ECSP034641A - Proceso para el aislamiento y purificacion de epotilonas - Google Patents

Proceso para el aislamiento y purificacion de epotilonas

Info

Publication number
ECSP034641A
ECSP034641A EC2003004641A ECSP034641A ECSP034641A EC SP034641 A ECSP034641 A EC SP034641A EC 2003004641 A EC2003004641 A EC 2003004641A EC SP034641 A ECSP034641 A EC SP034641A EC SP034641 A ECSP034641 A EC SP034641A
Authority
EC
Ecuador
Prior art keywords
purification
epotilones
insulation
epothilones
resins
Prior art date
Application number
EC2003004641A
Other languages
English (en)
Inventor
Ernst Kuesters
Heinz Unternaehrer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP034641A publication Critical patent/ECSP034641A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Silicon Polymers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

La invención se refiere a un proceso de desorción para epotilonas, en especial epotilona Ay/o epotilona B, a partir de resinas, y a nuevos procesos de producción procesamiento o purificación o a métodos de fabricación para epotilonas que comprenden dicho proceso de desorción, así como al uso de ciertos solventes para la desorción de epotilonas a partir de resinas.
EC2003004641A 2000-12-07 2003-06-03 Proceso para el aislamiento y purificacion de epotilonas ECSP034641A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0029895.0A GB0029895D0 (en) 2000-12-07 2000-12-07 Organic compounds

Publications (1)

Publication Number Publication Date
ECSP034641A true ECSP034641A (es) 2003-07-25

Family

ID=9904660

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004641A ECSP034641A (es) 2000-12-07 2003-06-03 Proceso para el aislamiento y purificacion de epotilonas

Country Status (31)

Country Link
US (2) US6946561B2 (es)
EP (1) EP1345944B1 (es)
JP (1) JP4287650B2 (es)
KR (1) KR100894990B1 (es)
CN (1) CN1263761C (es)
AR (1) AR031902A1 (es)
AT (1) ATE292132T1 (es)
AU (2) AU2002224936B2 (es)
BR (1) BR0115991A (es)
CA (1) CA2433414C (es)
CZ (1) CZ301664B6 (es)
DE (1) DE60109814T2 (es)
DK (1) DK1345944T3 (es)
EC (1) ECSP034641A (es)
ES (1) ES2239687T3 (es)
GB (1) GB0029895D0 (es)
HU (1) HU224910B1 (es)
IL (2) IL156088A0 (es)
MX (1) MXPA03005097A (es)
MY (1) MY128409A (es)
NO (1) NO329164B1 (es)
NZ (1) NZ526197A (es)
PE (1) PE20020568A1 (es)
PL (1) PL209406B1 (es)
PT (1) PT1345944E (es)
RU (1) RU2285007C2 (es)
SI (1) SI1345944T1 (es)
SK (1) SK287356B6 (es)
TW (1) TWI286137B (es)
WO (1) WO2002046196A1 (es)
ZA (1) ZA200304296B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2273083C (en) 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
DE60310916T2 (de) * 2002-08-23 2007-11-15 Sloan-Kettering Institute For Cancer Research Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen
RS20050235A (sr) * 2002-09-23 2007-06-04 Bristol Myers Squibb Company, Postupci za pripremanje,izolaciju i prečišćavanje epotilona b i kristalne strukture epotilona b dobijene primenom x-zraka
FR2846520B1 (fr) 2002-11-06 2006-09-29 Roquette Freres Utilisation de maltodextrines branchees comme liants de granulation
KR100681811B1 (ko) * 2005-03-15 2007-02-12 성균관대학교산학협력단 생물학적 대사부산물의 효율적인 제거를 통한 유용 이차대사산물의 제조방법
MX2009001635A (es) 2006-08-16 2009-02-23 Novartis Ag Forma de cristal de epotilona b y su uso en composiciones farmaceuticas.
EP2241566B1 (en) 2008-02-01 2013-08-21 Zhejiang Hisun Pharmaceutical Co. Ltd. A method for the separation and purification of epothilones
MX2012013100A (es) 2010-05-18 2013-01-22 Cerulean Pharma Inc Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades.
KR101372563B1 (ko) * 2011-12-26 2014-03-14 주식회사 삼양바이오팜 에포틸론 함유물질로부터 에포틸론 ａ와 ｂ의 추출 및 정제 방법
CN110964029B (zh) * 2019-12-19 2020-11-03 鲁南制药集团股份有限公司 一种埃博霉素b发酵液的预处理方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
JP2001500851A (ja) * 1996-08-30 2001-01-23 ノバルティス アクチエンゲゼルシャフト エポシロンの製造法および製造過程中に得られる中間生産物
DE59712968D1 (de) * 1996-11-18 2008-10-30 Biotechnolog Forschung Gmbh Epothilone E und F
DK1001951T3 (da) * 1997-07-16 2002-12-23 Schering Ag Thiazolderivater, fremgangsmåde til fremstilling deraf og anvendelse af disse
US6365749B1 (en) * 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
KR100832145B1 (ko) * 2000-04-28 2008-05-27 코산 바이오사이언시즈, 인코포레이티드 폴리케타이드의 제조방법
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
CZ20031565A3 (cs) 2003-10-15
HU224910B1 (en) 2006-04-28
PE20020568A1 (es) 2002-07-22
PT1345944E (pt) 2005-08-31
PL209406B1 (pl) 2011-08-31
BR0115991A (pt) 2004-01-13
JP2004521879A (ja) 2004-07-22
HK1059618A1 (en) 2004-07-09
KR100894990B1 (ko) 2009-04-24
US6946561B2 (en) 2005-09-20
ZA200304296B (en) 2004-04-23
PL361884A1 (en) 2004-10-04
US7569698B2 (en) 2009-08-04
CA2433414C (en) 2011-01-25
US20040054188A1 (en) 2004-03-18
CN1479741A (zh) 2004-03-03
NO20032591L (no) 2003-06-06
AU2002224936B2 (en) 2005-09-22
EP1345944A1 (en) 2003-09-24
NO20032591D0 (no) 2003-06-06
MXPA03005097A (es) 2003-09-05
WO2002046196A1 (en) 2002-06-13
DE60109814D1 (de) 2005-05-04
HUP0302579A3 (en) 2004-10-28
DK1345944T3 (da) 2005-05-30
MY128409A (en) 2007-01-31
SK287356B6 (sk) 2010-08-09
SK6892003A3 (en) 2004-01-08
KR20030053535A (ko) 2003-06-28
RU2285007C2 (ru) 2006-10-10
HUP0302579A2 (hu) 2003-11-28
NO329164B1 (no) 2010-09-06
DE60109814T2 (de) 2006-02-16
JP4287650B2 (ja) 2009-07-01
AR031902A1 (es) 2003-10-08
US20050288514A1 (en) 2005-12-29
ATE292132T1 (de) 2005-04-15
EP1345944B1 (en) 2005-03-30
GB0029895D0 (en) 2001-01-24
AU2493602A (en) 2002-06-18
ES2239687T3 (es) 2005-10-01
NZ526197A (en) 2005-01-28
SI1345944T1 (sl) 2005-12-31
IL156088A0 (en) 2003-12-23
CZ301664B6 (cs) 2010-05-19
IL156088A (en) 2008-08-07
CA2433414A1 (en) 2002-06-13
CN1263761C (zh) 2006-07-12
TWI286137B (en) 2007-09-01

