TR199801857T2 - Lökotrien-antagonistik etkisine sahip olan benzopiran türevleri. - Google Patents

Lökotrien-antagonistik etkisine sahip olan benzopiran türevleri.

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Publication number
TR199801857T2
TR199801857T2 TR1998/01857T TR9801857T TR199801857T2 TR 199801857 T2 TR199801857 T2 TR 199801857T2 TR 1998/01857 T TR1998/01857 T TR 1998/01857T TR 9801857 T TR9801857 T TR 9801857T TR 199801857 T2 TR199801857 T2 TR 199801857T2
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TR
Turkey
Prior art keywords
group
benzopyran derivatives
lecotriene
so2nr7
ch2o
Prior art date
Application number
TR1998/01857T
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English (en)
Inventor
Carganico Germano
Mauleon Casellas David
Pascual Avellana Jaime
Luisa Garcia Perez M(Alfa)
Palomer Benet Albert
Original Assignee
Laboratories Menarini S.A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Laboratories Menarini S.A filed Critical Laboratories Menarini S.A
Publication of TR199801857T2 publication Critical patent/TR199801857T2/tr

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    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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Abstract

Bu bulus (I) formülünün yeni benzopiran türevlerine ilskindir, bu formülde, A, bir oksijen ya da kükürt atomudur ya da bir metilen grubudur; B ve C, a) B, içindeki (a)'da U, bir O, S ya da N atomu olan, Z-Y, bir ikili ya ta tekli bag ile baglanmis iki karbon atomu olan ve T bir tek Bag, bir Metilen ya da karbonil grubu olan, benzo-kaynamali heterosikl oldugunda,C, bir-CONR7, CSNR7-SO2NR7-,-CH2O-,-CH=CH-grubu olabilmektedir; b) B bir (b) fenil grubu oldugunda, C, bir-SO2NR7-,-CH2O-,-CH=CH-grubu olabilmektedir; D, bir-COOR8 grubudur, bu grupta, R8, hidrojen, bir (C1-C4)-alkil ya da fenilakli grubudur; ve m ve n 0 ve 4 arasinda tamsayilardir. Bahsedilen bilesikler bir lökotrien-antagonistik etkinligi göstermektedir ve alerji ve iltihaplanmaya karsi tibbi maddeler olarak ya da kardiyovaskular hastaliklarin tedavisinde degerli maddelerdir.
TR1998/01857T 1996-03-21 1997-03-20 Lökotrien-antagonistik etkisine sahip olan benzopiran türevleri. TR199801857T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009600682A ES2127106B1 (es) 1996-03-21 1996-03-21 Derivados benzopiranicos con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de los mismos.

Publications (1)

Publication Number Publication Date
TR199801857T2 true TR199801857T2 (tr) 1998-12-21

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ID=8294261

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TR1998/01857T TR199801857T2 (tr) 1996-03-21 1997-03-20 Lökotrien-antagonistik etkisine sahip olan benzopiran türevleri.

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US (1) US5990142A (tr)
EP (1) EP0888327B1 (tr)
JP (1) JP3914575B2 (tr)
KR (1) KR100378892B1 (tr)
CN (1) CN1182129C (tr)
AT (1) ATE219073T1 (tr)
AU (1) AU707282B2 (tr)
BG (1) BG63433B1 (tr)
BR (1) BR9708215A (tr)
CA (1) CA2249402C (tr)
CU (1) CU22777A3 (tr)
CZ (1) CZ296260B6 (tr)
DE (1) DE69713300T2 (tr)
DK (1) DK0888327T3 (tr)
EA (1) EA001680B1 (tr)
EE (1) EE03526B1 (tr)
ES (2) ES2127106B1 (tr)
GE (1) GEP20012416B (tr)
HK (1) HK1018701A1 (tr)
HU (1) HUP9901326A3 (tr)
IL (1) IL126296A (tr)
NO (1) NO319612B1 (tr)
NZ (1) NZ331953A (tr)
PL (1) PL189562B1 (tr)
PT (1) PT888327E (tr)
RS (1) RS49588B (tr)
SI (1) SI0888327T1 (tr)
SK (1) SK282979B6 (tr)
TR (1) TR199801857T2 (tr)
UA (1) UA65535C2 (tr)
WO (1) WO1997034885A1 (tr)

