CN104940878A - Traditional Chinese medicine ointment for treating rheumatoid bone diseases and preparation method of traditional Chinese medicine ointment - Google Patents
Traditional Chinese medicine ointment for treating rheumatoid bone diseases and preparation method of traditional Chinese medicine ointment Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine ointment for treating rheumatoid bone diseases and a preparation method of the traditional Chinese medicine ointment, and belongs to the technical field of medicines for treating orthopedic diseases. The traditional Chinese medicine ointment disclosed by the invention is prepared from the following raw materials in parts by weight: 20-30 parts of phryma leptostachya, 20-30 parts of caulis spatholobi, 10-20 parts of fructus psoraleae, 10-20 parts of rhizoma dioscoreae nipponicae, 10-20 parts of polygonum cuspidatum, 10-20 parts of eucommia ulmoides, 5-15 parts of scorpio, 5-15 parts of radix angelicae pubescentis, 10-20 parts of rhizoma zingiberis, 20-30 parts of caulis trachelospermi, 20-30 parts of tuber fleeceflower stem, 20-30 parts of nux vomica, 15-25 parts of caesalpinia cucullata, 15-25 parts of lycopodium clavatum, 15-25 parts of rhizoma acori graminei, 5-15 parts of folium artemisiae argyi, 5-15 parts of cinnabar, 5-15 parts of aconite and 15-25 parts of rhizoma drynariae. The invention further provides a preparation method of the traditional Chinese medicine ointment. By virtue of acupoint absorption, the traditional Chinese medicine ointment is through to the lesion; an internal illness is treated from outside; and the traditional Chinese medicine ointment has a good effect on rheumatoid bone diseases, and is safe and reliable.
Description
Technical field
The invention belongs to the technical field of the medicine for the treatment of orthopaedic disease, refer to a kind of Chinese medicine ointment for the treatment of rheumatic osteopathia and preparation method thereof especially.
Background technology
The blood circulation that rheumatic osteopathia mainly causes due to wind and cold is obstructed, causes the bad disease caused of nutrition supply comprising flesh, ligament, synovial bursa, fascia.Arthropathy, apart from outside pain, still with swelling and moving obstacle, is outbreak and the alleviation chronic course of disease alternately.According to ancient Chinese medicine doctor experience, from the viewpoint of etiological classification, be generally divided into by rheumatic osteopathia migratory arthralgia, arthralgia due to cold, arthralgia chiefly caused by damp pathogen, pyretic arthralgia, dry numbness, anemofrigid-damp arthralgia, damp-heat arthralgia etc. several.Clinical manifestation is arthralgia, aching and tired, numb, limitation of activity, stiffness and deforming etc., and serious hurt like hell, can't take care of oneself.
Along with present information and scientific and technological developing rapidly, the life joint of people gathers to be accelerated day by day, and very large change also occurs the living habit of people, and the living environment in addition goes from bad to worse, and the outbreak crowd of rheumatic osteopathia gets more and more, morbidity crowd rejuvenation increasingly.
At present, rheumatic osteopathia patient many employings doctor trained in Western medicine is treated, with anti-inflammatory analgetic, hormone, close, ultraviolet radiation traction, the method such as operation, its costly, weak curative effect, cures the symptoms, not the disease.Along with the development of lunar physics technique, rheumatic osteopathia patient also starts to adopt the traditional Chinese medical science to treat, and mostly Chinese traditional treatment rheumatic osteopathia is Chinese medicine for oral administration, DeGrain, and curative effect is impermanent, and relapse rate is high, and side effect is large, brings great misery to patient.
Summary of the invention
The invention provides a kind of Chinese medicine ointment for the treatment of rheumatic osteopathia and preparation method thereof, solve that the drug side effect for the treatment of rheumatic osteopathia in prior art is large, the course for the treatment of long and weak curative effect problem.
A kind of Chinese medicine ointment for the treatment of rheumatic osteopathia of the present invention, it is mainly realized by the following technical programs:
A kind of Chinese medicine ointment for the treatment of rheumatic osteopathia of the present invention, is made up of the raw material of Chinese medicine of following weight portion: Herba speranskiae tuberculatae 20-30 part, Caulis Spatholobi 20-30 part, Fructus Psoraleae 10-20 part, Rhizoma Dioscoreae Nipponicae 10-20 part, Rhizoma Polygoni Cuspidati 10-20 part, Cortex Eucommiae 10-20 part, Scorpio 5-15 part, Radix Angelicae Pubescentis 5-15 part, Rhizoma Zingiberis 10-20 part, Caulis Trachelospermi 20-30 part, Caulis Polygoni Multiflori 20-30 part, Semen Strychni 20-30 part, Radix Zanthoxyli Spinifolii 15-25 part, Herba Lycopodii 15-25 part, Rhizoma Acori Graminei 15-25 part, Folium Artemisiae Argyi 5-15 part, Cinnabaris 5-15 part, Aconitum carmichjaelii Debx. 5-15 part, Rhizoma Drynariae 15-25 part.
