SK283088B6 - Spôsob získania antigénu, ktorý imunologicky reaguje s protilátkami proti B burgdorferi antigénom a spôsob výroby vakcíny obsahujúcej takýto antigén - Google Patents

Spôsob získania antigénu, ktorý imunologicky reaguje s protilátkami proti B burgdorferi antigénom a spôsob výroby vakcíny obsahujúcej takýto antigén Download PDF

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Publication number
SK283088B6
SK283088B6 SK1510-98A SK151098A SK283088B6 SK 283088 B6 SK283088 B6 SK 283088B6 SK 151098 A SK151098 A SK 151098A SK 283088 B6 SK283088 B6 SK 283088B6
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SK
Slovakia
Prior art keywords
antigen
burgdorferi
mice
ospa
antibody
Prior art date
Application number
SK1510-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK151098A3 (en
Inventor
Markus M. Simon
Ulrich E. Schaible
Klaus Eichmann
Michael Kramer
Wallich Reinhard
Original Assignee
Max-Planck Gesellschaft Zur F�Rderung Der Wissenschaften E. V.
Deutsches Krebsforschungszentrum Stiftung Des �Ffentlichen Rec
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25885304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK283088(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Max-Planck Gesellschaft Zur F�Rderung Der Wissenschaften E. V., Deutsches Krebsforschungszentrum Stiftung Des �Ffentlichen Rec filed Critical Max-Planck Gesellschaft Zur F�Rderung Der Wissenschaften E. V.
Publication of SK151098A3 publication Critical patent/SK151098A3/sk
Publication of SK283088B6 publication Critical patent/SK283088B6/sk

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1207Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SK1510-98A 1989-09-19 1990-09-19 Spôsob získania antigénu, ktorý imunologicky reaguje s protilátkami proti B burgdorferi antigénom a spôsob výroby vakcíny obsahujúcej takýto antigén SK283088B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3931236 1989-09-19
DE4015911A DE4015911A1 (de) 1989-09-19 1990-05-17 Impfstoff gegen die lyme-krankheit

Publications (2)

Publication Number Publication Date
SK151098A3 SK151098A3 (en) 1999-04-13
SK283088B6 true SK283088B6 (sk) 2003-02-04

Family

ID=25885304

Family Applications (3)

Application Number Title Priority Date Filing Date
SK1510-98A SK283088B6 (sk) 1989-09-19 1990-09-19 Spôsob získania antigénu, ktorý imunologicky reaguje s protilátkami proti B burgdorferi antigénom a spôsob výroby vakcíny obsahujúcej takýto antigén
SK1511-98A SK283089B6 (sk) 1989-09-19 1990-09-19 Patogénny mikroorganizmus B.burgdorferi a spôsob jeho izolácie a rekultivácie
SK4560-90A SK280285B6 (sk) 1989-09-19 1990-09-19 Očkovacia látka proti borelióze a spôsob jej výrob

Family Applications After (2)

Application Number Title Priority Date Filing Date
SK1511-98A SK283089B6 (sk) 1989-09-19 1990-09-19 Patogénny mikroorganizmus B.burgdorferi a spôsob jeho izolácie a rekultivácie
SK4560-90A SK280285B6 (sk) 1989-09-19 1990-09-19 Očkovacia látka proti borelióze a spôsob jej výrob

Country Status (24)

