SU628813A3 - Способ получени амидов 5-оксипропиониламино-2,4,6-трийодизофталевой кислоты - Google Patents
Способ получени амидов 5-оксипропиониламино-2,4,6-трийодизофталевой кислотыInfo
- Publication number
- SU628813A3 SU628813A3 SU752196656A SU2196656A SU628813A3 SU 628813 A3 SU628813 A3 SU 628813A3 SU 752196656 A SU752196656 A SU 752196656A SU 2196656 A SU2196656 A SU 2196656A SU 628813 A3 SU628813 A3 SU 628813A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- acid
- bis
- mol
- water
- amino
- Prior art date
Links
- 239000002253 acid Substances 0.000 title claims 24
- 238000000034 method Methods 0.000 title claims 4
- 150000001408 amides Chemical class 0.000 title claims 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 33
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 24
- 239000000243 solution Substances 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 19
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 16
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 15
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 15
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 12
- 238000006243 chemical reaction Methods 0.000 claims 12
- 238000003756 stirring Methods 0.000 claims 11
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 8
- 238000000354 decomposition reaction Methods 0.000 claims 8
- 229940113088 dimethylacetamide Drugs 0.000 claims 8
- 235000011121 sodium hydroxide Nutrition 0.000 claims 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 238000004809 thin layer chromatography Methods 0.000 claims 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 6
- 229910021529 ammonia Inorganic materials 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000000047 product Substances 0.000 claims 6
- 239000000741 silica gel Substances 0.000 claims 6
- 229910002027 silica gel Inorganic materials 0.000 claims 6
- KJJPLEZQSCZCKE-UHFFFAOYSA-N 2-aminopropane-1,3-diol Chemical compound OCC(N)CO KJJPLEZQSCZCKE-UHFFFAOYSA-N 0.000 claims 5
- 125000003277 amino group Chemical group 0.000 claims 5
- -1 hydroxypropylamino Chemical group 0.000 claims 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- 238000001953 recrystallisation Methods 0.000 claims 4
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 claims 4
- IPHVGAPABXWWLO-UHFFFAOYSA-N 2,4,6-triiodobenzene-1,3-dicarboxylic acid Chemical compound OC(=O)C1=C(I)C=C(I)C(C(O)=O)=C1I IPHVGAPABXWWLO-UHFFFAOYSA-N 0.000 claims 3
- NBDAHKQJXVLAID-UHFFFAOYSA-N 5-nitroisophthalic acid Chemical compound OC(=O)C1=CC(C(O)=O)=CC([N+]([O-])=O)=C1 NBDAHKQJXVLAID-UHFFFAOYSA-N 0.000 claims 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 3
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 3
- 230000002378 acidificating effect Effects 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 239000003054 catalyst Substances 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 238000001704 evaporation Methods 0.000 claims 3
- 230000008020 evaporation Effects 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 230000007062 hydrolysis Effects 0.000 claims 3
- 238000006460 hydrolysis reaction Methods 0.000 claims 3
- 239000004310 lactic acid Substances 0.000 claims 3
- 230000008018 melting Effects 0.000 claims 3
- 238000002844 melting Methods 0.000 claims 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims 3
- ALHZEIINTQJLOT-UHFFFAOYSA-N (1-chloro-1-oxopropan-2-yl) acetate Chemical compound ClC(=O)C(C)OC(C)=O ALHZEIINTQJLOT-UHFFFAOYSA-N 0.000 claims 2
- DEWLEGDTCGBNGU-UHFFFAOYSA-N 1,3-dichloropropan-2-ol Chemical compound ClCC(O)CCl DEWLEGDTCGBNGU-UHFFFAOYSA-N 0.000 claims 2
- ADLFBRNPQMLXTQ-UHFFFAOYSA-N 2,2-dimethyl-1,3-dioxan-5-amine Chemical compound CC1(C)OCC(N)CO1 ADLFBRNPQMLXTQ-UHFFFAOYSA-N 0.000 claims 2
