DE69912590D1 - Pde-iv-hemmende pyridin-derivate - Google Patents

Pde-iv-hemmende pyridin-derivate

Info

Publication number
DE69912590D1
DE69912590D1 DE69912590T DE69912590T DE69912590D1 DE 69912590 D1 DE69912590 D1 DE 69912590D1 DE 69912590 T DE69912590 T DE 69912590T DE 69912590 T DE69912590 T DE 69912590T DE 69912590 D1 DE69912590 D1 DE 69912590D1
Authority
DE
Germany
Prior art keywords
pde
pyridine derivatives
inhibiting
inhibiting pyridine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69912590T
Other languages
English (en)
Other versions
DE69912590T2 (de
Inventor
Jean Freyne
Stanislas Diels
Campo De Matesanz-Ballesteros
Adolfo Diaz-Martinez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of DE69912590D1 publication Critical patent/DE69912590D1/de
Publication of DE69912590T2 publication Critical patent/DE69912590T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69912590T 1998-04-01 1999-03-24 Pde-iv-hemmende pyridin-derivate Expired - Lifetime DE69912590T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98201020 1998-04-01
EP98201020 1998-04-01
PCT/EP1999/002045 WO1999050262A1 (en) 1998-04-01 1999-03-24 Pde iv inhibiting pyridine derivatives

Publications (2)

Publication Number Publication Date
DE69912590D1 true DE69912590D1 (de) 2003-12-11
DE69912590T2 DE69912590T2 (de) 2004-09-16

Family

ID=8233543

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69912590T Expired - Lifetime DE69912590T2 (de) 1998-04-01 1999-03-24 Pde-iv-hemmende pyridin-derivate

Country Status (34)

Country Link
US (1) US6656959B1 (de)
EP (1) EP1068194B1 (de)
JP (1) JP4778612B2 (de)
KR (1) KR100596664B1 (de)
CN (1) CN1172930C (de)
AR (1) AR014972A1 (de)
AT (1) ATE253569T1 (de)
AU (1) AU760771B2 (de)
BG (1) BG64705B1 (de)
BR (1) BR9909326A (de)
CA (1) CA2326045C (de)
CZ (1) CZ298747B6 (de)
DE (1) DE69912590T2 (de)
DK (1) DK1068194T3 (de)
EA (1) EA004207B1 (de)
EE (1) EE04718B1 (de)
ES (1) ES2211061T3 (de)
HK (1) HK1033579A1 (de)
HR (1) HRP20000619B1 (de)
HU (1) HU229412B1 (de)
ID (1) ID27207A (de)
IL (2) IL138745A0 (de)
MY (1) MY124696A (de)
NO (1) NO319531B1 (de)
NZ (1) NZ507022A (de)
PL (1) PL196026B1 (de)
PT (1) PT1068194E (de)
SI (1) SI1068194T1 (de)
SK (1) SK284468B6 (de)
TR (1) TR200002801T2 (de)
TW (1) TWI242558B (de)
UA (1) UA66842C2 (de)
WO (1) WO1999050262A1 (de)
ZA (1) ZA200006190B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY123585A (en) 2000-03-23 2006-05-31 Merck Canada Inc Tri-aryl-substituted-ethane pde4 inhibitors.
US6639077B2 (en) 2000-03-23 2003-10-28 Merck Frosst Canada & Co. Tri-aryl-substituted-ethane PDE4 inhibitors
DE10130397A1 (de) * 2001-06-23 2003-01-09 Bayer Cropscience Gmbh Herbizide substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbzide und Pflanzenwachstumsregulatoren
DE10318610A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 7-Azaindole und deren Verwendung als Therapeutika
AP2006003771A0 (en) 2004-04-30 2006-10-31 Warner Lambert Co Substituted morpholine compounds for the treatmentof central nervous system disorders
US7863446B2 (en) 2006-01-19 2011-01-04 Orchid Research Laboratories Limited Heterocycles
US8354434B2 (en) 2006-01-30 2013-01-15 Purdue Pharma L.P. Cyclourea compounds as calcium channel blockers
PT2076508E (pt) 2006-10-18 2011-03-07 Pfizer Prod Inc Compostos de ureia de éter biarílico
AU2009208712B2 (en) 2008-02-01 2013-03-14 Orchid Chemicals & Pharmaceuticals Limited Novel heterocycles
JOP20190060A1 (ar) 2016-09-26 2019-03-26 Chugai Pharmaceutical Co Ltd مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876657A (en) * 1971-06-03 1975-04-08 Ashland Oil Inc Preparation of 1-substituted-2-imidazolidinones
US4600430A (en) 1985-02-22 1986-07-15 Eli Lilly And Company Pyridinylimidazolidinone compounds
ZA945609B (en) 1993-07-28 1995-05-12 Rhone Poulenc Rorer Ltd [Di(ether or thioether)heteroaryl or fluoro substituted aryl] compounds
GB9401460D0 (en) * 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
AU3272195A (en) * 1994-08-03 1996-03-04 Gics & Vermee, L.P. Ovenable food package
TW332201B (en) * 1995-04-06 1998-05-21 Janssen Pharmaceutica Nv 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
TW375612B (en) * 1995-04-06 1999-12-01 Janssen Pharmaceutica Nv 1,3-dihydro-2H-imidazol-2-one derivatives for the treatment of disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase type IV, preparation thereof and pharmaceutical composition containing the same
TW424087B (en) 1995-04-06 2001-03-01 Janssen Pharmaceutica Nv 1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives
AU6526896A (en) * 1995-07-22 1997-02-18 Rhone-Poulenc Rorer Limited Substituted aromatic compounds and their pharmaceutical use
CA2241724A1 (en) * 1995-12-29 1997-07-10 Smithkline Beecham Corporation Vitronectin receptor antagonists
AU719561B2 (en) * 1996-10-02 2000-05-11 Janssen Pharmaceutica N.V. PDE IV inhibiting 2-cyanoiminoimidazole derivatives

