HUP0302579A2 - Eljárás epotilonok izolálására és tisztítására - Google Patents
Eljárás epotilonok izolálására és tisztításáraInfo
- Publication number
- HUP0302579A2 HUP0302579A2 HU0302579A HUP0302579A HUP0302579A2 HU P0302579 A2 HUP0302579 A2 HU P0302579A2 HU 0302579 A HU0302579 A HU 0302579A HU P0302579 A HUP0302579 A HU P0302579A HU P0302579 A2 HUP0302579 A2 HU P0302579A2
- Authority
- HU
- Hungary
- Prior art keywords
- epothilones
- resin
- desorption
- purification
- apolar solvent
- Prior art date
Links
- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title abstract 7
- 229930013356 epothilone Natural products 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- 238000000746 purification Methods 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title 1
- 239000011347 resin Substances 0.000 abstract 4
- 229920005989 resin Polymers 0.000 abstract 4
- 238000003795 desorption Methods 0.000 abstract 3
- HESCAJZNRMSMJG-HGYUPSKWSA-N epothilone A Natural products O=C1[C@H](C)[C@H](O)[C@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C HESCAJZNRMSMJG-HGYUPSKWSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- QXRSDHAAWVKZLJ-OXZHEXMSSA-N Epothilone B Natural products O=C1[C@H](C)[C@H](O)[C@@H](C)CCC[C@@]2(C)O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C QXRSDHAAWVKZLJ-OXZHEXMSSA-N 0.000 abstract 2
- QXRSDHAAWVKZLJ-PVYNADRNSA-N epothilone B Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 QXRSDHAAWVKZLJ-PVYNADRNSA-N 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Silicon Polymers (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A találmány tárgya eljárás epotilonok, különösen epotilon A és/vagy B,főleg epotilon B deszorpciójára egy gyantáról, különösen egyszintetikus gyantáról egy gyengén poláros vagy apoláros oldószerrel. Atalálmány további tárgya eljárás az epotilonok feldolgozására vagytisztítására, különösen egy kémiai szintézisre szolgáláló standardközegben vagy előnyösen epotilonok termelésére alkalmasmikroorganizmusokat és komplexképző komponenst tartalmazó tenyésztőközegben történő előállításuk után, mely eljárást, egy gyengén polárosvagy apoláros oldószer alkalmazását tartalmazza az említett epotilonokdeszorpciójára egy gyantáról. A találmány harmadik tárgya egy gyengénpoláros vagy apoláros oldószer alkalmazása az epotilonokdeszorpciójára egy gyantáról. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0029895.0A GB0029895D0 (en) | 2000-12-07 | 2000-12-07 | Organic compounds |
PCT/EP2001/014771 WO2002046196A1 (en) | 2000-12-07 | 2001-12-05 | Process for the isolation and purification of epothilones |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0302579A2 true HUP0302579A2 (hu) | 2003-11-28 |
HUP0302579A3 HUP0302579A3 (en) | 2004-10-28 |
HU224910B1 HU224910B1 (en) | 2006-04-28 |
Family
ID=9904660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0302579A HU224910B1 (en) | 2000-12-07 | 2001-12-05 | Process for the isolation and purification of epothilones |
Country Status (32)
Country | Link |
---|---|
US (2) | US6946561B2 (hu) |
EP (1) | EP1345944B1 (hu) |
JP (1) | JP4287650B2 (hu) |
KR (1) | KR100894990B1 (hu) |
CN (1) | CN1263761C (hu) |
AR (1) | AR031902A1 (hu) |
AT (1) | ATE292132T1 (hu) |
AU (2) | AU2493602A (hu) |
BR (1) | BR0115991A (hu) |
CA (1) | CA2433414C (hu) |
CZ (1) | CZ301664B6 (hu) |
DE (1) | DE60109814T2 (hu) |
DK (1) | DK1345944T3 (hu) |
EC (1) | ECSP034641A (hu) |
ES (1) | ES2239687T3 (hu) |
GB (1) | GB0029895D0 (hu) |
HK (1) | HK1059618A1 (hu) |
HU (1) | HU224910B1 (hu) |
IL (2) | IL156088A0 (hu) |
MX (1) | MXPA03005097A (hu) |
MY (1) | MY128409A (hu) |
NO (1) | NO329164B1 (hu) |
NZ (1) | NZ526197A (hu) |
PE (1) | PE20020568A1 (hu) |
PL (1) | PL209406B1 (hu) |
PT (1) | PT1345944E (hu) |
RU (1) | RU2285007C2 (hu) |
SI (1) | SI1345944T1 (hu) |
SK (1) | SK287356B6 (hu) |
