CN106798915A - A kind of utilization rhEGF treatment cervical erosion and the gel of damage and preparation method thereof - Google Patents
A kind of utilization rhEGF treatment cervical erosion and the gel of damage and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of utilization rhEGF treatment cervical erosion and the gel for damaging and preparation method thereof, the gel includes according to the raw material of weight portion：38 parts of rhEGF, 15 parts of KGF, 3 20 parts of Herba Solani Lyrati extract, 3 20 parts of Cortex Dictamni extract, 18 parts of shrubby sophora extract, 2 12 parts of Radix Cynanchi Atrati extract, 3 25 parts of Fructus Kochiae extract, 2 12 parts of herba hedyotis diffusae extract, 3 25 parts of Rhizoma Paridis extract, 3 25 parts of bletilla striata extract, 3 25 parts of Bai Maka extracts.Also include 20 50 parts of Seabuckthorm Seed Oil, 2 10 parts of ash essential oil, 0.2 2 parts of placental hormone.Each raw material is weighed into rear mixing and stirring according to weight portion to obtain final product.Obtained gel antibiotic property of the invention is strong, has good effect to vagina mucous membrane, cervical erosion, the reparation for damaging.Healing time of the present invention is short, it is rapid to recover, nontoxic to vaginal mucosa, nonirritant, without hypersensitivity, and preparation process is simple, materials are simple, are suitable to industrialized production.
Description
Technical field
The present invention relates to pharmaceutical technology field, the gel of specifically a kind of utilization rhEGF treatment cervical erosion and damage
And preparation method thereof.
Background technology
The cervix erosion of women, i.e., generally described chronic cervicitis, is common disease, the frequently-occurring disease of numerous women, its
Illness rate accounts for 70% or so of adult female's sum, if the women of illness is after illness, that illness cannot be obtained is reasonable, effectively control
Treat, the state of an illness then by mild-moderate-severe, or even can develop into cervical atypical hyperplasia, ultimately result in the generation of cervical carcinoma.
In the prior art, treatment cervix erosion not yet finds preferable treatment method both at home and abroad at present, though there are hundreds and thousands of kinds of gynaecology
Lotion, irrigation, bolt, gel, including oral formulations, but more this problem can not be finally solved, especially treat more than moderate
Cervix erosion, still to adopt it is traditional ironed with laser, freezing, electricity or the method such as LEEP knives, but these methods can be in women
Locally cause different degrees of damage, scar in palace.Meanwhile, traditional treatment method cannot be suitable for use with intrauterine contraceptive loop and hair
The women of raw cervix erosion cures illness.《Chinese Journal of Clinical Pharmacy》03 phase in 2003《Recombinant human epidermal growth factor pair
The influence of wound healing after cervical erosion physical treatment》In point out that rhEGF can promote wound healing after cervical erosion physical treatment,
Improve cure rate.But the document does not provide a kind of being used for clinic, and universal cervicitis and vaginal injury are treated
Effective medicine.In sum, a kind of medicine is there are no at present can be while effectively repair the medicine of vaginal injury or cervical erosion
Thing.
The content of the invention
It is an object of the invention to provide a kind of utilization rhEGF treatment cervical erosion and the gel and its preparation side for damaging
Method, to solve the problems, such as to be proposed in above-mentioned background technology.
To achieve the above object, the present invention provides following technical scheme：
A kind of utilization rhEGF treatment cervical erosion and the gel for damaging, include according to the raw material of weight portion：rhEGF 3-
8 parts, KGF 1-5 parts, Herba Solani Lyrati extract 3-20 parts, Cortex Dictamni extract 3-20 parts, shrubby sophora extract 1-8 parts, Radix Cynanchi Atrati extract
2-12 parts, Fructus Kochiae extract 3-25 parts, herba hedyotis diffusae extract 2-12 parts, Rhizoma Paridis extract 3-25 parts, the bletilla striata
Extract 3-25 parts, 3-25 parts of Bai Maka extracts.
