SMT201500017B - Composti di pirrolopirimidina quali inibitori di cdk - Google Patents

Composti di pirrolopirimidina quali inibitori di cdk

Info

Publication number
SMT201500017B
SMT201500017B SM201500017T SM201500017T SMT201500017B SM T201500017 B SMT201500017 B SM T201500017B SM 201500017 T SM201500017 T SM 201500017T SM 201500017 T SM201500017 T SM 201500017T SM T201500017 B SMT201500017 B SM T201500017B
Authority
SM
San Marino
Prior art keywords
cdk inhibitors
pyrrolopyrimidine compounds
pyrrolopyrimidine
compounds
cdk
Prior art date
Application number
SM201500017T
Other languages
English (en)
Inventor
Christopher Thomas Brain
Bharat Lagu
Gilbert Besong
Clinton A Brooks
Miles Stuart Congreve
Claudio Dagostin
Guo He
Ying Hou
Steven Howard
Yue Li
Yipin Lu
Paul Mortenson
Troy Smith
Moo Sung
Steven Woodhead
Wojciech Wrona
Original Assignee
Novartis Ag
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41171100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201500017(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Astex Therapeutics Ltd filed Critical Novartis Ag
Publication of SMT201500017B publication Critical patent/SMT201500017B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SM201500017T 2008-08-22 2015-01-20 Composti di pirrolopirimidina quali inibitori di cdk SMT201500017B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9103708P 2008-08-22 2008-08-22
PCT/EP2009/060793 WO2010020675A1 (en) 2008-08-22 2009-08-20 Pyrrolopyrimidine compounds as cdk inhibitors

Publications (1)

Publication Number Publication Date
SMT201500017B true SMT201500017B (it) 2015-03-05

Family

ID=41171100

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201500017T SMT201500017B (it) 2008-08-22 2015-01-20 Composti di pirrolopirimidina quali inibitori di cdk

Country Status (49)

Country Link
US (8) US8685980B2 (it)
EP (2) EP2716643A1 (it)
JP (2) JP5560496B2 (it)
KR (2) KR20130140222A (it)
CN (2) CN103788100A (it)
AR (2) AR073116A1 (it)
AU (1) AU2009284098B2 (it)
BR (1) BRPI0917791B1 (it)
CA (1) CA2734802C (it)
CL (1) CL2011000306A1 (it)
CO (1) CO6341561A2 (it)
CR (1) CR20110101A (it)
CU (1) CU24062B1 (it)
CY (2) CY1115703T1 (it)
DK (1) DK2331547T3 (it)
DO (1) DOP2011000057A (it)
EA (1) EA019094B1 (it)
EC (1) ECSP11010843A (it)
ES (1) ES2522346T3 (it)
FR (1) FR17C1059I2 (it)
GE (1) GEP20135785B (it)
HK (1) HK1156625A1 (it)
HN (1) HN2011000542A (it)
HR (1) HRP20141018T1 (it)
HU (1) HUS1700051I1 (it)
IL (1) IL211164A (it)
JO (1) JO2924B1 (it)
LT (1) LTC2331547I2 (it)
LU (1) LUC00048I2 (it)
MA (1) MA32555B1 (it)
ME (1) ME01282B (it)
MX (1) MX2011001879A (it)
MY (1) MY150560A (it)
NI (1) NI201100042A (it)
NL (1) NL300909I2 (it)
NO (1) NO2017059I1 (it)
NZ (1) NZ591176A (it)
PE (1) PE20110419A1 (it)
PL (1) PL2331547T3 (it)
PT (1) PT2331547E (it)
RS (1) RS53574B1 (it)
SI (1) SI2331547T1 (it)
SM (1) SMT201500017B (it)
TN (1) TN2011000062A1 (it)
TW (1) TWI468409B (it)
UA (1) UA103628C2 (it)
UY (2) UY38935A (it)
WO (1) WO2010020675A1 (it)
ZA (1) ZA201100994B (it)

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