TW (1) | TWI286137B (hu) |
WO (1) | WO2002046196A1 (hu) |
ZA (1) | ZA200304296B (hu) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
JP4579351B2 (ja) * | 1996-12-03 | 2010-11-10 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロンの合成とその中間体及びその類似物並びにその使用 |
US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
GB0029895D0 (en) * | 2000-12-07 | 2001-01-24 | Novartis Ag | Organic compounds |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
DK1767535T3 (da) * | 2002-08-23 | 2010-04-12 | Sloan Kettering Inst Cancer | Syntese af epothiloner, mellemprodukter deraf, analoge og deres anvendelse |
MXPA05003006A (es) * | 2002-09-23 | 2005-06-22 | Squibb Bristol Myers Co | Metodos para la preparacion, aislamiento y purificacion de epotilona b y estructuras cristalinas de rayos x y de epotilona b. |
FR2846520B1 (fr) | 2002-11-06 | 2006-09-29 | Roquette Freres | Utilisation de maltodextrines branchees comme liants de granulation |
KR100681811B1 (ko) * | 2005-03-15 | 2007-02-12 | 성균관대학교산학협력단 | 생물학적 대사부산물의 효율적인 제거를 통한 유용 이차대사산물의 제조방법 |
NZ574194A (en) | 2006-08-16 | 2011-12-22 | Novartis Ag | Crystal form of epothilone b and use in pharmaceutical compositions |
US8906947B2 (en) | 2008-02-01 | 2014-12-09 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Method for the separation and purification of epothilones |
CN105797168A (zh) | 2010-05-18 | 2016-07-27 | 天蓝制药公司 | 用于治疗自身免疫性疾病或其它疾病的组合物和方法 |
KR101372563B1 (ko) * | 2011-12-26 | 2014-03-14 | 주식회사 삼양바이오팜 | 에포틸론 함유물질로부터 에포틸론 a와 b의 추출 및 정제 방법 |
CN110964029B (zh) * | 2019-12-19 | 2020-11-03 | 鲁南制药集团股份有限公司 | 一种埃博霉素b发酵液的预处理方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4138042C2 (de) * | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
EP1367057B1 (de) * | 1996-11-18 | 2008-09-17 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Epothilone E und F |
ATE224882T1 (de) * | 1997-07-16 | 2002-10-15 | Schering Ag | Thiazolderivate, verfahren zur herstellung und verwendung |
US6365749B1 (en) * | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
DE19826988A1 (de) * | 1998-06-18 | 1999-12-23 | Biotechnolog Forschung Gmbh | Epothilon-Nebenkomponenten |
EP1652926B1 (en) * | 2000-04-28 | 2009-09-30 | Kosan Biosciences, Inc. | Crystalline epothilone d |
GB0029895D0 (en) * | 2000-12-07 | 2001-01-24 | Novartis Ag | Organic compounds |
-
2000
- 2000-12-07 GB GBGB0029895.0A patent/GB0029895D0/en not_active Ceased
-
2001
- 2001-11-28 PE PE2001001192A patent/PE20020568A1/es not_active Application Discontinuation
- 2001-12-03 TW TW090129838A patent/TWI286137B/zh not_active IP Right Cessation
- 2001-12-05 AT AT01994791T patent/ATE292132T1/de active
- 2001-12-05 AR ARP010105667A patent/AR031902A1/es active IP Right Grant
- 2001-12-05 BR BR0115991-7A patent/BR0115991A/pt not_active IP Right Cessation
- 2001-12-05 DE DE60109814T patent/DE60109814T2/de not_active Expired - Lifetime
- 2001-12-05 CZ CZ20031565A patent/CZ301664B6/cs not_active IP Right Cessation
- 2001-12-05 DK DK01994791T patent/DK1345944T3/da active
- 2001-12-05 CN CNB018201415A patent/CN1263761C/zh not_active Expired - Fee Related
- 2001-12-05 AU AU2493602A patent/AU2493602A/xx active Pending
- 2001-12-05 PL PL361884A patent/PL209406B1/pl not_active IP Right Cessation
- 2001-12-05 KR KR1020037007114A patent/KR100894990B1/ko not_active IP Right Cessation
- 2001-12-05 SK SK689-2003A patent/SK287356B6/sk not_active IP Right Cessation
- 2001-12-05 CA CA2433414A patent/CA2433414C/en not_active Expired - Fee Related
- 2001-12-05 ES ES01994791T patent/ES2239687T3/es not_active Expired - Lifetime
- 2001-12-05 MX MXPA03005097A patent/MXPA03005097A/es active IP Right Grant
- 2001-12-05 RU RU2003119659/04A patent/RU2285007C2/ru not_active IP Right Cessation
- 2001-12-05 US US10/433,808 patent/US6946561B2/en not_active Expired - Fee Related
