SK286162B6 - Stabilné soli kyseliny o-acetylsalicylovej s bázickými aminokyselinami - Google Patents

Stabilné soli kyseliny o-acetylsalicylovej s bázickými aminokyselinami Download PDF

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Publication number
SK286162B6
SK286162B6 SK67-2003A SK672003A SK286162B6 SK 286162 B6 SK286162 B6 SK 286162B6 SK 672003 A SK672003 A SK 672003A SK 286162 B6 SK286162 B6 SK 286162B6
Authority
SK
Slovakia
Prior art keywords
amino acid
basic amino
acid
composition according
glycine
Prior art date
Application number
SK67-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK672003A3 (en
Inventor
Gerhard Franckowiak
Hubert Appolt
Gregor Leifker
Hans-Peter Wirges
Wolfram Ledwoch
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of SK672003A3 publication Critical patent/SK672003A3/sk
Publication of SK286162B6 publication Critical patent/SK286162B6/sk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
SK67-2003A 2000-07-18 2001-07-05 Stabilné soli kyseliny o-acetylsalicylovej s bázickými aminokyselinami SK286162B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10034802A DE10034802A1 (de) 2000-07-18 2000-07-18 Stabile Salze von O-Acetylsalicylsäure mit basischen Aminosäuren
PCT/EP2001/007669 WO2002005782A2 (de) 2000-07-18 2001-07-05 Stabile salze von o-acetylsalicylsäure mit basischen aminosäuren

Publications (2)

Publication Number Publication Date
SK672003A3 SK672003A3 (en) 2003-06-03
SK286162B6 true SK286162B6 (sk) 2008-04-07

Family

ID=7649258

Family Applications (1)

Application Number Title Priority Date Filing Date
SK67-2003A SK286162B6 (sk) 2000-07-18 2001-07-05 Stabilné soli kyseliny o-acetylsalicylovej s bázickými aminokyselinami

Country Status (34)

Country Link
US (2) US6773724B2 (xx)
EP (1) EP1365737B1 (xx)
JP (2) JP2004507463A (xx)
KR (1) KR100773658B1 (xx)
CN (1) CN1205176C (xx)
AR (1) AR030305A1 (xx)
AT (1) ATE293589T1 (xx)
AU (2) AU7847101A (xx)
BR (1) BR0112538A (xx)
CA (1) CA2416288C (xx)
CR (1) CR6888A (xx)
CZ (1) CZ300337B6 (xx)
DE (2) DE10034802A1 (xx)
DK (1) DK1365737T3 (xx)
EC (1) ECSP034437A (xx)
ES (1) ES2241849T3 (xx)
GT (1) GT200100134A (xx)
HK (1) HK1061811A1 (xx)
HR (1) HRP20030108B1 (xx)
HU (1) HUP0302053A3 (xx)
IL (2) IL153873A0 (xx)
MX (1) MXPA03000510A (xx)
MY (1) MY134521A (xx)
NO (1) NO20030222L (xx)
PE (1) PE20020267A1 (xx)
PL (1) PL204593B1 (xx)
PT (1) PT1365737E (xx)
RS (1) RS50329B (xx)
SK (1) SK286162B6 (xx)
SV (1) SV2002000557A (xx)
TW (1) TWI299729B (xx)
UY (1) UY26841A1 (xx)
WO (1) WO2002005782A2 (xx)
ZA (1) ZA200300469B (xx)

