SE409993B - Rontgenkontrastmedel - Google Patents

Rontgenkontrastmedel

Info

Publication number
SE409993B
SE409993B SE7514076A SE7514076A SE409993B SE 409993 B SE409993 B SE 409993B SE 7514076 A SE7514076 A SE 7514076A SE 7514076 A SE7514076 A SE 7514076A SE 409993 B SE409993 B SE 409993B
Authority
SE
Sweden
Prior art keywords
contrast agent
ray contrast
ray
agent
contrast
Prior art date
Application number
SE7514076A
Other languages
English (en)
Other versions
SE7514076L (sv
Inventor
E Felder
D Pitre
Original Assignee
Bracco Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Ind Chimica Spa filed Critical Bracco Ind Chimica Spa
Publication of SE7514076L publication Critical patent/SE7514076L/sv
Publication of SE409993B publication Critical patent/SE409993B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE7514076A 1974-12-13 1975-12-12 Rontgenkontrastmedel SE409993B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1658874A CH608189A5 (sv) 1974-12-13 1974-12-13

Publications (2)

Publication Number Publication Date
SE7514076L SE7514076L (sv) 1976-06-14
SE409993B true SE409993B (sv) 1979-09-17

Family

ID=4418593

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7514076A SE409993B (sv) 1974-12-13 1975-12-12 Rontgenkontrastmedel

Country Status (29)

