CN112076340A - Skin barrier repairing dressing mask and preparation method thereof - Google Patents
Skin barrier repairing dressing mask and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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Abstract
The invention provides a skin barrier repair dressing mask and a preparation method thereof, wherein the mask comprises the following raw materials in parts by weight: 30-60 parts of trehalose, 25-50 parts of sodium hyaluronate, 20-55 parts of collagen, 18-38 parts of glycerol, 12-30 parts of strawberry saxifrage extract, 18-35 parts of radix peucedani, 10-30 parts of platycodon root extract, 10-20 parts of nipagin ester, 11-30 parts of phenoxyethanol and 30-60 parts of water.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a skin barrier repair dressing mask and a preparation method thereof.
Background
The skin is a barrier between the human body and the external environment, and protects various tissues and organs in the body from external physical, mechanical, chemical and pathogenic microorganisms. When the skin is damaged, if the skin can not heal in time, the wound surface needs to be covered with the dressing in time. Currently, skin barrier function is affected by damage to the sebaceous membrane and the stratum corneum on the skin surface due to medical plastic cosmetology, and the skin barrier mainly refers to a physical barrier composed of a plurality of substances such as the sebaceous membrane, the stratum corneum keratin and lipid. The method and means of medical beauty for skin are all to play a role through the skin barrier, and especially many improper facial cleaning care, skin care product use containing glucocorticoid, photoacoustic electric treatment technology, chemical stripping technology and the like can cause the skin barrier to be damaged to different degrees, so that the reduction of the damage of the structure and the function of the skin barrier and the acceleration of the repair of the skin barrier function are very important aspects for improving the clinical curative effect of medical beauty.
Disclosure of Invention
In view of the above, the present invention provides a skin barrier repair dressing and a preparation method thereof, which solve the above problems.
The technical scheme of the invention is realized as follows: a skin barrier repair dressing: the feed comprises the following raw materials in parts by weight: 30-60 parts of trehalose, 25-50 parts of sodium hyaluronate, 20-55 parts of collagen, 18-38 parts of glycerol, 12-30 parts of strawberry saxifrage extract, 18-35 parts of radix peucedani yellow, 10-30 parts of platycodon root extract, 10-20 parts of nipagin ester, 11-30 parts of phenoxyethanol and 30-60 parts of water;
preferably, a skin barrier repair dressing: the feed comprises the following raw materials in parts by weight: 50 parts of trehalose, 40 parts of sodium hyaluronate, 35 parts of collagen, 28 parts of glycerol, 22 parts of strawberry saxifrage extract, 25 parts of radix peucedani, 20 parts of platycodon root extract, 15 parts of nipagin ester, 25 parts of phenoxyethanol and 50 parts of water.
Further, the preparation method of the skin barrier repair dressing mask comprises the following steps:
s1, pouring the trehalose, the sodium hyaluronate, the collagen, the glycerol and the water in parts by weight into an emulsifying pot, and stirring the materials by using a high-speed stirrer to uniformly mix the materials to obtain a mixed material A;
s2, stirring and heating the strawberry saxifrage extract, the radix peucedani yellow flower extract, the platycodon root extract and water at a constant speed to 70-90 ℃, and preserving heat for 40-60 min to obtain a mixed material B;
s3, mixing the mixture A and the mixture B, adding nipagin ester and phenoxyethanol, heating to 100-120 ℃, and continuously stirring to obtain a dressing;
s4, filling the dressing into a mask bag containing a mask carrier, performing microwave vacuum drying, and sealing to obtain a finished product.
Preferably, in the step S1, the stirring speed is 400-600 rpm, and the stirring time is 10-30 min.
Preferably, in the step S2, the strawberry saxifrage is prepared by leaching dried and pulverized strawberry saxifrage for 10-24 hours with an extractant, then extracting for 0.5-1 hour under 20-60 ℃ and 20-50 KHz frequency ultrasonic waves, and collecting the extract; wherein the mass-volume ratio of the strawberry saxifrage to the extracting agent is 1g: 5-15 mL; the extractant is 85-90 wt% of ethanol.
Preferably, in the step S2, the peucedanum falcatum extract is obtained by performing reflux extraction 1-3 times with 80-95% ethanol 2-4 times the mass of peucedanum falcatum, performing reflux extraction for 60-80 min each time, filtering at 30-65 ℃, and recovering ethanol from the filtrate under reduced pressure at 0.05-0.1 Mpa, 80-140 ℃ and 1-3 hours.
