AR031902A1 - Proceso para el aislamiento y la purificacion de epotilonas - Google Patents

Proceso para el aislamiento y la purificacion de epotilonas

Info

Publication number
AR031902A1
AR031902A1 ARP010105667A ARP010105667A AR031902A1 AR 031902 A1 AR031902 A1 AR 031902A1 AR P010105667 A ARP010105667 A AR P010105667A AR P010105667 A ARP010105667 A AR P010105667A AR 031902 A1 AR031902 A1 AR 031902A1
Authority
AR
Argentina
Prior art keywords
purification
epotilones
insulation
epothilones
resins
Prior art date
Application number
ARP010105667A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR031902A1 publication Critical patent/AR031902A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicon Polymers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente se refiere a un proceso de desorcion para epotilonas, en especial epotilona A y/o epotilona B, a partir de resinas, y a nuevos procesos de produccion, procesamiento, o purificacion, o métodos de fabricacion para epotilonas que comprenden dicho proceso de desorcion, así como al uso de ciertos solventes para la desorcion de epotilonas a partir de resinas.
ARP010105667A 2000-12-07 2001-12-05 Proceso para el aislamiento y la purificacion de epotilonas AR031902A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0029895.0A GB0029895D0 (en) 2000-12-07 2000-12-07 Organic compounds

Publications (1)

Publication Number Publication Date
AR031902A1 true AR031902A1 (es) 2003-10-08

Family

ID=9904660

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010105667A AR031902A1 (es) 2000-12-07 2001-12-05 Proceso para el aislamiento y la purificacion de epotilonas

Country Status (32)

Country Link
US (2) US6946561B2 (es)
EP (1) EP1345944B1 (es)
JP (1) JP4287650B2 (es)
KR (1) KR100894990B1 (es)
CN (1) CN1263761C (es)
AR (1) AR031902A1 (es)
AT (1) ATE292132T1 (es)
AU (2) AU2493602A (es)
BR (1) BR0115991A (es)
CA (1) CA2433414C (es)
CZ (1) CZ301664B6 (es)
DE (1) DE60109814T2 (es)
DK (1) DK1345944T3 (es)
EC (1) ECSP034641A (es)
ES (1) ES2239687T3 (es)
GB (1) GB0029895D0 (es)
HK (1) HK1059618A1 (es)
HU (1) HU224910B1 (es)
IL (2) IL156088A0 (es)
MX (1) MXPA03005097A (es)
MY (1) MY128409A (es)
NO (1) NO329164B1 (es)
NZ (1) NZ526197A (es)
PE (1) PE20020568A1 (es)
PL (1) PL209406B1 (es)
PT (1) PT1345944E (es)
RU (1) RU2285007C2 (es)
SI (1) SI1345944T1 (es)
SK (1) SK287356B6 (es)
TW (1) TWI286137B (es)
WO (1) WO2002046196A1 (es)
ZA (1) ZA200304296B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP0977563B1 (en) * 1996-12-03 2005-10-12 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds
CN1759115A (zh) * 2002-08-23 2006-04-12 索隆-基特林癌症研究协会 埃坡霉素(epothilone),合成埃坡霉素的中间体,其类似物及其用途
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
KR101406635B1 (ko) * 2002-09-23 2014-06-11 브리스톨-마이어스 스큅 컴퍼니 에포틸론 ｂ의 제조, 분리 및 정제 방법, 및 에포틸론 ｂ의 ｘ-선 결정 구조
FR2846520B1 (fr) 2002-11-06 2006-09-29 Roquette Freres Utilisation de maltodextrines branchees comme liants de granulation
KR100681811B1 (ko) * 2005-03-15 2007-02-12 성균관대학교산학협력단 생물학적 대사부산물의 효율적인 제거를 통한 유용 이차대사산물의 제조방법
CA2658475A1 (en) 2006-08-16 2008-02-21 Novartis Ag Organic compounds
CN101918400B (zh) 2008-02-01 2012-08-29 浙江海正药业股份有限公司 一种分离和提纯埃博霉素的方法
MX2012013100A (es) 2010-05-18 2013-01-22 Cerulean Pharma Inc Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades.
KR101372563B1 (ko) * 2011-12-26 2014-03-14 주식회사 삼양바이오팜 에포틸론 함유물질로부터 에포틸론 ａ와 ｂ의 추출 및 정제 방법
CN110964029B (zh) * 2019-12-19 2020-11-03 鲁南制药集团股份有限公司 一种埃博霉素b发酵液的预处理方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) * 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
PT941227E (pt) * 1996-11-18 2004-08-31 Biotechnolog Forschung Mbh Gbf Epothilona d sua preparacao e sua utilizacao como agente citostatico ou como agente de proteccao fitossanitaria
AU8542898A (en) * 1997-07-16 1999-02-10 Schering Aktiengesellschaft Thiazole derivatives, method for their production and use
US6365749B1 (en) * 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
NZ546497A (en) * 2000-04-28 2008-04-30 Kosan Biosciences Inc Production of polyketides
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
CN1263761C (zh) 2006-07-12
SK287356B6 (sk) 2010-08-09
HUP0302579A3 (en) 2004-10-28
IL156088A0 (en) 2003-12-23
CZ20031565A3 (cs) 2003-10-15
DE60109814T2 (de) 2006-02-16
RU2285007C2 (ru) 2006-10-10
PL209406B1 (pl) 2011-08-31
AU2493602A (en) 2002-06-18
CA2433414C (en) 2011-01-25
US20050288514A1 (en) 2005-12-29
NZ526197A (en) 2005-01-28
ES2239687T3 (es) 2005-10-01
NO329164B1 (no) 2010-09-06
EP1345944B1 (en) 2005-03-30
SI1345944T1 (sl) 2005-12-31
US6946561B2 (en) 2005-09-20
EP1345944A1 (en) 2003-09-24
JP2004521879A (ja) 2004-07-22
CZ301664B6 (cs) 2010-05-19
ZA200304296B (en) 2004-04-23
MXPA03005097A (es) 2003-09-05
SK6892003A3 (en) 2004-01-08
HUP0302579A2 (hu) 2003-11-28
MY128409A (en) 2007-01-31
BR0115991A (pt) 2004-01-13
PT1345944E (pt) 2005-08-31
KR100894990B1 (ko) 2009-04-24
IL156088A (en) 2008-08-07
HK1059618A1 (en) 2004-07-09
CN1479741A (zh) 2004-03-03
WO2002046196A1 (en) 2002-06-13
NO20032591D0 (no) 2003-06-06
AU2002224936B2 (en) 2005-09-22
US7569698B2 (en) 2009-08-04
ATE292132T1 (de) 2005-04-15
PL361884A1 (en) 2004-10-04
KR20030053535A (ko) 2003-06-28
PE20020568A1 (es) 2002-07-22
DE60109814D1 (de) 2005-05-04
HU224910B1 (en) 2006-04-28
TWI286137B (en) 2007-09-01
CA2433414A1 (en) 2002-06-13
JP4287650B2 (ja) 2009-07-01
GB0029895D0 (en) 2001-01-24
DK1345944T3 (da) 2005-05-30
US20040054188A1 (en) 2004-03-18
ECSP034641A (es) 2003-07-25
NO20032591L (no) 2003-06-06

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