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DE10202019A1 (de) * 2002-01-18 2003-07-24 Bayer Ag Stabile Salze von o-Acetylsalicylsäure mit basischen Aminosäuren II
US8142810B2 (en) 2002-05-30 2012-03-27 The Procter & Gamble Company Dietary method for modulating glucose metabolism and associated conditions and increasing longevity
EP1477476B1 (en) * 2003-05-16 2009-09-09 Cephalon France Modafinil synthesis process
US20060063930A1 (en) * 2004-08-20 2006-03-23 Agoston Gregory E Compositions and methods comprising proteinase activated receptor antagonists
US20060166901A1 (en) * 2005-01-03 2006-07-27 Yu Ruey J Compositions comprising O-acetylsalicyl derivatives of aminocarbohydrates and amino acids
DE102005025283A1 (de) 2005-06-02 2006-12-07 Bayer Healthcare Ag Stabiler Wirkstoffkomplex von Salzen der o-Acetylsalicylsäure mit basischen Aminosäuren und Glycin
DE102005049293A1 (de) * 2005-10-15 2007-04-26 Bayer Healthcare Ag Kombinationspräparate von Salzen oder o-Acetylsalicylsäure
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
WO2008007171A1 (en) 2006-07-09 2008-01-17 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aspirin
KR20180049144A (ko) * 2007-06-04 2018-05-10 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도
DE102008004386A1 (de) 2008-01-14 2009-07-23 Activaero Gmbh Verwendung eines Acetylsalicylsäuresalzes zur Behandlung viraler Infektionen
CN101314029B (zh) * 2008-06-18 2010-12-08 四川省农业科学院实验场 乙酰水杨酸肽及其制备方法
WO2010056919A2 (en) * 2008-11-12 2010-05-20 Kyphia Pharmaceuticals, Inc. Eflornithine prodrugs, conjugates and salts, and methods of use thereof
JP2012511027A (ja) 2008-12-04 2012-05-17 チョンシー ユー 高透過性組成物およびその用途
EA021588B1 (ru) * 2009-06-25 2015-07-30 Тетра Сиа Бетаиновые соли ацетилсалициловой кислоты
CN101633624B (zh) * 2009-08-04 2013-05-01 蚌埠丰原医药科技发展有限公司 改进的赖氨匹林的制备方法
FR2950625B1 (fr) * 2009-09-30 2016-12-02 Holis Tech Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue
FR2965261B1 (fr) * 2009-09-30 2012-10-26 Holis Technologies Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue par ce procede
FR2973370B1 (fr) * 2011-03-29 2013-05-03 Holis Technologies Procede a faible cout pour la preparation d'un acide o-acetylsalicyclique et d'un acide amine basique
CN102503845A (zh) * 2011-09-28 2012-06-20 广州普星药业有限公司 一种dl-赖氨酸阿司匹林盐的制备方法及其应用
KR102309973B1 (ko) 2012-01-18 2021-10-06 테크필즈 파마 코., 엘티디. 폐 병태의 치료를 위한 고침투 전구약물 조성물 및 그의 약제학적 조성물
CN102976962B (zh) * 2012-11-20 2015-02-04 南京工业大学 L-鸟氨酸阿司匹林复盐及其制备方法和应用
FR3021654B1 (fr) 2014-05-28 2016-06-24 Unither Pharmaceuticals Procede de preparation d'un sel d'acide acetylsalicylique et d'un acide amine basique
DK3558920T3 (da) * 2016-12-23 2021-07-05 Aspiair Gmbh Forbedret syntese af lysinacetylsalicylat-glycin-partikler
EP3630120A4 (en) 2017-05-30 2021-01-13 Rhoshan Pharmaceuticals, Inc. STABLE, STERILE AND CRYSTALLINE O-ACETYLSALICYLIC ACID (ASPIRIN) BOTTLE DEPOSIT
WO2019026992A1 (ja) * 2017-08-03 2019-02-07 参天製薬株式会社 クロルヘキシジンを含有する医薬組成物
CN113105326A (zh) * 2021-03-24 2021-07-13 海南卓华制药有限公司 赖氨匹林的制备方法及应用
CN114478287A (zh) * 2021-12-31 2022-05-13 蚌埠丰原医药科技发展有限公司 一种赖氨匹林晶型及制备方法和应用
CN118510750A (zh) 2022-01-05 2024-08-16 阿斯皮亚尔股份有限公司 赖氨匹林·甘氨酸颗粒的改进合成

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Also Published As

Publication number Publication date
CR6888A (es) 2004-10-28
HRP20030108B1 (en) 2006-12-31
ZA200300469B (en) 2004-06-21
PE20020267A1 (es) 2002-06-08
US7449198B2 (en) 2008-11-11
PT1365737E (pt) 2005-08-31
RS50329B (sr) 2009-09-08
GT200100134A (es) 2002-03-22
IL153873A0 (en) 2003-07-31
HRP20030108A2 (en) 2005-02-28
CA2416288A1 (en) 2003-01-15
IL153873A (en) 2009-05-04
PL365648A1 (en) 2005-01-10
NO20030222D0 (no) 2003-01-16
ATE293589T1 (de) 2005-05-15
YU2003A (sh) 2006-08-17
HK1061811A1 (en) 2004-10-08
CN1468209A (zh) 2004-01-14
JP2012131824A (ja) 2012-07-12
BR0112538A (pt) 2003-09-09
EP1365737B1 (de) 2005-04-20
SK672003A3 (en) 2003-06-03
KR100773658B1 (ko) 2007-11-05
AU2001278471B2 (en) 2004-07-22
ECSP034437A (es) 2003-03-31
ES2241849T3 (es) 2005-11-01
MXPA03000510A (es) 2004-04-20
JP2004507463A (ja) 2004-03-11
CN1205176C (zh) 2005-06-08
US20020091108A1 (en) 2002-07-11
WO2002005782A3 (de) 2003-10-02
DK1365737T3 (da) 2005-07-11
MY134521A (en) 2007-12-31
CZ2003164A3 (cs) 2003-04-16
DE10034802A1 (de) 2002-01-31
US20050009791A1 (en) 2005-01-13
WO2002005782A2 (de) 2002-01-24
KR20030019586A (ko) 2003-03-06
US6773724B2 (en) 2004-08-10
PL204593B1 (pl) 2010-01-29
NO20030222L (no) 2003-01-16
SV2002000557A (es) 2002-10-24
TWI299729B (en) 2008-08-11
HUP0302053A3 (en) 2010-03-29
AR030305A1 (es) 2003-08-20
AU7847101A (en) 2002-01-30
CZ300337B6 (cs) 2009-04-22
CA2416288C (en) 2009-12-22
EP1365737A2 (de) 2003-12-03
DE50105985D1 (de) 2005-05-25
UY26841A1 (es) 2002-02-28
HUP0302053A2 (hu) 2003-09-29

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Legal Events

Date Code Title Description
PC4A Assignment and transfer of rights

Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, BERL, DE

Free format text: FORMER OWNER: BAYER HEALTHCARE AG, LEVERKUSEN, DE

Effective date: 20100614

MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20110705