SK284468B6 - Pyridínový derivát, spôsob jeho prípravy a použitie, kompozícia s jeho obsahom a spôsob jej prípravy - Google Patents

Pyridínový derivát, spôsob jeho prípravy a použitie, kompozícia s jeho obsahom a spôsob jej prípravy Download PDF

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Publication number
SK284468B6
SK284468B6 SK1387-2000A SK13872000A SK284468B6 SK 284468 B6 SK284468 B6 SK 284468B6 SK 13872000 A SK13872000 A SK 13872000A SK 284468 B6 SK284468 B6 SK 284468B6
Authority
SK
Slovakia
Prior art keywords
formula
hydrogen
compounds
alkyl
acid
Prior art date
Application number
SK1387-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK13872000A3 (sk
Inventor
Eddy Jean Edgard Freyne
Gaston Stanislas Marcella Diels
Maria Encarnacion Matesanz-Ballesteros
Adolfo Diaz-Martinez
Original Assignee
Janssen Pharmaceutica N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.
Publication of SK13872000A3 publication Critical patent/SK13872000A3/sk
Publication of SK284468B6 publication Critical patent/SK284468B6/sk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
SK1387-2000A 1998-04-01 1999-03-24 Pyridínový derivát, spôsob jeho prípravy a použitie, kompozícia s jeho obsahom a spôsob jej prípravy SK284468B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201020 1998-04-01
PCT/EP1999/002045 WO1999050262A1 (en) 1998-04-01 1999-03-24 Pde iv inhibiting pyridine derivatives

Publications (2)

Publication Number Publication Date
SK13872000A3 SK13872000A3 (sk) 2001-11-06
SK284468B6 true SK284468B6 (sk) 2005-04-01

Family

ID=8233543

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1387-2000A SK284468B6 (sk) 1998-04-01 1999-03-24 Pyridínový derivát, spôsob jeho prípravy a použitie, kompozícia s jeho obsahom a spôsob jej prípravy

Country Status (34)

Country Link
US (1) US6656959B1 (et)
EP (1) EP1068194B1 (et)
JP (1) JP4778612B2 (et)
KR (1) KR100596664B1 (et)
CN (1) CN1172930C (et)
AR (1) AR014972A1 (et)
AT (1) ATE253569T1 (et)
AU (1) AU760771B2 (et)
BG (1) BG64705B1 (et)
BR (1) BR9909326A (et)
CA (1) CA2326045C (et)
CZ (1) CZ298747B6 (et)
DE (1) DE69912590T2 (et)
DK (1) DK1068194T3 (et)
EA (1) EA004207B1 (et)
EE (1) EE04718B1 (et)
ES (1) ES2211061T3 (et)
HK (1) HK1033579A1 (et)
HR (1) HRP20000619B1 (et)
HU (1) HU229412B1 (et)
ID (1) ID27207A (et)
IL (2) IL138745A0 (et)
MY (1) MY124696A (et)
NO (1) NO319531B1 (et)
NZ (1) NZ507022A (et)
PL (1) PL196026B1 (et)
PT (1) PT1068194E (et)
SI (1) SI1068194T1 (et)
SK (1) SK284468B6 (et)
TR (1) TR200002801T2 (et)
TW (1) TWI242558B (et)
UA (1) UA66842C2 (et)
WO (1) WO1999050262A1 (et)
ZA (1) ZA200006190B (et)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6639077B2 (en) 2000-03-23 2003-10-28 Merck Frosst Canada & Co. Tri-aryl-substituted-ethane PDE4 inhibitors
MY123585A (en) 2000-03-23 2006-05-31 Merck Canada Inc Tri-aryl-substituted-ethane pde4 inhibitors.
DE10130397A1 (de) * 2001-06-23 2003-01-09 Bayer Cropscience Gmbh Herbizide substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbzide und Pflanzenwachstumsregulatoren
DE10318610A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 7-Azaindole und deren Verwendung als Therapeutika
MXPA06012505A (es) 2004-04-30 2006-12-15 Warner Lambert Co Compuestos de morfolina sustituida para el tratamiento de trastornos del sistema nervioso central.
US7863446B2 (en) 2006-01-19 2011-01-04 Orchid Research Laboratories Limited Heterocycles
WO2007085357A1 (en) 2006-01-30 2007-08-02 Euro-Celtique S.A. Cyclourea compounds as calcium channel blockers
PT2076508E (pt) 2006-10-18 2011-03-07 Pfizer Prod Inc Compostos de ureia de éter biarílico
EP2245017A4 (en) 2008-02-01 2011-12-28 Orchid Res Lab Ltd NEW HETEROCYCLES
JOP20190060A1 (ar) 2016-09-26 2019-03-26 Chugai Pharmaceutical Co Ltd مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876657A (en) * 1971-06-03 1975-04-08 Ashland Oil Inc Preparation of 1-substituted-2-imidazolidinones
US4600430A (en) 1985-02-22 1986-07-15 Eli Lilly And Company Pyridinylimidazolidinone compounds
EP0711282B1 (en) * 1993-07-28 2002-06-05 Aventis Pharma Limited Compounds as pde iv and tnf inhibitors
GB9401460D0 (en) * 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
WO1996004186A1 (en) * 1994-08-03 1996-02-15 Gics & Vermee, L.P. Ovenable food package
TW332201B (en) 1995-04-06 1998-05-21 Janssen Pharmaceutica Nv 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
TW424087B (en) * 1995-04-06 2001-03-01 Janssen Pharmaceutica Nv 1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives
TW375612B (en) * 1995-04-06 1999-12-01 Janssen Pharmaceutica Nv 1,3-dihydro-2H-imidazol-2-one derivatives for the treatment of disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase type IV, preparation thereof and pharmaceutical composition containing the same
WO1997003967A1 (en) * 1995-07-22 1997-02-06 Rhone-Poulenc Rorer Limited Substituted aromatic compounds and their pharmaceutical use
BR9612378A (pt) * 1995-12-29 1999-07-13 Smithkline Beecham Corp Antagonistas receptores de vitronectina
DE69720757T2 (de) * 1996-10-02 2004-03-04 Janssen Pharmaceutica N.V. Pde-iv hemmende 2-cyanoiminoimidazol-derivate