Preferably, in the step S2, the platycodon root extract is obtained by leaching dried and crushed platycodon root with methanol of which the volume is 3-8 times of that of the dried and crushed platycodon root for 3-8 hours, then extracting for 0.5-1 hour at 40-60 ℃ under 20-50 KHz frequency ultrasonic waves, and collecting the extract.
Preferably, in the step S3, the mixing speed is 500-800 rpm, and the mixing time is 10-50 min.
Compared with the prior art, the invention has the beneficial effects that:
the skin barrier repair dressing disclosed by the invention has the advantages that the active ingredients are scientifically matched, the strawberry saxifrage extract, the peucedanum fallax root extract and the platycodon root extract are added, mixed and stirred, the dressing has excellent biocompatibility, biodegradability and good air permeability, can absorb a large amount of tissue exudates, has a certain water retention property, can promote hemostasis and regeneration of primary tissues, has an induced repair function, can promote healing of a wound surface and growth of epithelial cells, and is favorable for the regeneration function of the wound surface.
Detailed Description
In order to better understand the technical content of the invention, specific examples are provided below to further illustrate the invention.
The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.
The materials, reagents and the like used in the examples of the present invention can be obtained commercially without specific description.
Example 1
A skin barrier repair dressing: the feed comprises the following raw materials in parts by weight: 30 parts of trehalose, 25 parts of sodium hyaluronate, 20 parts of collagen, 18 parts of glycerol, 12 parts of strawberry saxifrage extract, 18 parts of radix peucedani, 10 parts of platycodon root extract, 10 parts of nipagin ester, 11 parts of phenoxyethanol and 30 parts of water.
Example 2
A skin barrier repair dressing: the feed comprises the following raw materials in parts by weight: 60 parts of trehalose, 50 parts of sodium hyaluronate, 55 parts of collagen, 38 parts of glycerol, 30 parts of strawberry saxifrage extract, 35 parts of radix peucedani, 30 parts of platycodon root extract, 20 parts of nipagin ester, 30 parts of phenoxyethanol and 60 parts of water.
Example 3
A skin barrier repair dressing: the feed comprises the following raw materials in parts by weight: 50 parts of trehalose, 40 parts of sodium hyaluronate, 35 parts of collagen, 28 parts of glycerol, 22 parts of strawberry saxifrage extract, 25 parts of radix peucedani, 20 parts of platycodon root extract, 15 parts of nipagin ester, 25 parts of phenoxyethanol and 50 parts of water.
The following preparation methods were used in the above examples 1 to 3:
s1, pouring the trehalose, the sodium hyaluronate, the collagen, the glycerol and the water in parts by weight into an emulsifying pot, and stirring the materials by using a high-speed stirrer at a stirring speed of 500rpm for 10-30 min to uniformly mix the materials to obtain a mixed material A;
s2, stirring and heating the strawberry saxifrage extract, the radix peucedani yellow flower extract, the platycodon root extract and water at a constant speed to 80 ℃, and preserving heat for 50min to obtain a mixed material B;
the strawberry saxifrage is prepared by leaching dried and pulverized strawberry saxifrage with extractant for 18h, then extracting at 40 deg.C under 40KHz frequency ultrasonic for 0.8h, and collecting extractive solution; wherein the mass-volume ratio of the strawberry saxifrage to the extracting agent is 1g: 10 mL; the extractant is 88 wt% ethanol;
the Peucedanum japonicum Thunb extract is prepared by extracting Peucedanum japonicum Thunb with 90% ethanol 3 times of the mass of Peucedanum japonicum Thunb under reflux for 2 times, extracting under reflux for 70min each time, filtering at 45 deg.C, and recovering ethanol from the filtrate under reduced pressure at 0.08Mpa, 110 deg.C for 2 hr to obtain Peucedanum japonicum Thunb extract;
the platycodon root extract is prepared by leaching dried and crushed platycodon root with 5 times of methanol for 5h, then extracting for 0.8h under the condition of 50 ℃ and 40KHz frequency ultrasonic wave, and collecting the extract;
s3, mixing the mixture A and the mixture B, adding paraben and phenoxyethanol, heating to 110 ℃, and continuing stirring at the stirring speed of 600rpm for 30min to obtain a dressing;
s4, filling the dressing into a mask bag containing a mask carrier, performing microwave vacuum drying, and sealing to obtain a finished product.
