MX2019013589A - Deteccion de proteina tau con plegamiento incorrecto. - Google Patents

Deteccion de proteina tau con plegamiento incorrecto.

Info

Publication number
MX2019013589A
MX2019013589A MX2019013589A MX2019013589A MX2019013589A MX 2019013589 A MX2019013589 A MX 2019013589A MX 2019013589 A MX2019013589 A MX 2019013589A MX 2019013589 A MX2019013589 A MX 2019013589A MX 2019013589 A MX2019013589 A MX 2019013589A
Authority
MX
Mexico
Prior art keywords
tau protein
detection
misfolded tau
misfolded
tauopathies
Prior art date
Application number
MX2019013589A
Other languages
English (en)
Inventor
Russell M Lebovitz
Mohammad Shahnawaz
Claudio Soto-Jara
Benedikt K Vollrath
Nicolas Mendez Dinamarca
Original Assignee
Claudio Soto Jara
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Claudio Soto Jara filed Critical Claudio Soto Jara
Publication of MX2019013589A publication Critical patent/MX2019013589A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se proporcionan métodos y kits para amplificar y detectar la proteína tau con plegamiento incorrecto de muestras, por ejemplo, de pacientes que tienen tauopatías tales como la Enfermedad de Alzheimer, la Parálisis Supranuclear Progresiva y similares.
MX2019013589A 2017-05-16 2018-05-16 Deteccion de proteina tau con plegamiento incorrecto. MX2019013589A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762507166P 2017-05-16 2017-05-16
PCT/US2018/032962 WO2018213440A1 (en) 2017-05-16 2018-05-16 Detection of misfolded tau protein

Publications (1)

Publication Number Publication Date
MX2019013589A true MX2019013589A (es) 2020-07-20

Family

ID=64271488

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019013589A MX2019013589A (es) 2017-05-16 2018-05-16 Deteccion de proteina tau con plegamiento incorrecto.

Country Status (12)

Country Link
US (2) US11249092B2 (es)
EP (1) EP3635393A4 (es)
JP (1) JP7308154B2 (es)
KR (1) KR20200007945A (es)
CN (1) CN110869763B (es)
AU (1) AU2018268839A1 (es)
BR (1) BR112019024138A2 (es)
CA (1) CA3062876A1 (es)
MX (1) MX2019013589A (es)
PH (1) PH12019550236A1 (es)
TW (1) TW201901153A (es)
WO (1) WO2018213440A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10989718B2 (en) 2014-09-11 2021-04-27 Amprion, Inc. Detection of misfolded alpha synuclein protein
GB201720975D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Anti-alpha synuclein antibodies
GB201720970D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Antibodies
WO2021198098A1 (en) 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample
CN112881707B (zh) * 2021-01-15 2022-06-17 温州医科大学 一种总蛋白刚果红染色作为内参标准的免疫印迹定量检测方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE05675B1 (et) 2000-07-07 2013-08-15 Applied Research Systems Ars Holding N.V. Meetod konformse haiguse diagnoosimiseks v?i tuvastamiseks, selleks vajalik katsemenetlus, reaktiivikomplekt ning seade
GB0203446D0 (en) 2002-02-14 2002-04-03 Univ Lancaster Detection and/or monitoring of synuclein-related diseases
US20060263767A1 (en) 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification
US20070218491A1 (en) * 2006-02-08 2007-09-20 Oligomerix, Inc. Oligomerization of amyloid proteins
US20080118938A1 (en) 2006-09-06 2008-05-22 Lisbell Estrada Methods and Compositions for the Detection of Protein Folding Disorders
US20090163594A1 (en) 2007-10-31 2009-06-25 Elan Pharmaceuticals, Inc. Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors
JP2013511734A (ja) 2009-11-24 2013-04-04 プロビオドルグ エージー アルツハイマー病又は軽度認知障害の診断のための新規診断方法
WO2011104696A1 (en) 2010-02-26 2011-09-01 Bioarctic Neuroscience Ab Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other alpha-synucleinopathies
US9910049B2 (en) 2014-09-11 2018-03-06 Amprion, Inc. Detection of misfolded amyloid beta protein
US10989718B2 (en) 2014-09-11 2021-04-27 Amprion, Inc. Detection of misfolded alpha synuclein protein
US20130289022A1 (en) 2010-11-05 2013-10-31 Brandeis University Tetrameric alpha-synuclein and use thereof
WO2013051266A1 (ja) 2011-10-03 2013-04-11 独立行政法人国立長寿医療研究センター タウ凝集阻害剤
CA2881189A1 (en) 2012-08-07 2014-02-13 Buck Institute For Research On Aging Multi-component formulation for improving neurological function
US9910048B2 (en) 2012-12-03 2018-03-06 Washington University Method for detection of aggregates in biological samples
KR20140128229A (ko) * 2013-04-26 2014-11-05 한국과학기술연구원 체내 단백질 응집체의 용해를 이용한 단백질의 비정상적인 응집 또는 미스폴딩과 관련된 질환 또는 질병을 진단하는 혈액진단키트
EP2963421A1 (en) 2014-07-01 2016-01-06 SeNostic GmbH Process for diagnosis of neurodegenerative diseases
HRP20231232T1 (hr) * 2014-09-11 2024-01-19 Board Of Regents Of The University Of Texas System Otkrivanje pogrešno savijenih proteina
WO2016123401A1 (en) 2015-01-28 2016-08-04 University Of Delaware Detection of disease-associated tau protein conformations and applications thereof

Also Published As

Publication number Publication date
PH12019550236A1 (en) 2020-07-13
CA3062876A1 (en) 2018-11-22
US11249092B2 (en) 2022-02-15
CN110869763B (zh) 2022-07-29
US20220137073A1 (en) 2022-05-05
WO2018213440A1 (en) 2018-11-22
EP3635393A1 (en) 2020-04-15
CN110869763A (zh) 2020-03-06
EP3635393A4 (en) 2021-03-10
JP2020523556A (ja) 2020-08-06
KR20200007945A (ko) 2020-01-22
US20180335438A1 (en) 2018-11-22
TW201901153A (zh) 2019-01-01
BR112019024138A2 (pt) 2020-06-02
JP7308154B2 (ja) 2023-07-13
AU2018268839A1 (en) 2020-01-02

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