Also Published As

Publication number Publication date
HRP20000619B1 (en) 2004-06-30
ES2211061T3 (es) 2004-07-01
HU229412B1 (en) 2013-12-30
DE69912590T2 (de) 2004-09-16
TWI242558B (en) 2005-11-01
NZ507022A (en) 2002-06-28
AU760771B2 (en) 2003-05-22
CA2326045A1 (en) 1999-10-07
HUP0101239A3 (en) 2002-09-30
BG104718A (en) 2001-04-30
PL343194A1 (en) 2001-07-30
AR014972A1 (es) 2001-04-11
CN1295571A (zh) 2001-05-16
EP1068194B1 (de) 2003-11-05
US6656959B1 (en) 2003-12-02
PL196026B1 (pl) 2007-11-30
EP1068194A1 (de) 2001-01-17
KR20010040681A (ko) 2001-05-15
NO319531B1 (no) 2005-08-29
SI1068194T1 (en) 2004-04-30
TR200002801T2 (tr) 2000-12-21
IL138745A (en) 2007-06-17
CZ298747B6 (cs) 2008-01-16
HK1033579A1 (en) 2001-09-07
EE04718B1 (et) 2006-10-16
SK13872000A3 (sk) 2001-11-06
ATE253569T1 (de) 2003-11-15
HRP20000619A2 (en) 2001-10-31
BG64705B1 (bg) 2005-12-30
CZ20003338A3 (cs) 2001-02-14
BR9909326A (pt) 2000-12-12
CN1172930C (zh) 2004-10-27
WO1999050262A1 (en) 1999-10-07
AU3147499A (en) 1999-10-18
MY124696A (en) 2006-06-30
HUP0101239A2 (hu) 2002-05-29
ID27207A (id) 2001-03-08
EA004207B1 (ru) 2004-02-26
KR100596664B1 (ko) 2006-07-06
ZA200006190B (en) 2001-10-31
IL138745A0 (en) 2001-10-31
PT1068194E (pt) 2004-03-31
SK284468B6 (sk) 2005-04-01
NO20004906D0 (no) 2000-09-29
UA66842C2 (uk) 2004-06-15
EE200000569A (et) 2002-04-15
JP2002509927A (ja) 2002-04-02
NO20004906L (no) 2000-11-28
DK1068194T3 (da) 2004-03-15
JP4778612B2 (ja) 2011-09-21
CA2326045C (en) 2008-12-09
EA200001009A1 (ru) 2001-02-26

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