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US7001723B1 (en) 1999-11-24 2006-02-21 The Research Foundation Of State University Of New York Catalytic RNAs with aminoacylation activity
AU2003213136A1 (en) * 2002-02-15 2003-09-09 The Research Foundation Of State University Of New York At Buffalo RIBOZYMES WITH BROAD tRNA AMINOACYLATION ACTIVITY
WO2004035741A2 (en) * 2002-10-17 2004-04-29 Decode Genetics Ehf. Susceptibility gene for myocardial infarction; methods of treatment
US7851486B2 (en) 2002-10-17 2010-12-14 Decode Genetics Ehf. Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
US7514461B2 (en) * 2003-09-19 2009-04-07 Edison Pharmaceuticals, Inc. Chroman derivatives
JP3997255B2 (ja) 2004-02-13 2007-10-24 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー アンドロゲンレセプターモジュレーター
CN100475781C (zh) * 2004-02-13 2009-04-08 沃尼尔·朗伯有限责任公司 雄激素受体调节剂
EP1737813A1 (en) 2004-04-13 2007-01-03 Warner-Lambert Company LLC Androgen modulators
MXPA06015169A (es) * 2004-07-08 2007-08-21 Warner Lambert Co Moduladores de androgenos.
BRPI0514469A (pt) * 2004-08-18 2008-06-10 Warner Lambert Co moduladores de androgênio
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
US20090170886A1 (en) * 2005-08-08 2009-07-02 Pfizer Inc Androgen modulators
WO2007066627A1 (ja) * 2005-12-06 2007-06-14 The University Of Tokyo 多目的アシル化触媒とその用途
ITMI20061606A1 (it) * 2006-08-09 2008-02-10 Dipharma Spa Procedimento per la preparazione di composti nitrilici
CN102304052A (zh) * 2011-07-28 2012-01-04 浙江大学 一种制备5-溴-2-羟基-3-硝基苯乙酮的方法
CN103980257B (zh) * 2014-05-28 2016-04-27 苏州开元民生科技股份有限公司 8-硝基-2-四氮唑基-4-羰基苯并吡喃的合成方法
CN104402711A (zh) * 2014-11-12 2015-03-11 平湖优康药物研发有限公司 一种抗哮喘药物普伦斯特中间体的合成工艺
CN113651788B (zh) * 2021-09-16 2023-11-21 东华理工大学 一种3-胺烷基色酮化合物及其制备方法

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US4977162A (en) * 1989-07-13 1990-12-11 Rorer Pharmaceutical Corporation Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments
JPH0395144A (ja) * 1989-08-04 1991-04-19 Ono Pharmaceut Co Ltd アミノフェノール誘導体の製造方法

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CN1182129C (zh) 2004-12-29
EP0888327B1 (en) 2002-06-12
GEP20012416B (en) 2001-04-25
PT888327E (pt) 2002-11-29
NO319612B1 (no) 2005-08-29
RS49588B (sr) 2007-06-04
EA199800738A1 (ru) 1999-06-24
DE69713300T2 (de) 2002-09-26
WO1997034885A1 (en) 1997-09-25
CU22777A3 (es) 2002-07-24
CZ296260B6 (cs) 2006-02-15
CA2249402A1 (en) 1997-09-25
NO984330L (no) 1998-10-09
SK282979B6 (sk) 2003-01-09
AU2158797A (en) 1997-10-10
DE69713300D1 (de) 2002-07-18
ES2127106A1 (es) 1999-04-01
CA2249402C (en) 2006-10-24
EE03526B1 (et) 2001-10-15
BG102775A (en) 1999-08-31
HUP9901326A2 (hu) 1999-08-30
YU40798A (en) 1999-11-22
EA001680B1 (ru) 2001-06-25
SK127298A3 (en) 1999-03-12
HK1018701A1 (en) 1999-12-30
PL189562B1 (pl) 2005-08-31
KR20000064682A (ko) 2000-11-06
ES2176719T3 (es) 2002-12-01
ATE219073T1 (de) 2002-06-15
PL329027A1 (en) 1999-03-01
JP2000506878A (ja) 2000-06-06
NO984330D0 (no) 1998-09-17
JP3914575B2 (ja) 2007-05-16
CZ299598A3 (cs) 1999-03-17
US5990142A (en) 1999-11-23
IL126296A (en) 2002-08-14
AU707282B2 (en) 1999-07-08
BG63433B1 (bg) 2002-01-31
UA65535C2 (en) 2004-04-15
SI0888327T1 (en) 2002-10-31
EE9800318A (et) 1999-04-15
IL126296A0 (en) 1999-05-09
HUP9901326A3 (en) 2000-12-28
BR9708215A (pt) 2000-01-04
CN1214048A (zh) 1999-04-14
ES2127106B1 (es) 1999-11-16
KR100378892B1 (ko) 2005-11-14
DK0888327T3 (da) 2002-09-16
NZ331953A (en) 1999-03-29
EP0888327A1 (en) 1999-01-07

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