In Chinese medicine ointment of the present invention, Herba speranskiae tuberculatae: sweet in the mouth, property is put down, tepor; Return Liver Channel; There is wind-damp dispelling, invigorate blood circulation, relaxing muscles and tendons, effect of pain relieving; Cure mainly rheumatalgia, sprain and contusion are hindered, innominate toxic swelling, eczema scrotum.
In Chinese medicine ointment of the present invention, Caulis Spatholobi: bitter in the mouth, micro-sweet, warm in nature; Return liver, the heart, kidney channel; Red complexion enters blood, and matter profit row is loose, has relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation; Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.
In Chinese medicine ointment of the present invention, Fructus Psoraleae: acrid in the mouth, property are bitter, tepor; Return kidney, spleen, lung meridian; There is warming the kidney to activate YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha effect; Cure mainly impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea, external curing vitiligo, the diseases such as alopecia areata.
In Chinese medicine ointment of the present invention, Rhizoma Dioscoreae Nipponicae: property is flat, bitter in the mouth; Return liver, lung meridian; There is expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, effect of cough-relieving; Before curing mainly rheumatism numbness, numb limbs and tense tendons, obstruction of qi in the chest and cardialgia, chronic tracheitis, traumatic injury, Malaria, carbuncle.
In Chinese medicine ointment of the present invention, Rhizoma Polygoni Cuspidati: micro-hardship, is slightly cold; Return liver, gallbladder, lung meridian; There is heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, effect of relieving cough and resolving phlegm; Cure mainly arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.
In Chinese medicine ointment of the present invention, the Cortex Eucommiae: sweet in the mouth, warm in nature; Return liver, kidney channel; There is invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect; Cure mainly spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, frequent fetal movement, hypertension.
In Chinese medicine ointment of the present invention, Scorpio: acrid in the mouth, property is put down, poisonous; Return Liver Channel; There is endogenous wind stopping spasmolytic, dispersing pathogen accumulation, effect of removing obstruction in the collateral to relieve pain; Cure mainly infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
In Chinese medicine ointment of the present invention, Radix Angelicae Pubescentis: bitter in the mouth, property are pungent, tepor; Return liver, kidney, urinary bladder channel; There is expelling wind and dampness, effect of dispersing cold for relieving pain; Cure mainly anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache, headache toothache.
In Chinese medicine ointment of the present invention, Rhizoma Zingiberis: acrid in the mouth, hot in nature; Return spleen, stomach, the heart, lung meridian; There is warming spleen and stomach for dispelling cold, recuperating depleted YANG promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention effect; Cure mainly coldness and pain in the epigastrium, vomiting, have loose bowels, YANG-depletion is fainted inverse, and cold fluid-retention is breathed with cough, arthralgia due to cold-dampnes.
In Chinese medicine ointment of the present invention, Caulis Trachelospermi: bitter in the mouth, is slightly cold; GUIXIN, liver, kidney channel; There is expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, clearing away heat and cooling blood, effect of removing toxic substances and promoting subsidence of swelling; Cure mainly dispelling wind and removing obstruction in the collateral, removing heat from blood is subsided a swelling, beriberoid pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.
In Chinese medicine ointment of the present invention, Caulis Polygoni Multiflori: taste is dry, micro-hardship, property are flat; GUIXIN, Liver Channel; There is effect of tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral; Cure mainly insomnia, dreaminess, blood deficiency general pain, numbness of the skin, rheumatic arthralgia, rubella pruritus.
In Chinese medicine ointment of the present invention, Semen Strychni: bitter in the mouth, cold in nature, poisonous; Return liver, spleen two warp; Main containing the multiple alkaloid such as strychnine and brucine; There is activating collaterals and eliminating stagnation, effect of reducing swelling and alleviating pain; Cure mainly numb limbs and tense tendons, paralysis, inappetence, mass in the abdomen, carbuncle pyogenic infections from tumour or sore, laryngopharynx swelling and pain.
In Chinese medicine ointment of the present invention, Radix Zanthoxyli Spinifolii: acrid in the mouth, warm in nature; Enter liver, lung meridian; There is expelling wind and cold, relaxing muscles and tendons to promote blood circulation, analgesic effect; Cure mainly cough due to wind and cold, rheumatic numbness, traumatic injury, traumatic hemorrhage, constipation.
In Chinese medicine ointment of the present invention, Herba Lycopodii: bitter in the mouth, property are pungent, tepor; Enter Liver Channel; There is expelling wind and cold, dehumidifying detumescence, effect of relaxing muscles and tendons and activating QI and blood in the collateral; Cure mainly anemofrigid-damp arthralgia, muscle arteries and veins contracture pain carbuncle, external is controlled osteopatia sprain and is swollen and ache.
In Chinese medicine ointment of the present invention, Rhizoma Acori Graminei: property is pungent, bitter in the mouth, tepor; GUIXIN, stomach warp; There is removing dampness appetizing, eliminating phlegm of having one's ideas straightened out, effect of refreshment Fructus Alpiniae Oxyphyllae; Cure mainly gastral cavity painful abdominal mass not hungry, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.