Example 4
This example differs from example 3 in that: a skin barrier repair dressing mask and a preparation method thereof comprise the following steps:
s1, pouring the trehalose, the sodium hyaluronate, the collagen, the glycerol and the water in parts by weight into an emulsifying pot, and stirring the materials by using a high-speed stirrer at the stirring speed of 400rpm for 10min to uniformly mix the materials to obtain a mixed material A;
s2, stirring and heating the strawberry saxifrage extract, the radix peucedani yellow flower extract, the platycodon root extract and water at a constant speed to 70 ℃, and preserving heat for 40min to obtain a mixed material B;
the strawberry saxifrage is prepared by extracting dried and pulverized strawberry saxifrage with extractant for 10h, then extracting at 20 deg.C under 20KHz frequency ultrasonic for 0.5h, and collecting extractive solution; wherein the mass-volume ratio of the strawberry saxifrage to the extracting agent is 1g: 5 mL; the extractant is 85 wt% ethanol;
the Peucedanum japonicum Thunb extract is prepared by reflux-extracting Peucedanum japonicum Thunb with 80% ethanol 2 times of the mass of Peucedanum japonicum Thunb for 1 time, 60min each time, filtering at 30 deg.C, and recovering ethanol from the filtrate under reduced pressure at 0.05Mpa, 80 deg.C and 1 hr to obtain Peucedanum japonicum Thunb extract;
the platycodon root extract is prepared by leaching dried and crushed platycodon root with 3 times of methanol for 3h, then extracting for 0.5h under the condition of 40 ℃ and 20KHz frequency ultrasonic wave, and collecting the extract;
s3, mixing the mixture A and the mixture B, adding paraben and phenoxyethanol, heating to 100 ℃, and continuing stirring, wherein the stirring speed of the mixing is 500rpm, and the stirring time is 10min, so as to obtain the dressing;
s4, filling the dressing into a mask bag containing a mask carrier, performing microwave vacuum drying, and sealing to obtain a finished product.
Example 5
This example differs from example 3 in that: a skin barrier repair dressing mask and a preparation method thereof comprise the following steps:
s1, pouring the trehalose, the sodium hyaluronate, the collagen, the glycerol and the water in parts by weight into an emulsifying pot, and stirring the materials by using a high-speed stirrer at the stirring speed of 600rpm for 30min to uniformly mix the materials to obtain a mixed material A;
s2, stirring and heating the strawberry saxifrage extract, the radix peucedani yellow flower extract, the platycodon root extract and water at a constant speed to 90 ℃, and preserving heat for 60min to obtain a mixed material B;
the strawberry saxifrage is prepared by leaching dried and pulverized strawberry saxifrage with extractant for 24h, then extracting for 1h at 60 deg.C under 50KHz frequency ultrasonic wave, and collecting extractive solution; wherein the mass volume ratio of the strawberry saxifrage to the extracting agent is 1g:15 mL; the extractant is 90 wt% ethanol;
the peucedanum praeruptorum dunn extract is obtained by extracting peucedanum praeruptorum dunn with 80-95% ethanol with the mass 2-4 times of that of the peucedanum praeruptorum dunn for 3 times in a refluxing way, extracting for 80min each time in a refluxing way, filtering at 65 ℃, and recovering ethanol from filtrate under reduced pressure at the conditions of 0.1Mpa, 140 ℃ and 3 hours;
the platycodon root extract is prepared by leaching dried and crushed platycodon root with methanol 8 times the volume of the platycodon root for 8 hours, then extracting for 1 hour under the condition of 60 ℃ and ultrasonic waves with the frequency of 50KHz, and collecting the extract;
s3, mixing the mixture A and the mixture B, adding paraben and phenoxyethanol, heating to 120 ℃, and continuing stirring at the stirring speed of 800rpm for 50min to obtain a dressing;
s4, filling the dressing into a mask bag containing a mask carrier, performing microwave vacuum drying, and sealing to obtain a finished product.
Example 6
This example differs from example 3 in that: in the step S2, the stirring temperature is 100 ℃, and the temperature is kept for 30 min.