- KQIGMPWTAHJUMN-UHFFFAOYSA-N 3-aminopropane-1,2-diol Chemical compound NCC(O)CO KQIGMPWTAHJUMN-UHFFFAOYSA-N 0.000 claims 2
- JEZJSNULLBSYHV-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid Chemical compound NC1=C(I)C(C(O)=O)=C(I)C(C(O)=O)=C1I JEZJSNULLBSYHV-UHFFFAOYSA-N 0.000 claims 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 238000009835 boiling Methods 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- 238000011033 desalting Methods 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 2
- 229910052763 palladium Inorganic materials 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 238000005245 sintering Methods 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims 2
- KQIGMPWTAHJUMN-GSVOUGTGSA-N (2r)-3-aminopropane-1,2-diol Chemical compound NC[C@@H](O)CO KQIGMPWTAHJUMN-GSVOUGTGSA-N 0.000 claims 1
- RBNPOMFGQQGHHO-UHFFFAOYSA-N -2,3-Dihydroxypropanoic acid Natural products OCC(O)C(O)=O RBNPOMFGQQGHHO-UHFFFAOYSA-N 0.000 claims 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical class CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 1
- HDGHQFQMWUTHKL-UHFFFAOYSA-N 2-methyl-1,3-dioxane Chemical compound CC1OCCCO1 HDGHQFQMWUTHKL-UHFFFAOYSA-N 0.000 claims 1
- CAHWDGJDQYAFHM-UHFFFAOYSA-N 2-nitroisophthalic acid Chemical class OC(=O)C1=CC=CC(C(O)=O)=C1[N+]([O-])=O CAHWDGJDQYAFHM-UHFFFAOYSA-N 0.000 claims 1
- KBZFDRWPMZESDI-UHFFFAOYSA-N 5-aminobenzene-1,3-dicarboxylic acid Chemical class NC1=CC(C(O)=O)=CC(C(O)=O)=C1 KBZFDRWPMZESDI-UHFFFAOYSA-N 0.000 claims 1
- WDYVUKGVKRZQNM-UHFFFAOYSA-N 6-phosphonohexylphosphonic acid Chemical compound OP(O)(=O)CCCCCCP(O)(O)=O WDYVUKGVKRZQNM-UHFFFAOYSA-N 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- RBNPOMFGQQGHHO-UWTATZPHSA-N D-glyceric acid Chemical compound OC[C@@H](O)C(O)=O RBNPOMFGQQGHHO-UWTATZPHSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 1
- ALHZEIINTQJLOT-VKHMYHEASA-N [(2s)-1-chloro-1-oxopropan-2-yl] acetate Chemical compound ClC(=O)[C@H](C)OC(C)=O ALHZEIINTQJLOT-VKHMYHEASA-N 0.000 claims 1
- 238000006359 acetalization reaction Methods 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 239000003957 anion exchange resin Substances 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 239000000010 aprotic solvent Substances 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000036760 body temperature Effects 0.000 claims 1
- 239000006227 byproduct Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 238000005341 cation exchange Methods 0.000 claims 1
- 239000003729 cation exchange resin Substances 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 150000001805 chlorine compounds Chemical class 0.000 claims 1
- 239000007859 condensation product Substances 0.000 claims 1
- 239000012043 crude product Substances 0.000 claims 1
- GGTSJKFPGKFLCZ-UHFFFAOYSA-N dimethyl 5-nitrobenzene-1,3-dicarboxylate Chemical compound COC(=O)C1=CC(C(=O)OC)=CC([N+]([O-])=O)=C1 GGTSJKFPGKFLCZ-UHFFFAOYSA-N 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000005457 ice water Substances 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 238000005342 ion exchange Methods 0.000 claims 1
- 239000003456 ion exchange resin Substances 0.000 claims 1
- 229920003303 ion-exchange polymer Polymers 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000155 melt Substances 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 239000012074 organic phase Substances 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 1
- 230000007928 solubilization Effects 0.000 claims 1
- 238000005063 solubilization Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1658874A CH608189A5 (enExample) | 1974-12-13 | 1974-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU628813A3 true SU628813A3 (ru) | 1978-10-15 |
