ECSP034641A - Proceso para el aislamiento y purificacion de epotilonas - Google Patents

Proceso para el aislamiento y purificacion de epotilonas

Info

Publication number
ECSP034641A
ECSP034641A EC2003004641A ECSP034641A ECSP034641A EC SP034641 A ECSP034641 A EC SP034641A EC 2003004641 A EC2003004641 A EC 2003004641A EC SP034641 A ECSP034641 A EC SP034641A EC SP034641 A ECSP034641 A EC SP034641A
Authority
EC
Ecuador
Prior art keywords
purification
epotilones
insulation
epothilones
resins
Prior art date
Application number
EC2003004641A
Other languages
English (en)
Inventor
Ernst Kuesters
Heinz Unternaehrer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP034641A publication Critical patent/ECSP034641A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Silicon Polymers (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

La invención se refiere a un proceso de desorción para epotilonas, en especial epotilona Ay/o epotilona B, a partir de resinas, y a nuevos procesos de producción procesamiento o purificación o a métodos de fabricación para epotilonas que comprenden dicho proceso de desorción, así como al uso de ciertos solventes para la desorción de epotilonas a partir de resinas.
EC2003004641A 2000-12-07 2003-06-03 Proceso para el aislamiento y purificacion de epotilonas ECSP034641A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0029895.0A GB0029895D0 (en) 2000-12-07 2000-12-07 Organic compounds

Publications (1)

Publication Number Publication Date
ECSP034641A true ECSP034641A (es) 2003-07-25

Family

ID=9904660

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004641A ECSP034641A (es) 2000-12-07 2003-06-03 Proceso para el aislamiento y purificacion de epotilonas

Country Status (31)

Country Link
US (2) US6946561B2 (es)
EP (1) EP1345944B1 (es)
JP (1) JP4287650B2 (es)
KR (1) KR100894990B1 (es)
CN (1) CN1263761C (es)
AR (1) AR031902A1 (es)
AT (1) ATE292132T1 (es)
AU (2) AU2002224936B2 (es)
BR (1) BR0115991A (es)
CA (1) CA2433414C (es)
CZ (1) CZ301664B6 (es)
DE (1) DE60109814T2 (es)
DK (1) DK1345944T3 (es)
EC (1) ECSP034641A (es)
ES (1) ES2239687T3 (es)
GB (1) GB0029895D0 (es)
HU (1) HU224910B1 (es)
IL (2) IL156088A0 (es)
MX (1) MXPA03005097A (es)
MY (1) MY128409A (es)
NO (1) NO329164B1 (es)
NZ (1) NZ526197A (es)
PE (1) PE20020568A1 (es)
PL (1) PL209406B1 (es)
PT (1) PT1345944E (es)
RU (1) RU2285007C2 (es)
SI (1) SI1345944T1 (es)
SK (1) SK287356B6 (es)
TW (1) TWI286137B (es)
WO (1) WO2002046196A1 (es)
ZA (1) ZA200304296B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
NZ538522A (en) * 2002-08-23 2008-03-28 Sloan Kettering Inst Cancer Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
TWI291464B (en) * 2002-09-23 2007-12-21 Bristol Myers Squibb Co Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B
FR2846520B1 (fr) 2002-11-06 2006-09-29 Roquette Freres Utilisation de maltodextrines branchees comme liants de granulation
KR100681811B1 (ko) * 2005-03-15 2007-02-12 성균관대학교산학협력단 생물학적 대사부산물의 효율적인 제거를 통한 유용 이차대사산물의 제조방법
MY148355A (en) 2006-08-16 2013-03-29 Novartis Ag Crystal form of epothilone b and use in pharmaceutical compositions
WO2009100571A1 (zh) 2008-02-01 2009-08-20 Zhejiang Hisun Pharmaceutical Co., Ltd. 一种分离和提纯埃博霉素的方法
US20110300150A1 (en) 2010-05-18 2011-12-08 Scott Eliasof Compositions and methods for treatment of autoimmune and other disease
KR101372563B1 (ko) 2011-12-26 2014-03-14 주식회사 삼양바이오팜 에포틸론 함유물질로부터 에포틸론 ａ와 ｂ의 추출 및 정제 방법
CN110964029B (zh) * 2019-12-19 2020-11-03 鲁南制药集团股份有限公司 一种埃博霉素b发酵液的预处理方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) * 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
AU716610B2 (en) * 1996-08-30 2000-03-02 Novartis Ag Method for producing epothilones, and intermediate products obtained during the production process
WO1998022461A1 (de) 1996-11-18 1998-05-28 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Epothilone c, d, e und f, deren herstellung und deren verwendung als cytostatische mittel bzw. als pflanzenschutzmittel
DK1001951T3 (da) * 1997-07-16 2002-12-23 Schering Ag Thiazolderivater, fremgangsmåde til fremstilling deraf og anvendelse af disse
US6365749B1 (en) * 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
ATE444368T1 (de) * 2000-04-28 2009-10-15 Kosan Biosciences Inc Kristallines epothilon d
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
TWI286137B (en) 2007-09-01
SK6892003A3 (en) 2004-01-08
KR100894990B1 (ko) 2009-04-24
CN1479741A (zh) 2004-03-03
IL156088A (en) 2008-08-07
PL361884A1 (en) 2004-10-04
MXPA03005097A (es) 2003-09-05
AU2493602A (en) 2002-06-18
DE60109814T2 (de) 2006-02-16
NO329164B1 (no) 2010-09-06
CN1263761C (zh) 2006-07-12
KR20030053535A (ko) 2003-06-28
EP1345944B1 (en) 2005-03-30
AR031902A1 (es) 2003-10-08
US6946561B2 (en) 2005-09-20
NZ526197A (en) 2005-01-28
ATE292132T1 (de) 2005-04-15
MY128409A (en) 2007-01-31
BR0115991A (pt) 2004-01-13
ZA200304296B (en) 2004-04-23
NO20032591D0 (no) 2003-06-06
CA2433414A1 (en) 2002-06-13
HU224910B1 (en) 2006-04-28
CA2433414C (en) 2011-01-25
ES2239687T3 (es) 2005-10-01
SI1345944T1 (sl) 2005-12-31
EP1345944A1 (en) 2003-09-24
JP2004521879A (ja) 2004-07-22
NO20032591L (no) 2003-06-06
US20050288514A1 (en) 2005-12-29
CZ301664B6 (cs) 2010-05-19
US20040054188A1 (en) 2004-03-18
IL156088A0 (en) 2003-12-23
DE60109814D1 (de) 2005-05-04
WO2002046196A1 (en) 2002-06-13
RU2285007C2 (ru) 2006-10-10
PE20020568A1 (es) 2002-07-22
SK287356B6 (sk) 2010-08-09
CZ20031565A3 (cs) 2003-10-15
HUP0302579A2 (hu) 2003-11-28
PT1345944E (pt) 2005-08-31
AU2002224936B2 (en) 2005-09-22
US7569698B2 (en) 2009-08-04
JP4287650B2 (ja) 2009-07-01
PL209406B1 (pl) 2011-08-31
HK1059618A1 (en) 2004-07-09
HUP0302579A3 (en) 2004-10-28
DK1345944T3 (da) 2005-05-30
GB0029895D0 (en) 2001-01-24

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