Comparative example 1
This comparative example differs from example 3 in that: the skin barrier repair dressing comprises the following raw materials in parts by weight: 70 parts of trehalose, 20 parts of sodium hyaluronate, 15 parts of collagen, 10 parts of glycerol, 10 parts of strawberry saxifrage extract, 40 parts of radix peucedani, 40 parts of platycodon root extract, 25 parts of nipagin ester, 10 parts of phenoxyethanol and 70 parts of water.
Comparative example 2
This comparative example differs from example 3 in that: a skin barrier repair dressing contains no extract of herba Saxifragae and radix Peucedani.
Comparative example 3
This comparative example differs from example 3 in that: a skin barrier repair dressing does not contain radix Platycodi root extract.
First, clinical test
(1) Randomly extracting 200 volunteers, the age of which is 16-40 years, half of each of male and female, and testing the dressings of examples 1-6 and comparative examples 1-3 on laser burn patients or allergic persons;
(2) the using method comprises the following steps: after cleaning the face, the product was applied to the repaired site, gently massaged until absorption, once in the morning and evening, and after 7 days of use, the therapeutic effect was recorded.
(3) And (3) effect measurement:
the effect is shown: the healing rate of the laser burned surface is more than 90 percent, the pain relieving rate is more than 80 percent, no scar is left after healing, and the symptoms are relieved;
the method has the following advantages: the laser burned surface has a healing rate of more than 70 percent, a pain relieving rate of more than 60 percent, no scar left after healing and relieved symptoms;
and (4) invalidation: no reduction in symptoms.
(4) The specific therapeutic effects are shown in the following table:
according to the clinical test results, the dressing can effectively promote wound healing, relieve pain and reduce scar formation, and compared with the comparative examples 1-3, the dressing in the examples 1-5 can effectively promote wound healing by adding the strawberry saxifrage extract, the peucedanum fallaxum extract and the platycodon root extract; in comparison with examples 4 and 5, in the preparation process of examples 1 to 3, specific process parameters are adjusted, so that the infiltration rate of the dressing is improved, and the absorption is promoted.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (8)
1. A skin barrier repair dressing characterized by: the feed comprises the following raw materials in parts by weight: 30-60 parts of trehalose, 25-50 parts of sodium hyaluronate, 20-55 parts of collagen, 18-38 parts of glycerol, 12-30 parts of strawberry saxifrage extract, 18-35 parts of radix peucedani, 10-30 parts of platycodon root extract, 10-20 parts of nipagin ester, 11-30 parts of phenoxyethanol and 30-60 parts of water.
2. A skin barrier repair dressing as claimed in claim 1 wherein: 50 parts of trehalose, 40 parts of sodium hyaluronate, 35 parts of collagen, 28 parts of glycerol, 22 parts of strawberry saxifrage extract, 25 parts of radix peucedani, 20 parts of platycodon root extract, 15 parts of nipagin ester, 25 parts of phenoxyethanol and 50 parts of water.
3. The method of making a skin barrier repair dressing mask of claim 1, wherein: the method comprises the following steps:
s1, pouring the trehalose, the sodium hyaluronate, the collagen, the glycerol and the water in parts by weight into an emulsifying pot, and stirring the materials by using a high-speed stirrer to uniformly mix the materials to obtain a mixed material A;
s2, stirring and heating the strawberry saxifrage extract, the radix peucedani yellow flower extract and the platycodon root extract and water at a constant speed to 70-90 ℃, and preserving heat for 40-60 min to obtain a mixed material B;
s3, mixing the mixture A and the mixture B, adding nipagin ester and phenoxyethanol, heating to 100-120 ℃, and continuously stirring to obtain a dressing;
s4, filling the dressing into a mask bag containing a mask carrier, performing microwave vacuum drying, and sealing to obtain a finished product.
4. A method of making a skin barrier repair dressing mask as claimed in claim 3, wherein: in the step S1, the stirring speed is 400-600 rpm, and the stirring time is 10-30 min.
5. A method of making a skin barrier repair dressing mask as claimed in claim 3, wherein: in the step S2, the strawberry saxifrage extract is prepared by leaching dried and crushed strawberry saxifrage for 10-24 hours by using an extractant, then extracting for 0.5-1 hour under the condition of 20-60 ℃ and under the ultrasonic wave of 20-50 KHz frequency, and collecting an extracting solution; wherein the mass-volume ratio of the strawberry saxifrage to the extracting agent is 1g: 5-15 mL; the extractant is 85-90 wt% of ethanol.