Family
ID=4418593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU752196656A SU628813A3 (ru) | 1974-12-13 | 1975-12-10 | Способ получени амидов 5-оксипропиониламино-2,4,6-трийодизофталевой кислоты |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4001323A (enExample) |
| JP (1) | JPS5182236A (enExample) |
| AR (1) | AR211853A1 (enExample) |
| AT (2) | AT340582B (enExample) |
| AU (1) | AU475785B2 (enExample) |
| BE (1) | BE836355A (enExample) |
| BG (1) | BG26512A3 (enExample) |
| CA (1) | CA1046082A (enExample) |
| CH (1) | CH608189A5 (enExample) |
| CS (1) | CS194234B2 (enExample) |
| DD (1) | DD122475A5 (enExample) |
| DK (1) | DK147336C (enExample) |
| ES (1) | ES442651A1 (enExample) |
| FR (1) | FR2293919A1 (enExample) |
| GB (1) | GB1472050A (enExample) |
| HU (1) | HU170216B (enExample) |
| IE (1) | IE42620B1 (enExample) |
| IL (1) | IL48484A (enExample) |
| IN (1) | IN142089B (enExample) |
| MX (1) | MX3174E (enExample) |
| NL (1) | NL157295B (enExample) |
| NO (1) | NO145096C (enExample) |
| PH (1) | PH12321A (enExample) |
| PL (1) | PL96082B1 (enExample) |
| RO (1) | RO69615A (enExample) |
| SE (1) | SE409993B (enExample) |
| SU (1) | SU628813A3 (enExample) |
| YU (2) | YU40448B (enExample) |
| ZA (1) | ZA757222B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2512358C2 (ru) * | 2009-03-20 | 2014-04-10 | Бракко Имэджинг Спа | Способ получения трийодированных карбоксильных ароматических производных |
Families Citing this family (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1495679A (en) * | 1974-06-17 | 1977-12-21 | Mallinckrodt Inc | Substituted isophthalamic acids |
| US4314055A (en) * | 1975-09-29 | 1982-02-02 | Mallinckrodt, Inc. | 3,5-Disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids |
| JPS52130923A (en) * | 1976-04-27 | 1977-11-02 | Mallinckrodt Chemical Works | Xxray photographic agent |
| GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| CH626873A5 (enExample) * | 1977-03-28 | 1981-12-15 | Bracco Ind Chimica Spa | |
| DE2909439A1 (de) * | 1979-03-08 | 1980-09-18 | Schering Ag | Neue nichtionische roentgenkontrastmittel |
| US4256729A (en) * | 1979-03-23 | 1981-03-17 | Mallinckrodt, Inc. | N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same |
| NL8002388A (nl) * | 1979-05-21 | 1980-11-25 | Mallinckrodt Inc | Roentgencontrastmiddel. |
| IT1207226B (it) * | 1979-08-09 | 1989-05-17 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono. |
| DE3001292A1 (de) * | 1980-01-11 | 1981-07-16 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Nichtionische 5-c-substituierte 2,4,6-trijod-isophthalsaeure-derivate |
| DE3038853A1 (de) * | 1980-10-10 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii) |
| DE3150916A1 (de) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel" |
| DE3150917A1 (de) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung" |
| US4396598A (en) * | 1982-01-11 | 1983-08-02 | Mallinckrodt, Inc. | Triiodoisophthalamide X-ray contrast agent |
| US5204086A (en) * | 1982-10-01 | 1993-04-20 | Nycomed Imaging As | X-ray contrast agent |
| US4584401A (en) * | 1983-10-20 | 1986-04-22 | Biophysica Foundation | Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media |
| JPH0813794B2 (ja) * | 1985-08-09 | 1996-02-14 | クツク イマジング，インコ−ポレイテイド | イオン性コントラスト媒体からの非イオン性ポリオ−ルコントラスト媒体 |
| US5035877A (en) * | 1985-08-09 | 1991-07-30 | Cook Imaging Corporation | Non-ionic contrast media from ionic contrast media |
| IL86450A (en) * | 1987-05-22 | 1994-05-30 | Bracco Int Bv | Process for making a history of 5-acylamino-2,4,6-triiodo and tribromo-benzoic acid, and some such new compounds |
