TW200534796A - Delivery of functional ingredients - Google Patents
Delivery of functional ingredients Download PDFInfo
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- TW200534796A TW200534796A TW094108127A TW94108127A TW200534796A TW 200534796 A TW200534796 A TW 200534796A TW 094108127 A TW094108127 A TW 094108127A TW 94108127 A TW94108127 A TW 94108127A TW 200534796 A TW200534796 A TW 200534796A
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- A61Q19/08—Anti-ageing preparations
Description
200534796 九、發明說明: 【發明所屬之技術領域】 本發明係關於包含水果或植物物f的所有基本養分之主 要組合物,其具增加的穩定性、生體利用率、及溶混性; 及其形成方法,亦相關於包含食品、食物補充劑、化妝品 ”周製品或醫藥調製品中主要組合物之口服組合物。 【先前技術】 自水果或植物物質萃取的色素及生物活性化合物廣泛地 用於食品工業做為功能性成分,在它們之中,枸杞(寧夏 枸to)為在中國最有價值功能性成分的其中一個,特別是 其對於視力、免疫系統、及抗老化性質的益處,伴隨存在 於水果的多重生物活性化合物,其習慣上經由熱水萃取消 耗。 許多其他成分亦由消費者了解它們的有利性質,但是它 =食物產品的應用為困難的或是產生差的生體可用率。 2 IV'上’水果—般在減少糖分為豐富的,使得乾燥及處理 它們的粉末為非常困難的。 大里的卒取技術為已知,例如,在W003020053,敘述 自含類胡蘿蔔素植物萃取類胡蘿蔔素的方法, 合植物與水以得到不大於10DE_nx,刚碎階= 的-合物及將固體自液體分開以得到兩相,漿液及乳漿, ㈣萃取黎液以得到含類胡蘿葡素植物油性樹脂。此種水 卒取技術為天'然的,但是與使用溶劑相較不為有效率的。 例如’美國專利6648564敘述一種藉由矣化丙二醇及鹼 100197.doc 200534796 水溶液的組合物中的含葉黃質二s旨植物提取物而形成、隔 離、她匕葉黃質晶體以形成葉黃素晶體的方法。如此得 到的μ貝上純的葉黃質晶體適合人類消耗及可用做營養補 充品及做為食品添加劑。然而,溶劑萃取技術更困難處 理及使用/合劑會有損產品的自然印象及/或營養功能。 而且,習知萃取技術總是萃取較少植物或水果物質的化 口物遠下些其他生物活性化合物於餘留物。例如,多 糖、多齡及其他非親脂性化合物未與親脂性成分如類胡蘿 蔔素、脂溶維他命及其他親脂物質一起萃取。 例如,美國專利_996 B1敘述一種藉由處理含類黃嗣 素原料與水相萃取介質以得到提出物及藉由吸收及/或吸 附分離類黃酮素與該提出物而得到包含一或更多類黃嗣素 的組合物之方法。再次此種萃取方法僅提供主要包含一部 份原料的生物活性原則之提出物。 【發明内容】 本毛月目的因而為藉由提供—種配方以改良穩定性、混 …欠相系統中分散性及生物活性化合物的增加生體利 用率β自水果或植物物質萃取及遞送多重營養成分而強調以 1題本毛日月目的亦為提供一種可直接使用或容易濃缩 或乾燥成為粉末的主要組合物以應用於食品產品、營養補 充劑、化妝品或醫藥調製品。 