CN109453099B - Paris polyphylla composition and preparation method thereof - Google Patents
Paris polyphylla composition and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention discloses a paris polyphylla composition, which mainly comprises the following raw materials in parts by weight, 10-12 parts of paris polyphylla extract, 3-4 parts of bletilla striata extract, 2-2.5 parts of abrus herb extract, 2-2.5 parts of curculigo orchioides extract and 5-6 parts of grape seed oil, wherein the paris polyphylla composition is used as an anti-aging component in cosmetics; also, a method for preparing the paris polyphylla composition. The invention has the advantages of stable state, skin friendliness, easy absorption, good anti-aging effect and the like.
Description
Technical Field
The invention relates to the technical field of cosmetic preparation. More specifically, the invention relates to a paris polyphylla composition and a preparation method thereof.
Background
With age, the skin becomes progressively older, mainly manifested by increased wrinkles, sagging, dullness, and pigmentation, which seriously affect the aesthetic appearance. In order to delay skin aging, people usually adopt anti-aging cosmetics for daily skin care, and the market demand of the anti-aging cosmetics is very high, wherein Chinese herbal medicine skin care is pursued by more and more people due to the advantages of greenness, naturalness, purity, mildness, small toxic and side effects and the like. Shennong shelf located at juncture of west and north edges of eastern province, domestic medicinal plants and abundant medicinal plants, Paris polyphylla resource has obvious advantages, and application of extracted Paris polyphylla as main anti-aging active ingredient in cosmetics has not been reported.
Disclosure of Invention
One object of the invention is to provide a paris polyphylla composition, which is prepared by paris polyphylla extract, bletilla striata extract, abrus cantoniensis hance extract, curculigo orchioides extract and grape seed oil according to a certain proportion, so that the advantages of the components are combined to generate a synergistic effect, and the anti-aging effect of the composition is improved.
The invention aims to provide a preparation method of a paris polyphylla composition, which is characterized in that paris polyphylla extract, bletilla striata extract, abrus cantoniensis hance extract and curculigo orchioides extract are mixed in a certain order, the obtained mixed liquid I is subjected to ultrahigh pressure treatment and then is mixed and emulsified with grape seed oil, so that the composition is uniform and stable in tissue state, the sensitization of the composition is reduced, the anti-aging performance of the composition is improved, and the prepared cream is stable in state, mild in property, good in skin feel and good in anti-aging effect.
To achieve the objects and other advantages in accordance with the present invention, there is provided a paris polyphylla composition consisting essentially of, by weight, 10-12 parts of paris polyphylla extract, 3-4 parts of bletilla striata extract, 2-2.5 parts of abrus herb extract, 2-2.5 parts of curculigo orchioides extract and 5-6 parts of grape seed oil, the paris polyphylla composition being used in cosmetics as an anti-aging ingredient. The cosmetic includes lotion, cream and facial mask.
Preferably, the paris polyphylla composition is mainly composed of the following raw materials in parts by weight, 11 parts of paris polyphylla extract, 3.5 parts of bletilla striata extract, 2.2 parts of abrus herb extract, 2.2 parts of curculigo orchioides extract and 5.5 parts of grape seed oil, and the paris polyphylla composition is used as an anti-aging component and is used in cream.
The preparation method of the paris polyphylla composition comprises the following steps:
step one, weighing 10-12 parts by weight of paris polyphylla extract, adding the paris polyphylla extract into 50-60 parts by weight of water, adjusting the pH value to 7.3 +/-0.05 by using a sodium hydroxide solution with the mass fraction of 10% after ultrasonic dispersion, sequentially adding 3-4 parts by weight of bletilla striata extract, 2-2.5 parts by weight of abrus cantoniensis hance extract and 2-2.5 parts by weight of curculigo orchioides extract, and obtaining a mixed solution I after ultrasonic dispersion;
step two, subpackaging the mixed solution I into polyethylene bags, sealing the polyethylene bags, placing the polyethylene bags into an ultrahigh pressure container, and maintaining the pressure at 400 plus 500MPa for 20-25min to obtain a mixed solution II;
and step three, adding 5-6 parts by weight of grape seed oil and 1-1.2 parts by weight of glycerol stearate into the mixed solution II, and emulsifying at 45-50 ℃ and 2400-.
