UA66842C2 - Похідні піридину як інгібітори pde iv - Google Patents
Похідні піридину як інгібітори pde ivInfo
- Publication number
- UA66842C2 UA66842C2 UA2000105769A UA2000105769A UA66842C2 UA 66842 C2 UA66842 C2 UA 66842C2 UA 2000105769 A UA2000105769 A UA 2000105769A UA 2000105769 A UA2000105769 A UA 2000105769A UA 66842 C2 UA66842 C2 UA 66842C2
- Authority
- UA
- Ukraine
- Prior art keywords
- 6alkyl
- hydrogen
- substituted
- pde
- 6alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Даний винахід відноситься до похідних піридину формули (І), їх N-оксидних форм, фармацевтично прийнятних адитивних солей та стереохімічних ізомерних форм, де L являє водень; С1-6алкіл; С1-6алкілкарбоніл; С1-6алкілоксикарбоніл, заміщений С1-6алкілом; С3-6алкеніл; піперидил; заміщений піперидил; С1-6алкілсульфоніл або арилсульфоніл; -А-В- являє собою -CR4=CR5- або -CHR4-CHR5-; D являє собою О або NR6; R1 являє собою водень або С1-4алкіл; R являє собою водень; гало; С1-6алкіл; трифторметил; С3-6циклоалкіл; карбоксил; С1-4алкілоксикарбоніл; С3-6циклоалкіламінокарбоніл; арил; Het1; або С1-6алкіл; або R2 є O-R9 або NH-R10; R3 являє собою водень, гало, гідрокси, С1-6алкіл або С1-6алкілокси; або R2 та R1, або R2 та R3 взяті разом можуть утворювати бівалентний радикал; Q являє собою дизаміщений піридин; R7 та R8 кожний, незалежно, являє собою водень; С1-6алкіл; дифторметил; трифторметил; С3-6циклоалкіл; насичений 5-, 6- або 7-членний гетероцикл, що вміщує один або два гетероатоми, кожний незалежно вибраний з кисню, сірки або азоту; інданіл; 6,7-дигідро-5Н-циклопентапіридил; біцикло[2.2.1]-2-гептеніл; біцикло[2.2.1]гептаніл; С1-6алкілсульфоніл; арилсульфоніл; або заміщений С1-10алкіл; що мають здатність інгібувати (PDE IV) та цитокін. Даний винахід також відноситься до способу отримання сполук формули (І), до їх фармацевтичних композицій та до їх використання як лікарських засобів. EMBED ISISServer (I)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98201020 | 1998-04-01 | ||
| PCT/EP1999/002045 WO1999050262A1 (en) | 1998-04-01 | 1999-03-24 | Pde iv inhibiting pyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA66842C2 true UA66842C2 (uk) | 2004-06-15 |
Family
ID=8233543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2000105769A UA66842C2 (uk) | 1998-04-01 | 1999-03-24 | Похідні піридину як інгібітори pde iv |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6656959B1 (uk) |
| EP (1) | EP1068194B1 (uk) |
| JP (1) | JP4778612B2 (uk) |
| KR (1) | KR100596664B1 (uk) |
| CN (1) | CN1172930C (uk) |
| AR (1) | AR014972A1 (uk) |
| AT (1) | ATE253569T1 (uk) |
| AU (1) | AU760771B2 (uk) |
| BG (1) | BG64705B1 (uk) |
| BR (1) | BR9909326A (uk) |
| CA (1) | CA2326045C (uk) |
| CZ (1) | CZ298747B6 (uk) |
| DE (1) | DE69912590T2 (uk) |
| DK (1) | DK1068194T3 (uk) |
| EA (1) | EA004207B1 (uk) |
| EE (1) | EE04718B1 (uk) |
| ES (1) | ES2211061T3 (uk) |
| HK (1) | HK1033579A1 (uk) |
| HR (1) | HRP20000619B1 (uk) |
| HU (1) | HU229412B1 (uk) |
| ID (1) | ID27207A (uk) |
| IL (2) | IL138745A0 (uk) |
| MY (1) | MY124696A (uk) |
| NO (1) | NO319531B1 (uk) |
| NZ (1) | NZ507022A (uk) |
| PL (1) | PL196026B1 (uk) |
| PT (1) | PT1068194E (uk) |
| SI (1) | SI1068194T1 (uk) |
| SK (1) | SK284468B6 (uk) |
| TR (1) | TR200002801T2 (uk) |
| TW (1) | TWI242558B (uk) |
| UA (1) | UA66842C2 (uk) |
| WO (1) | WO1999050262A1 (uk) |
| ZA (1) | ZA200006190B (uk) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6639077B2 (en) | 2000-03-23 | 2003-10-28 | Merck Frosst Canada & Co. | Tri-aryl-substituted-ethane PDE4 inhibitors |
| MY123585A (en) | 2000-03-23 | 2006-05-31 | Merck Canada Inc | Tri-aryl-substituted-ethane pde4 inhibitors. |
| DE10130397A1 (de) * | 2001-06-23 | 2003-01-09 | Bayer Cropscience Gmbh | Herbizide substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbzide und Pflanzenwachstumsregulatoren |
| DE10318610A1 (de) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 7-Azaindole und deren Verwendung als Therapeutika |
| EP1745029A1 (en) | 2004-04-30 | 2007-01-24 | Warner-Lambert Company LLC | Substituted morpholine compounds for the treatment of central nervous system disorders |
| US7863446B2 (en) | 2006-01-19 | 2011-01-04 | Orchid Research Laboratories Limited | Heterocycles |