As further scheme of the invention：The utilization rhEGF treatment cervical erosion and the gel for damaging, according to weight
The raw material for measuring part includes：RhEGF 4-7 parts, KGF 2-4 parts, Herba Solani Lyrati extract 4-18 parts, Cortex Dictamni extract 4-18 parts, kuh-seng
Extract 1-6 parts, Radix Cynanchi Atrati extract 3-10 parts, Fructus Kochiae extract 4-22 parts, herba hedyotis diffusae extract 3-10 parts, seven leaves one
4-22 parts of flower extract of branch, bletilla striata extract 4-22 parts, 3-22 parts of Bai Maka extracts.
As further scheme of the invention：The utilization rhEGF treatment cervical erosion and the gel for damaging, according to weight
The raw material for measuring part includes：5 parts of rhEGF, 3 parts of KGF, Herba Solani Lyrati extract 5-15 parts, Cortex Dictamni extract 5-15 parts, kuh-seng extraction
Thing 1-5 parts, Radix Cynanchi Atrati extract 3-8 parts, Fructus Kochiae extract 5-18 parts, herba hedyotis diffusae extract 3-8 parts, paris polyphylla carries
Take thing 5-20 parts, bletilla striata extract 5-18 parts, 5-20 parts of Bai Maka extracts.
As further scheme of the invention：Also include Seabuckthorm Seed Oil 20-50 parts, 2-10 parts of ash essential oil, placental hormone
0.2-2 parts.
A kind of utilization rhEGF treatment cervical erosion and the preparation method of the gel for damaging, comprise the following steps：
1) bittersweet is placed in into supercritical extraction unit to be extracted, Herba Solani Lyrati extract is obtained；
The root bark of shaggy-fruited dittany is placed in into supercritical extraction unit to be extracted, Cortex Dictamni extract is obtained；
Kuh-seng is placed in into supercritical extraction unit to be extracted, shrubby sophora extract is obtained；
Radix cynanchi atrati is placed in into supercritical extraction unit to be extracted, Radix Cynanchi Atrati extract is obtained；
The fruit of summer cypress is placed in into supercritical extraction unit to be extracted, Fructus Kochiae extract is obtained；
Oldenlandia diffusa is placed in into supercritical extraction unit to be extracted, herba hedyotis diffusae extract is obtained；
Paris polyphylla is placed in into supercritical extraction unit to be extracted, Rhizoma Paridis extract is obtained；
The bletilla striata is placed in into supercritical extraction unit to be extracted, bletilla striata extract is obtained；
White agate is placed in into supercritical extraction unit to be extracted, Bai Maka extracts are obtained；
2) rhEGF, KGF, Herba Solani Lyrati extract, Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are carried
Thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, Bai Maka extracts is taken to be weighed according to weight portion
Mixing and stirring obtains final product gel afterwards.
As further scheme of the invention：Step 2) in also include weigh Seabuckthorm Seed Oil, ash essential oil, placental hormone, with
RhEGF, KGF, Herba Solani Lyrati extract, Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, Fructus Kochiae extract, oldenlandia
Careless extract, Rhizoma Paridis extract, bletilla striata extract, Bai Maka extract mixing and stirrings.
As further scheme of the invention：Extracting pressure is 15-30MPa, and temperature is 30-50 DEG C, static extracting, extraction
Time is 1-6h.