Preferably, in the preparation method of the paris polyphylla composition, 11 parts by weight of paris polyphylla extract, 3.5 parts by weight of bletilla striata extract, 2.2 parts by weight of abrus herb extract, 2.2 parts by weight of curculigo orchioides extract, 5.5 parts by weight of grape seed oil and 1.1 parts by weight of glycerol stearate are adopted.
Preferably, the preparation method of the paris polyphylla composition further comprises the steps of adding the paris polyphylla composition accounting for 5-8% of the mass of the cream base into the cream base, and mixing for 2-4min at 50-55 ℃ and 300-400r/min to prepare the cream. The cream base material consists of an emollient, a humectant, an emulsifier and water.
Preferably, the preparation method of the paris polyphylla composition comprises the following steps: A. after coarse powder of paris polyphylla, sieving the coarse powder by a 20-mesh sieve, taking undersize products, adding water, and adjusting the water content to be 45-50% to obtain wet powder of paris polyphylla; B. carrying out hot-pressing steam spray explosion treatment on the paris polyphylla wet powder, wherein the steam explosion pressure is 2.2-2.5MPa, the saturated steam temperature is 180-; C. freeze-drying the paris polyphylla explosion initiating powder, and extracting by supercritical carbon dioxide to obtain the paris polyphylla extract, wherein the supercritical carbon dioxide extraction conditions are as follows: the extraction temperature is 45-50 ℃, the extraction pressure is 18-20MPa, the extraction time is 3-4h, and the extraction flow is 40L/h.
The invention at least comprises the following beneficial effects:
firstly, the paris polyphylla extract can resist oxidation, remove free radicals and enhance the skin elasticity; the bletilla striata extract can astringe skin and accelerate cell reproduction; the herba abri extract can dilate blood vessel and accelerate blood circulation; the rhizoma Curculiginis extract can supplement skin nutrition and improve skin immunity; the grape seed oil can resist oxidation, remove free radicals and preserve moisture, and the components are prepared according to a certain proportion, so that the advantages of the components are combined to generate a synergistic effect, and the anti-aging effect of the composition is improved;
secondly, the paris polyphylla extract, the bletilla striata extract, the abrus cantoniensis hance extract and the curculigo orchioides extract are mixed in a certain order, then are subjected to ultrahigh pressure treatment, and are mixed and emulsified with the grape seed oil, so that the tissue state of the composition is uniform and stable, the allergenicity of the composition is reduced, the anti-aging performance of the composition is improved, and the prepared cream is stable in state, skin-friendly, easy to absorb and good in anti-aging effect.
The invention provides a preparation method of a paris polyphylla extract, which can effectively promote the dissolution of active ingredients in the paris polyphylla and improve the anti-aging capability of the paris polyphylla extract by adding hot-pressing steam spray explosion treatment before supercritical carbon dioxide extraction.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Drawings
FIG. 1 is a graph showing the changes in skin elasticity before and after application of the samples of examples 2, 4 and 6 of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the following examples and the accompanying drawings so that those skilled in the art can practice the invention with reference to the description.
It is to be noted that the experimental methods described in the following embodiments are all conventional methods unless otherwise specified, and the reagents and materials are commercially available unless otherwise specified.
Example 1:
a paris polyphylla composition is mainly composed of the following raw materials, by weight, 10 parts of paris polyphylla extract, 3 parts of bletilla striata extract, 2 parts of abrus cantoniensis hance extract, 2 parts of rhizoma curculiginis extract and 5 parts of grape seed oil.