In Chinese medicine ointment of the present invention, Folium Artemisiae Argyi: property is pungent, bitter in the mouth, tepor is nontoxic, returns liver,spleen,kidney warp; There is dispersing cold for relieving pain, effect of warming the meridian for stopping bleeding; Cure mainly few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spits blood, epistaxis, and metrorrhagia is through many, and gestation hemorrhage, external treatment skin pruritus, peels, vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.
In Chinese medicine ointment of the present invention, Cinnabaris: property is sweet, is slightly cold, slightly poisonous; GUIXIN warp; Have clear away heart-fire relieving convulsion, calm the nerves removing toxic substances effect; Cure mainly palpitation and being susceptible to fright, insomnia and dreamful sleep, epilepsy is gone mad, infantile convulsion, blurring of vision, aphtha, sore throat, sore swollen toxin, malaise, palpitation and insomnia, infantile convulsion, epilepsy, and skin infection swells and ache, laryngopharynx swelling and pain, aphtha of the mouth and tongue.
In Chinese medicine ointment of the present invention, Aconitum carmichjaelii Debx.: acrid in the mouth, hot in nature, poisonous; GUIXIN, liver, spleen channel; There is effect of the blood stasis dispelling that dispels the wind, dispersing cold for relieving pain; Cure mainly anemofrigid-damp arthralgia, numb limbs and tense tendons ached, the disease such as trusted subordinate's cold type of pain, Shan pain.
In Chinese medicine ointment of the present invention, Rhizoma Drynariae: bitter in the mouth, warm in nature; Return kidney, Liver Channel; There is the kidney invigorating bone strengthening, continuous effect of hindering pain relieving; Cure mainly lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone, external treatment alopecia areata, vitiligo.
Preferably, a kind of Chinese medicine ointment for the treatment of rheumatic osteopathia of the present invention, is made up of the raw material of Chinese medicine of following weight portion: Herba speranskiae tuberculatae 25 parts, Caulis Spatholobi 25 parts, Fructus Psoraleae 15 parts, Rhizoma Dioscoreae Nipponicae 15 parts, Rhizoma Polygoni Cuspidati 15 parts, the Cortex Eucommiae 15 parts, Scorpio 10 parts, Radix Angelicae Pubescentis 10 parts, Rhizoma Zingiberis 15 parts, Caulis Trachelospermi 25 parts, Caulis Polygoni Multiflori 25 parts, Semen Strychni 25 parts, Radix Zanthoxyli Spinifolii 20 parts, Herba Lycopodii 20 parts, Rhizoma Acori Graminei 20 parts, Folium Artemisiae Argyi 10 parts, 10 parts, Cinnabaris, Aconitum carmichjaelii Debx. 10 parts, Rhizoma Drynariae 20 parts.
A kind of preparation method for the treatment of the Chinese medicine ointment of rheumatic osteopathia of the present invention, it is mainly realized by the following technical programs: comprise the following steps:
1) Herba speranskiae tuberculatae, Caulis Spatholobi, Fructus Psoraleae, Rhizoma Dioscoreae Nipponicae, Rhizoma Polygoni Cuspidati, the Cortex Eucommiae, Scorpio, Radix Angelicae Pubescentis, Rhizoma Zingiberis, Caulis Trachelospermi, Caulis Polygoni Multiflori, Semen Strychni, Radix Zanthoxyli Spinifolii, Herba Lycopodii, Rhizoma Acori Graminei, Folium Artemisiae Argyi, Aconitum carmichjaelii Debx., Rhizoma Drynariae is got, roguing, cleaning, dries, pulverize, obtain mixed powder;
2) in step 1) gained mixed powder, adding weight is mixed powder weight 3-5 water doubly, decocts 1-3 time, decocts 1-3h at every turn, filter, obtain filtrate and filtering residue respectively, for subsequent use;
3) in step 2) in gained filtering residue, adding mass concentration is the ethanol of 75-95%, reflux, extract, 1-3 time, filters, concentrated, obtains extractum, described ethanol consumption is 4-6 times of described mixed powder weight;
4) get Cinnabaris, pulverize, sieve, obtain cinnabar powder, add cinnabar powder, step 3) gained extractum to step 2 respectively) in gained filtrate, mixing, stirs, obtains mixed liquor;
5) step 4) gained mixed liquor is condensed into the thick extractum that relative density is 1.20-1.30, at 60-80 DEG C, add pressure sensitive adhesive, grind well, and be applied on non-woven fabrics, overlay film, section, obtains finished product.
The usage of Chinese medicine ointment of the present invention and consumption: Chinese medicine ointment of the present invention, every night, note spread on the acupuncture point of sore place, and every day one pastes, and within 7 days, was a course for the treatment of.
Beneficial effect of the present invention: the present invention selects medicine many, wide coverage, each raw material of Chinese medicine compatibility is scientific and reasonable, and drug effect complements each other, and brings out the best in each other; Effect of reducing swelling and alleviating pain, expelling wind and removing dampness, heat clearing away cold expelling, channels sootheing and network vessel quickening and blood circulation promoting and blood stasis dispelling is reached by nourishing the liver and kidney, strong muscles and bones, regulation of mental activities reason lung, eliminating pathogenic factor for supporting vital QI; Be affixed on affected part outward to use, absorbed by acupuncture point, the through focus degree of depth, inner disease outer treat, short treating period, cure rate is high, determined curative effect, does not recur; This external application medical ointment, do not injure the intestines and stomach, do not lose Liver and kidney, secondary injury can not be caused to skin, paste solid, there will not be obscission, toxic effects, safe and reliable, may be used for treating each rheumatoid osteopathia, be particularly suitable for the treatment of the symptoms such as the arthralgia caused by anemofrigid-damp arthralgia, swelling and numb limbs and tense tendons.
