IL124994A - Taxoids preparation thereof and pharmaceutical compositions containing same - Google Patents

Taxoids preparation thereof and pharmaceutical compositions containing same

Info

Publication number
IL124994A
IL124994A IL12499496A IL12499496A IL124994A IL 124994 A IL124994 A IL 124994A IL 12499496 A IL12499496 A IL 12499496A IL 12499496 A IL12499496 A IL 12499496A IL 124994 A IL124994 A IL 124994A
Authority
IL
Israel
Prior art keywords
taxoids
preparation
pharmaceutical compositions
compositions containing
containing same
Prior art date
Application number
IL12499496A
Other languages
English (en)
Other versions
IL124994A0 (en
Original Assignee
Rhone Poulenc Rorer Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Gmbh filed Critical Rhone Poulenc Rorer Gmbh
Publication of IL124994A0 publication Critical patent/IL124994A0/xx
Publication of IL124994A publication Critical patent/IL124994A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL12499496A 1995-12-22 1996-12-19 Taxoids preparation thereof and pharmaceutical compositions containing same IL124994A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1996/002031 WO1997023473A1 (fr) 1995-12-22 1996-12-19 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
IL124994A0 IL124994A0 (en) 1999-01-26
IL124994A true IL124994A (en) 2000-12-06

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12499496A IL124994A (en) 1995-12-22 1996-12-19 Taxoids preparation thereof and pharmaceutical compositions containing same

Country Status (40)

Country Link
US (1) US5728849A (en:Method)
EP (1) EP0876362B1 (en:Method)
JP (1) JP3953106B2 (en:Method)
KR (1) KR100500351B1 (en:Method)
CN (1) CN1103766C (en:Method)
AR (1) AR005197A1 (en:Method)
AT (1) ATE250593T1 (en:Method)
AU (1) AU712597B2 (en:Method)
BG (1) BG63204B1 (en:Method)
BR (1) BR9612135A (en:Method)
CA (1) CA2238884C (en:Method)
CO (1) CO4520184A1 (en:Method)
CZ (1) CZ294972B6 (en:Method)
DE (1) DE69630145T2 (en:Method)
DK (1) DK0876362T3 (en:Method)
DZ (1) DZ2149A1 (en:Method)
EA (1) EA001533B1 (en:Method)
ES (1) ES2202490T3 (en:Method)
FR (1) FR2742751B1 (en:Method)
HU (1) HU225032B1 (en:Method)
IL (1) IL124994A (en:Method)
IN (4) IN186768B (en:Method)
MA (1) MA26412A1 (en:Method)
MX (1) MX9804688A (en:Method)
MY (1) MY113934A (en:Method)
NO (1) NO317358B1 (en:Method)
NZ (1) NZ324337A (en:Method)
OA (1) OA10700A (en:Method)
PE (1) PE25198A1 (en:Method)
PL (1) PL189311B1 (en:Method)
PT (1) PT876362E (en:Method)
RO (1) RO116194B1 (en:Method)
SK (1) SK282835B6 (en:Method)
TN (1) TNSN96169A1 (en:Method)
TR (1) TR199801179T2 (en:Method)
TW (1) TW371659B (en:Method)
UA (1) UA48205C2 (en:Method)
UY (1) UY24386A1 (en:Method)
WO (1) WO1997023473A1 (en:Method)
ZA (1) ZA9610737B (en:Method)

Families Citing this family (41)