A preparation method of a paris polyphylla composition comprises the following steps:
step one, weighing 10 parts by weight of paris polyphylla extract, adding the paris polyphylla extract into 50 parts by weight of water, adjusting the pH value to 7.3 +/-0.05 by using a sodium hydroxide solution with the mass fraction of 10% after ultrasonic dispersion, sequentially adding 3 parts by weight of bletilla striata extract, 2 parts by weight of abrus cantoniensis hance extract and 2 parts by weight of curculigo orchioides extract, and obtaining mixed liquid I after ultrasonic dispersion;
step two, subpackaging the mixed solution I into polyethylene bags, sealing the polyethylene bags, placing the polyethylene bags into an ultrahigh pressure container, and maintaining the pressure at 400Mpa for 25min to obtain a mixed solution II;
and step three, adding 5 parts by weight of grape seed oil and 1 part by weight of glycerol stearate into the mixed solution II, and emulsifying at 45 ℃ and 2400r/min for 6min to obtain the paris polyphylla composition.
Also comprises adding the paris polyphylla composition accounting for 5 percent of the mass of the cream base into the cream base, and mixing for 4min at 50 ℃ and 300r/min to prepare the cream. The cream base material comprises 6% of squalane, 3% of shea butter, 2% of jojoba oil, 8% of glycerol, 2% of propylene glycol, 1% of cetostearyl alcohol, 1% of glycerol stearate and the balance of water in percentage by weight, and is prepared by (1) mixing squalane, shea butter, jojoba oil, cetostearyl alcohol and glycerol stearate, and heating and stirring until the mixture is completely dissolved to obtain an oil phase; (2) mixing glycerol, propylene glycol and water uniformly, heating and stirring until the glycerol, the propylene glycol and the water are completely dissolved to obtain a water phase; (3) mixing the oil phase and the water phase, and stirring and emulsifying to obtain the product.
In the embodiment, the paris polyphylla extract is 20:1 in specification, the bletilla striata extract is 10:1 in specification, and the abrus cantoniensis hance extract is 10:1 in specification, which are purchased from the company of biological technology limited of Tianrui Xian; the specification of the curculigo orchioides extract is 8: 1, purchased from Lanolin biological resources of Hunan province, Ltd; the other components in this example are all conventionally commercially available.
Example 2:
a paris polyphylla composition is mainly composed of the following raw materials, by weight, 11 parts of paris polyphylla extract, 3.5 parts of bletilla striata extract, 2.2 parts of abrus herb extract, 2.2 parts of curculigo rhizome extract and 5.5 parts of grape seed oil.
A preparation method of a paris polyphylla composition comprises the following steps:
step one, weighing 11 parts by weight of paris polyphylla extract, adding 55 parts by weight of water, carrying out ultrasonic dispersion, adjusting the pH value to 7.3 +/-0.05 by using a sodium hydroxide solution with the mass fraction of 10%, sequentially adding 3.5 parts by weight of bletilla striata extract, 2.2 parts by weight of abrus cantoniensis hance extract and 2.2 parts by weight of curculigo orchioides extract, and carrying out ultrasonic dispersion to obtain a mixed solution one;
step two, subpackaging the mixed solution I into polyethylene bags, sealing the polyethylene bags, placing the polyethylene bags into an ultrahigh pressure container, and maintaining the pressure at 450MPa for 22min to obtain a mixed solution II;
and step three, adding 5.5 parts by weight of grape seed oil and 1.1 parts by weight of glycerol stearate into the mixed solution II, and emulsifying at 45 ℃ and 2500r/min for 5min to obtain the paris polyphylla composition.
Also comprises adding the paris polyphylla composition accounting for 6.5 percent of the mass of the cream base into the cream base, and mixing for 3min at 52 ℃ and 350r/min to prepare the cream. The cream base material comprises 6% of squalane, 3% of shea butter, 2% of jojoba oil, 8% of glycerol, 2% of propylene glycol, 1% of cetostearyl alcohol, 1% of glycerol stearate and the balance of water in percentage by weight, and is prepared by (1) mixing squalane, shea butter, jojoba oil, cetostearyl alcohol and glycerol stearate, and heating and stirring until the mixture is completely dissolved to obtain an oil phase; (2) mixing glycerol, propylene glycol and water uniformly, heating and stirring until the glycerol, the propylene glycol and the water are completely dissolved to obtain a water phase; (3) mixing the oil phase and the water phase, and stirring and emulsifying to obtain the product.