Detailed description of the invention
Be clearly and completely described technical scheme of the present invention below in conjunction with specific embodiment, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Treat a Chinese medicine ointment for rheumatic osteopathia, be made up of the raw material of Chinese medicine of following weight portion: Herba speranskiae tuberculatae 20-30 part, Caulis Spatholobi 20-30 part, Fructus Psoraleae 10-20 part, Rhizoma Dioscoreae Nipponicae 10-20 part, Rhizoma Polygoni Cuspidati 10-20 part, Cortex Eucommiae 10-20 part, Scorpio 5-15 part, Radix Angelicae Pubescentis 5-15 part, Rhizoma Zingiberis 10-20 part, Caulis Trachelospermi 20-30 part, Caulis Polygoni Multiflori 20-30 part, Semen Strychni 20-30 part, Radix Zanthoxyli Spinifolii 15-25 part, Herba Lycopodii 15-25 part, Rhizoma Acori Graminei 15-25 part, Folium Artemisiae Argyi 5-15 part, Cinnabaris 5-15 part, Aconitum carmichjaelii Debx. 5-15 part, Rhizoma Drynariae 15-25 part.
Further, Chinese medicine ointment of the present invention, is made up of the raw material of Chinese medicine of following weight portion: Herba speranskiae tuberculatae 25 parts, Caulis Spatholobi 25 parts, Fructus Psoraleae 15 parts, Rhizoma Dioscoreae Nipponicae 15 parts, Rhizoma Polygoni Cuspidati 15 parts, the Cortex Eucommiae 15 parts, Scorpio 10 parts, Radix Angelicae Pubescentis 10 parts, Rhizoma Zingiberis 15 parts, Caulis Trachelospermi 25 parts, Caulis Polygoni Multiflori 25 parts, Semen Strychni 25 parts, Radix Zanthoxyli Spinifolii 20 parts, Herba Lycopodii 20 parts, Rhizoma Acori Graminei 20 parts, Folium Artemisiae Argyi 10 parts, 10 parts, Cinnabaris, Aconitum carmichjaelii Debx. 10 parts, Rhizoma Drynariae 20 parts.
A kind of preparation method for the treatment of the Chinese medicine ointment of rheumatic osteopathia of the present invention, comprise the following steps: 1) get Herba speranskiae tuberculatae, Caulis Spatholobi, Fructus Psoraleae, Rhizoma Dioscoreae Nipponicae, Rhizoma Polygoni Cuspidati, the Cortex Eucommiae, Scorpio, Radix Angelicae Pubescentis, Rhizoma Zingiberis, Caulis Trachelospermi, Caulis Polygoni Multiflori, Semen Strychni, Radix Zanthoxyli Spinifolii, Herba Lycopodii, Rhizoma Acori Graminei, Folium Artemisiae Argyi, Aconitum carmichjaelii Debx., Rhizoma Drynariae, roguing, cleaning, dry, pulverize, obtain mixed powder; 2) in step 1) gained mixed powder, adding weight is mixed powder weight 3-5 water doubly, decocts 1-3 time, decocts 1-3h at every turn, filter, obtain filtrate and filtering residue respectively, for subsequent use; 3) in step 2) in gained filtering residue, adding mass concentration is the ethanol of 75-95%, reflux, extract, 1-3 time, filters, concentrated, obtains extractum, described ethanol consumption is 4-6 times of described mixed powder weight; 4) get Cinnabaris, pulverize, sieve, obtain cinnabar powder, add cinnabar powder, step 3) gained extractum to step 2 respectively) in gained filtrate, mixing, stirs, obtains mixed liquor; 5) step 4) gained mixed liquor is condensed into the thick extractum that relative density is 1.20-1.30, at 60-80 DEG C, add pressure sensitive adhesive, grind well, and be applied on non-woven fabrics, overlay film, section, obtains finished product.
embodiment one
Get Herba speranskiae tuberculatae 20g, Caulis Spatholobi 20g, Fructus Psoraleae 10g, Rhizoma Dioscoreae Nipponicae 10g, Rhizoma Polygoni Cuspidati 10g, Cortex Eucommiae 10g, Scorpio 5g, Radix Angelicae Pubescentis 5g, Rhizoma Zingiberis 10g, Caulis Trachelospermi 20g, Caulis Polygoni Multiflori 20g, Semen Strychni 20g, Radix Zanthoxyli Spinifolii 15g, Herba Lycopodii 15g, Rhizoma Acori Graminei 15g, Folium Artemisiae Argyi 5g, Aconitum carmichjaelii Debx. 5g, Rhizoma Drynariae 15, roguing, cleaning, dry, pulverize, obtain mixed powder;
In above-mentioned mixed powder, add the water that weight is mixed powder weight 3 times, decoct 3 times, decoct 1h at every turn, filter, obtain filtrate and filtering residue respectively, for subsequent use;
In above-mentioned filtering residue, adding mass concentration is the ethanol of 75%, reflux, extract, 2 times, filters, and concentrated, obtain extractum, ethanol consumption is 4 times of mixed powder weight;
Get Cinnabaris 5g, pulverize, sieve, obtain cinnabar powder, cinnabar powder, above-mentioned extractum are added in above-mentioned filtrate respectively, mixing, stir, obtain mixed liquor;
Above-mentioned mixed liquor is condensed into the thick extractum that relative density is 1.20, at 60 DEG C, itself and pressure sensitive adhesive is ground well, and be applied on non-woven fabrics, overlay film, section, obtains finished product.