| IL94718A (en) * | 1989-07-05 | 1994-10-21 | Schering Ag | Non-ionic carboxamide contrast agent and method of preparation |
| US5698739A (en) * | 1989-07-05 | 1997-12-16 | Schering Aktiengesellschaft | Carboxamide non-ionic contrast media |
| GB8919929D0 (en) | 1989-09-04 | 1989-10-18 | Nycomed As | Compositions |
| US5232685A (en) * | 1989-11-03 | 1993-08-03 | Schering Aktiengesellschaft | Nonionic x-ray contrast medium with high iodine content |
| DE3937118A1 (de) * | 1989-11-03 | 1991-05-08 | Schering Ag | Nichtionische roentgenkontrastmittel mit hohem jodgehalt |
| US5614638A (en) * | 1989-11-29 | 1997-03-25 | Bracco International B.V. | Nonionic radiographic contrast agents |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2053037B1 (enExample) * | 1969-06-27 | 1974-08-09 | Nyegaard & Co As | |
| DE2124904C3 (de) * | 1971-05-15 | 1980-09-18 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Hydroxy- und Alkoxyacetamido-trijodbenzoesäuren, deren Salze mit physiologisch verträglichen Basen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Röntgenkontrastmittel |
| BE788054A (fr) * | 1971-08-26 | 1973-02-26 | Bracco Ind Chimica Spa | Nouvel agent de contraste radiographique et procede pour le preparer |
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| CH583562A5 (enExample) * | 1973-07-17 | 1977-01-14 | Bracco Ind Chimica Spa |
-
1974
- 1974-12-13 CH CH1658874A patent/CH608189A5/xx active Protection Beyond IP Right Term
-
1975
- 1975-10-17 NL NL7512208.A patent/NL157295B/xx not_active IP Right Cessation
- 1975-11-11 BG BG031456A patent/BG26512A3/xx unknown
- 1975-11-14 ES ES442651A patent/ES442651A1/es not_active Expired
- 1975-11-17 IL IL48484A patent/IL48484A/xx unknown
- 1975-11-18 ZA ZA757222A patent/ZA757222B/xx unknown
- 1975-11-24 US US05/634,836 patent/US4001323A/en not_active Expired - Lifetime
- 1975-11-25 IN IN2245/CAL/75A patent/IN142089B/en unknown
- 1975-11-26 GB GB4862075A patent/GB1472050A/en not_active Expired
- 1975-11-26 CA CA240,580A patent/CA1046082A/en not_active Expired
- 1975-12-02 AR AR261439A patent/AR211853A1/es active
- 1975-12-03 MX MX004201U patent/MX3174E/es unknown
- 1975-12-05 AT AT925075A patent/AT340582B/de not_active IP Right Cessation
- 1975-12-05 BE BE162511A patent/BE836355A/xx not_active IP Right Cessation
- 1975-12-10 SU SU752196656A patent/SU628813A3/ru active
- 1975-12-10 PL PL1975185427A patent/PL96082B1/pl unknown
- 1975-12-10 HU HUSA2864A patent/HU170216B/hu unknown
- 1975-12-11 IE IE2706/75A patent/IE42620B1/en active Protection Beyond IP Right Term
- 1975-12-11 DD DD190060A patent/DD122475A5/xx unknown
- 1975-12-11 FR FR7537934A patent/FR2293919A1/fr active Granted
- 1975-12-12 SE SE7514076A patent/SE409993B/xx not_active IP Right Cessation
- 1975-12-12 JP JP50147492A patent/JPS5182236A/ja active Granted
- 1975-12-12 DK DK567475A patent/DK147336C/da not_active IP Right Cessation
- 1975-12-12 AU AU87516/75A patent/AU475785B2/en not_active Expired
- 1975-12-12 NO NO754241A patent/NO145096C/no unknown
- 1975-12-12 YU YU3155/75A patent/YU40448B/xx unknown
- 1975-12-12 RO RO7584187A patent/RO69615A/ro unknown
- 1975-12-12 CS CS758475A patent/CS194234B2/cs unknown
- 1975-12-15 PH PH7517872A patent/PH12321A/en unknown
- 1975-12-22 AT AT925175A patent/AT342579B/de not_active IP Right Cessation
-
1983
- 1983-09-30 YU YU1967/83A patent/YU41540B/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2512358C2 (ru) * | 2009-03-20 | 2014-04-10 | Бракко Имэджинг Спа | Способ получения трийодированных карбоксильных ароматических производных |
| US9096495B2 (en) | 2009-03-20 | 2015-08-04 | Bracco Imaging S.P.A. | Process for the preparation of triiodinated carboxylic aromatic derivatives |
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