In the embodiment, the paris polyphylla extract is 20:1 in specification, the bletilla striata extract is 10:1 in specification, and the abrus cantoniensis hance extract is 10:1 in specification, which are purchased from the company of biological technology limited of Tianrui Xian; the specification of the curculigo orchioides extract is 8: 1, purchased from Lanolin biological resources of Hunan province, Ltd; the other components in this example are all conventionally commercially available.
Example 3:
a paris polyphylla composition is mainly composed of the following raw materials, by weight, 12 parts of paris polyphylla extract, 4 parts of bletilla striata extract, 2.5 parts of abrus cantoniensis hance extract, 2.5 parts of rhizoma curculiginis extract and 6 parts of grape seed oil.
A preparation method of a paris polyphylla composition comprises the following steps:
step one, weighing 12 parts by weight of paris polyphylla extract, adding 60 parts by weight of water, carrying out ultrasonic dispersion, adjusting the pH value to 7.3 +/-0.05 by using a sodium hydroxide solution with the mass fraction of 10%, sequentially adding 4 parts by weight of bletilla striata extract, 2.5 parts by weight of abrus cantoniensis hance extract and 2.5 parts by weight of curculigo orchioides extract, and carrying out ultrasonic dispersion to obtain a mixed solution one;
step two, subpackaging the mixed solution I into polyethylene bags, sealing the polyethylene bags, placing the polyethylene bags into an ultrahigh pressure container, and maintaining the pressure at 500Mpa for 20min to obtain a mixed solution II;
and step three, adding 6 parts by weight of grape seed oil and 1.2 parts by weight of glycerol stearate into the mixed solution II, and emulsifying at 50 ℃ and 2600r/min for 3min to obtain the paris polyphylla composition.
Also comprises adding the paris polyphylla composition accounting for 8 percent of the mass of the cream base into the cream base, and mixing for 2min at 55 ℃ and 400r/min to prepare the cream. The cream base material comprises 6% of squalane, 3% of shea butter, 2% of jojoba oil, 8% of glycerol, 2% of propylene glycol, 1% of cetostearyl alcohol, 1% of glycerol stearate and the balance of water in percentage by weight, and is prepared by (1) mixing squalane, shea butter, jojoba oil, cetostearyl alcohol and glycerol stearate, and heating and stirring until the mixture is completely dissolved to obtain an oil phase; (2) mixing glycerol, propylene glycol and water uniformly, heating and stirring until the glycerol, the propylene glycol and the water are completely dissolved to obtain a water phase; (3) mixing the oil phase and the water phase, and stirring and emulsifying to obtain the product.
In the embodiment, the paris polyphylla extract is 20:1 in specification, the bletilla striata extract is 10:1 in specification, and the abrus cantoniensis hance extract is 10:1 in specification, which are purchased from the company of biological technology limited of Tianrui Xian; the specification of the curculigo orchioides extract is 8: 1, purchased from Lanolin biological resources of Hunan province, Ltd; the other components in this example are all conventionally commercially available.
Example 4:
on the basis of the example 2, the paris polyphylla extractive is prepared by a self-made method, and the specific preparation method comprises the following steps: A. after coarse powder of paris polyphylla, sieving the coarse powder by a 20-mesh sieve, taking undersize products, adding water, and adjusting the water content to 48% to obtain wet powder of paris polyphylla; B. carrying out hot-pressing steam spray explosion treatment on the paris polyphylla wet powder, wherein the steam explosion pressure is 2.3MPa, the saturated steam temperature is 190 ℃, the pressure maintaining time is 2.5min, and then instantly relieving pressure to obtain paris polyphylla explosion powder; C. freeze-drying the paris polyphylla explosion initiating powder, and extracting by supercritical carbon dioxide to obtain the paris polyphylla extract, wherein the supercritical carbon dioxide extraction conditions are as follows: the extraction temperature is 48 ℃, the extraction pressure is 19MPa, the extraction time is 3.5h, and the extraction flow is 40L/h. The other conditions were the same as in example 2.
Example 5:
on the basis of the embodiment 2, the first mixed solution is directly added with 5.5 weight parts of grape seed oil and 1.1 weight parts of glycerol stearate, and is emulsified for 5min at the temperature of 45 ℃ and at the speed of 2500r/min, so that the paris polyphylla composition is obtained. The other conditions were the same as in example 2.
Example 6:
a paris polyphylla composition is mainly composed of the following raw materials in parts by weight, 11 parts of paris polyphylla extract and 5.5 parts of grape seed oil.
A preparation method of a paris polyphylla composition comprises the following steps:
step one, weighing 11 parts by weight of paris polyphylla extract, adding the paris polyphylla extract into 35 parts by weight of water, carrying out ultrasonic dispersion, and then adjusting the pH value to 7.3 +/-0.05 by using a sodium hydroxide solution with the mass fraction of 10% to obtain a mixed solution I;
step two, subpackaging the mixed solution I into polyethylene bags, sealing the polyethylene bags, placing the polyethylene bags into an ultrahigh pressure container, and maintaining the pressure at 450MPa for 22min to obtain a mixed solution II;
and step three, adding 5.5 parts by weight of grape seed oil and 1.1 parts by weight of glycerol stearate into the mixed solution II, and emulsifying at 45 ℃ and 2500r/min for 5min to obtain the paris polyphylla composition.
Also comprises adding the paris polyphylla composition accounting for 6.5 percent of the mass of the cream base into the cream base, and mixing for 3min at 52 ℃ and 350r/min to prepare the cream. The cream base material comprises 6% of squalane, 3% of shea butter, 2% of jojoba oil, 8% of glycerol, 2% of propylene glycol, 1% of cetostearyl alcohol, 1% of glycerol stearate and the balance of water in percentage by weight, and is prepared by (1) mixing squalane, shea butter, jojoba oil, cetostearyl alcohol and glycerol stearate, and heating and stirring until the mixture is completely dissolved to obtain an oil phase; (2) mixing glycerol, propylene glycol and water uniformly, heating and stirring until the glycerol, the propylene glycol and the water are completely dissolved to obtain a water phase; (3) mixing the oil phase and the water phase, and stirring and emulsifying to obtain the product.
In the embodiment, the paris polyphylla extract is 20:1 in specification, the bletilla striata extract is 10:1 in specification, and the abrus cantoniensis hance extract is 10:1 in specification, which are purchased from the company of biological technology limited of Tianrui Xian; the specification of the curculigo orchioides extract is 8: 1, purchased from Lanolin biological resources of Hunan province, Ltd; the other components in this example are all conventionally commercially available.
Experimental example 1: stability test
The stability of the creams of examples 2, 4, 5 and 6 was determined by high and low temperature tests and the cold and heat cycle test and the results are shown in table 1.
TABLE 1 stability test results
As can be seen from table 1, the stability of the samples of examples 4 and 6 is the best among the above samples, and the stability of the sample of example 2 is the next, and the stability of the sample of example 5 is the worst.
Experimental example 2: patch test
Randomly selecting 50 volunteers, age 25-40 years, without allergic history, weighing 0.02g of the samples of example 2, example 4, example 5 and example 6, respectively, adding them into a chamber of a spot test tape, applying the spot test tape to a selected position on the upper back of the volunteer, gently pressing the chamber one by one to expel air, so that the samples are uniformly applied to the skin for 48 hours, during the experiment, advising the volunteer about vigorous activity, taking a bath, avoiding scratching, reducing sweating and avoiding sunlight irradiation, removing the spot test tape after applying 48 hours, removing the residual samples with wet soft paper or cotton swab, performing first observation at intervals of 30 minutes, and performing 2 nd and 3 rd observation at 72 and 96 hours, respectively. The skin adverse reaction rating standard of the patch test is shown in Table 2 and the test result is shown in Table 3.
TABLE 2 skin adverse reaction rating Scale
TABLE 3 Patch test results
As can be seen from Table 3, the samples of example 4 and example 6 were negative in 50 subjects (0), indicating that the samples of example 4 and example 6 did not cause adverse reaction to the human body, the samples of example 2 were negative in 1 out of 50 subjects (1) and the other subjects (0), indicating that the samples of example 2 did not substantially cause adverse reaction to the human body, the samples of example 5 were negative in 19 out of 50 subjects (1), the samples of 3 out of 50 subjects were erythema, and the other subjects were negative (0), indicating that the samples of example 2 did not cause adverse reaction to the human body.