、據此,本發明第一目的為提供至少包含全果、蔬菜及/ 或=物物質的基本親脂性及親水性生物活性成分(除了不 可岭、截維)於礼類或含乳蛋白載體的混溶主要組合物。 100197.doc 200534796 有利的是,該主要組合物具全果基本活性成份的準確輪 廓二^良好%疋性、混溶性、及於水相系統分散性,: 且,該主要組合物以較佳生體利用率及穩定性 加的:養價值’其具令人喜悅的味道及顏色,其可直接: 用或派縮或乾無為粉末以用於每日消耗食物產品或其他營 養用途之許多應用。 呂 據此,在進步目的該主要組合物係做為在口服食品的 添加劑’如在營養彡且I, 赞、、且口物、食物補充劑、寵物食物產品、 化妝調製品或在醫藥調製品的添加劑。該主要組合物亦為 在局部應用如化妝或醫藥產品的產品中的添加劑。 本毛月亦相關於形成該主要組合物的方法,製備該主要 組口物以遞^全果、蔬菜及/或植物物質的基本親脂性及 親水性生物活性成分之方法包括步驟: 1)此口及磨細水果、蔬菜及/或植物物質於乳類或含乳蛋 白質液體介質, ^分離不可溶纖維以得到水相懸浮液 Hi}選擇性地殺菌所得懸浮液 IV) 在處理期間遥擇性地加人合成或天然生物活性成分 (如類胡蘿«素) V) 及進v ^^擇性地乾燥該懸浮液以得到粉末。 該方法具為自然的及成本有效的進行以穩定化的水溶及 脂溶化合物,不含有機溶劑殘餘物的組合之形式的多重營 養物之改良傳送的主要優點。 在進v方面,本發明提供一種使用如上文所敘述方法 100197.doc 200534796 增加於水相系統混溶性或分散性、穩定性及水果、蔬菜及 /或植物物質的生物活性化合物的生體利用率之方法。特 別是,藉由使用來自植物的乳或乳蛋白,豆漿或似乳蛋白 以卒取及遞送水果、蔬菜及/或植物物質的功能性成分的 多重營養物。 本發明另一目的為提供使用如上文所敘述的主要組合物 以遞送具經改良生體利用率、混溶性及穩定性的水果、鋅 菜及/或植物物質的功能性成分的多重營養物。 進一步目的為提供使用如上文所敘述的主要組合物以製 備意欲用於改良肌膚健康,特別是對肌膚的光防護或是對 抗肌膚組織的老化的口服、化妝及醫藥組合物。 進一步目的為提供使用如上文所敘述的主要組合物以掣 備意欲用於眼睛健康(如老年黃斑病變)的口服、局部或醫 藥組合物。 本發明亦提供使用如上文所敘述的主要組合物以製備咅 欲用於增進免疫系統的食品或醫藥組合物。 最後,本發明亦提供使用如上文所敘述的主要組合物以 製備意欲用於治療糖尿病(如具降血糖作用)的食品或醫藥 組合物。 本發明現在提供消費者得自自然產品的經改良組合物, 其提供維持水果或植物物質或其混合物的重要生物活性成 分的主要組合物。生物活性成分的輪廓接近於在水果或植 物物質自然發生的。該主要組合物以特別高度生體可利 用、穩疋及混溶形式提供水果或植物物質的生物活性化人 100197.doc 200534796 物 優 可翏考下列敘述而更了解本發明特徵與進一步目的及 【實施方式】 ,下列敘述内,名稱生物活性化合物係了解為表示當口 月:肩化或施用於化妝品時顯示生物活性或健康影響的分 或成分。 含:=目的,關於一種混溶主要組合物,其包含乳或 :白载體中的至少全果、蔬菜及/或植物物質的基本 '、曰及親水性生物活性成分(除了不可溶纖維卜 =佳具體實施例中,該水果、蔬菜及/或植物物質可 為疏采、葦早、尹 r ^ 化、水果、種子及植物的其他部份、 混合物之形式。 a其 、㈣佳具體實_中’選擇漿果或任何其他類黃明素_ 力田類胡蘿勤素水果或蔬菜或種子。例如,可 ,用漿果如枸把、藍莓、蔓越莓、桑椹 醋栗、黑醋栗、紅醋栗、覆盆子、沙棘、草葛、二: 萄及其他水果如& 4 *㈡梅或葡 肩果、瓜類、可異果、櫻桃、紅棗、 水蜜桃、柿子,柑橘類水果如橘子、柳撥、蜜 柚。