embodiment two
Get Herba speranskiae tuberculatae 30g, Caulis Spatholobi 30g, Fructus Psoraleae 20g, Rhizoma Dioscoreae Nipponicae 20g, Rhizoma Polygoni Cuspidati 20g, Cortex Eucommiae 20g, Scorpio 15g, Radix Angelicae Pubescentis 15g, Rhizoma Zingiberis 20g, Caulis Trachelospermi 30g, Caulis Polygoni Multiflori 30g, Semen Strychni 30g, Radix Zanthoxyli Spinifolii 25g, Herba Lycopodii 25g, Rhizoma Acori Graminei 25g, Folium Artemisiae Argyi 15g, Aconitum carmichjaelii Debx. 15g, Rhizoma Drynariae 25, roguing, cleaning, dry, pulverize, obtain mixed powder;
In above-mentioned mixed powder, add the water that weight is mixed powder weight 5 times, decoct 1 time, decoct 2h at every turn, filter, obtain filtrate and filtering residue respectively, for subsequent use;
In above-mentioned filtering residue, adding mass concentration is the ethanol of 95%, reflux, extract, 1 time, filters, and concentrated, obtain extractum, ethanol consumption is 5 times of mixed powder weight;
Get Cinnabaris 15g, pulverize, sieve, obtain cinnabar powder, cinnabar powder, above-mentioned extractum are added in above-mentioned filtrate respectively, mixing, stir, obtain mixed liquor;
Above-mentioned mixed liquor is condensed into the thick extractum that relative density is 1.30, at 70 DEG C, itself and pressure sensitive adhesive is ground well, and be applied on non-woven fabrics, overlay film, section, obtains finished product.
embodiment three
Get Herba speranskiae tuberculatae 25g, Caulis Spatholobi 25g, Fructus Psoraleae 15g, Rhizoma Dioscoreae Nipponicae 15g, Rhizoma Polygoni Cuspidati 15g, Cortex Eucommiae 15g, Scorpio 10g, Radix Angelicae Pubescentis 10g, Rhizoma Zingiberis 15g, Caulis Trachelospermi 25g, Caulis Polygoni Multiflori 25g, Semen Strychni 25g, Radix Zanthoxyli Spinifolii 20g, Herba Lycopodii 20g, Rhizoma Acori Graminei 20g, Folium Artemisiae Argyi 10g, Aconitum carmichjaelii Debx. 10g, Rhizoma Drynariae 20, roguing, cleaning, dry, pulverize, obtain mixed powder;
In above-mentioned mixed powder, add the water that weight is mixed powder weight 4 times, decoct 2 times, decoct 3h at every turn, filter, obtain filtrate and filtering residue respectively, for subsequent use;
In above-mentioned filtering residue, adding mass concentration is the ethanol of 85%, reflux, extract, 3 times, filters, and concentrated, obtain extractum, ethanol consumption is 6 times of mixed powder weight;
Get Cinnabaris 10g, pulverize, sieve, obtain cinnabar powder, cinnabar powder, above-mentioned extractum are added in above-mentioned filtrate respectively, mixing, stir, obtain mixed liquor;
Above-mentioned mixed liquor is condensed into the thick extractum that relative density is 1.25, at 80 DEG C, add pressure sensitive adhesive, grind well, and be applied on non-woven fabrics, overlay film, section, obtains finished product.
Set forth the present invention further below in conjunction with concrete test example, wherein, comprise the animal toxicity test of Chinese medicine ointment of the present invention, pharmacodynamics test and clinical observation test.
animal toxicity test
Select the Wistar rat 20 of healthy adult, male and female half and half, before on-test, cut off animal trunk back intend contamination region by hair, unhairing answers extreme care, and loss of energy skin is not in order to avoid cutaneous permeability; Be divided into two groups, often organize 10, wherein one group 10 is overdose test group, and another group is normal dose test group; By Chinese medicine ointment of the present invention, be attached to back part of animal depilation district, overdose test group sticks 24h, and normal dose test group sticks 12h, then, takes out tested material, observes its tested side dermoreaction; Stick 7 days continuously, weigh once after the 7th day, and by the sacrifice of animal of normal dose test group and observe its general pathology change.
