ATE292132T1 - Prozess zur isolierung und reinigung von epothilonen - Google Patents

Prozess zur isolierung und reinigung von epothilonen

Info

Publication number
ATE292132T1
ATE292132T1 AT01994791T AT01994791T ATE292132T1 AT E292132 T1 ATE292132 T1 AT E292132T1 AT 01994791 T AT01994791 T AT 01994791T AT 01994791 T AT01994791 T AT 01994791T AT E292132 T1 ATE292132 T1 AT E292132T1
Authority
AT
Austria
Prior art keywords
epothilones
isolation
purification
Prior art date
Application number
AT01994791T
Other languages
English (en)
Inventor
Ernst Kuesters
Heinz Unternaehrer
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE292132T1 publication Critical patent/ATE292132T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Silicon Polymers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT01994791T 2000-12-07 2001-12-05 Prozess zur isolierung und reinigung von epothilonen ATE292132T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0029895.0A GB0029895D0 (en) 2000-12-07 2000-12-07 Organic compounds
PCT/EP2001/014771 WO2002046196A1 (en) 2000-12-07 2001-12-05 Process for the isolation and purification of epothilones

Publications (1)

Publication Number Publication Date
ATE292132T1 true ATE292132T1 (de) 2005-04-15

Family

ID=9904660

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01994791T ATE292132T1 (de) 2000-12-07 2001-12-05 Prozess zur isolierung und reinigung von epothilonen

Country Status (32)

Country Link
US (2) US6946561B2 (de)
EP (1) EP1345944B1 (de)
JP (1) JP4287650B2 (de)
KR (1) KR100894990B1 (de)
CN (1) CN1263761C (de)
AR (1) AR031902A1 (de)
AT (1) ATE292132T1 (de)
AU (2) AU2002224936B2 (de)
BR (1) BR0115991A (de)
CA (1) CA2433414C (de)
CZ (1) CZ301664B6 (de)
DE (1) DE60109814T2 (de)
DK (1) DK1345944T3 (de)
EC (1) ECSP034641A (de)
ES (1) ES2239687T3 (de)
GB (1) GB0029895D0 (de)
HK (1) HK1059618A1 (de)
HU (1) HU224910B1 (de)
IL (2) IL156088A0 (de)
MX (1) MXPA03005097A (de)
MY (1) MY128409A (de)
NO (1) NO329164B1 (de)
NZ (1) NZ526197A (de)
PE (1) PE20020568A1 (de)
PL (1) PL209406B1 (de)
PT (1) PT1345944E (de)
RU (1) RU2285007C2 (de)
SI (1) SI1345944T1 (de)
SK (1) SK287356B6 (de)
TW (1) TWI286137B (de)
WO (1) WO2002046196A1 (de)
ZA (1) ZA200304296B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP0977563B1 (de) 1996-12-03 2005-10-12 Sloan-Kettering Institute For Cancer Research Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
DK1506203T3 (da) * 2002-08-23 2007-05-14 Sloan Kettering Inst Cancer Syntese af epothiloner, mellemprodukter deraf, analoger deraf og anvendelser deraf
EP1542998A4 (de) * 2002-09-23 2007-01-31 Bristol Myers Squibb Co Verfahren zur herstellung, isolierung und aufreinigung von epothilon b, und r ntgenkristallstrukturen von epothilon b
FR2846520B1 (fr) 2002-11-06 2006-09-29 Roquette Freres Utilisation de maltodextrines branchees comme liants de granulation
KR100681811B1 (ko) * 2005-03-15 2007-02-12 성균관대학교산학협력단 생물학적 대사부산물의 효율적인 제거를 통한 유용 이차대사산물의 제조방법
EP2064216A2 (de) 2006-08-16 2009-06-03 Novartis AG Epothilon-b in kristalliner form und seine verwendung für pharmazeutische zusammensetzungen
WO2009100571A1 (zh) 2008-02-01 2009-08-20 Zhejiang Hisun Pharmaceutical Co., Ltd. 一种分离和提纯埃博霉素的方法
AU2011255647A1 (en) 2010-05-18 2012-11-15 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
KR101372563B1 (ko) * 2011-12-26 2014-03-14 주식회사 삼양바이오팜 에포틸론 함유물질로부터 에포틸론 ａ와 ｂ의 추출 및 정제 방법
CN110964029B (zh) * 2019-12-19 2020-11-03 鲁南制药集团股份有限公司 一种埃博霉素b发酵液的预处理方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
DE59711647D1 (de) * 1996-11-18 2004-06-24 Biotechnolog Forschung Gmbh Epothilon d, dessen herstellung und dessen verwendung als cytostatisches mittel bzw. als pflanzenschutzmittel
US6384230B1 (en) * 1997-07-16 2002-05-07 Schering Aktiengesellschaft Thiazole derivatives, method for their production and use
US6365749B1 (en) * 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
EP1652926B1 (de) * 2000-04-28 2009-09-30 Kosan Biosciences, Inc. Kristallines epothilon d
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
HK1059618A1 (en) 2004-07-09
JP2004521879A (ja) 2004-07-22
ZA200304296B (en) 2004-04-23
US6946561B2 (en) 2005-09-20
US20050288514A1 (en) 2005-12-29
CZ20031565A3 (cs) 2003-10-15
JP4287650B2 (ja) 2009-07-01
NO20032591D0 (no) 2003-06-06
WO2002046196A1 (en) 2002-06-13
ECSP034641A (es) 2003-07-25
SK6892003A3 (en) 2004-01-08
NO20032591L (no) 2003-06-06
AR031902A1 (es) 2003-10-08
MY128409A (en) 2007-01-31
DK1345944T3 (da) 2005-05-30
GB0029895D0 (en) 2001-01-24
PL361884A1 (en) 2004-10-04
US7569698B2 (en) 2009-08-04
RU2285007C2 (ru) 2006-10-10
CN1263761C (zh) 2006-07-12
CZ301664B6 (cs) 2010-05-19
AU2002224936B2 (en) 2005-09-22
PE20020568A1 (es) 2002-07-22
CN1479741A (zh) 2004-03-03
PT1345944E (pt) 2005-08-31
BR0115991A (pt) 2004-01-13
EP1345944B1 (de) 2005-03-30
PL209406B1 (pl) 2011-08-31
CA2433414C (en) 2011-01-25
EP1345944A1 (de) 2003-09-24
KR100894990B1 (ko) 2009-04-24
HUP0302579A2 (hu) 2003-11-28
CA2433414A1 (en) 2002-06-13
KR20030053535A (ko) 2003-06-28
NO329164B1 (no) 2010-09-06
AU2493602A (en) 2002-06-18
HUP0302579A3 (en) 2004-10-28
SI1345944T1 (sl) 2005-12-31
IL156088A (en) 2008-08-07
TWI286137B (en) 2007-09-01
IL156088A0 (en) 2003-12-23
HU224910B1 (en) 2006-04-28
DE60109814T2 (de) 2006-02-16
MXPA03005097A (es) 2003-09-05
DE60109814D1 (de) 2005-05-04
ES2239687T3 (es) 2005-10-01
NZ526197A (en) 2005-01-28
US20040054188A1 (en) 2004-03-18
SK287356B6 (sk) 2010-08-09

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