Similar Documents

Publication Publication Date Title
ECSP034641A (es) Proceso para el aislamiento y purificacion de epotilonas
TNSN07143A1 (en) Aqueous, radiation-hardenable resins, method for the production thereof, and use of the same
DE60113579D1 (de) Integriertes Abwasserbehandlungsverfahren für die Herstellung von Nitroaromaten
CO5601045A2 (es) Procedimiento para la fabricacion de compuestos organicos
BR0313226B1 (pt) processo para produÇço de produto de fermentaÇço.
ZA200702523B (en) Process for the purification of 1,4-butanediol
DE602007011930D1 (de) Prepreg-anordnung zur herstellung von strukturen, zum beispiel welche, die sich durch aufblasen entfalten
ATE406120T1 (de) Schutzhandschuh mit einer verstärkten mechanischen festigkeit und verfahren zu dessen herstellung
WO2005077008A3 (en) Methods for isolation of triptolide compounds from tripterygium wilfordii
DE60111121D1 (de) Klarlacke, sowie Verfahren zur Herstellung von Mehrschichtüberzügen
BR0116914B1 (pt) processo para a produção de aldeìdos.
IS7341A (is) Trísýklísk 2-pýrimídón efnasambönd, gagnleg sem HIV-víxlritatálmar
NO20052158L (no) Fremgangsmate for fremstilling av en benzimidazolforbindelse.
BRPI0510129A (pt) corpo de cerámica, processo para produzir o mesmo e processo para produzir um pó de oxinitreto de alumìnio
WO2005012227A3 (en) Process for preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, a metabolite of tolterodine
DE60105314D1 (de) Verfahren zur herstellung von taxanderivaten
BR0212585B1 (pt) processos para a preparaÇço de hidroperàxidos orgÂnicos, de compostos de oxirana e de uma alquenilarila.
BR0211897B1 (pt) processo para a produÇço de olefinas ramificadas.
DE60103671D1 (de) Flüssigkeitsgefülltes, elastisches, zylindrisches Lager mit Zwischenhülse zur Erhöhung der Verfomungsbeständigkeit, sowie Herstellverfahren hierzu
BR0116045B1 (pt) processo para a fabricação de uma bucha de rebordo.
ITMI20022185A1 (it) Processo per la preparazione di fenolo mediante idrodeossigenazione di benzendioli.
BRPI0515186A (pt) derivados de alquilideno-tetrahidronaftaleno, processo para a sua produção e seu uso como antiinflamatório
BR0111039B1 (pt) processo para preparaÇço de 2-cloro-5-clorometil-1,3-tiazol.
ITRM20010477A0 (it) Procedimento per la produzione o rigenerazione di un pneumatico, comepure dispositivo di riporto di battistrada.
NO20052329D0 (no) Fremgangsmate for rensingen av 1,4-butandiol-mononitrat