可使用花如甘益 # # 甸 斗 韌、翻化、苦柑橘、金銀花、茉莉及έ 化。可使用蔬菜如番矿 ^ ^ 姑 、 頭甘藍、香菜、/ 波采、^采、紅1^、碗豆、無 田齐、高簏菜、花菜、萵苣、芽甘藍、 羽衣甘藍、蓝眚芨 黍黑米、可、可亞、菌香'洋葱。亦可使用種子如玉蜀 、如啡及成份如茶、百里香、甜紅椒。 100197.doc 200534796 巩米或植物物質可以新鮮、 如,空氣或冷凌铲Ρ, 辰、、但忒钇紅物質, 東乾無材料的形式使用。 水果、疏采或植物物質的基本生物活性成份包括 化合物如類黃=二:水化合物、類胡蘿葡素、多齡系 活性化合物可Ά絲廿 订〜疋 β生物 ’ 酮素如黃酮類(如芽菜 精或香葉木素)、龙扪厅未素木犀黃色 盼)、黃产_ 黃素、揚梅樹皮素、山茶 沒食子兒茶素),花色以)兒伞素(如表兒茶素、 韌素)或大豆異黃綱素( ” 車 胡蘿葡素如胡蘿…: 木質素異黃酮);類 羅筒素類及节·色音违首彳石# 山 常類(如加紅素、胡蘿蔔 音八力卩紅素、八氣番蘇紅素、斑螫黃素、蝦紅青 素侧質、辣椒紅素、葉黃素、玉米黃素、或是以月 肪酸酯的形式之類胡麄芍 山 ”〆 曰 、蘿自素),奴水化合物如阿拉伯半乳 蛋白f (如枸把多糖);維他命(如維他命c、B、E···)· 礦物質(如硒、鈣、鎂、卸)。 忒主要組合物包括乳或含乳蛋白載體中的至少全杲、鋅 菜心或植物物質的基本生物活性成分(除W㈣/ ,礼載體可為來自動物或植物源(如豆聚、果汁或挪聚, ρ的脫脂牛奶或全脂牛奶之形式。在更佳具體實施例 、據所奴的水果或主要組合物,使用牛乳或豆漿。含 |載妝可為任何包含乳蛋白的可食液體如路蛋白或乳衆蛋 白疏菜油可選擇性地加至該液體介質。 如上所敘述的水果、蔬菜或植物物質以約1:1至1:1_, 100197.doc 200534796 較佳為自1:5至1:50的個別比值混合及磨細於該乳或含乳蛋 白質液體介質。該混合及磨細步驟可於自⑴代的溫, 進行,較佳為自20至80t及更佳為自4〇至m:。接著^ 可溶纖維被移除以得到水相懸浮液,此可由任何習知方法 完成。該所得主要組合物可藉由在該技藝中已知技術進1 步殺菌及/或乾燥為粉末,所得 凝膝形式。 “到主要組合物亦為液體或 本發明由此提供一種具類似全果的重 廓之主要組合物,其具良 1彳乂輪 艮好穩疋性、混溶性及生體利用 :。這些: 且合物可高度分散於水相系統,若選擇粉末形 式。在此貫例,粉末係分散於冷或熱水。 該組合物額外包括一或更多乳化劑、穩定劑、抗氧劑及 其他添加劑。使用於食物中相容的乳化劑,例如鱗脂,例 如㈣脂、聚氧乙埽山梨糖醇軒單或三硬脂酸醋、單月桂 酸醋、單棕櫚酸醋、單或三油酸醋、甘油單或二酸醋。亦 使用在食品、化妝品或醫藥已知的任何形式的穩定劑。使 用在食品、化妝品或醫藥為已知的任何型式的抗氧劑。使 用調味劑、染色劑及在食品、化妝品或醫藥已知的任何其 他添加劑做為添加劑。丄言此ξ . J &些礼化劑、穩定劑、抗氧劑及添 加劑係根據該主要組合物的最後使用而添加。 該組合物亦包括合成或天然生物活性成分如胺基酸、脂 肪酸、維他命、礦物質、類胡蘿葡素、多酉分,等,其可在 殺菌及/或乾燥前藉由乾或濕混合加至該組合物。’、 根據進一步目的,本發明係關於包含上文所敘述在食 100197.doc 200534796 品、食物補充劑、寵物食物產品 妝凋製品或在醫藥調 表口Π的該主要組合物的口服組合物。 在較佳具體實施例中,人類消杯 … 頌肩粍的的食品組合物係由上 述主要組合物所補充。此組合物 口 Μ』钓整營養配方、牛奶 產品、冷凍或常溫穩定飲料、礦物皙 ^ 廣物貝或純水、液體飲料、 湯、膳食補充品、正餐代用品、營養 ^ S脣條、贫餞、牛奶或發 酵乳製品、優格、乳基底粉末 木腸内營養劑產品、嬰兒配 方、嬰兒營養劑產品、穀類產〇々 貞屋或發酵榖類產品、冰淇 淋、巧克力、咖啡、烹調產品如美 又秀乃滋、番茄濃湯或沙拉 醬或寵物食品。 