Country Link
US (6) US5178859A (fr)
EP (5) EP0633028B1 (fr)
JP (3) JP3205932B2 (fr)
KR (2) KR100205462B1 (fr)
AT (4) ATE175576T1 (fr)
AU (1) AU651560B2 (fr)
CA (1) CA2025597C (fr)
CZ (2) CZ284616B6 (fr)
DE (5) DE4015911A1 (fr)
DK (4) DK0418827T3 (fr)
ES (4) ES2082812T3 (fr)
FI (1) FI102248B (fr)
GR (3) GR3018995T3 (fr)
HK (2) HK1002405A1 (fr)
HR (1) HRP940545B1 (fr)
HU (2) HU212716B (fr)
IE (1) IE903377A1 (fr)
NO (2) NO311767B1 (fr)
NZ (1) NZ235260A (fr)
PL (2) PL169804B1 (fr)
PT (1) PT95349B (fr)
SI (1) SI9011773B (fr)
SK (3) SK283088B6 (fr)
YU (2) YU48250B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK590288D0 (da) 1988-10-24 1988-10-24 Symbicom Ab Kemiske forbindelser
WO1993008306A1 (fr) * 1991-10-22 1993-04-29 Symbicom Aktiebolag AMELIORATION DANS LE DIAGNOSTIC ET LA PROPHYLAXIE DE LA BORRELIOSE PROVOQUEE PAR $i(BORRELIA BURGDORFERI)
US7094391B1 (en) * 1988-10-24 2006-08-22 The University Of Texas System Compositions and methods for administering Borrelia burgdorferi antigens
US5777095A (en) * 1988-10-24 1998-07-07 Symbicom Aktiebolag Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90
US6143872A (en) * 1988-10-24 2000-11-07 Symbicom Aktiebolag Borrelia burdorferi Osp A and B proteins and immunogenic peptides
DE4015911A1 (de) * 1989-09-19 1991-03-28 Max Planck Gesellschaft Impfstoff gegen die lyme-krankheit
US5582829A (en) * 1990-04-05 1996-12-10 Rx Technologies, Inc. Sonicated borrelia burgdorferi vaccine
CA2084413A1 (fr) * 1990-06-15 1991-12-16 Richard A. Flavell Compositions et methodes pour la prevention et le diagnostic de la maladie de lyme
DK0465204T3 (da) * 1990-07-06 2000-10-09 American Home Prod Vaccine mod Lyme sygdom
CA2057536C (fr) * 1990-12-21 1999-10-26 John J. Dunn Clonage et expression des lipoproteines de borrelia
US6221363B1 (en) * 1991-07-11 2001-04-24 Baxter Aktiengesellschaft Vaccine for the prevention of lyme disease
US6872550B1 (en) 1991-07-11 2005-03-29 Baxter Vaccine Ag Immunogenic formulation of OspC antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens
CA2115554A1 (fr) * 1991-08-15 1993-03-04 Yves Lobet Proteines osp-a de sous-groupes de borrelia burgdorferi, genes codant pour ces proteines et vaccins en contenant
US6676942B1 (en) 1991-08-15 2004-01-13 Smithkline Beecham Biologicals (S.A.) Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines
JPH06511154A (ja) * 1991-10-18 1994-12-15 コノート ラボラトリーズ インコーポレイテッド 組換えBorreliaタンパクの製造法
US6303129B1 (en) * 1992-07-28 2001-10-16 Rx Technologies Production of borrelia burgdorferi vaccine, product produced thereby and method of use
US5656451A (en) * 1993-07-30 1997-08-12 Yale University OspE, OspF, and S1 polypeptides in borrelia burgdorferi
US6716591B1 (en) 1993-07-30 2004-04-06 Yale University B. burgdorferi polypeptides
US7008625B2 (en) 1993-11-01 2006-03-07 Research Foundation Of The State University Of New York Recombinant constructs of Borrelia burgdorferi
US5558993A (en) * 1994-06-17 1996-09-24 The Regents Of The University Of California Cloned Borrelia burgdorferi virulence protein
GB9511909D0 (en) * 1995-06-12 1995-08-09 Microbiological Res Authority Vaccine
AU2191597A (en) 1996-02-21 1997-09-10 Board Of Regents, The University Of Texas System Vmp-like sequences of pathogenic borrelia
DE19632862B4 (de) 1996-08-14 2006-08-03 Mikrogen Molekularbiologische Entwicklungs-Gmbh Immunologisch aktive Proteine von Borrelia burgdorferi, dafür kodierende Nukleinsäuren sowie deren Verwendung in Testkits und als Impfstoffe
