SK657890A3 - Chroman derivative, methods for producing the same and pharmaceutical composition containing the same - Google Patents

Chroman derivative, methods for producing the same and pharmaceutical composition containing the same Download PDF

Info

Publication number
SK657890A3
SK657890A3 SK6578-90A SK657890A SK657890A3 SK 657890 A3 SK657890 A3 SK 657890A3 SK 657890 A SK657890 A SK 657890A SK 657890 A3 SK657890 A3 SK 657890A3
Authority
SK
Slovakia
Prior art keywords
group
formula
carbon atoms
alkyl
alkenyl
Prior art date
Application number
SK6578-90A
Other languages
English (en)
Slovak (sk)
Other versions
SK280261B6 (sk
Inventor
Lars-Gunnar Larsson
Rolf Noreen
Lucy A Renyi
Svante B Ross
Daniel D Sohn
Bjorn E Svensson
Seth O Thorberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of SK280261B6 publication Critical patent/SK280261B6/sk
Publication of SK657890A3 publication Critical patent/SK657890A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Liquid Crystal Substances (AREA)
  • Threshing Machine Elements (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Harvester Elements (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
SK6578-90A 1989-12-22 1990-12-21 Chroman derivative, methods for producing the same and pharmaceutical composition containing the same SK657890A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8904361A SE8904361D0 (sv) 1989-12-22 1989-12-22 New chroman and thiochroman derivatives

Publications (2)

Publication Number Publication Date
SK280261B6 SK280261B6 (sk) 1999-10-08
SK657890A3 true SK657890A3 (en) 1999-10-08

Family

ID=20377869

Family Applications (1)

Application Number Title Priority Date Filing Date
SK6578-90A SK657890A3 (en) 1989-12-22 1990-12-21 Chroman derivative, methods for producing the same and pharmaceutical composition containing the same

Country Status (42)

Country Link
EP (1) EP0460169B1 (fr)
JP (1) JP2879972B2 (fr)
KR (1) KR0178991B1 (fr)
CN (1) CN1037438C (fr)
AT (1) ATE138918T1 (fr)
AU (1) AU641204B2 (fr)
CA (1) CA2047237C (fr)
CY (1) CY1991A (fr)
CZ (1) CZ283630B6 (fr)
DE (1) DE69027311T2 (fr)
DK (1) DK0460169T3 (fr)
DZ (1) DZ1469A1 (fr)
EG (1) EG19749A (fr)
ES (1) ES2087993T3 (fr)
FI (1) FI102177B1 (fr)
GR (1) GR3020497T3 (fr)
HK (1) HK55897A (fr)
HR (1) HRP920851B1 (fr)
HU (1) HU211860A9 (fr)
ID (1) ID945B (fr)
IE (1) IE80753B1 (fr)
IL (1) IL96712A (fr)
IS (1) IS1665B (fr)
LT (1) LT3967B (fr)
LV (2) LV10449B (fr)
MX (1) MX23889A (fr)
NO (1) NO180336C (fr)
NZ (1) NZ236407A (fr)
PH (1) PH30797A (fr)
PL (3) PL164592B1 (fr)
PT (1) PT96304B (fr)
RU (1) RU2092483C1 (fr)
SA (1) SA90110186B1 (fr)
SE (1) SE8904361D0 (fr)
SG (1) SG48043A1 (fr)
SI (1) SI9012429B (fr)
SK (1) SK657890A3 (fr)
TW (1) TW221056B (fr)
UA (1) UA34416C2 (fr)
WO (1) WO1991009853A1 (fr)
YU (2) YU47936B (fr)
ZA (1) ZA909708B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
DK0471515T3 (da) * 1990-08-15 1997-07-21 Lilly Co Eli Ringsubstituerede 2-amino-1,2,3,4-tetrahydronphtalener, 3-aminochromaner og 3-aminothiochromaner
ES2153071T3 (es) * 1991-02-08 2001-02-16 Lilly Co Eli 2-amino-1,2,3,4-tetrahidronaftalenos y 3-aminocromanos sustituidos en anillo.
HRP920935A2 (en) * 1991-10-08 1995-08-31 Astra Ab New therapeutically active compound
SE9103745D0 (sv) * 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5434174A (en) * 1992-07-17 1995-07-18 Eli Lilly And Company Isoxazole derivatives for the treatment of irritable bowel syndrome
SE9301732D0 (sv) * 1993-05-18 1993-05-18 Haakan Wilhelm Wikstroem New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins
SE9703377D0 (sv) * 1997-09-18 1997-09-18 Astra Ab New compounds
SE9703378D0 (sv) * 1997-09-18 1997-09-18 Astra Ab New compounds
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
MXPA03006250A (es) 2001-01-16 2003-09-22 Astrazeneca Ab Compuestos heterociclicos terapeuticos.
CN1592745A (zh) 2001-01-16 2005-03-09 阿斯特拉曾尼卡有限公司 治疗用苯并－γ－吡喃酮化合物
WO2002055014A2 (fr) * 2001-01-16 2002-07-18 Astrazeneca Ab Composes therapeutiques de chromane
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
SE0301796D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use II
SE0301795D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use I
US20080221193A1 (en) * 2006-12-22 2008-09-11 Wyeth 3-amino chromane derivatives
SA08290245B1 (ar) * 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
CN101712672B (zh) * 2008-10-06 2013-02-06 中国中医科学院中药研究所 一种治疗心脑血管系统疾病新化合物及其制备方法、用途
DE102010041948A1 (de) 2010-10-04 2012-04-05 Mahle International Gmbh Filtereinrichtung
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE63744T1 (de) * 1985-09-03 1991-06-15 Ciba Geigy Ag 3-amino-dihydro-(1>-benzopyrane und benzothiopyrane.
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel chroman derivatives
US5258287A (en) * 1988-03-22 1993-11-02 Genentech, Inc. DNA encoding and methods of production of insulin-like growth factor binding protein BP53

