SK46599A3 - Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates for treating special diseases of the cardiovascular and the central nervous systems - Google Patents
Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates for treating special diseases of the cardiovascular and the central nervous systems Download PDFInfo
- Publication number
- SK46599A3 SK46599A3 SK465-99A SK46599A SK46599A3 SK 46599 A3 SK46599 A3 SK 46599A3 SK 46599 A SK46599 A SK 46599A SK 46599 A3 SK46599 A3 SK 46599A3
- Authority
- SK
- Slovakia
- Prior art keywords
- indazole
- hydroxymethylfuran
- formula
- compounds
- carbon atoms
- Prior art date
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- 201000010099 disease Diseases 0.000 title claims description 10
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- 230000002526 effect on cardiovascular system Effects 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 28
- 229940082615 organic nitrates used in cardiac disease Drugs 0.000 claims abstract description 6
- 230000003222 cGMP degradation Effects 0.000 claims abstract description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 21
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 16
- 238000011282 treatment Methods 0.000 claims description 15
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- 125000005843 halogen group Chemical group 0.000 claims description 4
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- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- NCGICGYLBXGBGN-UHFFFAOYSA-N 3-morpholin-4-yl-1-oxa-3-azonia-2-azanidacyclopent-3-en-5-imine;hydrochloride Chemical compound Cl.[N-]1OC(=N)C=[N+]1N1CCOCC1 NCGICGYLBXGBGN-UHFFFAOYSA-N 0.000 description 1
- XATBTRGIZVKLLZ-UHFFFAOYSA-N 5-[1-[(2-fluorophenyl)methyl]indazol-3-yl]furan-2-carbaldehyde Chemical compound FC1=CC=CC=C1CN1C2=CC=CC=C2C(C=2OC(C=O)=CC=2)=N1 XATBTRGIZVKLLZ-UHFFFAOYSA-N 0.000 description 1
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- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 description 1
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- 235000011054 acetic acid Nutrition 0.000 description 1
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- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
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- 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 1
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- 229910052749 magnesium Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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- YZMHQCWXYHARLS-UHFFFAOYSA-N naphthalene-1,2-disulfonic acid Chemical compound C1=CC=CC2=C(S(O)(=O)=O)C(S(=O)(=O)O)=CC=C21 YZMHQCWXYHARLS-UHFFFAOYSA-N 0.000 description 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19642255A DE19642255A1 (de) | 1996-10-14 | 1996-10-14 | Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten |
| PCT/EP1997/005381 WO1998016223A1 (de) | 1996-10-14 | 1997-10-01 | Verwendung von 1-benzyl-3-(substituiertes-hetaryl)-kondensierten pyrazol-derivaten zur belandlung von speziellen erkrankungen des herz-kreislaufsystems und des zentralnervensystems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK46599A3 true SK46599A3 (en) | 2000-02-14 |
Family
