SU1333237A3 - Способ получени производных пиперидиндиона-2,6 или их солей - Google Patents

Способ получени производных пиперидиндиона-2,6 или их солей Download PDF

Info

Publication number
SU1333237A3
SU1333237A3 SU833661804A SU3661804A SU1333237A3 SU 1333237 A3 SU1333237 A3 SU 1333237A3 SU 833661804 A SU833661804 A SU 833661804A SU 3661804 A SU3661804 A SU 3661804A SU 1333237 A3 SU1333237 A3 SU 1333237A3
Authority
SU
USSR - Soviet Union
Prior art keywords
pyridyl
piperidinedione
mixture
added
followed
Prior art date
Application number
SU833661804A
Other languages
English (en)
Russian (ru)
Inventor
Бернар Клод
Готрельс Вернер
Готье Патрик
Original Assignee
Санофи (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи (Фирма) filed Critical Санофи (Фирма)
Application granted granted Critical
Publication of SU1333237A3 publication Critical patent/SU1333237A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
SU833661804A 1982-11-08 1983-11-05 Способ получени производных пиперидиндиона-2,6 или их солей SU1333237A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8218706A FR2535721A1 (fr) 1982-11-08 1982-11-08 Derives de la piperidinedione protecteurs du myocarde presentant une acticite antiarythmique, leur procede de preparation et les medicaments qui contiennent lesdits derives

Publications (1)

Publication Number Publication Date
SU1333237A3 true SU1333237A3 (ru) 1987-08-23

Family

ID=9279000

Family Applications (3)

Application Number Title Priority Date Filing Date
SU833661804A SU1333237A3 (ru) 1982-11-08 1983-11-05 Способ получени производных пиперидиндиона-2,6 или их солей
SU843786916A SU1333238A3 (ru) 1982-11-08 1984-09-06 Способ получени производных 2,6-пиперидиндиона
SU843786907A SU1316558A3 (ru) 1982-11-08 1984-09-06 Способ получени производных пиперидиндиона

Family Applications After (2)

Application Number Title Priority Date Filing Date
SU843786916A SU1333238A3 (ru) 1982-11-08 1984-09-06 Способ получени производных 2,6-пиперидиндиона
SU843786907A SU1316558A3 (ru) 1982-11-08 1984-09-06 Способ получени производных пиперидиндиона

Country Status (29)

Country Link
US (1) US4721710A (https=)
EP (1) EP0110755B1 (https=)
JP (1) JPS59161377A (https=)
KR (1) KR900006721B1 (https=)
AT (1) ATE22561T1 (https=)
AU (1) AU565519B2 (https=)
CA (1) CA1221967A (https=)
CS (1) CS244681B2 (https=)
DD (3) DD229407A5 (https=)
DE (1) DE3366623D1 (https=)
DK (1) DK511383A (https=)
ES (1) ES527091A0 (https=)
FI (1) FI79536C (https=)
FR (1) FR2535721A1 (https=)
GR (1) GR78747B (https=)
HU (1) HU191494B (https=)
IE (1) IE56209B1 (https=)
IL (1) IL70099A (https=)
MA (1) MA19948A1 (https=)
NO (1) NO159852C (https=)
NZ (1) NZ206177A (https=)
OA (1) OA07582A (https=)
PH (1) PH20421A (https=)
PL (3) PL139946B1 (https=)
PT (1) PT77607B (https=)
SG (1) SG1989G (https=)
SU (3) SU1333237A3 (https=)
YU (3) YU221183A (https=)
ZA (1) ZA838065B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2174516C2 (ru) * 1993-07-02 2001-10-10 Селген Корпорейшн Имиды как ингибиторы tnf-альфа

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668689A (en) * 1984-07-19 1987-05-26 National Research Development Corporation Glutarimide derivatives for treating oestrogen-dependent tumors
US5238947A (en) * 1990-04-12 1993-08-24 University Of Georgia Research Foundation, Inc. Synthetic piperidinediones with cytostatic activity
DE19703763C1 (de) * 1997-02-01 1998-10-01 Gruenenthal Gmbh Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione
WO2012158795A1 (en) 2011-05-17 2012-11-22 Principia Biopharma Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
ES2770550T3 (es) 2011-05-17 2020-07-02 Univ California Inhibidores de quinasa
PL2710005T3 (pl) 2011-05-17 2017-07-31 Principia Biopharma Inc. Inhibitory kinazy tyrozynowej
SI2892900T1 (en) 2012-09-10 2018-01-31 Principia Biopharma Inc. Pyrazolopyrimidine compounds as kinase inhibitors
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
CN112353806A (zh) 2014-02-21 2021-02-12 普林斯匹亚生物制药公司 Btk抑制剂的盐和固体形式
SG11201704808VA (en) 2014-12-18 2017-07-28 Principia Biopharma Inc Treatment of pemphigus
WO2016210165A1 (en) 2015-06-24 2016-12-29 Principia Biopharma Inc. Tyrosine kinase inhibitors
CN115054586B (zh) 2016-06-29 2024-08-02 普林斯匹亚生物制药公司 改性的释放制剂
US20210106584A1 (en) 2019-10-14 2021-04-15 Principia Biopharma Inc. Methods for treating immune thrombocytopenia by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
US11814390B2 (en) 2020-01-22 2023-11-14 Principia Biopharma Inc. Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2664424A (en) * 1953-12-29 Dioxo-piperidines
GB1455687A (en) * 1972-12-28 1976-11-17 Aspro Nicholas Ltd Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines
FR2467200A1 (fr) * 1979-10-11 1981-04-17 Clin Midy Derives du pyrrole actifs sur les troubles du rythme cardiovasculaire