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GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
SK13632001A3 (sk) 2000-02-02 2002-06-04 Florida State University Research Foundation, Inc. C10 karbonátom substituované taxány ako protinádorové činidlá
EP1757606B1 (de) * 2001-02-24 2009-05-06 Boehringer Ingelheim Pharma GmbH & Co. KG Xanthinderivate Verwendung als Arzneimittel sowie deren Verfahren zur deren Herstellung
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
AU2003239511A1 (en) * 2003-05-20 2004-12-13 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1669358A1 (en) * 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxic agents comprising new taxanes
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
AU2007247190A1 (en) * 2006-05-04 2007-11-15 Boehringer Ingelheim International Gmbh Polymorphs
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
JP5769966B2 (ja) * 2007-08-17 2015-08-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｆａｂ関連疾患治療用プリン誘導体
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
EA031225B1 (ru) * 2008-08-15 2018-12-28 Бёрингер Ингельхайм Интернациональ Гмбх Ингибиторы дпп-4 для заживления ран
KR20110067096A (ko) 2008-09-10 2011-06-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 및 관련 상태를 치료하기 위한 병용 요법
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
TWI508965B (zh) 2008-12-23 2015-11-21 Boehringer Ingelheim Int 有機化合物的鹽形式
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
EA034869B1 (ru) 2009-11-27 2020-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
NZ602921A (en) 2010-05-05 2016-01-29 Boehringer Ingelheim Int Combination therapy comprising the administration of a glp-1 receptor agonist and a ddp-4 inhibitor
KR20220025926A (ko) 2010-06-24 2022-03-03 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
CA2841552C (en) 2011-07-15 2020-06-23 Boehringer Ingelheim International Gmbh Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP2849754B1 (en) 2012-05-14 2022-09-14 Boehringer Ingelheim International GmbH Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis
WO2013171167A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
WO2014080251A1 (en) 2012-11-24 2014-05-30 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
AU2014384434B2 (en) 2014-02-28 2016-11-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
US9526728B2 (en) 2014-02-28 2016-12-27 Boehringer Ingelheim International Gmbh Medical use of a DPP-4 inhibitor
JP6759326B2 (ja) 2015-07-12 2020-09-23 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 細胞結合分子の共役のための架橋連結体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CN109310697A (zh) 2016-06-10 2019-02-05 勃林格殷格翰国际有限公司 利格列汀和二甲双胍的组合
CN110099682B (zh) 2016-11-14 2023-03-31 杭州多禧生物科技有限公司 偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
RU2059631C1 (ru) * 1991-11-29 1996-05-10 Дзе Юниверсити оф Канзас Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
ES2134847T3 (es) * 1992-04-17 1999-10-16 Abbott Lab Derivados de taxol.
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
MX9307777A (es) * 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.

Also Published As

Publication number Publication date
IL124994A0 (en) 1999-01-26
DK0876362T3 (da) 2004-02-02
FR2742751B1 (fr) 1998-01-30
PT876362E (pt) 2004-02-27
NO982580L (no) 1998-06-05
RO116194B1 (ro) 2000-11-30
OA10700A (fr) 2002-11-27
BG102569A (en) 1999-04-30
DZ2149A1 (fr) 2002-10-23
EA001533B1 (ru) 2001-04-23
NO982580D0 (no) 1998-06-05
IN186768B (en:Method) 2001-11-03
EP0876362A1 (fr) 1998-11-11
AR005197A1 (es) 1999-04-14
HK1017895A1 (en) 1999-12-03
KR100500351B1 (ko) 2005-12-21
PE25198A1 (es) 1998-05-10
MX9804688A (es) 1998-10-31
AU1180997A (en) 1997-07-17
TW371659B (en) 1999-10-11
DE69630145T2 (de) 2004-07-15
SK282835B6 (sk) 2002-12-03
HUP9904046A3 (en) 2001-08-28
CA2238884C (fr) 2007-02-06
ES2202490T3 (es) 2004-04-01
HU225032B1 (en) 2006-05-29
IN188470B (en:Method) 2002-09-28
CO4520184A1 (es) 1997-10-15
ZA9610737B (en) 1997-06-27
IN188680B (en:Method) 2002-10-26
CZ196198A3 (cs) 1998-09-16
SK85398A3 (en) 1998-11-04
FR2742751A1 (fr) 1997-06-27
DE69630145D1 (de) 2003-10-30
JP2000502671A (ja) 2000-03-07
EP0876362B1 (fr) 2003-09-24
UA48205C2 (uk) 2002-08-15
BR9612135A (pt) 1999-07-13
PL327405A1 (en) 1998-12-07
BG63204B1 (bg) 2001-06-29
NO317358B1 (no) 2004-10-18
TNSN96169A1 (fr) 2005-03-15
TR199801179T2 (xx) 1998-10-21
UY24386A1 (es) 2001-08-27
KR19990076680A (ko) 1999-10-15
MA26412A1 (fr) 2004-12-20
HUP9904046A1 (hu) 2001-04-28
CN1103766C (zh) 2003-03-26
EA199800588A1 (ru) 1998-12-24
MY113934A (en) 2002-06-29
CN1205697A (zh) 1999-01-20
IN188469B (en:Method) 2002-09-28
CA2238884A1 (fr) 1997-07-03
PL189311B1 (pl) 2005-07-29
NZ324337A (en) 2000-03-27
WO1997023473A1 (fr) 1997-07-03
US5728849A (en) 1998-03-17
JP3953106B2 (ja) 2007-08-08
ATE250593T1 (de) 2003-10-15
CZ294972B6 (cs) 2005-04-13
AU712597B2 (en) 1999-11-11

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Legal Events

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