Result of the test shows, the animal of overdose test group and normal dose test group, stick period, this patch does not all come off, all lighter when taking off patch, do not cause secondary injury to tested side skin, and tested side skin does not all occur that erythema, edema, eczema etc. are abnormal, in the observation period, animal is all without dead.All there is not poisoning sign in the animal of 10 normal dose test group, general pathology anatomical examination no abnormality seen; Therefore, Chinese medicine ointment of the present invention, sticks firmly, non-stimulated to skin, nontoxic to experimenter, and it is also easy to remove, and can not cause secondary injury to skin.
animal pharmacodynamics test
The experimentation that Chinese medicine ointment of the present invention affects adjuvant arthritic rats arthritis
Choose the healthy SD rat 50 at 3-4 monthly age, body weight 200-250g, male and female half and half; Rat divides 5 groups at random, often organizes 10, wherein, first four groups is administration group, the i.e. Chinese medicine ointment administration group of the embodiment of the present invention one to embodiment three and the Chinese medicine external tincture contrast administration group of certain commercially available treatment rheumatic osteopathia, last group is for blank group, and note spreading smears the gauze of vaseline.
Five groups of Rat Right foot sole of the foot Intradermal are all injected Freund's complete adjuvant 0.1ml, second day after injection, there is swelling in the right whole sole of the foot; Test beginning modeling in the 1st day to be treated simultaneously, rat is fixed on special Mus frame prostrate, select DAZHUI acupoint, after surface, rat acupuncture point unhairing also sterilization, the circle that the embodiment of the present invention one cuts a diameter 2cm to Chinese medicine ointment and the commercially available Chinese medicine external tincture of embodiment three is sticked on selected acupuncture point, treat weekly 1 time, paste 4 times altogether; Each treatment is all carried out between Beijing time 14:00-16:00.
After treatment terminates, put to death rat, get right back ankle joint, be placed in 10% formalin solution and fix.Then EDTA decalcification, specimens paraffin embedding slices, puts microscope slide, with h and E dyeing, completes pathological section and makes, carry out pathological observation and evaluate classification, with calculating of giving a mark under 400 × high power lens visual field.Evaluation grade scale is: 1. synovial cell proliferation: the cell number of plies calculating backing layer 3 different parts, gets the cell number of plies of its meansigma methods as synovial membrane backing layer; Without synovial cell proliferation (-), cell monolayer swelling intensive (+), two confluent monolayer cells swelling intensive (++), three layers and above cellular swelling intensive (+++); 2. inflammatory cell infiltration: without inflammatory cell (-), is sparsely dispersed in inflammatory cell (+), comparatively dense inflammatory cell (++), a large amount of inflammatory cell (+++); 3. proliferation of fibrous tissue: without proliferation of fibrous tissue (-), a small amount of proliferation of fibrous tissue (+), moderate proliferation of fibrous tissue (++), a large amount of proliferation of fibrous tissue (+++); 4. hugely bite like cell hypertrophy: bite like cell hypertrophy (-) without huge, be sparsely dispersed in huge like cell of biting and assemble (+), the huge like cell of biting of comparatively dense assembles (++), and huge like cell of biting assembles (+++) in a large number; 5. articular cartilage damage: without articular cartilage damage (-), slight articular cartilage damage (+), moderate articular cartilage damage (++), severe articular cartilage damage (+++); Above-mentioned (-) to (+++) 0-3 that scores respectively divides.Experimental result is as shown in table 1, represents with means standard deviation, carries out data statistic analysis by SPSS10.0 software parameter data with variance test, is that difference has significance with P<0.05.
Table 1 pathological effect experimental result
| Project | Thin film hyperplasia | Inflammatory cell infiltration | Macrophage hamartoplasia | Proliferation of fibrous tissue | Articular cartilage damage | Sum up and divide |
| Embodiment one | 1.24±0.92 ** | 0.98±0.72 * | 0.32±0.87 ** | 0.64±1.24 * | 0.38±0.68 * | 3.29±2.26 ** |
| Embodiment two | 1.22±0.78 ** | 1.00±0.59 * | 0.35±0.72 ** | 0.70±1.55 * | 0.40±0.85 * | 3.50±3.42 ** |
| Embodiment three | 1.20±0.85 ** | 0.88±0.67 * | 0.30±0.69 ** | 0.65±1.32 * | 0.41±0.60 * | 3.17±4.48 ** |
| Matched group | 1.98±0.85* | 1.26±0.78 * | 1.53±0.34 | 1.21±0.99* | 0.67±1.23 | 6.82±3.98 * |
| Blank group | 2.82±0.35 | 2.76±0.63 | 2.04±0.67 | 2.63±0.43 | 1.28±0.87 | 11.50±4.15 |
Remarks: compared with blank group, *---P<0.05; *---P<0.01.