| JP2009525269A (ja) | 2006-01-30 | 2009-07-09 | ユーロ−セルティーク エス．エイ． | カルシウムチャネルブロッカーとしての環状尿素化合物 |
| AP2780A (en) | 2006-10-18 | 2013-09-30 | Pfizer Prod Inc | Biaryl ether urea compounds |
| RU2572616C2 (ru) | 2008-02-01 | 2016-01-20 | Оркид Рисерч Лабораториз Лимитед | Новые гетероциклы |
| JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3876657A (en) * | 1971-06-03 | 1975-04-08 | Ashland Oil Inc | Preparation of 1-substituted-2-imidazolidinones |
| US4600430A (en) | 1985-02-22 | 1986-07-15 | Eli Lilly And Company | Pyridinylimidazolidinone compounds |
| JP3775685B2 (ja) * | 1993-07-28 | 2006-05-17 | ローン−プーラン・ロレ・リミテツド | Ｐｄｅ▲ｉｖ▼およびｔｎｆ抑制剤としての化合物 |
| GB9401460D0 (en) * | 1994-01-26 | 1994-03-23 | Rhone Poulenc Rorer Ltd | Compositions of matter |
| WO1996004186A1 (en) * | 1994-08-03 | 1996-02-15 | Gics & Vermee, L.P. | Ovenable food package |
| TW332201B (en) * | 1995-04-06 | 1998-05-21 | Janssen Pharmaceutica Nv | 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives |
| TW375612B (en) * | 1995-04-06 | 1999-12-01 | Janssen Pharmaceutica Nv | 1,3-dihydro-2H-imidazol-2-one derivatives for the treatment of disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase type IV, preparation thereof and pharmaceutical composition containing the same |
| TW424087B (en) | 1995-04-06 | 2001-03-01 | Janssen Pharmaceutica Nv | 1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives |
| AU6526896A (en) | 1995-07-22 | 1997-02-18 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
| JP2000502708A (ja) * | 1995-12-29 | 2000-03-07 | スミスクライン・ビーチャム・コーポレイション | ビトロネクチン受容体拮抗物質 |
| WO1998014432A1 (en) * | 1996-10-02 | 1998-04-09 | Janssen Pharmaceutica N.V. | Pde iv inhibiting 2-cyanoiminoimidazole derivatives |
-
1999
- 1999-03-24 JP JP2000541166A patent/JP4778612B2/ja not_active Expired - Lifetime
- 1999-03-24 EE EEP200000569A patent/EE04718B1/xx unknown
- 1999-03-24 CA CA002326045A patent/CA2326045C/en not_active Expired - Lifetime
- 1999-03-24 EA EA200001009A patent/EA004207B1/ru not_active IP Right Cessation
- 1999-03-24 NZ NZ507022A patent/NZ507022A/en not_active IP Right Cessation
- 1999-03-24 CZ CZ20003338A patent/CZ298747B6/cs not_active IP Right Cessation
- 1999-03-24 KR KR1020007008557A patent/KR100596664B1/ko not_active IP Right Cessation
- 1999-03-24 PT PT99913302T patent/PT1068194E/pt unknown
- 1999-03-24 DK DK99913302T patent/DK1068194T3/da active
- 1999-03-24 DE DE69912590T patent/DE69912590T2/de not_active Expired - Lifetime
- 1999-03-24 SI SI9930470T patent/SI1068194T1/xx unknown
- 1999-03-24 UA UA2000105769A patent/UA66842C2/uk unknown
- 1999-03-24 TR TR2000/02801T patent/TR200002801T2/xx unknown
- 1999-03-24 AU AU31474/99A patent/AU760771B2/en not_active Expired
- 1999-03-24 ES ES99913302T patent/ES2211061T3/es not_active Expired - Lifetime
- 1999-03-24 EP EP99913302A patent/EP1068194B1/en not_active Expired - Lifetime
- 1999-03-24 SK SK1387-2000A patent/SK284468B6/sk not_active IP Right Cessation
- 1999-03-24 US US09/647,668 patent/US6656959B1/en not_active Expired - Lifetime
- 1999-03-24 ID IDW20001941A patent/ID27207A/id unknown
- 1999-03-24 AT AT99913302T patent/ATE253569T1/de active
- 1999-03-24 IL IL13874599A patent/IL138745A0/xx active IP Right Grant
- 1999-03-24 CN CNB998047376A patent/CN1172930C/zh not_active Expired - Lifetime
- 1999-03-24 HU HU0101239A patent/HU229412B1/hu unknown
- 1999-03-24 WO PCT/EP1999/002045 patent/WO1999050262A1/en active IP Right Grant
- 1999-03-24 PL PL99343194A patent/PL196026B1/pl unknown
- 1999-03-24 BR BR9909326-0A patent/BR9909326A/pt not_active Application Discontinuation
- 1999-03-26 MY MYPI99001169A patent/MY124696A/en unknown
- 1999-03-29 TW TW088104881A patent/TWI242558B/zh not_active IP Right Cessation
- 1999-03-31 AR ARP990101489A patent/AR014972A1/es not_active Application Discontinuation
-
2000
- 2000-08-28 BG BG104718A patent/BG64705B1/bg unknown
- 2000-09-19 HR HR20000619A patent/HRP20000619B1/xx not_active IP Right Cessation
- 2000-09-28 IL IL138745A patent/IL138745A/en not_active IP Right Cessation
- 2000-09-29 NO NO20004906A patent/NO319531B1/no not_active IP Right Cessation
- 2000-10-31 ZA ZA200006190A patent/ZA200006190B/en unknown
-
2001
- 2001-05-19 HK HK01103462A patent/HK1033579A1/xx not_active IP Right Cessation
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