Country Link
US (1) US4001323A (sv)
JP (1) JPS5182236A (sv)
AR (1) AR211853A1 (sv)
AT (2) AT340582B (sv)
AU (1) AU475785B2 (sv)
BE (1) BE836355A (sv)
BG (1) BG26512A3 (sv)
CA (1) CA1046082A (sv)
CH (1) CH608189A5 (sv)
CS (1) CS194234B2 (sv)
DD (1) DD122475A5 (sv)
DK (1) DK147336C (sv)
ES (1) ES442651A1 (sv)
FR (1) FR2293919A1 (sv)
GB (1) GB1472050A (sv)
HU (1) HU170216B (sv)
IE (1) IE42620B1 (sv)
IL (1) IL48484A (sv)
IN (1) IN142089B (sv)
MX (1) MX3174E (sv)
NL (1) NL157295B (sv)
NO (1) NO145096C (sv)
PH (1) PH12321A (sv)
PL (1) PL96082B1 (sv)
RO (1) RO69615A (sv)
SE (1) SE409993B (sv)
SU (1) SU628813A3 (sv)
YU (2) YU40448B (sv)
ZA (1) ZA757222B (sv)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495679A (en) * 1974-06-17 1977-12-21 Mallinckrodt Inc Substituted isophthalamic acids
US4314055A (en) * 1975-09-29 1982-02-02 Mallinckrodt, Inc. 3,5-Disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids
JPS52130923A (en) * 1976-04-27 1977-11-02 Mallinckrodt Chemical Works Xxray photographic agent
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
CH626873A5 (sv) * 1977-03-28 1981-12-15 Bracco Ind Chimica Spa
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same
NL8002388A (nl) * 1979-05-21 1980-11-25 Mallinckrodt Inc Roentgencontrastmiddel.
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3001292A1 (de) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin Nichtionische 5-c-substituierte 2,4,6-trijod-isophthalsaeure-derivate
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
DE3150917A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
US5035877A (en) * 1985-08-09 1991-07-30 Cook Imaging Corporation Non-ionic contrast media from ionic contrast media
EP0233249B1 (en) * 1985-08-09 1993-11-24 Cook Imaging Corporation Non-ionic polyol contrast media from ionic contrast media
KR960016747B1 (ko) * 1987-05-22 1996-12-20 브라코 인터내셔날 비. 브이 5-아실아미노-2,4,6-트리요오도-또는 트리브로모-벤조산 유도체의 제조 방법
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
GB8919929D0 (en) 1989-09-04 1989-10-18 Nycomed As Compositions
DE3937118A1 (de) * 1989-11-03 1991-05-08 Schering Ag Nichtionische roentgenkontrastmittel mit hohem jodgehalt
US5232685A (en) * 1989-11-03 1993-08-03 Schering Aktiengesellschaft Nonionic x-ray contrast medium with high iodine content
US5614638A (en) * 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US4997983A (en) * 1990-01-31 1991-03-05 Mallinckrodt, Inc. Process for production of ioversol
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
US5169864A (en) * 1991-11-15 1992-12-08 Baxter International Inc. Unbuffered premixed ranitidine formulation
US5463080A (en) * 1992-08-27 1995-10-31 Bracco International B.V. 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as radiolabelling reagents
IT1256162B (it) * 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1256163B (it) * 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
US5424056A (en) * 1993-03-01 1995-06-13 Sterling Wintrhop Inc. X-ray contrast compositions containing iodoaniline derivatives and pharmaceutically acceptable clays
US5330740A (en) * 1993-03-01 1994-07-19 Sterling Winthrop Inc. Compositions of iodoaniline derivatives in film-forming materials for visualization of the gastrointestinal tract
IL110391A (en) * 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
IT1271469B (it) * 1993-09-10 1997-05-28 Zambon Spa Processo per la preparazione di 5-ammino-2,2-dialchil-1,3 diossani
IT1274027B (it) * 1994-03-03 1997-07-14 Zambon Spa Processo per la preparazione e purificazione di mezzi di contrasto iodurati
IT1275429B (it) * 1995-05-18 1997-08-07 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di composti organici
ATE176663T1 (de) * 1995-05-23 1999-02-15 Fructamine Spa Verfahren zur herstellung von dicarbonsäurechlorid
CN1068582C (zh) * 1995-05-23 2001-07-18 弗鲁克泰明公司 制备二酰氯的方法
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
BR9606624A (pt) * 1995-09-08 1997-11-11 Bracco Int Bv Processo para a cristalização de (s)-n,n'-bisÚ2-hidróxi-1-(hidroximetil)etil¾-5-Ú(2-hidróxi-1-oxopropil)amino¾-2,4,6-triiodo-1,3-benzonodicar-boxamida a partir de água
EP0809519B1 (en) * 1995-12-19 2002-09-11 Bracco Research S.A. Compositions comprising tricodobenzene polymers for imaging the gastrointestinal tract
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1288114B1 (it) * 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US5705692A (en) * 1996-09-27 1998-01-06 Abbott Laboratories Process for the preparation of iohexol
US5861138A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Ligands for MRI contrast agent
US5861140A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Tripodal paramagnetic contrast agents for MR imaging
GB9624612D0 (en) 1996-11-26 1997-01-15 Nycomed Imaging As Process
IT1286522B1 (it) * 1996-12-04 1998-07-15 Dibra Spa Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico
IT1289520B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1289521B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la purificazione di un intermedio
IT1289519B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
CZ299420B6 (cs) * 1997-02-11 2008-07-23 Bracco International B. V. Zpusob krystalizace iopamidolu
IT1292037B1 (it) * 1997-05-30 1999-01-25 Bracco Spa Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen-
US5824288A (en) * 1997-08-21 1998-10-20 Hoechst Celanese Corporation Thio-substituted pyridines as MRI ligand precursors
US5869025A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corporation Tripodal aromatic heterocycle carboxamide MRI contrast agents
US5820851A (en) * 1997-08-21 1998-10-13 Hoechst Celanese Corporation Tripodal pyridine ligands as MRI contrast agents
US5858329A (en) * 1997-08-21 1999-01-12 Hoechst Celanese Corporation MRI diagnostic procedures using tripodal pyridinyl metal complexes
US5869026A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corp. Tripodal carboxamide ligands for MRI contrast agents
IT1299202B1 (it) * 1998-05-08 2000-02-29 Dibra Spa Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
US6262303B1 (en) 1998-05-08 2001-07-17 Dibra S.P.A. Process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamide
IT1302200B1 (it) * 1998-09-11 2000-07-31 Dibra Spa PROCESSO PER LA PREPARAZIONE DELLA S-N,N'-BIS°2-IDROSSI-1-(IDROSSIMETIL)ETILé-5-°(2-IDROSSI-1-
GB9825095D0 (en) 1998-11-16 1999-01-13 Nycomed Imaging As Chemical process
US6803485B2 (en) * 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
SE520688C2 (sv) * 2000-04-11 2003-08-12 Bone Support Ab Ett injicerbart ersättningsmaterial för benmineral
SE517168C2 (sv) * 2000-07-17 2002-04-23 Bone Support Ab En komposition för ett injicerbart ersättningsmaterial för benmineral
US6660248B2 (en) 2000-11-10 2003-12-09 William Marsh Rice University Fullerene (C60)-based X-ray contrast agent for diagnostic imaging
IT1319671B1 (it) 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
SE522098C2 (sv) * 2001-12-20 2004-01-13 Bone Support Ab Ett nytt benmineralsubstitut
SE0300620D0 (sv) * 2003-03-05 2003-03-05 Bone Support Ab A new bone substitute composition
SE0302983D0 (sv) * 2003-11-11 2003-11-11 Bone Support Ab Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed
SE527528C2 (sv) 2004-06-22 2006-04-04 Bone Support Ab Anordning för framställning av härdbar massa samt användning av anordningen
SI1836239T1 (sl) 2005-01-13 2009-04-30 Cinv Ag Kompozitni materiali, ki vsebujejo ogljikove nanodelce
WO2008087214A1 (en) * 2007-01-19 2008-07-24 Cinvention Ag Porous, non-degradable implant made by powder molding
WO2008104599A1 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system bag
US7955234B1 (en) 2007-02-28 2011-06-07 Pursley Michael G Exercise device and method
US20080213742A1 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system
EP2093206A1 (en) 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Process for the iodination of aromatic compounds
KR101098553B1 (ko) * 2008-04-30 2011-12-26 주식회사 엘지생명과학 이오프로마이드의 신규한 제조방법
JP5536087B2 (ja) * 2008-11-18 2014-07-02 ブラッコ・イメージング・ソシエタ・ペル・アチオニ ヨウ化造影剤の製造方法
EP2385845A1 (en) 2009-01-09 2011-11-16 Ge Healthcare As Contrast media compositions
EP2230227A1 (en) 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
EP2243767A1 (en) * 2009-04-21 2010-10-27 Bracco Imaging S.p.A Process for the iodination of aromatic compounds
PL2451994T3 (pl) 2009-07-07 2014-04-30 Bracco Imaging Spa Proces wytwarzania środka jodującego
US9180137B2 (en) 2010-02-09 2015-11-10 Bone Support Ab Preparation of bone cement compositions
PT105770B (pt) 2011-06-24 2013-07-08 Hovione Farmaciencia S A Novo intermediário e seu uso na preparação de agente de contrate triiodado
WO2014090650A1 (en) 2012-12-11 2014-06-19 Bracco Imaging Spa Continuous process for the preparation of (s)-2-acetyloxypropionic acid chloride
US10294107B2 (en) 2013-02-20 2019-05-21 Bone Support Ab Setting of hardenable bone substitute
MX2016005829A (es) 2013-11-05 2017-03-10 Bracco Imaging Spa Procedimiento para la preparacion de iopamidol.
CN106458830B (zh) 2014-06-10 2019-03-05 伯拉考成像股份公司 制备(s)-2-乙酰氧基丙酸及其衍生物的方法
CN104230731B (zh) * 2014-09-24 2016-01-20 武汉理工大学 造影剂中间体三碘异酞酰氯的制备方法
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
CN105461581A (zh) * 2015-11-17 2016-04-06 浙江海洲制药有限公司 碘帕醇杂质a和杂质b的合成方法
CN107778191A (zh) * 2016-08-26 2018-03-09 正大天晴药业集团股份有限公司 一种碘普罗胺及其中间体的制备方法
CN110023279B (zh) 2016-12-05 2022-03-11 伯拉考成像股份公司 放射照相剂中间体的机械化学合成
NZ757793A (en) 2017-06-07 2022-04-29 Bracco Imaging Spa A process for the recovery of iodine from aqueous solutions
US20240199530A1 (en) 2021-03-22 2024-06-20 Bracco Imaging S.P.A. Industrial synthesis of serinol
CN118414325A (zh) 2021-12-20 2024-07-30 伯拉考成像股份公司 制备2,4,6-三碘间苯二甲酸双酰胺的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
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US3701771A (en) * 1969-06-27 1972-10-31 Nyegaard & Co As N-(2,4,6-triiodobenzoyl)-sugar amines
DE2124904C3 (de) * 1971-05-15 1980-09-18 Schering Ag, 1000 Berlin Und 4619 Bergkamen Hydroxy- und Alkoxyacetamido-trijodbenzoesäuren, deren Salze mit physiologisch verträglichen Basen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Röntgenkontrastmittel
BE788054A (fr) * 1971-08-26 1973-02-26 Bracco Ind Chimica Spa Nouvel agent de contraste radiographique et procede pour le preparer
CH576256A5 (sv) * 1973-07-17 1976-06-15 Bracco Ind Chimica Spa
CH583562A5 (sv) * 1973-07-17 1977-01-14 Bracco Ind Chimica Spa