Also Published As

Publication number Publication date
DZ1469A1 (fr) 2004-09-13
PH30797A (en) 1997-10-17
ATE138918T1 (de) 1996-06-15
PT96304B (pt) 1998-09-30
YU47936B (sh) 1996-05-20
LV11894B (en) 1998-05-20
FI102177B (fi) 1998-10-30
FI102177B1 (fi) 1998-10-30
SG48043A1 (en) 1998-04-17
KR920701193A (ko) 1992-08-11
NO913273D0 (no) 1991-08-21
CN1037438C (zh) 1998-02-18
ZA909708B (en) 1991-08-28
NO913273L (no) 1991-10-08
ID945B (id) 1996-09-20
EG19749A (en) 1996-01-31
IE80753B1 (en) 1999-01-13
FI913943A0 (fi) 1991-08-21
DE69027311T2 (de) 1996-10-24
ES2087993T3 (es) 1996-08-01
LT3967B (en) 1996-05-27
LV11894A (lv) 1997-12-20
CZ657890A3 (cs) 1998-02-18
WO1991009853A1 (fr) 1991-07-11
EP0460169A1 (fr) 1991-12-11
PL164592B1 (pl) 1994-08-31
CA2047237C (fr) 2003-02-11
JP2879972B2 (ja) 1999-04-05
YU47923B (sh) 1996-05-20
PT96304A (pt) 1991-09-30
SK280261B6 (sk) 1999-10-08
PL164608B1 (pl) 1994-08-31
JPH04503682A (ja) 1992-07-02
NO180336B (no) 1996-12-23
IS3662A7 (is) 1991-06-23
CY1991A (en) 1997-09-05
EP0460169B1 (fr) 1996-06-05
IS1665B (is) 1997-07-04
HRP920851A2 (en) 1995-10-31
PL293066A1 (en) 1992-08-10
DK0460169T3 (da) 1996-09-23
YU72191A (sh) 1995-01-31
SI9012429A (en) 1997-12-31
IE904535A1 (en) 1991-07-03
UA34416C2 (uk) 2001-03-15
SA90110186B1 (ar) 2001-11-11
IL96712A (en) 1995-08-31
RU2092483C1 (ru) 1997-10-10
CZ283630B6 (cs) 1998-05-13
HU211860A9 (en) 1995-12-28
PL164609B1 (en) 1994-08-31
HRP920851B1 (en) 2000-02-29
KR0178991B1 (ko) 1999-03-20
AU641204B2 (en) 1993-09-16
NZ236407A (en) 1993-08-26
LTIP1730A (en) 1995-08-25
CA2047237A1 (fr) 1991-06-23
AU6977091A (en) 1991-07-24
PL293065A1 (en) 1992-08-10
DE69027311D1 (en) 1996-07-11
IL96712A0 (en) 1991-09-16
GR3020497T3 (en) 1996-10-31
HK55897A (en) 1997-05-09
LV10449A (lv) 1995-02-20
CN1052669A (zh) 1991-07-03
TW221056B (fr) 1994-02-11
NO180336C (no) 1997-04-02
LV10449B (en) 1995-10-20
MX23889A (es) 1993-10-01
SE8904361D0 (sv) 1989-12-22
SI9012429B (sl) 1998-10-31
YU242990A (sh) 1993-10-20

Similar Documents

Publication Publication Date Title
SK657890A3 (en) Chroman derivative, methods for producing the same and pharmaceutical composition containing the same
US5650524A (en) Process for preparing (R)-3-amino-5-methoxychroman
KR19990029570A (ko) 도파민 작용물질 요법과 관련된 운동 이상증을 치료하기 위한알파-아미노-3-하이드록시-5-메틸-4-이속사졸프로피온산 수용 체길항제를 포함한약학 조성물
WO2006010965A1 (fr) Derives de indole-2 -carboxamidine utilises comme antagonistes du recepteur nmda
IL109234A (en) History of indole, their preparation and pharmaceutical preparations containing them
SK256090A3 (en) 8-substituted 2-aminotetralines, process for their preparation, pharmaceutical composition containing the same and their use
JP3204456B2 (ja) ２，７―置換オクタヒドロ―ピロロ［１，２―ａ］ピラジン誘導体
KR20030015889A (ko) 신규한 화합물 및 글라이신 전달 억제제로서의 이들의 용도
SK36194A3 (en) 3-(n-isopropyl-n-n-propylamino)-5-(n-isopropyl)- -carbamoylchroman
JP3786983B2 (ja) ピロリジノン誘導体
JP3786984B2 (ja) ピペラジン誘導体
CN115135644A (zh) 3-芳氧基-3-五元杂芳基-丙胺类化合物的制备方法及晶型
JP2023530314A (ja) 新規なオキソピリダジニル－フェニル－カルボノヒドラゾノイルジシアニド化合物及びその用途
JPS6322578A (ja) 活性化合物、その製法及びそれを含む医薬組成物