- 2001-12-05 AU AU2002224936A patent/AU2002224936B2/en not_active Ceased
- 2001-12-05 EP EP01994791A patent/EP1345944B1/en not_active Expired - Lifetime
- 2001-12-05 WO PCT/EP2001/014771 patent/WO2002046196A1/en active Application Filing
- 2001-12-05 MY MYPI20015563A patent/MY128409A/en unknown
- 2001-12-05 JP JP2002547933A patent/JP4287650B2/ja not_active Expired - Fee Related
- 2001-12-05 PT PT01994791T patent/PT1345944E/pt unknown
- 2001-12-05 NZ NZ526197A patent/NZ526197A/en not_active IP Right Cessation
- 2001-12-05 SI SI200130358T patent/SI1345944T1/sl unknown
- 2001-12-05 IL IL15608801A patent/IL156088A0/xx active IP Right Grant
- 2001-12-05 HU HU0302579A patent/HU224910B1/hu not_active IP Right Cessation
-
2003
- 2003-05-22 IL IL156088A patent/IL156088A/en not_active IP Right Cessation
- 2003-06-02 ZA ZA200304296A patent/ZA200304296B/en unknown
- 2003-06-03 EC EC2003004641A patent/ECSP034641A/es unknown
- 2003-06-06 NO NO20032591A patent/NO329164B1/no not_active IP Right Cessation
-
2004
- 2004-02-11 HK HK04100923A patent/HK1059618A1/xx not_active IP Right Cessation
-
2005
- 2005-08-17 US US11/205,892 patent/US7569698B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0302579A2 (hu) | Eljárás epotilonok izolálására és tisztítására | |
DE50015677D1 (de) | Methode zur isolierung von dna aus biologischen materialien | |
MX2007010716A (es) | Purificacion de rapamicina. | |
WO2003016552A3 (en) | Dna purification and recovery from high particulate and solids samples | |
DE60130477D1 (de) | Verfahren zur herstellung von hochreinem zirkonium und hafnium für zerstäubungstargets | |
FR2881755B1 (fr) | Milieux pour la detection specifique de micro-organismes resistants | |
WO2007044345A3 (en) | Method and apparatus for treating wastewater | |
NO20050929L (no) | Fremgangsmater for fremstilling, isolering og rensing av epotilon B og rontgen krystallstrukturer av eptilon B | |
DE60144094D1 (de) | Drucksensor des kapazitätstyps und verfahren zu seiner herstellung | |
ATE362530T1 (de) | Verfahren und vorrichtung zur reinigung von nukleinsäuren | |
EP1542928A4 (en) | AIRLIFT MEMBRANE DEVICE AND MENBRANE BIOREACTOR AND BIOREACTOR PROCESS WITH THIS | |
DE60122328D1 (de) | Verfahren zur herstellung von keramikkörpern | |
DE602006020201D1 (de) | Aerobes-anaerobes Verfahren zur Behandlung von organisch belasteten Abwässern | |
ATE522619T1 (de) | Selektives kulturmedium zur isolation und/oder detektion von spezies des streptococcus genus | |
WO2007012605A3 (en) | Static support bed for purification, separation, detection, modification and/or immobilization of target entities and method using thereof | |
DE50206295D1 (de) | Verfahren zur Aufbereitung von Industrieabwässern | |
NO20053290D0 (no) | Fremgangsmate og anlegg for termisk behandling av kornet torrstoff. | |
HK1099074A1 (en) | Purification methods and uses thereof | |
DE10085394T1 (de) | Verfahren zur thermischen Verarbeitung von Biomasse | |
DE602004029711D1 (de) | Trukturkörper, medium zur herstellung des strukturkörpers und optisches aufzeichnungsmedium und verfahren zur herstellung des optischen aufzeichnungsmediums | |
DE602004004708D1 (de) | Vorrichtung und Verfahren zur Bestimmung von Bakterien | |
NO20051794D0 (no) | Fremgangsmate for fremstilling av epotilonderivater, og nye mellomprodukter for fremgangsmaten, samt fremgangsmater for fremstilling av slike | |
DE60210607D1 (de) | Nährboden zum nachweis und/oder zur unterscheidung von enterokokken | |
DE10085484T1 (de) | Verfahren zur Herstellung von stabilen und wiederverwendbaren, bioempfindlichen Granulaten | |
DE10192906D2 (de) | Verfahren zur Herstellung diamantartiger Stoffe, diamantartige Stoffe und Verwendung derartiger Stoffe |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of definitive patent protection due to non-payment of fees |