As can be seen from Table 1, the embodiment of the present invention one to embodiment three Chinese medicine ointment administration group synovial cell proliferation, it is huge that to bite like cell hyperplasia degree the lightest, this has pole significant difference compared with blank group; Meanwhile, its inflammatory cell infiltration degree and proliferation of fibrous tissue degree and cartilage destruction degree all minimum, this has significant difference compared with blank group.Compared with matched group, the embodiment of the present invention one can alleviate thin film hyperplasia and the macrophage hypertrophy of adjuvant arthritis model rat significantly to the Chinese medicine ointment of embodiment three, in inflammation-inhibiting cellular infiltration, proliferation of fibrous tissue and cartilage destruction, also have certain advantage.Therefore, Chinese medicine ointment of the present invention can alleviate the serious pathological infringement of adjuvant arthritis model rat significantly, and its certain more commercially available Chinese medicine external tincture has certain advantage.
clinical observation is tested
Patient data
Choose anemofrigid-damp arthralgia rheumatoid osteopathia patient 200 example, wherein, man 80 example, female 120 example, minimum 20 years old of age, oldest 75 years old, in the majority with more than 45 years old person, the course of disease one month to 10 years, two groups are divided into according to the method for M-F, ratio of age and course of disease balanced proportion, matched group 100 example, treatment group 100 example, does not have diversity statistically between these two groups of patients; They all show arthralgia in various degree, swelling and numb limbs and tense tendons.Before accepting this treatment, all once adopted the Therapeutic Method such as other Western medicine, Chinese medicine, but effect is not remarkable, easily recurs, can not dig up the roots.
Therapeutic scheme
Matched group: patient sticks the Chinese medicine external tincture of certain commercially available treatment rheumatic osteopathia, before sleep in evening, stick on the acupuncture point of sore place, every day one pastes, and within 1 month, is a course for the treatment of, sticks 3 courses for the treatment of;
Treatment group: patient sticks Chinese medicine ointment of the present invention, before sleep in evening, stick on the acupuncture point of sore place, every day one pastes, and within 7 days, is a course for the treatment of, sticks 3 courses for the treatment of.
Follow up a case by regular visits to every day once, stick before ointment and evaluate respectively after sticking ointment, treatment group and matched group treat 3 courses for the treatment of respectively, treat complete after, continue to follow up a case by regular visits to 1 year, before treatment, further consultation and fill in case report form when following up a case by regular visits to.
All experimenters all must not merge the medicine using other treatment rheumatic osteopathia any and the medicine that may affect clinical efficacy and untoward reaction evaluation at duration of test.
Therapeutic effect
Cure: clinical symptom disappearance after treatment, functional activity recovers normal;
Effective: after treatment, the basic or major part of clinical symptoms disappears;
Effective: after treatment, clinical symptoms is clearly better or takes a turn for the better;
Invalid: after treatment, Clinical symptom and sign is without change.
Therapeutic effect
Matched group: in 100 routine patients, recovery from illness 52 example, effective 27 examples, effective 12 examples, no effect 9, total effective rate is 91%;
Treatment group: in 100 routine patients, recovery from illness 75 example, effective 17 examples, effective 7 examples, invalid 1 example, total effective rate is 99%.
Clinical observation result
Above-mentioned Clinical observation result shows, Chinese medicine ointment of the present invention has good curative effect to treatment anemofrigid-damp arthralgia rheumatoid osteopathia, clearly, cure rate reaches 75% to advantage, and obvious effective rate reaches 17%, total effective rate reaches 99%, its instant effect, short treating period, easy to use, non-stimulated to skin, have no side effect.
Model case
Case 1: model, man, 54 years old, government functionary, readme, because of after wind and cold, causes both legs arthralgia, joint stuffiness, continues 5 years; Just started pain comparatively light, bend and stretch and be easier to, pain was aggravated gradually afterwards, bent and stretched difficulty all the more.Once took many Chinese medicine and western medicine such as ibuprofen, indometacin, effect is all not good, and symptom does not take a turn for the better.After note applies Chinese medicine ointment of the present invention, one the course for the treatment of pain relief; Continue note and apply a course for the treatment of, both legs arthralgia obviously alleviates, and bends and stretches and starts to become easy; After note applies three courses for the treatment of, pain symptom disappears, and bends and stretches the limbs freely; Follow up a case by regular visits to 1 year, have no recurrence.
Case 2: suddenly certain, female, 22 years old, student, the right lower limb knee joint of readme and ankle joint cause pain because having a cold repeatly, and rainy weather increases the weight of, hurt like hell, continue 3 years; Just started pain comparatively light, identify oneself oneself youth, do not draw attention, pain was aggravated gradually afterwards.When hurt like hell and note apply pain relieving plaster, poor effect, can not dig up the roots, easily recur.After note applies Chinese medicine ointment of the present invention, one the course for the treatment of leg joint pain relief; Continue note and apply a course for the treatment of, the pain in leg joint and ankle joint all obviously alleviates; After note applies three courses for the treatment of, pain symptom disappears, and rainy weather does not have pain yet; Follow up a case by regular visits to 1 year, have no recurrence.
Case 3: go into business certain, female, 65 years old, peasant, readme, because of long-term painstaking farming, causes the right lower limb gonalgia, swelling and numbness, and overcast and rainy, symptom aggravation cold season, continues 10 years; Walk or stand up time slightly length, namely can hurt like hell.Once took the herbal decoction of multiple treatment rheumatism, and took inconvenience, injure the intestines and stomach, and DeGrain, easily recurs.After note applies Chinese medicine ointment of the present invention, pain relief after the course for the treatment of; Continue note and apply a course for the treatment of, walk or no longer hurt like hell when standing; After note applies three courses for the treatment of, pain symptom disappears, and activity freely; Follow up a case by regular visits to 1 year, have no recurrence.