ID=7808650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK465-99A SK46599A3 (en) | 1996-10-14 | 1997-10-01 | Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates for treating special diseases of the cardiovascular and the central nervous systems |
Country Status (21)
| Country | Link |
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| US (1) | US6180656B1 (https=) |
| EP (1) | EP0932403B1 (https=) |
| JP (2) | JP2001502318A (https=) |
| AT (1) | ATE311184T1 (https=) |
| AU (1) | AU733967B2 (https=) |
| BR (1) | BR9712304A (https=) |
| CA (1) | CA2268314C (https=) |
| CZ (1) | CZ129299A3 (https=) |
| DE (2) | DE19642255A1 (https=) |
| EE (1) | EE9900156A (https=) |
| ES (1) | ES2252777T3 (https=) |
| HU (1) | HUP9903885A3 (https=) |
| ID (1) | ID22162A (https=) |
| IL (1) | IL129318A (https=) |
| NO (1) | NO991685L (https=) |
| NZ (1) | NZ335091A (https=) |
| PL (1) | PL332719A1 (https=) |
| SK (1) | SK46599A3 (https=) |
| TR (1) | TR199900782T2 (https=) |
| TW (1) | TW442482B (https=) |
| WO (1) | WO1998016223A1 (https=) |
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| EP3227287B1 (de) | 2014-12-02 | 2019-08-07 | Bayer Pharma Aktiengesellschaft | Heteroaryl-substituierte imidazo[1,2-a]pyridine und ihre verwendung |
| JP2018505886A (ja) | 2015-02-05 | 2018-03-01 | バイエル・ファルマ・アクティエンゲゼルシャフト | 心血管疾患を治療するための可溶性グアニル酸シクラーゼ（ＳＧＣ）の刺激物質としてのＮ−置換８−［（２，６−ジフルオロベンジル）オキシ］−２，６−ジメチルイミダゾ［１，２−ａ］ピラジン−３−カルボキサミド誘導体 |
| EP3286185A1 (de) | 2015-02-05 | 2018-02-28 | Bayer Pharma Aktiengesellschaft | Substituierte pyrazolo[1,5-a]pyridin-3-carboxamide und ihre verwendung |
| MX2017014057A (es) | 2015-05-06 | 2018-04-10 | Bayer Pharma AG | El uso de estimuladores sgc, activadores gc, solos y combinaciones con inhibidores pde5 para el tratamiento de ulceras digitales (du) concomitante con esclerosis sistemica (ssc). |
| JP6849618B2 (ja) | 2015-07-23 | 2021-03-24 | バイエル・ファルマ・アクティエンゲゼルシャフト | 中性エンドペプチダーゼの阻害剤（ＮＥＰ阻害剤）および／またはアンジオテンシンＩＩ拮抗薬と組み合わせた可溶性グアニル酸シクラーゼ（ｓＧＣ）の刺激薬および／または活性化薬ならびにその使用 |
| US20180344735A1 (en) | 2015-12-14 | 2018-12-06 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF GASTROINTESTINAL SPHINCTER DYSFUNCTION |
| WO2017121692A1 (de) | 2016-01-15 | 2017-07-20 | Bayer Pharma Aktiengesellschaft | Substituierte sulfamide und ihre verwendung |
| WO2017121700A1 (de) | 2016-01-15 | 2017-07-20 | Bayer Pharma Aktiengesellschaft | 1,3-disubstituierte 1h-pyrazolo[3,4-b]pyridin- derivate und ihre verwendung als stimulatoren der löslichen guanylatcyclase |
| WO2017121693A1 (de) | 2016-01-15 | 2017-07-20 | Bayer Pharma Aktiengesellschaft | Substituierte thiazol- und thiadiazolamide und ihre verwendung |
| CN109890379A (zh) | 2016-10-11 | 2019-06-14 | 拜耳制药股份公司 | 包含sGC活化剂和盐皮质激素受体拮抗剂的组合产品 |
| EP3525779B1 (de) | 2016-10-11 | 2024-06-05 | Bayer Pharma Aktiengesellschaft | Kombination enthaltend den sgc stimulator vericuguat und den mineralcorticoid-rezeptor-antagonist finerenone |
| EP3554488A2 (en) | 2016-12-13 | 2019-10-23 | Cyclerion Therapeutics, Inc. | Use of sgc stimulators for the treatment of esophageal motility disorders |
| WO2018184976A1 (de) | 2017-04-05 | 2018-10-11 | Bayer Pharma Aktiengesellschaft | Substituierte imidazo[1,2-a]pyridincarboxamide und ihre verwendung |
| ES2924359T3 (es) | 2017-04-11 | 2022-10-06 | Sunshine Lake Pharma Co Ltd | Compuestos de indazol sustituidos con flúor y usos de los mismos |
