SK285669B6 - Ekteinascidínová zlúčenina, farmaceutický prostriedok s jej obsahom a jej použitie - Google Patents

Ekteinascidínová zlúčenina, farmaceutický prostriedok s jej obsahom a jej použitie Download PDF

Info

Publication number
SK285669B6
SK285669B6 SK1501-2000A SK15012000A SK285669B6 SK 285669 B6 SK285669 B6 SK 285669B6 SK 15012000 A SK15012000 A SK 15012000A SK 285669 B6 SK285669 B6 SK 285669B6
Authority
SK
Slovakia
Prior art keywords
mammalian
ecteinascidin
iso
ecteinascidin compound
fab
Prior art date
Application number
SK1501-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK15012000A3 (sk
Inventor
Kenneth L. Rinehart
Jose J. Morales
Original Assignee
The Board Of Trustees Of The University Of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The University Of Illinois filed Critical The Board Of Trustees Of The University Of Illinois
Publication of SK15012000A3 publication Critical patent/SK15012000A3/sk
Publication of SK285669B6 publication Critical patent/SK285669B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Dental Preparations (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SK1501-2000A 1998-04-06 1999-04-05 Ekteinascidínová zlúčenina, farmaceutický prostriedok s jej obsahom a jej použitie SK285669B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8080298P 1998-04-06 1998-04-06
PCT/US1999/007471 WO1999051238A1 (en) 1998-04-06 1999-04-05 Semi-synthetic ecteinascidins

Publications (2)

Publication Number Publication Date
SK15012000A3 SK15012000A3 (sk) 2001-08-06
SK285669B6 true SK285669B6 (sk) 2007-06-07

Family

ID=22159716

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1501-2000A SK285669B6 (sk) 1998-04-06 1999-04-05 Ekteinascidínová zlúčenina, farmaceutický prostriedok s jej obsahom a jej použitie

Country Status (28)

Country Link
US (1) US6124293A (uk)
EP (2) EP1067933B1 (uk)
JP (1) JP4443043B2 (uk)
KR (1) KR100603219B1 (uk)
CN (1) CN1157189C (uk)
AT (1) ATE370148T1 (uk)
AU (1) AU758100B2 (uk)
BG (1) BG65088B1 (uk)
BR (1) BR9909488B1 (uk)
CA (1) CA2327468C (uk)
CY (1) CY1106988T1 (uk)
CZ (1) CZ301083B6 (uk)
DE (1) DE69936845T2 (uk)
DK (1) DK1067933T3 (uk)
ES (1) ES2292237T3 (uk)
HK (1) HK1033651A1 (uk)
HU (1) HUP0104273A3 (uk)
IL (2) IL138856A0 (uk)
MX (1) MXPA00009840A (uk)
NO (1) NO328147B1 (uk)
NZ (1) NZ507350A (uk)
PL (1) PL196809B1 (uk)
PT (1) PT1067933E (uk)
RU (1) RU2217432C2 (uk)
SK (1) SK285669B6 (uk)
TR (1) TR200002921T2 (uk)
UA (1) UA59439C2 (uk)
WO (1) WO1999051238A1 (uk)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
ES2239442T3 (es) * 1998-05-11 2005-09-16 Pharma Mar, S.A. Metabolitos de ecteinascidina 743.
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) * 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
CA2397597A1 (en) * 2000-01-19 2001-07-26 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US6809099B2 (en) 2000-11-03 2004-10-26 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
CZ20031327A3 (cs) * 2000-11-06 2003-11-12 Pharma Mar, S. A. Užití ET-743 k výrobě léků pro účinnou protinádorovou léčbu
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
CA2544320A1 (en) * 2003-11-13 2005-06-02 Pharma Mar, S.A.U. Method of treating cancer using a combination comprising et-743 and 5-fluorouracil
CN1897949A (zh) * 2003-11-14 2007-01-17 马尔药品公司 包含使用et－743和紫杉醇来治疗癌症的联合疗法
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
WO2006005602A2 (en) * 2004-07-09 2006-01-19 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
CN101068596A (zh) * 2004-09-29 2007-11-07 法马马私人股份有限公司 艾可特耐思地作抗炎药
SI1827500T1 (sl) * 2004-10-26 2009-10-31 Pharma Mar Sa Pegiliran liposomski doksorubicin v kombinaciji s ekteinescidinom 743
SI1658848T1 (sl) 2004-10-29 2007-12-31 Pharma Mar Sa Formulacije vsebujoäśe ekteinascidin in disaharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CN100355775C (zh) * 2006-01-20 2007-12-19 南方医科大学 一种海鞘多肽及其制备方法
AU2008313634A1 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for ET-743 treatment
RS54648B1 (en) 2010-11-12 2016-08-31 Pharma Mar S.A. COMBINED THERAPY WITH ANTITUMOR ALKALOID
AU2017215603A1 (en) * 2016-02-04 2018-08-09 Jiangsu Hengrui Medicine Co., Ltd. Trabectedin-inclusive injectable pharmaceutical composition for gastrointestinal external use and method for manufacturing the same
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds

Also Published As

Publication number Publication date
KR20010074474A (ko) 2001-08-04
SK15012000A3 (sk) 2001-08-06
UA59439C2 (uk) 2003-09-15
ATE370148T1 (de) 2007-09-15
CZ301083B6 (cs) 2009-11-04
HUP0104273A3 (en) 2003-12-29
NZ507350A (en) 2003-03-28
PL196809B1 (pl) 2008-02-29
DE69936845D1 (de) 2007-09-27
MXPA00009840A (es) 2002-04-24
EP1876180A3 (en) 2009-12-16
EP1876180A2 (en) 2008-01-09
HK1033651A1 (en) 2001-09-14
NO20004978D0 (no) 2000-10-03
EP1067933A4 (en) 2002-12-18
PT1067933E (pt) 2007-11-15
DE69936845T2 (de) 2008-05-08
CA2327468A1 (en) 1999-10-14
BR9909488A (pt) 2000-12-26
RU2000128058A (ru) 2004-02-20
TR200002921T2 (tr) 2001-02-21
BG65088B1 (bg) 2007-02-28
NO20004978L (no) 2000-12-05
CY1106988T1 (el) 2012-09-26
KR100603219B1 (ko) 2006-07-20
WO1999051238A1 (en) 1999-10-14
EP1067933A1 (en) 2001-01-17
US6124293A (en) 2000-09-26
DK1067933T3 (da) 2007-12-27
AU758100B2 (en) 2003-03-13
CN1304309A (zh) 2001-07-18
CN1157189C (zh) 2004-07-14
CA2327468C (en) 2008-05-06
HUP0104273A2 (hu) 2002-03-28
BR9909488B1 (pt) 2011-02-08
ES2292237T3 (es) 2008-03-01
AU3471399A (en) 1999-10-25
JP4443043B2 (ja) 2010-03-31
JP2002510633A (ja) 2002-04-09
BG104902A (en) 2001-07-31
NO328147B1 (no) 2009-12-21
EP1067933B1 (en) 2007-08-15
IL138856A (en) 2007-07-24
CZ20003650A3 (en) 2001-06-13
WO1999051238A9 (en) 2000-01-27
RU2217432C2 (ru) 2003-11-27
IL138856A0 (en) 2001-10-31
PL343439A1 (en) 2001-08-13

Similar Documents

Publication Publication Date Title
SK285669B6 (sk) Ekteinascidínová zlúčenina, farmaceutický prostriedok s jej obsahom a jej použitie
JP2010540471A (ja) ガンボギン酸グリコシド誘導体及びアナログ、並びにその製法及び応用
CA2457056C (en) Pharmaceutical compositions comprising polysaccharide conjugates for inhibiting the metastasis or preventing the recurrence of malignant tumor
EP2824108B1 (en) Tetracyclic anthraquinone derivatives
JPH10506410A (ja) 抗腫瘍剤及び抗ウイルス剤としてのビス−（２−ハロエチル）アミノフェニル置換ジスタマイシン誘導体
US20020173468A1 (en) Modified cytostatic agents
HU217630B (hu) 3'-Aziridino-antraciklin-származékok, eljárás ezek előállítására és e vegyületeket tartalmazó gyógyászati készítmények
ES2339152T3 (es) Dimeros halogenados de quindolina para el tratamiento del cancer.
JPH05247001A (ja) 置換ベンゾイルウレア誘導体又はその塩、それらの製造方法及びそれらを含有する抗癌剤
FI61187B (fi) Foerfarande foer framstaellning av antitumoera 1,2-5,6-dianhydro-3,4-di-0-acylgalaktitolderivat
KR102162351B1 (ko) 약물-결합 화합물 및 이의 용도
KR100390767B1 (ko) 아지리디닐퀴놀린디온 유도체와 그의 제조방법
CN115887687A (zh) 一种透明质酸(ha)-ca-4偶联物及其合成方法和应用
KR20180015266A (ko) 스테로이드성 락탐 및 비스(2-클로로에틸)아미노페녹시 프로피온산 유도체의 에스테르
HU206087B (en) Process for producing n-acylated derivatives of 9,10-anthracene-dicarboxaldehyde-bis(2-imidazolin-2-yl-hydrazole) and pharmaceutical compositions comprising same as active ingredient
JPH0834788A (ja) ピロロベンゾカルバゾール誘導体及びその製造方法
GB2287463A (en) Bis-anthracycline derivatives
JPH08151379A (ja) ビス（ピロロインドール）誘導体及びその製造方法

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20110405