Experimental example 3: human body experiment
Selecting 90 volunteers with age of 30-35 years, no allergy history, randomly dividing into 3 groups of 30 persons, selecting 5 × 5cm at symmetrical positions of left and right sides of face of subject2The area of the size was used as the experimental area, wherein the right face side of each group of subjects was smeared with the appropriate amount of the sample of example 2, example 4 or example 6, and the right face side was smeared with the same amount of the sample of example 2The cream base prepared in (1) was applied twice a day, the face was washed with a mild facial cleanser before application for 12 weeks, and the skin elasticity R2 value (R2: the ratio of the amount of skin rebound without negative pressure to the maximum amount of stretch with negative pressure, the closer the ratio is to 1, the better the elasticity of the skin) in the experimental area was tested with a skin tester (CK, MPA580, germany) after 4, 8, 10 and 12 weeks of application, respectively, and the average value was taken 5 times per experimental area. The results of the experiment are shown in FIG. 1. As can be seen from fig. 1, the skin elasticity was improved when the samples of examples 2, 4 and 6 were used, as compared with the cream base, wherein the skin elasticity was the best when the sample of example 4 was used, followed by the samples of examples 2 and 6.
While embodiments of the invention have been described above, it is not limited to the applications set forth in the description and the embodiments, which are fully applicable in various fields of endeavor to which the invention pertains, and further modifications may readily be made by those skilled in the art, it being understood that the invention is not limited to the details shown and described herein without departing from the general concept defined by the appended claims and their equivalents.
Claims (4)
1. The paris polyphylla composition is characterized by mainly comprising the following raw materials in parts by weight, 10-12 parts of paris polyphylla extract, 3-4 parts of bletilla striata extract, 2-2.5 parts of abrus herb extract, 2-2.5 parts of curculigo orchioides extract and 5-6 parts of grape seed oil, wherein the paris polyphylla composition is used as an anti-aging component in cosmetics;
the preparation method of the paris polyphylla composition comprises the following steps:
step one, weighing 10-12 parts by weight of paris polyphylla extract, adding the paris polyphylla extract into 50-60 parts by weight of water, adjusting the pH value to 7.3 +/-0.05 by using a sodium hydroxide solution with the mass fraction of 10% after ultrasonic dispersion, sequentially adding 3-4 parts by weight of bletilla striata extract, 2-2.5 parts by weight of abrus cantoniensis hance extract and 2-2.5 parts by weight of curculigo orchioides extract, and obtaining a mixed solution I after ultrasonic dispersion;
step two, subpackaging the mixed solution I into polyethylene bags, sealing the polyethylene bags, placing the polyethylene bags into an ultrahigh pressure container, and maintaining the pressure for 20-25min at 400-500MPa to obtain a mixed solution II;
step three, adding 5-6 parts by weight of grape seed oil and 1-1.2 parts by weight of glycerol stearate into the mixed solution II, and emulsifying at 45-50 ℃ and 2400-;
the preparation method of the paris polyphylla extract comprises the following steps: A. preparing paris polyphylla into coarse powder, sieving the coarse powder with a 20-mesh sieve, taking undersize products, adding water, and adjusting the water content to be 45-50% to obtain paris polyphylla wet powder; B. carrying out hot-pressing steam spray explosion treatment on the paris polyphylla wet powder, wherein the steam explosion pressure is 2.2-2.5MPa, the saturated steam temperature is 180-; C. freeze-drying the paris polyphylla vapor explosion powder, and extracting by supercritical carbon dioxide to obtain the paris polyphylla extract, wherein the supercritical carbon dioxide extraction conditions are as follows: the extraction temperature is 45-50 ℃, the extraction pressure is 18-20MPa, the extraction time is 3-4h, and the extraction flow is 40L/h.
2. The paris polyphylla composition as claimed in claim 1, which is mainly composed of, by weight, 11 parts of paris polyphylla extract, 3.5 parts of bletilla striata extract, 2.2 parts of abrus herb extract, 2.2 parts of curculigo orchioides extract and 5.5 parts of grape seed oil, and is used as an anti-aging ingredient in cream.
