SK287768B6 - Spôsob diagnostiky alebo detekcie konformačného ochorenia, testovanie markera konformačného ochorenia, diagnostický kit a zariadenie na vykonávanie tohto spôsobu - Google Patents

Spôsob diagnostiky alebo detekcie konformačného ochorenia, testovanie markera konformačného ochorenia, diagnostický kit a zariadenie na vykonávanie tohto spôsobu Download PDF

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Publication number
SK287768B6
SK287768B6 SK1858-2002A SK18582002A SK287768B6 SK 287768 B6 SK287768 B6 SK 287768B6 SK 18582002 A SK18582002 A SK 18582002A SK 287768 B6 SK287768 B6 SK 287768B6
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SK
Slovakia
Prior art keywords
pathogenic
sample
prp
pathogenic conformer
conformer
Prior art date
Application number
SK1858-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK18582002A3 (sk
Inventor
Jara Claudio Soto
Gabriella Saborio
Original Assignee
Laboratoires Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono Sa filed Critical Laboratoires Serono Sa
Publication of SK18582002A3 publication Critical patent/SK18582002A3/sk
Publication of SK287768B6 publication Critical patent/SK287768B6/sk

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK1858-2002A 2000-07-07 2001-06-13 Spôsob diagnostiky alebo detekcie konformačného ochorenia, testovanie markera konformačného ochorenia, diagnostický kit a zariadenie na vykonávanie tohto spôsobu SK287768B6 (sk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07
PCT/GB2001/002584 WO2002004954A2 (en) 2000-07-07 2001-06-13 Early diagnosis of conformational diseases

Publications (2)

Publication Number Publication Date
SK18582002A3 SK18582002A3 (sk) 2003-05-02
SK287768B6 true SK287768B6 (sk) 2011-09-05

Family

ID=27223071

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1858-2002A SK287768B6 (sk) 2000-07-07 2001-06-13 Spôsob diagnostiky alebo detekcie konformačného ochorenia, testovanie markera konformačného ochorenia, diagnostický kit a zariadenie na vykonávanie tohto spôsobu

Country Status (31)

Country Link
US (1) US7351526B2 (ja)
EP (2) EP1299729B1 (ja)
JP (1) JP4790966B2 (ja)
KR (1) KR100764981B1 (ja)
CN (1) CN1221807C (ja)
AR (1) AR029583A1 (ja)
AT (2) ATE426816T1 (ja)
AU (2) AU6408901A (ja)
BG (1) BG66272B1 (ja)
BR (1) BRPI0112262B8 (ja)
CA (1) CA2413078C (ja)
CY (1) CY1109106T1 (ja)
CZ (1) CZ304365B6 (ja)
DE (2) DE60138146D1 (ja)
DK (2) DK1712920T3 (ja)
EA (1) EA007391B1 (ja)
EE (1) EE05675B1 (ja)
ES (2) ES2264691T3 (ja)
HK (1) HK1058065A1 (ja)
HR (1) HRP20030033B1 (ja)
HU (1) HU228813B1 (ja)
IL (2) IL153824A0 (ja)
MX (1) MXPA03000226A (ja)
NO (1) NO331624B1 (ja)
NZ (1) NZ523213A (ja)
PL (1) PL211154B1 (ja)
PT (2) PT1712920E (ja)
RS (1) RS51523B (ja)
SI (2) SI1712920T1 (ja)
SK (1) SK287768B6 (ja)
WO (1) WO2002004954A2 (ja)

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EP1373904A1 (de) * 2001-03-13 2004-01-02 Eigen, Manfred, Prof. Dr. Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
JP4235544B2 (ja) * 2001-05-31 2009-03-11 アドライフ インコーポレーティッド 欠陥折畳み蛋白質センサー方法
CA2525517C (en) 2003-06-19 2016-05-31 Applied Research Systems Ars Holding N.V. Use of prion conversion modulating agents
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
WO2005010533A2 (en) * 2003-07-31 2005-02-03 Hadasit Medical Research Services & Development Ltd. Methods and kits for the detection of prion diseases
NZ545385A (en) 2003-08-13 2010-12-24 Novartis Vaccines & Diagnostic Prion-specific peptide reagents
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
JP5048522B2 (ja) * 2005-02-15 2012-10-17 エイディーライフ インコーポレイティッド 誤って折り畳まれたタンパク質およびプリオンを検出する方法
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification
EP1731911A1 (fr) * 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé utile pour la détection d'encéphalopathies
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
AU2006287299B2 (en) 2005-09-09 2012-08-23 Novartis Ag Prion-specific peptoid reagents
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
MX2009001079A (es) * 2006-07-28 2009-02-10 Adlyfe Inc Sondas de peptido para diagnosis y terapeutica.
US20080118938A1 (en) * 2006-09-06 2008-05-22 Lisbell Estrada Methods and Compositions for the Detection of Protein Folding Disorders
US8216788B2 (en) 2007-07-20 2012-07-10 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Detection of infectious prion protein by seeded conversion of recombinant prion protein
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
WO2009145195A1 (ja) 2008-05-28 2009-12-03 独立行政法人農業・食品産業技術総合研究機構 Ｂｓｅ由来異常プリオン蛋白質の効率的増幅方法
JP5209711B2 (ja) 2008-05-28 2013-06-12 独立行政法人農業・食品産業技術総合研究機構 羊スクレイピー由来異常プリオン蛋白質の効率的増幅方法
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
EP2496947A1 (en) * 2009-11-04 2012-09-12 Novartis AG Positively charged species as binding reagents in the separation of protein aggregates from monomers
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
US10989718B2 (en) 2014-09-11 2021-04-27 Amprion, Inc. Detection of misfolded alpha synuclein protein
US9910049B2 (en) 2014-09-11 2018-03-06 Amprion, Inc. Detection of misfolded amyloid beta protein
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
US20130288389A1 (en) * 2011-01-18 2013-10-31 Prionics Ag Methods for amplification and detection of prions
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (en) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) A method for diagnosing tse
KR101483438B1 (ko) * 2014-04-17 2015-01-16 한림대학교 산학협력단 극미량 병원성 프리온 단백질 검출방법 및 장치
HRP20231232T1 (hr) 2014-09-11 2024-01-19 Board Of Regents Of The University Of Texas System Otkrivanje pogrešno savijenih proteina
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
MX2019013589A (es) 2017-05-16 2020-07-20 Claudio Soto Jara Deteccion de proteina tau con plegamiento incorrecto.
US20190353669A1 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of Brain Injury or Neurological Disease using Tau Protein
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (en) * 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample

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US5262332A (en) * 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
NZ335290A (en) * 1996-10-15 2001-08-31 D Gen Ltd Diagnosis an typing of spongiform encephalopathy (or bovine spongiform encephalopathy (BSE))
AU5778400A (en) 1999-06-29 2001-01-31 Caprion Pharmaceuticals, Inc. Prion protein binding proteins and uses thereof
JP2003517848A (ja) * 1999-12-10 2003-06-03 ミソニクス インコーポレイテッド 超音波角アッセンブリ
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification

Also Published As

Publication number Publication date
CZ304365B6 (cs) 2014-04-02
EE05675B1 (et) 2013-08-15
BG66272B1 (bg) 2012-11-30
IL153824A0 (en) 2003-07-31
IL153824A (en) 2010-02-17
BRPI0112262B8 (pt) 2021-07-27
US20050064505A1 (en) 2005-03-24
ATE335204T1 (de) 2006-08-15
WO2002004954A2 (en) 2002-01-17
EA007391B1 (ru) 2006-10-27
NO20030059L (no) 2003-03-07
SI1299729T1 (sl) 2006-10-31
AU2001264089B2 (en) 2006-03-30
HRP20030033A2 (en) 2004-02-29
EP1712920B1 (en) 2009-03-25
SK18582002A3 (sk) 2003-05-02
HUP0301020A2 (hu) 2003-07-28
SI1712920T1 (sl) 2009-10-31
DE60121958D1 (de) 2006-09-14
EP1299729A2 (en) 2003-04-09
HK1058065A1 (en) 2004-04-30
CN1449497A (zh) 2003-10-15
DK1299729T3 (da) 2006-12-04
WO2002004954A3 (en) 2002-10-24
CA2413078C (en) 2010-08-03
HU228813B1 (en) 2013-05-28
HUP0301020A3 (en) 2010-03-29
AR029583A1 (es) 2003-07-02
DE60138146D1 (de) 2009-05-07
CZ200336A3 (cs) 2003-06-18
CN1221807C (zh) 2005-10-05
RS51523B (sr) 2011-06-30
PT1299729E (pt) 2006-10-31
ATE426816T1 (de) 2009-04-15
MXPA03000226A (es) 2004-05-21
HRP20030033B1 (en) 2008-04-30
DK1712920T3 (da) 2009-05-11
DE60121958T2 (de) 2007-02-01
CY1109106T1 (el) 2014-07-02
KR20030036257A (ko) 2003-05-09
JP4790966B2 (ja) 2011-10-12
YU101202A (sh) 2006-01-16
NO20030059D0 (no) 2003-01-06
CA2413078A1 (en) 2002-01-17
PT1712920E (pt) 2009-04-09
EP1712920A1 (en) 2006-10-18
JP2004503748A (ja) 2004-02-05
PL360397A1 (en) 2004-09-06
ES2322660T3 (es) 2009-06-24
AU6408901A (en) 2002-01-21
NO331624B1 (no) 2012-02-06
EP1299729B1 (en) 2006-08-02
BR0112262A (pt) 2003-05-20
ES2264691T3 (es) 2007-01-16
US7351526B2 (en) 2008-04-01
BRPI0112262B1 (pt) 2016-08-09
KR100764981B1 (ko) 2007-10-09
NZ523213A (en) 2005-01-28
PL211154B1 (pl) 2012-04-30
EE200300005A (et) 2004-08-16
BG107498A (bg) 2003-11-28
EA200300126A1 (ru) 2003-06-26

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Legal Events

Date Code Title Description
TC4A Change of owner's name

Owner name: MERCK SERONO SA, COINSINS, VAUD, CH

Effective date: 20120709

MK4A Expiry of patent

Expiry date: 20210613