在此情況’該主要組合物’其較佳為粉末形式,可分散 於上述食品或飲料以具上述生物活性營養素曰常吸取,其 主要依據所使用水果、蔬菜或植物、所欲效用及目標組織 而定。要由個人消耗以得到有益效用的該主要組合物或食 物組合物的量亦依據其尺寸、其㈣及其年齡而定。 口服提供的營養補充劑可為默蚤 Ν』馮膠囊、凝膠、軟膠囊、錠 劑、糖衣鍵劑、藥丸、膏狀物充私 月狀物或軟糖、口香糖、或可飲用 溶液或乳液、糖漿或凝膠,且南丨旦 立刻里為約〇.1至1〇〇%的該主 要組合物’其可接者以水或θ驻士 飞疋错由任何其他已知方式直接 取用。此補充劑亦包括甜味劑、— 不釗 穩疋劑、抗氧劑、添加 劑、調味劑或染色劑。化妝目的沾 欣目的的補充劑可額外包括關於 肌膚活化的化合物。製備它們的古 匕1門的方法為一般知識。 在另一具體實施例中,醫藥幻人k 条、、且a物可被給藥用於預防疾 病及/或醫療治療。在醫療庫用,,、,口 < ^"用以足夠的量給藥組合物 100197.doc 200534796 於已患病(如下文所敘述)的病人以治療或至少部份停止疾 病及其併發症的徵狀。茂 " 扪倣狀足以元成此的量定義為"醫療有效 量”,有效於此的量會依據疾病的i重性及病Λ的重量及 大體:悲而疋。在預防疾病應用,給藥根據本發明組合物 於易罹患或特定疾病的危險群之病人,此種量定義為,,預 防有效里。在此用途,精確量再次依據病人的健康狀離 及重量而定。 〜 本發明化合物較佳為隨醫藥可接受載體給藥,該載體的 本質隨給藥模式如腸的、口服及局部(包括眼的)路徑而不 同。所欲配方可使用各種賦形劑包括如甘露糖醇、乳糖、 澱粉、硬醋酸鎂、糖酸鈉、纖維素、碳酸鎮的醫藥等級製 備。此組合物可為錠劑、膠囊、藥丸、溶液、懸浮液、糖 漿、乾式口服補充劑、濕式口服補充劑。 要了解經驗豐富的人可基於其自己的知識選擇適當成份 及草藥形式以考慮給藥途徑將該活化化合物定目標於所欲 組織,如肌膚、結腸、胃、眼睛、腎或肝。 本發明係亦關於包含上述主要組合物的化妝品組合物, 其可以乳液、洗髮精、乳霜、防曬乳、曬後乳霜、抗老化 霜及/或油膏配方。可局部使用的此組合物額外包括可用 於化妝品的脂或油,如在CTFA工作,C〇smetic ingrediems Handbook,Washington所提及的。亦可能加入其他化妝用 活性成份。該組合物額外包括結構劑及乳化劑。其他賦形 劑、染色劑、香味劑或遮光劑亦可加至該組合物。要了解 本化妝品產物包括經驗豐富人士所知的不同成份之混合 100197.doc •14- 200534796 物’確保該物質快速滲人肌膚及防止其在儲存期間的降 解。 要了解本發明觀念同樣地可應用為協助 治療的辅藥治療,因為本發明化合物可容易地與食物= -起給樂’特殊臨床食物可包含高量的該物質而施用。明 顯地在閱讀本專利說明書及所附申請專利範圍經驗豐富人 士可擬想此處所提及的特定具體實施例的各種不同替代方 案。 如上所述供給食品、營養補充劑、化肤品或醫藥組合物 於龍物或人類,產生改良的肌膚健康,特別是對肌膚的光 防錢是保護肌膚組織抗老化,例如藉由抑制膠原酶及加 強膠原的合成而抑制肌膚及/或黏膜的損傷。事實上,上 述該主要組合物的使用使得可能增加該生物活性化合物於 ^體的生體利用率及減緩肌膚的老化,其亦有用於敏感 '、“或反應性肌膚的預防或治療,或是以改 密 度或緊緻度。 :述該主要組合物亦可用於視力的口服、局部或醫藥組 m 早汉宅平頁斑病變的風險。 亦可用於例如防止或治療心臟血管 ★么—^ 、’ 一乂失调或癌症及增 進免疫糸統,及減少血糖。 =實例更詳細說明本發明但不限制之,所有百分率為 重S除非特別指出。 實例 實例1:自枸杞製備該主要組合物 100197.doc 15 200534796 引入乾枸杞果實(40公克)及全脂牛奶(300公克)於丨公升 谷〇口中此e物維持10分鐘及以P〇lytron(KINEMATICA, PT3000刀政及此合技術)於26〇〇〇卬爪在氮氣壓下處理Η分 4里在Polytron~處理期間混合物溫度藉由水浴維持在8〇_ 85 C及之後λτ卻至室溫。接著於2〇〇〇〇離心所得混合物 分鐘,丟棄固體餘留物,冷凍乾燥液相(3〇6公克橘黃色 乳)。最後磨碎經乾燥產品以得到54公克橘黃色粉末。 實例2 ··自蕃茄製備該主要組合物 引入新鮮碎蕃茄(93公克)、脫脂奶粉(10公克)及自來水 (30公克)於250-毫升容器中,混合物在氮氣壓下於26〇〇〇 rpm均化(Polytr〇n)l〇分鐘。該混合物溫度藉由以冰浴冷卻 維持在低於30°C。接著於2000G離心混合物1〇分鐘,丟棄 固體餘留物及冷凍乾燥液相(96公克紅紫色乳)。最後磨碎 經乾燥產品及得到紅紫色粉末(1 7·5公克)。 實例3 :根據本發明的包含主要組合物的乳製品 如貫例1所製備的該主要組合物用於經發酵似優格乳製 品的製造,為進行此,包含2·8%脂肪及以2%脫脂奶粉及 6%蔗糖補充的1公升乳製品被製備、殺菌及接著降低其溫 度至42 C。嗜熱鏈球菌的非加厚株及保加利亞乳酸桿菌的 非黏性株之預培養在包含10%再造奶粉及〇1%市售酵母菌 卒取物的無菌MSK培養基再次活化。該經殺菌乳製品接著 以1 %這些再活化預培養的每一個掺入及此乳製品接著於 32°C發酵直到pH值達到值4.5。將如實例1(1%)的主要組合 物加入經發酵乳,似優格乳製品及儲存於4。〇。 100197.doc -16- 200534796 實例4 :寵物食品製品 飼料混合物係由玉米、玉米蛋白、雞及魚、鹽、維他命 及礦物質所組成。離開預優化器的經濕潤飼料接著注入擠 出一熱煉機及凝膠化,離開擠出機的凝膠化基質被強制經 過塑模及擠壓。離開模頭的擠壓物切割為適合餵養狗的塊 狀,於約110°C乾燥20分鐘,及冷卻以形成丸狀,所得丸 狀物水活性為約0.6。 丸狀物由喷霧包含動物脂及如實例1所製備的主要組合 物的塗覆基板而塗覆。 實例5 : 口服的化妝品 以硬膠囊形式的組合物具下列配方: 化合物 mg每膠囊 實例1的主要組合物 500 核心賦形劑 微結晶纖維素 70 Encompress TM 60 硬脂酸鎂 3 無水矽酸膠 1 塗覆劑 蟲膠 5 滑石 61 蔗糖 250 聚維酮 6 二氧化鈦 0.3 著色劑 5 表1 該組合物可以每日2至3膠囊的量供給至個人。 實例6 :自枸杞製備物的玉米黃素生體利用率 100197.doc 17 200534796 兩種不同枸杞製備物如下製備··
處理A 2公斤乾燥枸杞果實以自來水潤濕及於%艽在以 Ρτ丨2〇/4皿分散及混合技術)混合下 加至12公升牛奶(以1公斤脫脂奶粉使成原狀)。在氮氣壓下 將混合物溫度增加至80t及保持15分鐘。在Bo —處理 期間混合物溫度藉由水浴維持在8〇_85。。及之後冷卻至室 /皿接著於2000G離心所得混合物1〇分鐘,丢棄固體餘留 物,加人1.3公斤麥芽糖⑽6)後,冷凌乾燥液相。最後磨 碎經乾燥產品以得到3公斤橘黃色粉末。
處理C 使用Kenwood and BuhlerJ|碎機將〇·5公斤乾燥构把與 〇.5公斤乾冰磨為粉末。該粉末混合物在真空下於室溫保 持於爐子1小時。將所得粉末引人於配備有㈣器的雙夹 套反應器的0.8公升水(83t)中。在溫度回升至8代之後 所得懸浮液在氮氣下進行熱處理約7分鐘,接著冷束乾燥 懸#液以得到經殺菌枸杞粉末。 *
