SK287356B6 - Spôsob desorpcie epothilónov - Google Patents

Spôsob desorpcie epothilónov Download PDF

Info

Publication number
SK287356B6
SK287356B6 SK689-2003A SK6892003A SK287356B6 SK 287356 B6 SK287356 B6 SK 287356B6 SK 6892003 A SK6892003 A SK 6892003A SK 287356 B6 SK287356 B6 SK 287356B6
Authority
SK
Slovakia
Prior art keywords
epothilones
mixture
epothilone
group
resin
Prior art date
Application number
SK689-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK6892003A3 (en
Inventor
Ernst Ksters
Heinz Untern�Hrer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SK6892003A3 publication Critical patent/SK6892003A3/sk
Publication of SK287356B6 publication Critical patent/SK287356B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Silicon Polymers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
SK689-2003A 2000-12-07 2001-12-05 Spôsob desorpcie epothilónov SK287356B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0029895.0A GB0029895D0 (en) 2000-12-07 2000-12-07 Organic compounds
PCT/EP2001/014771 WO2002046196A1 (en) 2000-12-07 2001-12-05 Process for the isolation and purification of epothilones

Publications (2)

Publication Number Publication Date
SK6892003A3 SK6892003A3 (en) 2004-01-08
SK287356B6 true SK287356B6 (sk) 2010-08-09

Family

ID=9904660

Family Applications (1)

Application Number Title Priority Date Filing Date
SK689-2003A SK287356B6 (sk) 2000-12-07 2001-12-05 Spôsob desorpcie epothilónov

Country Status (32)

