SK285329B6 - Kryštalický hydrochlorid valacyklovíru, spôsob jeho výroby a jeho použitie - Google Patents

Kryštalický hydrochlorid valacyklovíru, spôsob jeho výroby a jeho použitie Download PDF

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Publication number
SK285329B6
SK285329B6 SK965-97A SK96597A SK285329B6 SK 285329 B6 SK285329 B6 SK 285329B6 SK 96597 A SK96597 A SK 96597A SK 285329 B6 SK285329 B6 SK 285329B6
Authority
SK
Slovakia
Prior art keywords
hydrochloride
valaciclovir
crystalline form
solvent
anhydrous crystalline
Prior art date
Application number
SK965-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK96597A3 (en
Inventor
Barry Howard Carter
Jane Muse Partin
Peter Gregory Varlashkin
Richard Augustus Winnike
Philip George Lake
David Michael Skinner
David James Whatrup
Gregory Alan Conway
William Bayne Grubb Iii
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10768347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK285329(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of SK96597A3 publication Critical patent/SK96597A3/sk
Publication of SK285329B6 publication Critical patent/SK285329B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
SK965-97A 1995-01-20 1996-01-19 Kryštalický hydrochlorid valacyklovíru, spôsob jeho výroby a jeho použitie SK285329B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9501178.9A GB9501178D0 (en) 1995-01-20 1995-01-20 Guanine derivative
PCT/GB1996/000117 WO1996022291A1 (en) 1995-01-20 1996-01-19 Guanine derivative

Publications (2)

Publication Number Publication Date
SK96597A3 SK96597A3 (en) 1998-02-04
SK285329B6 true SK285329B6 (sk) 2006-11-03

Family

ID=10768347

Family Applications (1)

Application Number Title Priority Date Filing Date
SK965-97A SK285329B6 (sk) 1995-01-20 1996-01-19 Kryštalický hydrochlorid valacyklovíru, spôsob jeho výroby a jeho použitie

Country Status (40)

Country Link
US (1) US6107302A (et)
EP (1) EP0804436B1 (et)
JP (1) JP3176633B2 (et)
KR (1) KR100376074B1 (et)
CN (1) CN1049893C (et)
AP (1) AP662A (et)
AR (1) AR002270A1 (et)
AT (1) ATE302777T1 (et)
AU (1) AU702794B2 (et)
BG (1) BG63393B1 (et)
BR (1) BR9606768A (et)
CA (1) CA2210799C (et)
CY (1) CY2531B1 (et)
CZ (1) CZ297065B6 (et)
DE (1) DE69635106T2 (et)
DK (1) DK0804436T3 (et)
EA (1) EA000364B1 (et)
EE (1) EE03528B1 (et)
ES (1) ES2248806T3 (et)
FI (1) FI973063A (et)
GB (1) GB9501178D0 (et)
GE (1) GEP20001940B (et)
HR (1) HRP960024B1 (et)
HU (1) HU222993B1 (et)
IL (1) IL116831A (et)
IN (1) IN182468B (et)
IS (1) IS2268B (et)
NO (1) NO315558B1 (et)
NZ (1) NZ298851A (et)
OA (1) OA10499A (et)
PL (1) PL182175B1 (et)
RO (1) RO118693B1 (et)
RS (1) RS49518B (et)
SI (1) SI0804436T1 (et)
SK (1) SK285329B6 (et)
TR (1) TR199700656T1 (et)
UA (1) UA46001C2 (et)
UY (1) UY25779A1 (et)
WO (1) WO1996022291A1 (et)
ZA (1) ZA96449B (et)

