TW200418511A

TW200418511A - Skin preparations for external use

Skin preparations for external use Download PDF

Info

Publication number: TW200418511A
Authority: TW; Taiwan
Prior art keywords: skin; zeolite; particle size; acid; alum
Prior art date: 2002-10-25

Application number

TW092129104A

Other languages

English (en)

Chinese (zh)

Other versions

TWI303568B (cg-RX-API-DMAC7.html

Inventor

Takashi Isa

Yukiko Kamiya

Nozomi Oguchi

Hirokazu Ishino

Naoki Tominaga

Original Assignee

Shiseido Co Ltd

Priority date

2002-10-25

Filing date

2003-10-21

Publication date

2004-10-01

2002-10-25 Priority claimed from JP2002311033A external-priority patent/JP2004143104A/ja

2003-04-04 Priority claimed from JP2003101489A external-priority patent/JP4274354B2/ja

2003-09-25 Priority claimed from JP2003332802A external-priority patent/JP4375609B2/ja

2003-10-21 Application filed by Shiseido Co Ltd filed Critical Shiseido Co Ltd

2004-10-01 Publication of TW200418511A publication Critical patent/TW200418511A/zh

2008-12-01 Application granted granted Critical

2008-12-01 Publication of TWI303568B publication Critical patent/TWI303568B/zh

Links

238000002360 preparation method Methods 0.000 title claims abstract description 112
HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims abstract description 206
239000010457 zeolite Substances 0.000 claims abstract description 206
229910021536 Zeolite Inorganic materials 0.000 claims abstract description 201
230000000844 anti-bacterial effect Effects 0.000 claims abstract description 147
229940037003 alum Drugs 0.000 claims abstract description 67
-1 polyethylene Polymers 0.000 claims description 197
239000002245 particle Substances 0.000 claims description 128
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 58
239000003795 chemical substances by application Substances 0.000 claims description 31
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 24
238000009826 distribution Methods 0.000 claims description 8
239000003814 drug Substances 0.000 claims description 6
239000000126 substance Substances 0.000 claims description 6
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QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims description 5
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 4
230000008901 benefit Effects 0.000 claims description 2
230000000699 topical effect Effects 0.000 claims 2
LTSWUFKUZPPYEG-UHFFFAOYSA-N 1-decoxydecane Chemical compound CCCCCCCCCCOCCCCCCCCCC LTSWUFKUZPPYEG-UHFFFAOYSA-N 0.000 claims 1
UYZQWKKNVBJVOF-UHFFFAOYSA-N 1-decoxytetradecane Chemical compound CCCCCCCCCCCCCCOCCCCCCCCCC UYZQWKKNVBJVOF-UHFFFAOYSA-N 0.000 claims 1
239000002253 acid Substances 0.000 abstract description 56
230000000694 effects Effects 0.000 abstract description 33
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GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 10
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239000000243 solution Substances 0.000 description 10
SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 10
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
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FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 9
UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 9
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QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 9
MTHSVFCYNBDYFN-UHFFFAOYSA-N anhydrous diethylene glycol Natural products OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 9
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 9
229910052802 copper Inorganic materials 0.000 description 9
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HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 7
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
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PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 7
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