6. A method of making a skin barrier repair dressing mask as claimed in claim 3, wherein: in the step of S2, the peucedanum fallax bunge extract is obtained by performing reflux extraction for 1-3 times by using 80-95% ethanol with the mass 2-4 times of that of the peucedanum fallax bunge, performing reflux extraction for 60-80 min each time, filtering at 30-65 ℃, and recovering ethanol from filtrate under reduced pressure at the conditions of 0.05-0.1 Mpa, 80-140 ℃ and 1-3 hours.
7. A method of making a skin barrier repair dressing mask as claimed in claim 3, wherein: in the step S2, the platycodon root extract is obtained by leaching dried and crushed platycodon roots for 3-8 hours by using methanol with the volume being 3-8 times of that of the dried and crushed platycodon roots, then extracting for 0.5-1 hour under the condition of 40-60 ℃ and the frequency of 20-50 KHz ultrasonic waves, and collecting an extracting solution.
8. A method of making a skin barrier repair dressing mask as claimed in claim 3, wherein: in the step S3, the mixing speed is 500-800 rpm, and the mixing time is 10-50 min.
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| CN202010992979.0A CN112076340B (en) | 2020-09-21 | 2020-09-21 | Skin barrier repairing dressing mask and preparation method thereof |
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| CN112076340B CN112076340B (en) | 2022-01-25 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117017886A (en) * | 2023-09-13 | 2023-11-10 | 广东格林邦卡新材料生物科技有限公司 | Composition and dressing capable of repairing skin screen barrier and manufacturing process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002053428A (en) * | 2000-08-12 | 2002-02-19 | Tadashi Fukiya | Skin care preparation |
| CN107376002A (en) * | 2017-06-27 | 2017-11-24 | 成都嘉宝祥生物科技有限公司 | A kind of preparation method for being used to treat dermopathic medical dressing |
| CN107822976A (en) * | 2017-11-29 | 2018-03-23 | 桂林华诺威生物科技有限公司 | A kind of plant collagen facial mask |
| CN108578310A (en) * | 2018-03-27 | 2018-09-28 | 吴海林 | A kind of nano peptide answers face exquisiteness essence and preparation method thereof |
| CN108685741A (en) * | 2018-08-06 | 2018-10-23 | 广州国宇医药科技有限公司 | It is a kind of promote skin barrier reparation composition and its application |
-
2020
- 2020-09-21 CN CN202010992979.0A patent/CN112076340B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002053428A (en) * | 2000-08-12 | 2002-02-19 | Tadashi Fukiya | Skin care preparation |
| CN107376002A (en) * | 2017-06-27 | 2017-11-24 | 成都嘉宝祥生物科技有限公司 | A kind of preparation method for being used to treat dermopathic medical dressing |
| CN107822976A (en) * | 2017-11-29 | 2018-03-23 | 桂林华诺威生物科技有限公司 | A kind of plant collagen facial mask |
| CN108578310A (en) * | 2018-03-27 | 2018-09-28 | 吴海林 | A kind of nano peptide answers face exquisiteness essence and preparation method thereof |
| CN108685741A (en) * | 2018-08-06 | 2018-10-23 | 广州国宇医药科技有限公司 | It is a kind of promote skin barrier reparation composition and its application |
Non-Patent Citations (6)
| Title |
|---|
| 李明: "《中药鉴定技术》", 31 August 2013, 黑龙江科学技术出版社 * |
| 李春深: "《民间土单方大全》", 30 September 2017, 天津科学技术出版社 * |
| 江美英等: "《家庭宠物用药指南》", 31 December 1994, 中国经济出版社 * |
| 汪多仁: "《绿色日用化学品》", 30 April 2007, 科学技术文献出版社 * |
| 程嘉艺: "《药食同源中药材药理研究与应用》", 31 March 2018, 辽宁科学技术出版社 * |
| 赵中振等: "《中药理性撰要》", 30 April 2019, 中国中医药出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117017886A (en) * | 2023-09-13 | 2023-11-10 | 广东格林邦卡新材料生物科技有限公司 | Composition and dressing capable of repairing skin screen barrier and manufacturing process thereof |
| CN117017886B (en) * | 2023-09-13 | 2024-04-16 | 广州梵之容化妆品有限公司 | Composition and dressing capable of repairing skin barrier and whitening skin and manufacturing process thereof |
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| CN112076340B (en) | 2022-01-25 |
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