EGF, epithelical cell growth factor, also known as people oligopeptides -1, are a kind of active materials in human body, by 53 amino groups
Into active peptides, by stimulate EGFR tyrosine phosphorylation, reach repairing hyperplasia skin surface
Cell, it is stated that excellent curative effect is possessed to injured, impaired epidermis skin.Its maximum feature is the propagation point that can promote cell
Change, so as to replace the cell of aging and death with newborn cell.EGF can also stop blooding, and with acceleration skin and mucous membrane wound
Healing, anti-inflammatory analgesic prevents effect of ulcer.The stability of EGF is fabulous, and flowing of scattering, energy and human body are difficult at normal temperatures
Interior various enzymes form good coordinating effect.Initial EGF is mainly employed for medical domain, is primarily to facilitate impaired epidermis
Reparation with regeneration, such as treatment burn, scald.Wherein, recombinant human epidermal growth factor (recombinant human
Epidermal Growth Factor, rhEGF) the effects such as medically have significant wound repair, healing of wound.Promote into
The growth of fibrocyte, promotes skin and mucous membrane wound healing and supports the lopsided hyperplasia of scar contraction and skin, rapidly and efficiently
Repair wound.Promote fibroblast, epidermal cell metabolism, propagation and grow, promote the development and enhancing of elastomer cell
Its function, activates the regeneration of aged cells, accelerates the metabolism of cell and updates, tachymetabolism aging cutin, repairs fracture
Shallow dermal fibroblasts, so as to smooth away wrinkles.To compared with casting skin and all kinds of cutaneous pigmentations, accelerating hyperplasia, promote
Enter the distribution of subcutaneous capillary net, stimulate circulation, dermal melanin is accelerated discharge, effectively reduce the deposition of melanin,
Play a part of Whitening, spot.
KGF functions：Participate in tissue, the development of organ；The damage for participating in the epitheliums such as skin, stomach, intestines, kidney, bladder, lung is repaiied
It is multiple；The side effect that Radiotherapy chemotherapy is brought is reduced, with injury protection function.
Bittersweet has functions that clearing heat and promoting diuresis, removing toxicity for detumescence, anticancer, for treat uterus erosion, jaundice, nephritic dropsy,
The diseases such as gonorrhoea, cholecystitis, gall stone, rheumatic arthritis.
The root bark of shaggy-fruited dittany has heat-clearing and damp-drying drug, dispelling wind and arresting itching, removing toxic substances, the effect except eczema.
Kuh-seng has heat-clearing and damp-drying drug, desinsection, the work(of diuresis.For hot dysentery, have blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva is cloudy
Itch, eczema, wet sore, pruitus, mange leprosy controls outward trichomonas vaginitis.
Radix cynanchi atrati has the effect that swollen, myogenic pain relieving is dissipated except dysphoria, heat-clearing, can control postpartum abnormal heat, yin asthenia generating intrinsic heat, dysphoria and vomit inverse, profit
Urinate treating stranguria, ephritis, urinary tract infections, oedema, bronchitis and rheumatic lumbocrural pain etc..
Fruit of summer cypress clearing heat and promoting diuresis, dispelling wind and arresting itching.For difficulty and pain in micturition, pruritus vulvae under band, rubella, eczema, pruitus.
Oldenlandia diffusa is clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness.Cure mainly：Vaginitis, urethritis, dyspnea and cough due to lung-heat；Throat
Swell and ache；Acute appendicitis；Furuncle sore；Venomous snake bite；Puckery pain of heat gonorrhea；Oedema；Dysentery；Enteritis；Jaundice with damp-heat pathogen；It is good at the various cancers for the treatment of
It is swollen.
Paris polyphylla internal heat anticance, swelling and pain relieving, heat-clearing arresting convulsion, antitussive and antiasthmatic.Cure mainly：It is clearing heat and detoxicating, swelling and pain relieving,
Japanese Type-B encephalitis, stomachache, appendicitis, scrofula, tonsillitis, parotitis, mastitis, poisonous snake, insect-bite, sore
Ulcer pyogenic infections.
The bletilla striata has astringing to arrest bleeding, detumescence and promoting granulation, effect promoting blood circulation and removing blood stasis, for removing necrosis and promoting granulation, mucosal ulcer reparation, inside and outside
The all cards of bleeding and carbuncle swells, scald, rhagadia manus et pedis, anal fissure etc..
Bai Maka is natural hormone engine, adjusts hormonal balance.Have antifatigue, regain one's strength of body, improve the health care of sleep, resist more
The effects such as term, active fertility, enhancing memory.
