HK1059618A1 - Process for the isolation and purification of epothilones. - Google Patents

Process for the isolation and purification of epothilones.

Info

Publication number
HK1059618A1
HK1059618A1 HK04100923A HK04100923A HK1059618A1 HK 1059618 A1 HK1059618 A1 HK 1059618A1 HK 04100923 A HK04100923 A HK 04100923A HK 04100923 A HK04100923 A HK 04100923A HK 1059618 A1 HK1059618 A1 HK 1059618A1
Authority
HK
Hong Kong
Prior art keywords
epothilones
isolation
purification
Prior art date
Application number
HK04100923A
Other languages
English (en)
Inventor
Ernst Kusters
Heinz Unternahrer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1059618A1 publication Critical patent/HK1059618A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Silicon Polymers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK04100923A 2000-12-07 2004-02-11 Process for the isolation and purification of epothilones. HK1059618A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0029895.0A GB0029895D0 (en) 2000-12-07 2000-12-07 Organic compounds
PCT/EP2001/014771 WO2002046196A1 (en) 2000-12-07 2001-12-05 Process for the isolation and purification of epothilones

Publications (1)

Publication Number Publication Date
HK1059618A1 true HK1059618A1 (en) 2004-07-09

Family

ID=9904660

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04100923A HK1059618A1 (en) 2000-12-07 2004-02-11 Process for the isolation and purification of epothilones.

Country Status (32)

Country Link
US (2) US6946561B2 (pt)
EP (1) EP1345944B1 (pt)
JP (1) JP4287650B2 (pt)
KR (1) KR100894990B1 (pt)
CN (1) CN1263761C (pt)
AR (1) AR031902A1 (pt)
AT (1) ATE292132T1 (pt)
AU (2) AU2493602A (pt)
BR (1) BR0115991A (pt)
CA (1) CA2433414C (pt)
CZ (1) CZ301664B6 (pt)
DE (1) DE60109814T2 (pt)
DK (1) DK1345944T3 (pt)
EC (1) ECSP034641A (pt)
ES (1) ES2239687T3 (pt)
GB (1) GB0029895D0 (pt)
HK (1) HK1059618A1 (pt)
HU (1) HU224910B1 (pt)
IL (2) IL156088A0 (pt)
MX (1) MXPA03005097A (pt)
MY (1) MY128409A (pt)
NO (1) NO329164B1 (pt)
NZ (1) NZ526197A (pt)
PE (1) PE20020568A1 (pt)
PL (1) PL209406B1 (pt)
PT (1) PT1345944E (pt)
RU (1) RU2285007C2 (pt)
SI (1) SI1345944T1 (pt)
SK (1) SK287356B6 (pt)
TW (1) TWI286137B (pt)
WO (1) WO2002046196A1 (pt)
ZA (1) ZA200304296B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
JP4579351B2 (ja) * 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
DK1767535T3 (da) * 2002-08-23 2010-04-12 Sloan Kettering Inst Cancer Syntese af epothiloner, mellemprodukter deraf, analoge og deres anvendelse
MXPA05003006A (es) * 2002-09-23 2005-06-22 Squibb Bristol Myers Co Metodos para la preparacion, aislamiento y purificacion de epotilona b y estructuras cristalinas de rayos x y de epotilona b.
FR2846520B1 (fr) 2002-11-06 2006-09-29 Roquette Freres Utilisation de maltodextrines branchees comme liants de granulation
KR100681811B1 (ko) * 2005-03-15 2007-02-12 성균관대학교산학협력단 생물학적 대사부산물의 효율적인 제거를 통한 유용 이차대사산물의 제조방법
NZ574194A (en) 2006-08-16 2011-12-22 Novartis Ag Crystal form of epothilone b and use in pharmaceutical compositions
US8906947B2 (en) 2008-02-01 2014-12-09 Zhejiang Hisun Pharmaceutical Co., Ltd. Method for the separation and purification of epothilones
CN105797168A (zh) 2010-05-18 2016-07-27 天蓝制药公司 用于治疗自身免疫性疾病或其它疾病的组合物和方法
KR101372563B1 (ko) * 2011-12-26 2014-03-14 주식회사 삼양바이오팜 에포틸론 함유물질로부터 에포틸론 ａ와 ｂ의 추출 및 정제 방법
CN110964029B (zh) * 2019-12-19 2020-11-03 鲁南制药集团股份有限公司 一种埃博霉素b发酵液的预处理方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) * 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
EP1367057B1 (de) * 1996-11-18 2008-09-17 Gesellschaft für biotechnologische Forschung mbH (GBF) Epothilone E und F
ATE224882T1 (de) * 1997-07-16 2002-10-15 Schering Ag Thiazolderivate, verfahren zur herstellung und verwendung
US6365749B1 (en) * 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
EP1652926B1 (en) * 2000-04-28 2009-09-30 Kosan Biosciences, Inc. Crystalline epothilone d
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
ZA200304296B (en) 2004-04-23
GB0029895D0 (en) 2001-01-24
PE20020568A1 (es) 2002-07-22
PT1345944E (pt) 2005-08-31
WO2002046196A1 (en) 2002-06-13
JP4287650B2 (ja) 2009-07-01
MY128409A (en) 2007-01-31
MXPA03005097A (es) 2003-09-05
JP2004521879A (ja) 2004-07-22
CZ20031565A3 (cs) 2003-10-15
AU2002224936B2 (en) 2005-09-22
PL361884A1 (en) 2004-10-04
HUP0302579A3 (en) 2004-10-28
IL156088A (en) 2008-08-07
SK6892003A3 (en) 2004-01-08
KR20030053535A (ko) 2003-06-28
NZ526197A (en) 2005-01-28
AU2493602A (en) 2002-06-18
NO329164B1 (no) 2010-09-06
CN1479741A (zh) 2004-03-03
US20040054188A1 (en) 2004-03-18
NO20032591D0 (no) 2003-06-06
CZ301664B6 (cs) 2010-05-19
US20050288514A1 (en) 2005-12-29
EP1345944B1 (en) 2005-03-30
KR100894990B1 (ko) 2009-04-24
ES2239687T3 (es) 2005-10-01
SK287356B6 (sk) 2010-08-09
DE60109814D1 (de) 2005-05-04
EP1345944A1 (en) 2003-09-24
AR031902A1 (es) 2003-10-08
DE60109814T2 (de) 2006-02-16
RU2285007C2 (ru) 2006-10-10
CN1263761C (zh) 2006-07-12
US7569698B2 (en) 2009-08-04
IL156088A0 (en) 2003-12-23
BR0115991A (pt) 2004-01-13
CA2433414C (en) 2011-01-25
ECSP034641A (es) 2003-07-25
CA2433414A1 (en) 2002-06-13
NO20032591L (no) 2003-06-06
PL209406B1 (pl) 2011-08-31
ATE292132T1 (de) 2005-04-15
HU224910B1 (en) 2006-04-28
US6946561B2 (en) 2005-09-20
SI1345944T1 (sl) 2005-12-31
DK1345944T3 (da) 2005-05-30
HUP0302579A2 (hu) 2003-11-28
TWI286137B (en) 2007-09-01

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20131205