Therefore, the beneficial effect of Chinese medicine ointment of the present invention is: the present invention selects medicine many, wide coverage, and each raw material of Chinese medicine compatibility is scientific and reasonable, and drug effect complements each other, and brings out the best in each other; Effect of reducing swelling and alleviating pain, expelling wind and removing dampness, heat clearing away cold expelling, channels sootheing and network vessel quickening and blood circulation promoting and blood stasis dispelling is reached by nourishing the liver and kidney, strong muscles and bones, regulation of mental activities reason lung, eliminating pathogenic factor for supporting vital QI; Be affixed on affected part outward to use, absorbed by acupuncture point, the through focus degree of depth, inner disease outer treat, short treating period, cure rate is high, determined curative effect, does not recur; This external application medical ointment, do not injure the intestines and stomach, do not lose Liver and kidney, secondary injury can not be caused to skin, paste solid, there will not be obscission, toxic effects, safe and reliable, may be used for treating each rheumatoid osteopathia, be particularly suitable for the treatment of the symptoms such as the arthralgia caused by anemofrigid-damp arthralgia, swelling and numb limbs and tense tendons.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (3)
1. treat a Chinese medicine ointment for rheumatic osteopathia, it is characterized in that: be made up of the raw material of Chinese medicine of following weight portion:
Herba speranskiae tuberculatae 20-30 part, Caulis Spatholobi 20-30 part, Fructus Psoraleae 10-20 part, Rhizoma Dioscoreae Nipponicae 10-20 part, Rhizoma Polygoni Cuspidati 10-20 part, Cortex Eucommiae 10-20 part, Scorpio 5-15 part, Radix Angelicae Pubescentis 5-15 part, Rhizoma Zingiberis 10-20 part, Caulis Trachelospermi 20-30 part, Caulis Polygoni Multiflori 20-30 part, Semen Strychni 20-30 part, Radix Zanthoxyli Spinifolii 15-25 part, Herba Lycopodii 15-25 part, Rhizoma Acori Graminei 15-25 part, Folium Artemisiae Argyi 5-15 part, Cinnabaris 5-15 part, Aconitum carmichjaelii Debx. 5-15 part, Rhizoma Drynariae 15-25 part.
2. the Chinese medicine ointment for the treatment of rheumatic osteopathia according to claim 1, is characterized in that: be made up of the raw material of Chinese medicine of following weight portion:
Herba speranskiae tuberculatae 25 parts, Caulis Spatholobi 25 parts, Fructus Psoraleae 15 parts, Rhizoma Dioscoreae Nipponicae 15 parts, Rhizoma Polygoni Cuspidati 15 parts, the Cortex Eucommiae 15 parts, Scorpio 10 parts, Radix Angelicae Pubescentis 10 parts, Rhizoma Zingiberis 15 parts, Caulis Trachelospermi 25 parts, Caulis Polygoni Multiflori 25 parts, Semen Strychni 25 parts, Radix Zanthoxyli Spinifolii 20 parts, Herba Lycopodii 20 parts, Rhizoma Acori Graminei 20 parts, Folium Artemisiae Argyi 10 parts, 10 parts, Cinnabaris, Aconitum carmichjaelii Debx. 10 parts, Rhizoma Drynariae 20 parts.
3. the preparation method of the Chinese medicine ointment for the treatment of rheumatic osteopathia according to claim 1 and 2, is characterized in that, comprise the following steps:
1) Herba speranskiae tuberculatae, Caulis Spatholobi, Fructus Psoraleae, Rhizoma Dioscoreae Nipponicae, Rhizoma Polygoni Cuspidati, the Cortex Eucommiae, Scorpio, Radix Angelicae Pubescentis, Rhizoma Zingiberis, Caulis Trachelospermi, Caulis Polygoni Multiflori, Semen Strychni, Radix Zanthoxyli Spinifolii, Herba Lycopodii, Rhizoma Acori Graminei, Folium Artemisiae Argyi, Aconitum carmichjaelii Debx., Rhizoma Drynariae is got, roguing, cleaning, dries, pulverize, obtain mixed powder;
2) in step 1) gained mixed powder, adding weight is mixed powder weight 3-5 water doubly, decocts 1-3 time, decocts 1-3h at every turn, filter, obtain filtrate and filtering residue respectively, for subsequent use;
3) in step 2) in gained filtering residue, adding mass concentration is the ethanol of 75-95%, reflux, extract, 1-3 time, filters, concentrated, obtains extractum, described ethanol consumption is 4-6 times of described mixed powder weight;
4) get Cinnabaris, pulverize, sieve, obtain cinnabar powder, add cinnabar powder, step 3) gained extractum to step 2 respectively) in gained filtrate, mixing, stirs, obtains mixed liquor;
5) step 4) gained mixed liquor is condensed into the thick extractum that relative density is 1.20-1.30, at 60-80 DEG C, add pressure sensitive adhesive, grind well, and be applied on non-woven fabrics, overlay film, section, obtains finished product.
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