Also Published As

Publication number Publication date
DE69912590T2 (de) 2004-09-16
AU3147499A (en) 1999-10-18
PL343194A1 (en) 2001-07-30
ID27207A (id) 2001-03-08
HRP20000619B1 (en) 2004-06-30
PT1068194E (pt) 2004-03-31
ZA200006190B (en) 2001-10-31
CA2326045C (en) 2008-12-09
KR100596664B1 (ko) 2006-07-06
HUP0101239A3 (en) 2002-09-30
NO20004906D0 (no) 2000-09-29
HRP20000619A2 (en) 2001-10-31
JP4778612B2 (ja) 2011-09-21
IL138745A (en) 2007-06-17
HK1033579A1 (en) 2001-09-07
EE200000569A (et) 2002-04-15
UA66842C2 (uk) 2004-06-15
EA200001009A1 (ru) 2001-02-26
CZ20003338A3 (cs) 2001-02-14
CZ298747B6 (cs) 2008-01-16
CN1172930C (zh) 2004-10-27
EP1068194B1 (en) 2003-11-05
BG64705B1 (bg) 2005-12-30
EA004207B1 (ru) 2004-02-26
HUP0101239A2 (hu) 2002-05-29
CN1295571A (zh) 2001-05-16
DK1068194T3 (da) 2004-03-15
ATE253569T1 (de) 2003-11-15
DE69912590D1 (de) 2003-12-11
SI1068194T1 (en) 2004-04-30
AU760771B2 (en) 2003-05-22
CA2326045A1 (en) 1999-10-07
EE04718B1 (et) 2006-10-16
NO20004906L (no) 2000-11-28
AR014972A1 (es) 2001-04-11
ES2211061T3 (es) 2004-07-01
KR20010040681A (ko) 2001-05-15
IL138745A0 (en) 2001-10-31
US6656959B1 (en) 2003-12-02
EP1068194A1 (en) 2001-01-17
PL196026B1 (pl) 2007-11-30
TR200002801T2 (tr) 2000-12-21
SK13872000A3 (sk) 2001-11-06
HU229412B1 (en) 2013-12-30
JP2002509927A (ja) 2002-04-02
MY124696A (en) 2006-06-30
BG104718A (en) 2001-04-30
WO1999050262A1 (en) 1999-10-07
NO319531B1 (no) 2005-08-29
TWI242558B (en) 2005-11-01
BR9909326A (pt) 2000-12-12
NZ507022A (en) 2002-06-28

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MK4A Expiry of patent

Expiry date: 20190324