3. A method of preparing a paris polyphylla composition as claimed in claim 1, comprising the steps of:
step one, weighing 10-12 parts by weight of paris polyphylla extract, adding the paris polyphylla extract into 50-60 parts by weight of water, adjusting the pH value to 7.3 +/-0.05 by using a sodium hydroxide solution with the mass fraction of 10% after ultrasonic dispersion, sequentially adding 3-4 parts by weight of bletilla striata extract, 2-2.5 parts by weight of abrus cantoniensis hance extract and 2-2.5 parts by weight of curculigo orchioides extract, and obtaining a mixed solution I after ultrasonic dispersion;
step two, subpackaging the mixed solution I into polyethylene bags, sealing the polyethylene bags, placing the polyethylene bags into an ultrahigh pressure container, and maintaining the pressure for 20-25min at 400-500MPa to obtain a mixed solution II;
step three, adding 5-6 parts by weight of grape seed oil and 1-1.2 parts by weight of glycerol stearate into the mixed solution II, and emulsifying at 45-50 ℃ and 2400-;
the preparation method of the paris polyphylla extract comprises the following steps: A. preparing paris polyphylla into coarse powder, sieving the coarse powder with a 20-mesh sieve, taking undersize products, adding water, and adjusting the water content to be 45-50% to obtain paris polyphylla wet powder; B. carrying out hot-pressing steam spray explosion treatment on the paris polyphylla wet powder, wherein the steam explosion pressure is 2.2-2.5MPa, the saturated steam temperature is 180-; C. freeze-drying the paris polyphylla vapor explosion powder, and extracting by supercritical carbon dioxide to obtain the paris polyphylla extract, wherein the supercritical carbon dioxide extraction conditions are as follows: the extraction temperature is 45-50 ℃, the extraction pressure is 18-20MPa, the extraction time is 3-4h, and the extraction flow is 40L/h.
4. The method of claim 3, wherein the paris polyphylla extract is 11 parts by weight, the bletilla striata extract is 3.5 parts by weight, the abrus herb extract is 2.2 parts by weight, the curculigo orchioides extract is 2.2 parts by weight, the grape seed oil is 5.5 parts by weight, and the glyceryl stearate is 1.1 parts by weight.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485814A (en) * | 2009-02-16 | 2009-07-22 | 李万忠 | Supercritical CO2 extraction method for saponin component in Paris polyphylla var. yunnanensis |
| CN105287282A (en) * | 2015-10-22 | 2016-02-03 | 上海应用技术学院 | Chocolate paste nutrition mask and preparation method thereof |
| CN106798915A (en) * | 2017-03-21 | 2017-06-06 | 郭燕立 | A kind of utilization rhEGF treatment cervical erosion and the gel of damage and preparation method thereof |
| CN107440992A (en) * | 2017-08-22 | 2017-12-08 | 安徽省中日农业环保科技有限公司 | A kind of preparation method of the anti-acne essence containing Rhizoma Paridis extract |
| CN108245463A (en) * | 2016-12-28 | 2018-07-06 | 西藏天麦力健康品有限公司 | A kind of preparation method of composition and moisturizing face cream with moisture-keeping efficacy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101485814A (en) * | 2009-02-16 | 2009-07-22 | 李万忠 | Supercritical CO2 extraction method for saponin component in Paris polyphylla var. yunnanensis |
| CN105287282A (en) * | 2015-10-22 | 2016-02-03 | 上海应用技术学院 | Chocolate paste nutrition mask and preparation method thereof |
| CN108245463A (en) * | 2016-12-28 | 2018-07-06 | 西藏天麦力健康品有限公司 | A kind of preparation method of composition and moisturizing face cream with moisture-keeping efficacy |
| CN106798915A (en) * | 2017-03-21 | 2017-06-06 | 郭燕立 | A kind of utilization rhEGF treatment cervical erosion and the gel of damage and preparation method thereof |
| CN107440992A (en) * | 2017-08-22 | 2017-12-08 | 安徽省中日农业环保科技有限公司 | A kind of preparation method of the anti-acne essence containing Rhizoma Paridis extract |
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