TR199801179T2 - Yeni taksoitler, bunlar�n haz�rlanmalar� ve ila� bile�imleri. - Google Patents

Yeni taksoitler, bunlar�n haz�rlanmalar� ve ila� bile�imleri.

Info

Publication number
TR199801179T2
TR199801179T2 TR1998/01179T TR9801179T TR199801179T2 TR 199801179 T2 TR199801179 T2 TR 199801179T2 TR 1998/01179 T TR1998/01179 T TR 1998/01179T TR 9801179 T TR9801179 T TR 9801179T TR 199801179 T2 TR199801179 T2 TR 199801179T2
Authority
TR
Turkey
Prior art keywords
preparations
drug compositions
new taxoids
taxoids
new
Prior art date
Application number
TR1998/01179T
Other languages
English (en)
Turkish (tr)
Inventor
Bouchard Herve
Commer�on Alain
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of TR199801179T2 publication Critical patent/TR199801179T2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TR1998/01179T 1995-12-22 1996-12-19 Yeni taksoitler, bunlar�n haz�rlanmalar� ve ila� bile�imleri. TR199801179T2 (xx)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
TR199801179T2 true TR199801179T2 (xx) 1998-10-21

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/01179T TR199801179T2 (xx) 1995-12-22 1996-12-19 Yeni taksoitler, bunlar�n haz�rlanmalar� ve ila� bile�imleri.

Country Status (40)

Country Link
US (1) US5728849A (en:Method)
EP (1) EP0876362B1 (en:Method)
JP (1) JP3953106B2 (en:Method)
KR (1) KR100500351B1 (en:Method)
CN (1) CN1103766C (en:Method)
AR (1) AR005197A1 (en:Method)
AT (1) ATE250593T1 (en:Method)
AU (1) AU712597B2 (en:Method)
BG (1) BG63204B1 (en:Method)
BR (1) BR9612135A (en:Method)
CA (1) CA2238884C (en:Method)
CO (1) CO4520184A1 (en:Method)
CZ (1) CZ294972B6 (en:Method)
DE (1) DE69630145T2 (en:Method)
DK (1) DK0876362T3 (en:Method)
DZ (1) DZ2149A1 (en:Method)
EA (1) EA001533B1 (en:Method)
ES (1) ES2202490T3 (en:Method)
FR (1) FR2742751B1 (en:Method)
HU (1) HU225032B1 (en:Method)
IL (1) IL124994A (en:Method)
IN (4) IN186768B (en:Method)
MA (1) MA26412A1 (en:Method)
MX (1) MX9804688A (en:Method)
MY (1) MY113934A (en:Method)
NO (1) NO317358B1 (en:Method)
NZ (1) NZ324337A (en:Method)
OA (1) OA10700A (en:Method)
PE (1) PE25198A1 (en:Method)
PL (1) PL189311B1 (en:Method)
PT (1) PT876362E (en:Method)
RO (1) RO116194B1 (en:Method)
SK (1) SK282835B6 (en:Method)
TN (1) TNSN96169A1 (en:Method)
TR (1) TR199801179T2 (en:Method)
TW (1) TW371659B (en:Method)
UA (1) UA48205C2 (en:Method)
UY (1) UY24386A1 (en:Method)
WO (1) WO1997023473A1 (en:Method)
ZA (1) ZA9610737B (en:Method)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
GEP20043239B (en) 2000-02-02 2004-05-25 Florida State Univ Research Foundation Us C10 Carbonate Substituted Taxanes as Antitumor Agents
CA2435730C (en) * 2001-02-24 2011-03-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
AU2003239511A1 (en) * 2003-05-20 2004-12-13 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1669358A1 (en) * 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxic agents comprising new taxanes
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
CN102838599A (zh) 2006-05-04 2012-12-26 贝林格尔.英格海姆国际有限公司 多晶型
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
MX2010001821A (es) * 2007-08-17 2010-03-10 Boehringer Ingelheim Int Derivados de purina para uso en el tratamiento de enfermedades relacionadas con fap.
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
CA2735562C (en) * 2008-08-15 2017-10-17 Boehringer Ingelheim International Gmbh Dpp-4 inhibitors for wound healing
WO2010029089A2 (en) 2008-09-10 2010-03-18 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
MX2011006713A (es) 2008-12-23 2011-07-13 Boehringer Ingelheim Int Formas salinas de compuesto organico.
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
PH12012501037A1 (en) 2009-11-27 2013-01-14 Boehringer Ingelheim Int Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
JP6034781B2 (ja) 2010-05-05 2016-11-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 併用療法
KR20130093012A (ko) 2010-06-24 2013-08-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
DK3517539T3 (en) 2011-07-15 2023-01-16 Boehringer Ingelheim Int Farmaceutiske sammensætninger til behandling af type i og type ii diabetes
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
EP2849754B1 (en) 2012-05-14 2022-09-14 Boehringer Ingelheim International GmbH Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2701076T3 (es) 2012-11-24 2019-02-20 Hangzhou Dac Biotech Co Ltd Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用
AU2014384434B2 (en) 2014-02-28 2016-11-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
WO2015151081A2 (en) 2015-07-12 2015-10-08 Suzhou M-Conj Biotech Co., Ltd Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
JP2019517542A (ja) 2016-06-10 2019-06-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング リナグリプチンおよびメトホルミンの組合せ
AU2016429272A1 (en) 2016-11-14 2019-05-02 Hangzhou Dac Biotech Co., Ltd. Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
WO2022078524A2 (en) 2021-11-03 2022-04-21 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
RU2059631C1 (ru) * 1991-11-29 1996-05-10 Дзе Юниверсити оф Канзас Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
DK0639186T3 (da) * 1992-04-17 1999-12-13 Abbott Lab Taxolderivater
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
MX9307777A (es) * 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.