Country Link
US (2) US6946561B2 (pt)
EP (1) EP1345944B1 (pt)
JP (1) JP4287650B2 (pt)
KR (1) KR100894990B1 (pt)
CN (1) CN1263761C (pt)
AR (1) AR031902A1 (pt)
AT (1) ATE292132T1 (pt)
AU (2) AU2002224936B2 (pt)
BR (1) BR0115991A (pt)
CA (1) CA2433414C (pt)
CZ (1) CZ301664B6 (pt)
DE (1) DE60109814T2 (pt)
DK (1) DK1345944T3 (pt)
EC (1) ECSP034641A (pt)
ES (1) ES2239687T3 (pt)
GB (1) GB0029895D0 (pt)
HK (1) HK1059618A1 (pt)
HU (1) HU224910B1 (pt)
IL (2) IL156088A0 (pt)
MX (1) MXPA03005097A (pt)
MY (1) MY128409A (pt)
NO (1) NO329164B1 (pt)
NZ (1) NZ526197A (pt)
PE (1) PE20020568A1 (pt)
PL (1) PL209406B1 (pt)
PT (1) PT1345944E (pt)
RU (1) RU2285007C2 (pt)
SI (1) SI1345944T1 (pt)
SK (1) SK287356B6 (pt)
TW (1) TWI286137B (pt)
WO (1) WO2002046196A1 (pt)
ZA (1) ZA200304296B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP1386922B1 (en) * 1996-12-03 2012-04-11 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereof, analogues and uses thereof
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
WO2004018478A2 (en) * 2002-08-23 2004-03-04 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
TWI291464B (en) * 2002-09-23 2007-12-21 Bristol Myers Squibb Co Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B
FR2846520B1 (fr) 2002-11-06 2006-09-29 Roquette Freres Utilisation de maltodextrines branchees comme liants de granulation
KR100681811B1 (ko) * 2005-03-15 2007-02-12 성균관대학교산학협력단 생물학적 대사부산물의 효율적인 제거를 통한 유용 이차대사산물의 제조방법
BRPI0715963A2 (pt) 2006-08-16 2013-08-06 Novartis Ag compostos orgÂnicos
WO2009100571A1 (zh) 2008-02-01 2009-08-20 Zhejiang Hisun Pharmaceutical Co., Ltd. 一种分离和提纯埃博霉素的方法
AU2011255647A1 (en) 2010-05-18 2012-11-15 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
KR101372563B1 (ko) * 2011-12-26 2014-03-14 주식회사 삼양바이오팜 에포틸론 함유물질로부터 에포틸론 ａ와 ｂ의 추출 및 정제 방법
CN110964029B (zh) * 2019-12-19 2020-11-03 鲁南制药集团股份有限公司 一种埃博霉素b发酵液的预处理方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) * 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
HU229833B1 (en) * 1996-11-18 2014-09-29 Biotechnolog Forschung Gmbh Epothilone d production process, and its use as cytostatic as well as phytosanitary agents
DE59805727D1 (de) * 1997-07-16 2002-10-31 Schering Ag Thiazolderivate, verfahren zur herstellung und verwendung
US6365749B1 (en) * 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
EP1320611B1 (en) * 2000-04-28 2005-11-09 Kosan Biosciences, Inc. Heterologous production of polyketides
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
US20050288514A1 (en) 2005-12-29
US7569698B2 (en) 2009-08-04
US20040054188A1 (en) 2004-03-18
DE60109814T2 (de) 2006-02-16
RU2285007C2 (ru) 2006-10-10
CZ301664B6 (cs) 2010-05-19
ES2239687T3 (es) 2005-10-01
PT1345944E (pt) 2005-08-31
SK6892003A3 (en) 2004-01-08
DE60109814D1 (de) 2005-05-04
BR0115991A (pt) 2004-01-13
HK1059618A1 (en) 2004-07-09
NO20032591L (no) 2003-06-06
CA2433414A1 (en) 2002-06-13
AR031902A1 (es) 2003-10-08
TWI286137B (en) 2007-09-01
PL209406B1 (pl) 2011-08-31
JP4287650B2 (ja) 2009-07-01
ATE292132T1 (de) 2005-04-15
IL156088A0 (en) 2003-12-23
NZ526197A (en) 2005-01-28
ZA200304296B (en) 2004-04-23
CA2433414C (en) 2011-01-25
PL361884A1 (en) 2004-10-04
HUP0302579A2 (hu) 2003-11-28
CN1479741A (zh) 2004-03-03
US6946561B2 (en) 2005-09-20
ECSP034641A (es) 2003-07-25
HU224910B1 (en) 2006-04-28
PE20020568A1 (es) 2002-07-22
KR20030053535A (ko) 2003-06-28
NO329164B1 (no) 2010-09-06
NO20032591D0 (no) 2003-06-06
AU2493602A (en) 2002-06-18
MXPA03005097A (es) 2003-09-05
EP1345944A1 (en) 2003-09-24
JP2004521879A (ja) 2004-07-22
HUP0302579A3 (en) 2004-10-28
CN1263761C (zh) 2006-07-12
CZ20031565A3 (cs) 2003-10-15
MY128409A (en) 2007-01-31
WO2002046196A1 (en) 2002-06-13
DK1345944T3 (da) 2005-05-30
SI1345944T1 (sl) 2005-12-31
IL156088A (en) 2008-08-07
AU2002224936B2 (en) 2005-09-22
KR100894990B1 (ko) 2009-04-24
EP1345944B1 (en) 2005-03-30
GB0029895D0 (en) 2001-01-24

Similar Documents

Publication Publication Date Title
US7569698B2 (en) Process for the isolation and purification of epothilones
KR101173510B1 (ko) 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도
AU2002224936A1 (en) Process for the isolation and purification of epothilones
RU2009122202A (ru) Чистая форма рапамицина и способ ее выделения и очистки
AU760242B2 (en) Method for high yield extraction of paclitaxel from paclitaxel-containing material
KR20020002476A (ko) 결정질 에키노칸딘 암모늄염의 형성 및 음이온 교환
WO2009100571A1 (zh) 一种分离和提纯埃博霉素的方法
CA2733837C (en) Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
KR100859670B1 (ko) 타크로리무스를 고수율 및 고순도로 정제하는 방법
KR101372563B1 (ko) 에포틸론 함유물질로부터 에포틸론 ａ와 ｂ의 추출 및 정제 방법
US8193345B2 (en) Purification method of lactone compounds containing unsaturated alkyl group by extraction with silver ion solution
EP2297109A1 (en) A process for isolation and purification of geldanamycin
JPS638759B2 (pt)

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20131205