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GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative
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GB0010446D0 (en) * 2000-04-28 2000-06-14 Glaxo Wellcome Kk Pharmaceutical formulation
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CN1551880A (zh) * 2001-09-07 2004-12-01 ������ҩ��ҵ���޹�˾ 阿昔洛韦缬氨酸酯盐酸盐的晶型
EP1453834A1 (en) * 2001-11-05 2004-09-08 Glaxo Group Limited Anhydrous crystal form of valaciclovir hydrochloride
IL161969A0 (en) * 2001-11-14 2005-11-20 Teva Pharma Synthesis and purification of valacyclovir
AU2003240213A1 (en) * 2002-06-24 2004-01-06 Ranbaxy Laboratories Limited Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
WO2004035583A1 (en) * 2002-10-16 2004-04-29 Teva Pharmaceutical Industries Ltd. Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
CA2548608A1 (en) * 2002-12-09 2004-06-24 Texcontor Etablissement Anhydrous crystalline form of valacyclovir hydrochloride
WO2004106338A1 (en) * 2003-05-30 2004-12-09 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Novel crystalline forms of valacyclovir hydrochloride
TW200510414A (en) 2003-06-02 2005-03-16 Teva Pharma Novel crystalline forms of valacyclovir hydrochloride
KR20060117355A (ko) * 2004-01-21 2006-11-16 테바 파마슈티컬 인더스트리즈 리미티드 발라시클로버 염산염의 제조 방법
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CA2572268A1 (en) * 2004-06-30 2006-02-02 Teva Pharmaceutical Industries Ltd. Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
US20060178512A1 (en) * 2005-02-04 2006-08-10 Cheruthur Govindan Method for preparing amino acid esters of nucleoside analogues
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EP1746098A1 (en) 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir polymorphs and a process for the preparation thereof
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US20070112193A1 (en) * 2005-11-14 2007-05-17 Khunt Mayur D Valacyclovir process
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
CN107235980A (zh) 2006-05-04 2017-10-10 勃林格殷格翰国际有限公司 多晶型
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
CN1903854B (zh) * 2006-08-09 2012-05-23 丽珠医药集团股份有限公司 一种合成盐酸伐昔洛韦的方法
US20080167325A1 (en) * 2006-12-27 2008-07-10 Bs Praveen Kumar Valacyclovir compositions
US20080281099A1 (en) * 2007-05-07 2008-11-13 Mayur Devjibhai Khunt Process for purifying valacyclovir hydrochloride and intermediates thereof
GB0710277D0 (en) * 2007-05-30 2007-07-11 Univ Birmingham Use of antivirals in the treatment of medical disorders
MX2010001821A (es) * 2007-08-17 2010-03-10 Boehringer Ingelheim Int Derivados de purina para uso en el tratamiento de enfermedades relacionadas con fap.
JPWO2009031576A1 (ja) * 2007-09-03 2010-12-16 味の素株式会社 バラシクロビル塩酸塩結晶の製造方法
US20090076039A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched valacyclovir
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
US8513264B2 (en) 2008-09-10 2013-08-20 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
JP2012512848A (ja) 2008-12-23 2012-06-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 有機化合物の塩の形態
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
UY32048A (es) * 2009-01-08 2010-03-26 Boehringer Ingelheim Int Derivados sustituido de 1-(sustituido)-3-metil-7-(sustituido)-8-(3-(R)-amino-piperidin-1-il)cantina y derivados sustituidos de 1-(sustituido) - 4 - fluoropirrolidin- 2 - carbonitrilo y sus sales famacéuticamente aceptables como inhibidores de DPP-4 y aplicaciones.
ES2760917T3 (es) 2009-11-27 2020-05-18 Boehringer Ingelheim Int Tratamiento de pacientes diabéticos genotipificados con inhibidores DPP-IV como la linagliptina
BR112012028136A2 (pt) 2010-05-05 2016-08-09 Boehringer Ingelheim Int terapia de combinaçao
WO2011158252A1 (en) 2010-06-15 2011-12-22 Matrix Laboratories Ltd Process for the preparation of valacyclovir hydrochloride polymorphic form ii
ES2953123T3 (es) 2010-06-24 2023-11-08 Boehringer Ingelheim Int Terapia para la diabetes
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
CN102584825B (zh) * 2011-01-17 2014-04-02 四川科伦药物研究有限公司 一种合成盐酸伐昔洛韦的方法
ES2713566T3 (es) 2011-07-15 2019-05-22 Boehringer Ingelheim Int Derivado de quinazolina dimérico sustituido, su preparación y su uso en composiciones farmacéuticas para el tratamiento de la diabetes de tipo I y II
EP2852592A4 (en) * 2011-11-25 2015-12-23 Piramal Entpr Ltd PROCESS FOR THE PREPARATION OF VALACYCLOVIR CHLORHYDRATE
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
WO2013171167A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
WO2017211979A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin
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AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
EP0702682B1 (en) * 1993-06-10 2001-03-14 Rolabo Sl Process for the preparation of amino acid esters of nucleoside analogues
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative

Also Published As

Publication number Publication date
AP9701058A0 (en) 1997-10-31
AU4453996A (en) 1996-08-07
HUP9801836A3 (en) 1999-06-28
AU702794B2 (en) 1999-03-04
NO973326D0 (no) 1997-07-18
OA10499A (en) 2002-04-10
DE69635106T2 (de) 2006-06-08
WO1996022291A1 (en) 1996-07-25
UA46001C2 (uk) 2002-05-15
EE03528B1 (et) 2001-10-15
US6107302A (en) 2000-08-22
RO118693B1 (ro) 2003-09-30
EA199700124A1 (ru) 1997-12-30
SK96597A3 (en) 1998-02-04
CN1179159A (zh) 1998-04-15
EP0804436A1 (en) 1997-11-05
CY2531B1 (en) 2006-04-12
CZ229497A3 (en) 1997-12-17
NZ298851A (en) 1999-01-28
NO973326L (no) 1997-09-16
PL182175B1 (pl) 2001-11-30
YU3396A (sh) 1998-12-23
DK0804436T3 (da) 2005-12-27
IL116831A0 (en) 1996-05-14
IL116831A (en) 1998-10-30
JP3176633B2 (ja) 2001-06-18
EA000364B1 (ru) 1999-06-24
BG101833A (en) 1998-04-30
JPH11503718A (ja) 1999-03-30
SI0804436T1 (sl) 2006-02-28
HU222993B1 (hu) 2004-01-28
CZ297065B6 (cs) 2006-08-16
TR199700656T1 (xx) 1998-03-21
CA2210799C (en) 2008-06-10
FI973063A (fi) 1997-09-18
DE69635106D1 (de) 2005-09-29
BR9606768A (pt) 1997-12-30
AR002270A1 (es) 1998-03-11
IS2268B (is) 2007-07-15
HRP960024A2 (en) 1997-10-31
ATE302777T1 (de) 2005-09-15
NO315558B1 (no) 2003-09-22
ZA96449B (en) 1996-08-07
BG63393B1 (bg) 2001-12-29
CN1049893C (zh) 2000-03-01
EE9700175A (et) 1998-02-16
AP662A (en) 1998-08-19
HRP960024B1 (en) 2005-08-31
IN182468B (et) 1999-04-17
IS4527A (is) 1997-07-15
ES2248806T3 (es) 2006-03-16
PL321326A1 (en) 1997-12-08
UY25779A1 (es) 2000-08-21
MX9705462A (es) 1997-10-31
FI973063A0 (fi) 1997-07-18
CA2210799A1 (en) 1996-07-25
KR19980701525A (ko) 1998-05-15
RS49518B (sr) 2006-10-27
GB9501178D0 (en) 1995-03-08
KR100376074B1 (ko) 2003-06-02
GEP20001940B (en) 2000-02-05
EP0804436B1 (en) 2005-08-24
HUP9801836A2 (hu) 1999-05-28

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20110119