Seabuckthorm Seed Oil has obvious biological agent, and its is anti-infective by force, promotion healing is fast, be widely used in treatment burns, boiling hot
The aspects such as wound, frostbite, knife wound.Seabuckthorm Seed Oil has good to tonsillitis, stomatitis, conjunctivitis, keratitis, Gynecological cervical inflammation etc.
Get well and the curative effect of stabilization.It can nourishes rough skin, enhance metabolism, antiallergy, bactericidal antiphlogistic, promote re-epithelilization, it is right
Skin has repair, can keep the sour environment of skin, with stronger permeability, thus is also the important original of beauty and skin care
Material.
Ash essential oil has good antibacterial action, strengthens cell repair function, and it is from Ramulus sophorae extractive of volatile oil
Obtain.
Placental hormone can stimulate circulation and cellular activity, have nourishing effect to vagina and Cervical Cell Growth, and
Can adjust immune.
Compared with prior art, the beneficial effects of the invention are as follows：
In the present invention containing rhEGF, KGF, Herba Solani Lyrati extract, Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract,
Fructus Kochiae extract, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, Bai Maka extracts, also include
Seabuckthorm Seed Oil, ash essential oil, placental hormone, obtained gel antibiotic property are strong, so as to suppress pathogen breeding, strengthen diseased region
To germ, virus resistivity and immunocompetence, to vagina mucous membrane, cervical erosion, damage reparation in particular for
There is good effect during treatment cervical erosion.The present invention not only has sterilizing function, while having, healing time is short, recover fast
Fast the advantages of, nontoxic to vaginal mucosa, nonirritant, without hypersensitivity, preparation process is simple, materials are simple, are suitable to industrialization
Production.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, the gel of a kind of utilization rhEGF treatment cervical erosion and damage, according to the original of weight portion
Material includes：3 parts of rhEGF, 1 part of KGF, 3 parts of Herba Solani Lyrati extract, 3 parts of Cortex Dictamni extract, 1 part of shrubby sophora extract, radix cynanchi atrati are extracted
2 parts of thing, 3 parts of Fructus Kochiae extract, 2 parts of herba hedyotis diffusae extract, 3 parts of Rhizoma Paridis extract, 3 parts of bletilla striata extract,
3 parts of Bai Maka extracts.
A kind of utilization rhEGF treatment cervical erosion and the preparation method of the gel for damaging, comprise the following steps：
1) bittersweet is placed in into supercritical extraction unit to be extracted, Herba Solani Lyrati extract is obtained；Extracting pressure is 15MPa, temperature
It is 30 DEG C to spend, and static extracting, extraction time is 1h.Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are extracted
Thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, the preparation process of Bai Maka extracts and bittersweet
Extract is consistent.
2) rhEGF, KGF, Herba Solani Lyrati extract, Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are carried
Thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, Bai Maka extracts is taken to be weighed according to weight portion
Mixing and stirring obtains final product gel afterwards.
Embodiment 2
In the embodiment of the present invention, the gel of a kind of utilization rhEGF treatment cervical erosion and damage, according to the original of weight portion
Material includes：8 parts of rhEGF, 5 parts of KGF, 20 parts of Herba Solani Lyrati extract, 20 parts of Cortex Dictamni extract, 8 parts of shrubby sophora extract, radix cynanchi atrati carry
12 parts of thing, 25 parts of Fructus Kochiae extract, 12 parts of herba hedyotis diffusae extract, 25 parts of Rhizoma Paridis extract, the bletilla striata is taken to extract
25 parts of thing, 25 parts of Bai Maka extracts.
A kind of utilization rhEGF treatment cervical erosion and the preparation method of the gel for damaging, comprise the following steps：
1) bittersweet is placed in into supercritical extraction unit to be extracted, Herba Solani Lyrati extract is obtained；Extracting pressure is 30MPa, temperature
It is 50 DEG C to spend, and static extracting, extraction time is 6h.Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are extracted
Thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, the preparation process of Bai Maka extracts and bittersweet
Extract is consistent.
2) rhEGF, KGF, Herba Solani Lyrati extract, Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are carried
Thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, Bai Maka extracts is taken to be weighed according to weight portion
Mixing and stirring obtains final product gel afterwards.