Also Published As

Publication number Publication date
NO145096C (no) 1982-01-13
IE42620B1 (en) 1980-09-10
IL48484A0 (en) 1976-01-30
FR2293919B1 (sv) 1980-06-20
MX3174E (es) 1980-06-09
AR211853A1 (es) 1978-03-31
PH12321A (en) 1979-01-16
DK147336B (da) 1984-06-25
BG26512A3 (bg) 1979-04-12
AU8751675A (en) 1976-09-02
DD122475A5 (sv) 1976-10-12
ZA757222B (en) 1976-11-24
DK147336C (da) 1985-01-21
NO754241L (sv) 1976-06-15
PL96082B1 (pl) 1977-12-31
YU196783A (en) 1984-12-31
NO145096B (no) 1981-10-05
HU170216B (sv) 1977-04-28
DK567475A (da) 1976-06-14
YU41540B (en) 1987-08-31
ES442651A1 (es) 1977-04-16
SU628813A3 (ru) 1978-10-15
CA1046082A (en) 1979-01-09
JPS5642581B2 (sv) 1981-10-06
ATA925175A (de) 1977-08-15
US4001323A (en) 1977-01-04
DE2547789A1 (de) 1976-06-24
JPS5182236A (en) 1976-07-19
IL48484A (en) 1978-08-31
ATA925075A (de) 1977-04-15
GB1472050A (en) 1977-04-27
YU315575A (en) 1982-02-28
YU40448B (en) 1986-02-28
AT340582B (de) 1977-12-27
RO69615A (ro) 1981-06-30
BE836355A (fr) 1976-06-08
IE42620L (en) 1976-06-13
IN142089B (sv) 1977-05-28
NL7512208A (nl) 1976-06-15
FR2293919A1 (fr) 1976-07-09
AU475785B2 (en) 1976-09-02
DE2547789B2 (de) 1977-02-24
CS194234B2 (en) 1979-11-30
CH608189A5 (sv) 1978-12-29
AT342579B (de) 1978-04-10
NL157295B (nl) 1978-07-17
SE7514076L (sv) 1976-06-14

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