Also Published As

Publication number Publication date
KR100500351B1 (ko) 2005-12-21
BR9612135A (pt) 1999-07-13
HU225032B1 (en) 2006-05-29
PT876362E (pt) 2004-02-27
IN188470B (en:Method) 2002-09-28
IN188469B (en:Method) 2002-09-28
EP0876362A1 (fr) 1998-11-11
CA2238884C (fr) 2007-02-06
DE69630145D1 (de) 2003-10-30
JP2000502671A (ja) 2000-03-07
IN188680B (en:Method) 2002-10-26
UY24386A1 (es) 2001-08-27
CA2238884A1 (fr) 1997-07-03
KR19990076680A (ko) 1999-10-15
AR005197A1 (es) 1999-04-14
SK85398A3 (en) 1998-11-04
PL327405A1 (en) 1998-12-07
NO982580D0 (no) 1998-06-05
OA10700A (fr) 2002-11-27
BG63204B1 (bg) 2001-06-29
EA199800588A1 (ru) 1998-12-24
FR2742751B1 (fr) 1998-01-30
ZA9610737B (en) 1997-06-27
NZ324337A (en) 2000-03-27
CZ196198A3 (cs) 1998-09-16
HUP9904046A1 (hu) 2001-04-28
RO116194B1 (ro) 2000-11-30
EA001533B1 (ru) 2001-04-23
ES2202490T3 (es) 2004-04-01
TW371659B (en) 1999-10-11
JP3953106B2 (ja) 2007-08-08
IL124994A0 (en) 1999-01-26
WO1997023473A1 (fr) 1997-07-03
PE25198A1 (es) 1998-05-10
CN1103766C (zh) 2003-03-26
MA26412A1 (fr) 2004-12-20
FR2742751A1 (fr) 1997-06-27
IN186768B (en:Method) 2001-11-03
UA48205C2 (uk) 2002-08-15
TNSN96169A1 (fr) 2005-03-15
HUP9904046A3 (en) 2001-08-28
AU1180997A (en) 1997-07-17
ATE250593T1 (de) 2003-10-15
NO317358B1 (no) 2004-10-18
DK0876362T3 (da) 2004-02-02
NO982580L (no) 1998-06-05
MX9804688A (es) 1998-10-31
SK282835B6 (sk) 2002-12-03
DE69630145T2 (de) 2004-07-15
CN1205697A (zh) 1999-01-20
US5728849A (en) 1998-03-17
BG102569A (en) 1999-04-30
EP0876362B1 (fr) 2003-09-24
CO4520184A1 (es) 1997-10-15
AU712597B2 (en) 1999-11-11
HK1017895A1 (en) 1999-12-03
PL189311B1 (pl) 2005-07-29
DZ2149A1 (fr) 2002-10-23
MY113934A (en) 2002-06-29
CZ294972B6 (cs) 2005-04-13
IL124994A (en) 2000-12-06

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