DE60109814D1 - Prozess zur isolierung und reinigung von epothilonen - Google Patents

Prozess zur isolierung und reinigung von epothilonen

Info

Publication number
DE60109814D1
DE60109814D1 DE60109814T DE60109814T DE60109814D1 DE 60109814 D1 DE60109814 D1 DE 60109814D1 DE 60109814 T DE60109814 T DE 60109814T DE 60109814 T DE60109814 T DE 60109814T DE 60109814 D1 DE60109814 D1 DE 60109814D1
Authority
DE
Germany
Prior art keywords
epothilones
isolating
cleaning
cleaning epothilones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60109814T
Other languages
English (en)
Other versions
DE60109814T2 (de
Inventor
Ernst Kuesters
Heinz Unternaehrer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE60109814D1 publication Critical patent/DE60109814D1/de
Application granted granted Critical
Publication of DE60109814T2 publication Critical patent/DE60109814T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Silicon Polymers (AREA)
  • Saccharide Compounds (AREA)
DE60109814T 2000-12-07 2001-12-05 Prozess zur isolierung und reinigung von epothilonen Expired - Lifetime DE60109814T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0029895 2000-12-07
GBGB0029895.0A GB0029895D0 (en) 2000-12-07 2000-12-07 Organic compounds
PCT/EP2001/014771 WO2002046196A1 (en) 2000-12-07 2001-12-05 Process for the isolation and purification of epothilones

Publications (2)

Publication Number Publication Date
DE60109814D1 true DE60109814D1 (de) 2005-05-04
DE60109814T2 DE60109814T2 (de) 2006-02-16

Family

ID=9904660

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60109814T Expired - Lifetime DE60109814T2 (de) 2000-12-07 2001-12-05 Prozess zur isolierung und reinigung von epothilonen

Country Status (32)

Country Link
US (2) US6946561B2 (de)
EP (1) EP1345944B1 (de)
JP (1) JP4287650B2 (de)
KR (1) KR100894990B1 (de)
CN (1) CN1263761C (de)
AR (1) AR031902A1 (de)
AT (1) ATE292132T1 (de)
AU (2) AU2002224936B2 (de)
BR (1) BR0115991A (de)
CA (1) CA2433414C (de)
CZ (1) CZ301664B6 (de)
DE (1) DE60109814T2 (de)
DK (1) DK1345944T3 (de)
EC (1) ECSP034641A (de)
ES (1) ES2239687T3 (de)
GB (1) GB0029895D0 (de)
HK (1) HK1059618A1 (de)
HU (1) HU224910B1 (de)
IL (2) IL156088A0 (de)
MX (1) MXPA03005097A (de)
MY (1) MY128409A (de)
NO (1) NO329164B1 (de)
NZ (1) NZ526197A (de)
PE (1) PE20020568A1 (de)
PL (1) PL209406B1 (de)
PT (1) PT1345944E (de)
RU (1) RU2285007C2 (de)
SI (1) SI1345944T1 (de)
SK (1) SK287356B6 (de)
TW (1) TWI286137B (de)
WO (1) WO2002046196A1 (de)
ZA (1) ZA200304296B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
WO1999001124A1 (en) 1996-12-03 1999-01-14 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
DK1506203T3 (da) * 2002-08-23 2007-05-14 Sloan Kettering Inst Cancer Syntese af epothiloner, mellemprodukter deraf, analoger deraf og anvendelser deraf
BRPI0314133A8 (pt) * 2002-09-23 2017-09-19 Bristol Myers Squibb Co Processo para isolamento de epotilona b, métodos para cultivo de microorganismo que produza epotilona a ou b e para purifiação de apotilona
FR2846520B1 (fr) 2002-11-06 2006-09-29 Roquette Freres Utilisation de maltodextrines branchees comme liants de granulation
KR100681811B1 (ko) * 2005-03-15 2007-02-12 성균관대학교산학협력단 생물학적 대사부산물의 효율적인 제거를 통한 유용 이차대사산물의 제조방법
AR062375A1 (es) 2006-08-16 2008-11-05 Novartis Ag Cristal de epotilona b y composiciones farmaceuticas
CN101918400B (zh) 2008-02-01 2012-08-29 浙江海正药业股份有限公司 一种分离和提纯埃博霉素的方法
CA2927832C (en) 2010-05-18 2021-03-23 Cerulean Pharma Inc. Cyclodextrin-containing polymer-therapeutic agent conjugates and their use
KR101372563B1 (ko) * 2011-12-26 2014-03-14 주식회사 삼양바이오팜 에포틸론 함유물질로부터 에포틸론 ａ와 ｂ의 추출 및 정제 방법
CN110964029B (zh) * 2019-12-19 2020-11-03 鲁南制药集团股份有限公司 一种埃博霉素b发酵液的预处理方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
BR9713363B1 (pt) * 1996-11-18 2011-02-08 processo para preparação de epotilona d.
AU8542898A (en) * 1997-07-16 1999-02-10 Schering Aktiengesellschaft Thiazole derivatives, method for their production and use
US6365749B1 (en) * 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
DE60114865T2 (de) * 2000-04-28 2006-07-27 Kosan Biosciences, Inc., Hayward Heterologe herstellung von polyketiden
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
NZ526197A (en) 2005-01-28
ECSP034641A (es) 2003-07-25
SK287356B6 (sk) 2010-08-09
ES2239687T3 (es) 2005-10-01
IL156088A (en) 2008-08-07
AU2002224936B2 (en) 2005-09-22
WO2002046196A1 (en) 2002-06-13
PL209406B1 (pl) 2011-08-31
EP1345944A1 (de) 2003-09-24
NO20032591L (no) 2003-06-06
CA2433414A1 (en) 2002-06-13
CA2433414C (en) 2011-01-25
DK1345944T3 (da) 2005-05-30
CZ20031565A3 (cs) 2003-10-15
KR100894990B1 (ko) 2009-04-24
ZA200304296B (en) 2004-04-23
HK1059618A1 (en) 2004-07-09
IL156088A0 (en) 2003-12-23
KR20030053535A (ko) 2003-06-28
CN1479741A (zh) 2004-03-03
PL361884A1 (en) 2004-10-04
GB0029895D0 (en) 2001-01-24
MXPA03005097A (es) 2003-09-05
US7569698B2 (en) 2009-08-04
ATE292132T1 (de) 2005-04-15
US6946561B2 (en) 2005-09-20
MY128409A (en) 2007-01-31
RU2285007C2 (ru) 2006-10-10
CZ301664B6 (cs) 2010-05-19
HUP0302579A3 (en) 2004-10-28
US20050288514A1 (en) 2005-12-29
PT1345944E (pt) 2005-08-31
JP2004521879A (ja) 2004-07-22
SI1345944T1 (sl) 2005-12-31
BR0115991A (pt) 2004-01-13
SK6892003A3 (en) 2004-01-08
TWI286137B (en) 2007-09-01
PE20020568A1 (es) 2002-07-22
JP4287650B2 (ja) 2009-07-01
NO20032591D0 (no) 2003-06-06
AR031902A1 (es) 2003-10-08
US20040054188A1 (en) 2004-03-18
AU2493602A (en) 2002-06-18
NO329164B1 (no) 2010-09-06
HUP0302579A2 (hu) 2003-11-28
DE60109814T2 (de) 2006-02-16
EP1345944B1 (de) 2005-03-30
HU224910B1 (en) 2006-04-28
CN1263761C (zh) 2006-07-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN