PE20020568A1 - Proceso para el aislamiento y la purificacion de epotilonas - Google Patents

Proceso para el aislamiento y la purificacion de epotilonas

Info

Publication number
PE20020568A1
PE20020568A1 PE2001001192A PE2001001192A PE20020568A1 PE 20020568 A1 PE20020568 A1 PE 20020568A1 PE 2001001192 A PE2001001192 A PE 2001001192A PE 2001001192 A PE2001001192 A PE 2001001192A PE 20020568 A1 PE20020568 A1 PE 20020568A1
Authority
PE
Peru
Prior art keywords
epotilones
synthetic resin
isolation
solvent
resin
Prior art date
Application number
PE2001001192A
Other languages
English (en)
Inventor
Heinz Unternahrer
Ernst Kusters
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20020568A1 publication Critical patent/PE20020568A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Silicon Polymers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA DESORBER EPOTILONAS A o B A PARTIR DE UNA RESINA UTILIZANDO UN SOLVENTE DEBILMENTE POLAR O APOLAR SELECCIONADO DE HALUROS DE ALQUILO INFERIOR, SOLVENTES AROMATICOS COMO NAFTALENO, BENCENO, NAFTALENO, ENTRE OTROS. LA RESINA ES UNA RESINA SINTETICA BASADA EN COPOLIMEROS DE ESTIRENO/DIVINILBENCENO. EL PROCESO PARA EL AISLAMIENTO DE EPOTILONAS ADSORBIDAS A UNA RESINA SINTETICA COMPRENDE: a) LA DESORCION DE LAS EPOTILONAS A PARTIR DE UNA RESINA SINTETICA CON UN SOLVENTE Y ii) SEPARACION DE LAS EPOTILONAS MEDIANTE CROMATOGRAFIA DE FASE INVERSA DESPUES DE RECUPERARSE EN UN SOLVENTE ADECUADO Y LA ELUCION CON UNA MEZCLA DE NITRILO Y AGUA Y LLEGAR A LAS EPOTILONAS RESPECTIVAS EN UNA FORMA PURA
PE2001001192A 2000-12-07 2001-11-28 Proceso para el aislamiento y la purificacion de epotilonas PE20020568A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0029895.0A GB0029895D0 (en) 2000-12-07 2000-12-07 Organic compounds

Publications (1)

Publication Number Publication Date
PE20020568A1 true PE20020568A1 (es) 2002-07-22

Family

ID=9904660

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001192A PE20020568A1 (es) 2000-12-07 2001-11-28 Proceso para el aislamiento y la purificacion de epotilonas

Country Status (32)