| EP3793553A1 (en) | 2018-05-15 | 2021-03-24 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| KR20250141845A (ko) | 2018-07-11 | 2025-09-29 | 티센토 쎄라퓨틱스 인크. | 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도 |
| WO2020164008A1 (en) | 2019-02-13 | 2020-08-20 | Bayer Aktiengesellschaft | Process for the preparation of porous microparticles |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK181190D0 (da) * | 1990-07-30 | 1990-07-30 | Lundbeck & Co As H | 3-aryl-indol- eller 3-aryl-indazolderivater |
| JP2928079B2 (ja) * | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途 |
-
1996
- 1996-10-14 DE DE19642255A patent/DE19642255A1/de not_active Withdrawn
-
1997
- 1997-10-01 NZ NZ335091A patent/NZ335091A/xx unknown
- 1997-10-01 HU HU9903885A patent/HUP9903885A3/hu unknown
- 1997-10-01 WO PCT/EP1997/005381 patent/WO1998016223A1/de not_active Ceased
- 1997-10-01 AT AT97913132T patent/ATE311184T1/de not_active IP Right Cessation
- 1997-10-01 CZ CZ991292A patent/CZ129299A3/cs unknown
- 1997-10-01 US US09/284,032 patent/US6180656B1/en not_active Expired - Fee Related
- 1997-10-01 ID IDW990187D patent/ID22162A/id unknown
- 1997-10-01 ES ES97913132T patent/ES2252777T3/es not_active Expired - Lifetime
- 1997-10-01 CA CA002268314A patent/CA2268314C/en not_active Expired - Fee Related
- 1997-10-01 IL IL12931897A patent/IL129318A/en not_active IP Right Cessation
- 1997-10-01 BR BR9712304-8A patent/BR9712304A/pt not_active Application Discontinuation
- 1997-10-01 SK SK465-99A patent/SK46599A3/sk unknown
- 1997-10-01 TR TR1999/00782T patent/TR199900782T2/xx unknown
- 1997-10-01 DE DE59712501T patent/DE59712501D1/de not_active Expired - Lifetime
- 1997-10-01 JP JP10517966A patent/JP2001502318A/ja active Pending
- 1997-10-01 EE EEP199900156A patent/EE9900156A/xx unknown
- 1997-10-01 EP EP97913132A patent/EP0932403B1/de not_active Expired - Lifetime
- 1997-10-01 AU AU50494/98A patent/AU733967B2/en not_active Ceased
- 1997-10-01 PL PL97332719A patent/PL332719A1/xx unknown
- 1997-10-14 TW TW086115207A patent/TW442482B/zh not_active IP Right Cessation
-
1999
- 1999-04-09 NO NO991685A patent/NO991685L/no not_active Application Discontinuation
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2009
- 2009-02-25 JP JP2009042383A patent/JP2009114205A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW442482B (en) | 2001-06-23 |
| BR9712304A (pt) | 1999-08-31 |
| CA2268314C (en) | 2006-12-12 |
| EP0932403B1 (de) | 2005-11-30 |
| ATE311184T1 (de) | 2005-12-15 |
| HUP9903885A3 (en) | 2000-12-28 |
| AU5049498A (en) | 1998-05-11 |
| CZ129299A3 (cs) | 1999-07-14 |
| US6180656B1 (en) | 2001-01-30 |
| WO1998016223A1 (de) | 1998-04-23 |
| NO991685D0 (no) | 1999-04-09 |
| IL129318A0 (en) | 2000-02-17 |
| NO991685L (no) | 1999-04-09 |
| DE19642255A1 (de) | 1998-04-16 |
| ID22162A (id) | 1999-09-09 |
| TR199900782T2 (xx) | 1999-07-21 |
| EP0932403A1 (de) | 1999-08-04 |
| IL129318A (en) | 2001-06-14 |
| EE9900156A (et) | 1999-12-15 |
| CA2268314A1 (en) | 1998-04-23 |
| HUP9903885A2 (hu) | 2000-11-28 |
| ES2252777T3 (es) | 2006-05-16 |
| JP2001502318A (ja) | 2001-02-20 |
| DE59712501D1 (de) | 2006-01-05 |
| JP2009114205A (ja) | 2009-05-28 |
| PL332719A1 (en) | 1999-10-11 |
| AU733967B2 (en) | 2001-05-31 |
| NZ335091A (en) | 2000-09-29 |
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