Embodiment 3
In the embodiment of the present invention, the gel of a kind of utilization rhEGF treatment cervical erosion and damage, according to the original of weight portion
Material includes：4 parts of rhEGF, 2 parts of KGF, 4 parts of Herba Solani Lyrati extract, 4 parts of Cortex Dictamni extract, 1 part of shrubby sophora extract, radix cynanchi atrati are extracted
3 parts of thing, 4 parts of Fructus Kochiae extract, 3 parts of herba hedyotis diffusae extract, 4 parts of Rhizoma Paridis extract, 4 parts of bletilla striata extract,
3 parts of Bai Maka extracts, 20 parts of Seabuckthorm Seed Oil, 2 parts of ash essential oil, 0.2 part of placental hormone.
A kind of utilization rhEGF treatment cervical erosion and the preparation method of the gel for damaging, comprise the following steps：
1) bittersweet is placed in into supercritical extraction unit to be extracted, Herba Solani Lyrati extract is obtained；Extracting pressure is 20MPa, temperature
It is 35 DEG C to spend, and static extracting, extraction time is 2h.Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are extracted
Thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, the preparation process of Bai Maka extracts and bittersweet
Extract is consistent.
2) rhEGF, KGF, Herba Solani Lyrati extract, Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are carried
Take thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, Bai Maka extracts, Seabuckthorm Seed Oil, ash
Essential oil, placental hormone weigh rear mixing and stirring and obtain final product gel according to weight portion.
Embodiment 4
In the embodiment of the present invention, the gel of a kind of utilization rhEGF treatment cervical erosion and damage, according to the original of weight portion
Material includes：7 parts of rhEGF, 4 parts of KGF, 18 parts of Herba Solani Lyrati extract, 18 parts of Cortex Dictamni extract, 6 parts of shrubby sophora extract, radix cynanchi atrati carry
10 parts of thing, 22 parts of Fructus Kochiae extract, 10 parts of herba hedyotis diffusae extract, 22 parts of Rhizoma Paridis extract, the bletilla striata is taken to extract
22 parts of thing, 22 parts of Bai Maka extracts, 50 parts of Seabuckthorm Seed Oil, 10 parts of ash essential oil, 2 parts of placental hormone.
A kind of utilization rhEGF treatment cervical erosion and the preparation method of the gel for damaging, comprise the following steps：
1) bittersweet is placed in into supercritical extraction unit to be extracted, Herba Solani Lyrati extract is obtained；Extracting pressure is 25MPa, temperature
It is 45 DEG C to spend, and static extracting, extraction time is 5h.Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are extracted
Thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, the preparation process of Bai Maka extracts and bittersweet
Extract is consistent.
2) rhEGF, KGF, Herba Solani Lyrati extract, Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are carried
Take thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, Bai Maka extracts, Seabuckthorm Seed Oil, ash
Essential oil, placental hormone weigh rear mixing and stirring and obtain final product gel according to weight portion.
Embodiment 5
In the embodiment of the present invention, the gel of a kind of utilization rhEGF treatment cervical erosion and damage, according to the original of weight portion
Material includes：5 parts of rhEGF, 3 parts of KGF, 5 parts of Herba Solani Lyrati extract, 15 parts of Cortex Dictamni extract, 1 part of shrubby sophora extract, radix cynanchi atrati carry
Take 8 parts of thing, 5 parts of Fructus Kochiae extract, 8 parts of herba hedyotis diffusae extract, 5 parts of Rhizoma Paridis extract, bletilla striata extract 18
Part, 5 parts of Bai Maka extracts.
A kind of utilization rhEGF treatment cervical erosion and the preparation method of the gel for damaging, comprise the following steps：
1) bittersweet is placed in into supercritical extraction unit to be extracted, Herba Solani Lyrati extract is obtained；Extracting pressure is 20MPa, temperature
It is 40 DEG C to spend, and static extracting, extraction time is 3h.Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are extracted
Thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, the preparation process of Bai Maka extracts and bittersweet
Extract is consistent.