Country Link
US (2) US6946561B2 (es)
EP (1) EP1345944B1 (es)
JP (1) JP4287650B2 (es)
KR (1) KR100894990B1 (es)
CN (1) CN1263761C (es)
AR (1) AR031902A1 (es)
AT (1) ATE292132T1 (es)
AU (2) AU2493602A (es)
BR (1) BR0115991A (es)
CA (1) CA2433414C (es)
CZ (1) CZ301664B6 (es)
DE (1) DE60109814T2 (es)
DK (1) DK1345944T3 (es)
EC (1) ECSP034641A (es)
ES (1) ES2239687T3 (es)
GB (1) GB0029895D0 (es)
HK (1) HK1059618A1 (es)
HU (1) HU224910B1 (es)
IL (2) IL156088A0 (es)
MX (1) MXPA03005097A (es)
MY (1) MY128409A (es)
NO (1) NO329164B1 (es)
NZ (1) NZ526197A (es)
PE (1) PE20020568A1 (es)
PL (1) PL209406B1 (es)
PT (1) PT1345944E (es)
RU (1) RU2285007C2 (es)
SI (1) SI1345944T1 (es)
SK (1) SK287356B6 (es)
TW (1) TWI286137B (es)
WO (1) WO2002046196A1 (es)
ZA (1) ZA200304296B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
JP4579351B2 (ja) * 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
DK1767535T3 (da) * 2002-08-23 2010-04-12 Sloan Kettering Inst Cancer Syntese af epothiloner, mellemprodukter deraf, analoge og deres anvendelse
MXPA05003006A (es) * 2002-09-23 2005-06-22 Squibb Bristol Myers Co Metodos para la preparacion, aislamiento y purificacion de epotilona b y estructuras cristalinas de rayos x y de epotilona b.
FR2846520B1 (fr) 2002-11-06 2006-09-29 Roquette Freres Utilisation de maltodextrines branchees comme liants de granulation
KR100681811B1 (ko) * 2005-03-15 2007-02-12 성균관대학교산학협력단 생물학적 대사부산물의 효율적인 제거를 통한 유용 이차대사산물의 제조방법
NZ574194A (en) 2006-08-16 2011-12-22 Novartis Ag Crystal form of epothilone b and use in pharmaceutical compositions
US8906947B2 (en) 2008-02-01 2014-12-09 Zhejiang Hisun Pharmaceutical Co., Ltd. Method for the separation and purification of epothilones
CN105797168A (zh) 2010-05-18 2016-07-27 天蓝制药公司 用于治疗自身免疫性疾病或其它疾病的组合物和方法
KR101372563B1 (ko) * 2011-12-26 2014-03-14 주식회사 삼양바이오팜 에포틸론 함유물질로부터 에포틸론 ａ와 ｂ의 추출 및 정제 방법
CN110964029B (zh) * 2019-12-19 2020-11-03 鲁南制药集团股份有限公司 一种埃博霉素b发酵液的预处理方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) * 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
EP1367057B1 (de) * 1996-11-18 2008-09-17 Gesellschaft für biotechnologische Forschung mbH (GBF) Epothilone E und F
ATE224882T1 (de) * 1997-07-16 2002-10-15 Schering Ag Thiazolderivate, verfahren zur herstellung und verwendung
US6365749B1 (en) * 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
EP1652926B1 (en) * 2000-04-28 2009-09-30 Kosan Biosciences, Inc. Crystalline epothilone d
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
ZA200304296B (en) 2004-04-23
GB0029895D0 (en) 2001-01-24
PT1345944E (pt) 2005-08-31
WO2002046196A1 (en) 2002-06-13
JP4287650B2 (ja) 2009-07-01
MY128409A (en) 2007-01-31
MXPA03005097A (es) 2003-09-05
JP2004521879A (ja) 2004-07-22
CZ20031565A3 (cs) 2003-10-15
HK1059618A1 (en) 2004-07-09
AU2002224936B2 (en) 2005-09-22
PL361884A1 (en) 2004-10-04
HUP0302579A3 (en) 2004-10-28
IL156088A (en) 2008-08-07
SK6892003A3 (en) 2004-01-08
KR20030053535A (ko) 2003-06-28
NZ526197A (en) 2005-01-28
AU2493602A (en) 2002-06-18
NO329164B1 (no) 2010-09-06
CN1479741A (zh) 2004-03-03
US20040054188A1 (en) 2004-03-18
NO20032591D0 (no) 2003-06-06
CZ301664B6 (cs) 2010-05-19
US20050288514A1 (en) 2005-12-29
EP1345944B1 (en) 2005-03-30
KR100894990B1 (ko) 2009-04-24
ES2239687T3 (es) 2005-10-01
SK287356B6 (sk) 2010-08-09
DE60109814D1 (de) 2005-05-04
EP1345944A1 (en) 2003-09-24
AR031902A1 (es) 2003-10-08
DE60109814T2 (de) 2006-02-16
RU2285007C2 (ru) 2006-10-10
CN1263761C (zh) 2006-07-12
US7569698B2 (en) 2009-08-04
IL156088A0 (en) 2003-12-23
BR0115991A (pt) 2004-01-13
CA2433414C (en) 2011-01-25
ECSP034641A (es) 2003-07-25
CA2433414A1 (en) 2002-06-13
NO20032591L (no) 2003-06-06
PL209406B1 (pl) 2011-08-31
ATE292132T1 (de) 2005-04-15
HU224910B1 (en) 2006-04-28
US6946561B2 (en) 2005-09-20
SI1345944T1 (sl) 2005-12-31
DK1345944T3 (da) 2005-05-30
HUP0302579A2 (hu) 2003-11-28
TWI286137B (en) 2007-09-01

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