseng fruit prepared according to the production method of claim 1 as an active ingredient.
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KR20170085990A (en) * 2016-01-15 2017-07-25 김유근 Method of increase the bioactive effectiveness of sprout ginseng
KR102614780B1 (en) * 2023-01-18 2023-12-15 주성수 Composition for improving hangover and hepatic function comprising ginseng berry extract, dried yeast, and milk thistle extract

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KR102106018B1 (en) * 2019-08-09 2020-05-15 (주)지에프씨생명과학 Method For Producing Steaming Ginseng Berry Fermented Extracts Having Preventive and Improving Effects of Liver Damage
KR102209028B1 (en) * 2020-02-14 2021-01-28 주성수 Pharmaceutical composition for preventing or treating of neurodegenerative diseases comprising fermented steam-dreid ginseng berry

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Publication number Priority date Publication date Assignee Title
KR20170085990A (en) * 2016-01-15 2017-07-25 김유근 Method of increase the bioactive effectiveness of sprout ginseng
KR102614780B1 (en) * 2023-01-18 2023-12-15 주성수 Composition for improving hangover and hepatic function comprising ginseng berry extract, dried yeast, and milk thistle extract

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