2) rhEGF, KGF, Herba Solani Lyrati extract, Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are carried
Thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, Bai Maka extracts is taken to be weighed according to weight portion
Mixing and stirring obtains final product gel afterwards.
Embodiment 6
In the embodiment of the present invention, the gel of a kind of utilization rhEGF treatment cervical erosion and damage, according to the original of weight portion
Material includes：5 parts of rhEGF, 3 parts of KGF, 15 parts of Herba Solani Lyrati extract, 5 parts of Cortex Dictamni extract, 5 parts of shrubby sophora extract, radix cynanchi atrati carry
Take 3 parts of thing, 18 parts of Fructus Kochiae extract, 3 parts of herba hedyotis diffusae extract, 20 parts of Rhizoma Paridis extract, bletilla striata extract 5
Part, 20 parts of Bai Maka extracts.
A kind of utilization rhEGF treatment cervical erosion and the preparation method of the gel for damaging, comprise the following steps：
1) bittersweet is placed in into supercritical extraction unit to be extracted, Herba Solani Lyrati extract is obtained；Extracting pressure is 20MPa, temperature
It is 40 DEG C to spend, and static extracting, extraction time is 4h.Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are extracted
Thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, the preparation process of Bai Maka extracts and bittersweet
Extract is consistent.
2) rhEGF, KGF, Herba Solani Lyrati extract, Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, the fruit of summer cypress are carried
Thing, herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, Bai Maka extracts is taken to be weighed according to weight portion
Mixing and stirring obtains final product gel afterwards.
Conventional and accelerated test result shows：The gel of embodiment of the present invention 1-6 is long-term through Wuhan Tongji Medical Univ.
The experiments such as toxicological experiment, acute toxicological experiment, skin hypersensitivity experiment, mucous membrane irritation experiment prove the biological controlled-released film to people
Body is nontoxic, harmless.
Experiment：Cervical erosion area change compares before and after patients of cervical ruin treatment
Have 30 patients of cervical ruin, wherein treatment group 20, control group 10.Cervical erosion face before and after two groups of treatments
Product change, is shown in Table 1.Treatment group uses the gel of embodiment 5, control group to use physiological saline.
Erosion area before and after 1 two groups of patient's treatments of table(cm2)
| Number of cases | Before treatment | After treatment | |
| Treatment group | 20 | 3.95±1.523 | 0.00±0.000 |
| Control group | 10 | 4.00±1.025 | 3.35±1.000 |
Illustrate that treatment group's control group reduces after treatment before rotten to the corn area is relatively treated, treatment group reduces compared with control group after treatment
Rotten to the corn area significant effective, no difference of science of statistics.Show the present invention with the uterus erosion face of women, make uterus erosion face
Isolated well, sterilized, anti-inflammatory causes palace erosion fast treating and reparation.Do not found during experimental observation in addition any
Adverse events, carry out hepatic and renal function, the no abnormal change of blood urine routine inspection, illustrate that Clinical practice of the present invention is safe.
Model case
1st, Xue, female 42 years old, has found " 2 degree of cervical erosion " 6 years, once with " Merrill Lynch is refined, and peaceful " and the method such as " microwave " is controlled
Treat, have certain effect in short term, easily repeatedly.After being treated using the gel of the embodiment of the present invention 5,1 year no relapse of follow-up.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined
May be appreciated other embodiment.
Claims (7)
1. a kind of utilization rhEGF treats cervical erosion with the gel for damaging, it is characterised in that according to the raw material bag of weight portion
Include：RhEGF 3-8 parts, KGF 1-5 parts, Herba Solani Lyrati extract 3-20 parts, Cortex Dictamni extract 3-20 parts, shrubby sophora extract 1-8 parts,
Radix Cynanchi Atrati extract 2-12 parts, Fructus Kochiae extract 3-25 parts, herba hedyotis diffusae extract 2-12 parts, Rhizoma Paridis extract 3-
25 parts, bletilla striata extract 3-25 parts, 3-25 parts of Bai Maka extracts.