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Яновска А.А. , Юфит, С.С. Органический синтез в двухфазных системах. - М.: Химил, 1982, с. 182. Патент FR №2212147, кл. С 07 D 29/00, 1974. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2174516C2 (ru) * 1993-07-02 2001-10-10 Селген Корпорейшн Имиды как ингибиторы tnf-альфа

Also Published As

Publication number Publication date
FR2535721A1 (fr) 1984-05-11
IL70099A (en) 1987-10-20
PL140021B1 (en) 1987-03-31
AU565519B2 (en) 1987-09-17
IE832581L (en) 1984-05-08
CA1221967A (en) 1987-05-19
ES8406070A1 (es) 1984-07-01
KR840006641A (ko) 1984-12-01
MA19948A1 (fr) 1984-07-01
KR900006721B1 (ko) 1990-09-20
IL70099A0 (en) 1984-01-31
CS244681B2 (en) 1986-08-14
SU1333238A3 (ru) 1987-08-23
HU191494B (en) 1987-02-27
NO159852B (no) 1988-11-07
SU1316558A3 (ru) 1987-06-07
OA07582A (fr) 1985-03-31
PL244462A1 (en) 1985-02-13
FI79536B (fi) 1989-09-29
PL249749A1 (en) 1985-03-12
FI834087A0 (fi) 1983-11-08
IE56209B1 (en) 1991-05-22
DD229402A5 (de) 1985-11-06
DK511383A (da) 1984-05-09
FR2535721B1 (https=) 1985-05-17
NZ206177A (en) 1985-11-08
PL249750A1 (en) 1985-03-12
GR78747B (https=) 1984-10-02
ZA838065B (en) 1984-06-27
DD219770A5 (de) 1985-03-13
DD229407A5 (de) 1985-11-06
YU184185A (en) 1986-06-30
YU221183A (en) 1986-06-30
DE3366623D1 (en) 1986-11-06
DK511383D0 (da) 1983-11-08
PL139946B1 (en) 1987-03-31
EP0110755B1 (fr) 1986-10-01
PT77607B (fr) 1986-03-18
NO834057L (no) 1984-05-09
NO159852C (no) 1989-02-15
YU184285A (en) 1986-06-30
JPS59161377A (ja) 1984-09-12
FI834087L (fi) 1984-05-09
PT77607A (fr) 1983-12-01
PL140992B1 (en) 1987-06-30
ATE22561T1 (de) 1986-10-15
FI79536C (fi) 1990-01-10
SG1989G (en) 1989-06-02
US4721710A (en) 1988-01-26
AU2089883A (en) 1984-05-17
EP0110755A1 (fr) 1984-06-13
ES527091A0 (es) 1984-07-01
PH20421A (en) 1987-01-05

Similar Documents

Publication Publication Date Title
SU1333237A3 (ru) Способ получени производных пиперидиндиона-2,6 или их солей
RU2036922C1 (ru) Производные 1,4-дигидропиридина или их гидрохлориды, обладающие антагонистическими свойствами по отношению к ионам кальция
JPS6222985B2 (https=)
JP3030780B2 (ja) 光学活性なケテンジチオアセタール誘導体及びその製造方法
SU1591805A3 (ru) Способ получения производного сульфонамцца
WO2003093242A2 (en) Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
DE4039559A1 (de) Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
US3481972A (en) Substituted hydroxyethyl acid hydrazides
JPH0115501B2 (https=)
GB2143814A (en) Quinazolines
FR2491470A1 (fr) Nouvelles cyclopropylmethyl piperazines, leur procede de preparation et leur application en therapeutique
SU1200849A3 (ru) Способ получени производных пиррола
SU1253428A3 (ru) Способ получени производных пиррола
KR840001106B1 (ko) 피리딘 유도체의 제조방법
CS244695B2 (cs) Způsob přípravy derivátů 2,6-piperidíndionu
JPS62178585A (ja) １−〔３−（２−ヒドロキシ−３−アルキルアミノプロポキシ）−２−チエニル〕−３−フエニル−１−プロパノン及びそれらの酸付加塩並びにそれらの製造法及びそれらを含む薬学的組成物
US4542134A (en) Derivatives of γ-butyrolactone with an anti-arrythmic activity and compositions
KR820001449B1 (ko) 퀴나졸린 유도체의 제조방법
PL117861B1 (en) Process for preparing novel derivatives of phthalaz-1-one
JPS5834465B2 (ja) トリフルオロトルアニリド類及びその製法
MC1393A1 (fr) Nouveaux derives de l'imidazole
JPS61172853A (ja) （±）−トランス−菊カルボン酸の光学分割法
HU191585B (en) Process for producing tetramethyl-proline-3-carboxamide derivatives and new cardiotherapeutic compositions containing them
CS216172B2 (cs) Způsob výroby N-substituovaných N-2-(2-furylethyl)-aminů
JPH04247077A (ja) トロポロン誘導体およびそれを有効成分とする虚血性疾患の予防・治療剤