處理D 1G為一種微 upusnarp v 丨-丨从—〇,仿又細粒狀粉 、、w微細分散於得自DSM的經改良食品澱粉 黍澱粉塗覆基質的合成玉米黃素。 1 以這三種調製品進行陟 ^ , t — 床研九,其中12個人以三週間隔 消耗母一個調製品(每一 、 為整為I5宅克内生玉米黃 與足夠量的油及碳水化合物於餐食中。 …、 100197.doc 200534796 觀察到自以處理A所得到的枸杞的玉米黃素之吸收顯著 較處理C所發現的為佳(表2),如在10小時後攝取時間所取 的血液樣品的乳糜粒分率所測量。玉米黃素的類似吸收亦 以處理D觀察。 處理 Cmax nmol/1 AUC nmol/Ph (未調整做為基準(0時間)) 基準線調整 A 1.72(0.46) 9.73(2.45) C 0.69(0.21) 3.14(1.09) D 1.86(0.39) 8.34(1.69) 表2 :自枸杞調製品的玉米黃素及經調配合成的玉米黃素 的生體利用率 實例7 :自枸杞主要組合物的調製品 3公斤乾燥枸杞果實以自來水潤濕及於30 °C在以 Polytron(KINEMATICA,PT120/4M分散及混合技術)混合下 加至18公升牛奶(以0.85公斤脫脂奶粉使成原狀)。將混合 物溫度維持在30°C及以Polytron處理在氮氣壓下持續進行 30分鐘。接著於2000G離心所得混合物10分鐘,丟棄固體 餘留物,加入2公斤麥芽糖(IT06)之後,殺菌液相及接著冷 凍乾燥。最後磨碎經乾燥產品以得到4.4公斤橘黃色粉 末,與枸杞果實粉末相較,其具非常好的水分散性質及經 改良的玉米黃素穩定性。 100197.doc 19
Claims (1)
- 200534796 十、申請專利範圍: 1. -種混溶主要組合物’其包含至少全果、蔬菜及/或植物 物質的基本親脂性及親水性生物活性成分,除了不可溶 纖維’於乳類或含乳蛋白载體中。 2. 根據請求項!的主要組合物,其中該水果、 物物質係為菸签、笹工 Μ f為^、葉子、&、水果、種子及植物的其他 邛伤、或其混合物之形式。 3. 根據請求項!或2的主要組合物,其中該 物物皙係& ^^ ^ ^ m 单…' 水果如(枸杷、藍莓、蔓越莓、白醋栗、 、,工酉日栗、黑贈栗、桑 草莓、楊梅、詰… 覆盆子、沙棘、 胡蘿二V菜或任:其他類黃酮素、多粉或富類 瓜類、奇|要、4 種子、花或植物物質(如蘋果、 # 裣桃、紅棗、棗、水蜜桃、柿子,柑橘 類水果如橘子、加卩执— 1 丁 w徜 柑橘、金銀花、菜^ 葡萄抽及甘菊、菊花、苦 蘿蔔、碗豆、益/ϋ紅化,及番蘇、疲菜、芽菜、紅 菜、萬苣、芽甘、r頭甘藍、香菜、水田芬、高麗菜、花 茶、玉萄黍、可;亞羽二甘藍、蒸青菜、茵香、洋葱、 4·根據請求項j的主力"非、百里香或甜紅椒)。 性生物活性成八、且口 4勿’其中該基本親脂性及親水 物、類胡蘿«素、、夕〆由月曰/生物驗、蛋白質、碳水化合 礦物質。 、齡系化合物如類黃酮素,維他命或 5·根據請求項4的主 類如芹菜素太、、、σ ,其中該類黃酮素係為黃酮 …犀黃色精或香葉木素,黃_醇如橡黃 100197.doc 200534796 皮素、及橙皮 花色素如天竺 酮素如金雀異 素、楊梅樹皮素、山茶酚,黃烷酮如柚 甘,兒茶素如表兒茶素及沒食子兒茶素, 葵色素、錦葵色素、矢車菊素或大豆異黃 育嗣、木吳素異黃酉同。 6·根據請求項4的 胡蘿简素、六氫番茄紅 蝦紅青素、心隱黃質、 或疋以脂肪酸酯類形式 蘿蔔素類及黃色素類如茄紅素 素、八氫番茄紅素、斑螫黃素 辣椒紅素、葉黃素、玉米黃素 之類胡蘿蔔素。 其中該乳類係來自動物或 7·根據請求項1的主要組合物 植物源。 8.根據請求項!或2的主要組合物,其係為粉末、凝膠或液 體形式。 