2. utilization rhEGF according to claim 1 treats cervical erosion with the gel for damaging, it is characterised in that according to
The raw material of weight portion includes：RhEGF 4-7 parts, KGF 2-4 parts, Herba Solani Lyrati extract 4-18 parts, Cortex Dictamni extract 4-18 parts, hardship
Conopsea extraction 1-6 parts, Radix Cynanchi Atrati extract 3-10 parts, Fructus Kochiae extract 4-22 parts, herba hedyotis diffusae extract 3-10 parts, seven leaves
4-22 parts of a flower extract, bletilla striata extract 4-22 parts, 3-22 parts of Bai Maka extracts.
3. utilization rhEGF according to claim 1 treats cervical erosion with the gel for damaging, it is characterised in that according to
The raw material of weight portion includes：5 parts of rhEGF, 3 parts of KGF, Herba Solani Lyrati extract 5-15 parts, Cortex Dictamni extract 5-15 parts, kuh-seng carries
Take thing 1-5 parts, Radix Cynanchi Atrati extract 3-8 parts, Fructus Kochiae extract 5-18 parts, herba hedyotis diffusae extract 3-8 parts, paris polyphylla
Extract 5-20 parts, bletilla striata extract 5-18 parts, 5-20 parts of Bai Maka extracts.
4., according to any described utilization rhEGF treatment cervical erosion of claim 1-3 and the gel for damaging, its feature exists
In also including Seabuckthorm Seed Oil 20-50 parts, 2-10 parts, placental hormone 0.2-2 parts of ash essential oil.
5. a kind of utilization rhEGF as described in claim 1-3 is any treats the preparation side of cervical erosion and the gel for damaging
Method, it is characterised in that comprise the following steps：
1）Bittersweet is placed in into supercritical extraction unit to be extracted, Herba Solani Lyrati extract is obtained；
The root bark of shaggy-fruited dittany is placed in into supercritical extraction unit to be extracted, Cortex Dictamni extract is obtained；
Kuh-seng is placed in into supercritical extraction unit to be extracted, shrubby sophora extract is obtained；
Radix cynanchi atrati is placed in into supercritical extraction unit to be extracted, Radix Cynanchi Atrati extract is obtained；
The fruit of summer cypress is placed in into supercritical extraction unit to be extracted, Fructus Kochiae extract is obtained；
Oldenlandia diffusa is placed in into supercritical extraction unit to be extracted, herba hedyotis diffusae extract is obtained；
Paris polyphylla is placed in into supercritical extraction unit to be extracted, Rhizoma Paridis extract is obtained；
The bletilla striata is placed in into supercritical extraction unit to be extracted, bletilla striata extract is obtained；
White agate is placed in into supercritical extraction unit to be extracted, Bai Maka extracts are obtained；
2）By rhEGF, KGF, Herba Solani Lyrati extract, Cortex Dictamni extract, shrubby sophora extract, Radix Cynanchi Atrati extract, Fructus Kochiae extract,
Herba hedyotis diffusae extract, Rhizoma Paridis extract, bletilla striata extract, Bai Maka extracts mix after being weighed according to weight portion
Stir and obtain final product gel.
6. utilization rhEGF according to claim 5 treats the preparation method of cervical erosion and the gel for damaging, its feature
It is, step 2）In also include weigh Seabuckthorm Seed Oil, ash essential oil, placental hormone, with rhEGF, KGF, Herba Solani Lyrati extract, the root bark of shaggy-fruited dittany
Extract, shrubby sophora extract, Radix Cynanchi Atrati extract, Fructus Kochiae extract, herba hedyotis diffusae extract, Rhizoma Paridis extract,
Bletilla striata extract, Bai Maka extract mixing and stirrings.
7. utilization rhEGF according to claim 5 treats the preparation method of cervical erosion and the gel for damaging, its feature
It is that extracting pressure is 15-30MPa, temperature is 30-50 DEG C, and static extracting, extraction time is 1-6h.
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Application publication date: 20170606 |