9· 一種製備根據請求項丨的組合物的方法,其包括步驟·· i) 混合及磨細該水果、蔬菜及/或植物物質於乳類或含 乳蛋白液體介質中, ii) 分離不可溶纖維以得到水相懸浮液 iii) 選擇性地殺菌該所得懸浮液 IV)在加工期間選擇性地加入合成或天然生物活性成分 v)及進一步選擇性地乾燥該懸浮液以得到粉末。 10· —種增加水果、蔬菜及/或植物物質的生物活性化合物於 水相系統的混溶性或分散性、穩定性、及生體利用率之 方法,其係使用根據請求項丨至8中任一項的主要組合物 或根據請求項9的方法。 100197.doc 200534796 11 ·根據請求項9或10的方法,其中該天然生物活性成分係 為胺基酸、脂肪酸、維他命、礦物質、類胡蘿蔔素、多 酉分等。 1 2 · —種包含根據請求項1至8中任一項的主要組合物的口服 組合物,其係在口服食品中,如在營養組合物、食物補 充劑、龍物食物產品、化妝調製品或在醫藥調製品中。 1 3 ·根據清求項12的口服組合物,其為完整營養配方、牛奶 產品、冷凍或常溫穩定飲料、礦物質或純水、液體飲 料、湯、膳食補充品、正餐代用品、營養條、蜜餞、牛 奶或發酵乳製品、優格、乳基底粉末、腸内營養劑產 。口、嬰兒配方、嬰兒營養劑產品、榖類產品或發酵榖類 基底產品、冰淇淋、巧克力、咖啡、烹調產品如美乃 滋、蕃祐濃湯或沙拉醬或寵物食品。製備用於眼睛健康的口 丨中任一項的主要組合物之用途,以 口服、局部或醫藥組合物。 100197.doc 200534796 1 8·種根據請求項1至8中任一項的主要組合物之用途,以 製備用於增進免疫系統的口服、化妝或醫藥組合物。 19·種根據請求項1至8中任一項的主要組合物之用途,以 製備用於防止或治療心臟血管疾病式 六柄或失調或癌症或糠展 病的口服、化妝或醫藥組合物。100197.doc 200534796 七、指定代表圖: (一) 本案指定代表圖為:(無) (二) 本代表圖之元件符號簡單說明: 八、本案若有化學式時,請揭示最能顯示發明特徵的化學式: (無)100197.doc
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US (4) | US20070202195A1 (zh) |
EP (2) | EP1727434B2 (zh) |
JP (2) | JP5086801B2 (zh) |
CN (2) | CN1933734A (zh) |
AR (1) | AR048181A1 (zh) |
AU (1) | AU2005226873B2 (zh) |
BR (1) | BRPI0508879A (zh) |
CA (1) | CA2559682C (zh) |
ES (1) | ES2399755T5 (zh) |
MX (1) | MXPA06010674A (zh) |
MY (1) | MY142017A (zh) |
NO (1) | NO331560B1 (zh) |
PL (1) | PL1727434T5 (zh) |
RU (1) | RU2387136C2 (zh) |
SA (1) | SA05260136B1 (zh) |
SG (1) | SG172618A1 (zh) |
TW (1) | TWI366443B (zh) |
WO (1) | WO2005092121A2 (zh) |
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CN104543981A (zh) * | 2015-01-29 | 2015-04-29 | 吉林农业大学 | 一种食用菌即冲饮品及其制备方法 |
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