US6458555B1 (en) * 1996-08-21 2002-10-01 Gerd Bach Cytologic method of examining mucous membranes
US6060082A (en) * 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
DE19740735A1 (de) * 1997-09-16 1999-03-18 Max Planck Gesellschaft Arzneimittel zur Therapie einer manifesten Lyme-Borreliose
US6306623B1 (en) 1998-02-24 2001-10-23 The University Of California Leptospiral major outer membrane protein LipL32
WO2000006745A1 (fr) 1998-07-31 2000-02-10 Gundersen Lutheran Medical Foundation, Inc. UTILISATIONS, EN TANT QUE VACCIN, D'EPITOPE(S) BORRELIACIDAL DE PROTEINE C DE SURFACE EXTERIEURE (OSPC) DE $i(BORRELIA BURGDORFERI)
WO2000056298A2 (fr) * 1999-03-19 2000-09-28 Luitpold Pharmaceuticals, Inc. Traitement de la maladie de la lyme au moyen de formulations de glycosaminoglycans polysulfates
US6592875B1 (en) 1999-06-21 2003-07-15 Milkhaus Laboratory, Inc. Method for treatment of lyme disease
ATE381575T1 (de) 2000-08-18 2008-01-15 Univ New York State Res Found Veränderte borrelia burgdorferi ospa
WO2004058181A2 (fr) 2002-12-20 2004-07-15 Board Of Regents, The University Of Texas System Sequences d'especes et de souches de borrelia pathogene de type vmp
RU2460538C2 (ru) 2006-11-03 2012-09-10 Шеринг-Плоу Лтд. Вакцина против лаймской болезни собак
EP2361930A3 (fr) 2007-03-26 2011-10-26 Dako Denmark A/S Multimeres du complexes peptide-cmh et leur utilisation dans des maladies infectieuses de borrelia
EP2167537A2 (fr) 2007-07-03 2010-03-31 Dako Denmark A/S Procedes compiles pour analyser et trier des echantillons
WO2009039854A2 (fr) 2007-09-27 2009-04-02 Dako Denmark A/S Multimères cmh dans le diagnostic, le vaccin et le traitement de la tuberculose
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
US10722562B2 (en) 2008-07-23 2020-07-28 Immudex Aps Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
WO2010037402A1 (fr) 2008-10-02 2010-04-08 Dako Denmark A/S Vaccins moléculaires contre les maladies infectieuses
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
WO2011063003A2 (fr) * 2009-11-17 2011-05-26 Abaxis, Inc. Peptides et procédés pour la détection d'anticorps contre la maladie de lyme
US8758772B2 (en) 2011-11-04 2014-06-24 Abaxis, Inc. Peptides and methods for the detection of lyme disease antibodies
PL223175B1 (pl) 2012-10-22 2016-10-31 Inst Chemii Bioorganicznej Polskiej Akademii Nauk Szczepionka przeciw boreliozie, konstrukt genetyczny, rekombinowane białko, sposób otrzymywania konstruktu genetycznego, sposób otrzymywania szczepionki, sposób otrzymywania rekombinowanych białek, zastosowanie rekombinowanych białek do wytwarzania szczepionki przeciwko boreliozie
US9610336B1 (en) * 2014-07-16 2017-04-04 Amiram Katz Immunotherapy for lyme disease

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK590288D0 (da) * 1988-10-24 1988-10-24 Symbicom Ab Kemiske forbindelser
US4772464A (en) 1985-08-01 1988-09-20 Miles Laboratories, Inc. Protective antibodies to serotypic determinants of flagellar antigens
US4888276A (en) 1986-06-26 1989-12-19 Minnesota Mining And Manufacturing Company Method and composition for the diagnosis of Lyme disease
US4721617A (en) 1986-08-14 1988-01-26 Regents Of The University Of Minnesota Vaccine against lyme disease
US5034515A (en) * 1987-09-22 1991-07-23 Wisconsin Alumni Research Foundation Staphylococcal fibronectin receptor, monoclonal antibodies thereto and methods of use
DE4015911A1 (de) * 1989-09-19 1991-03-28 Max Planck Gesellschaft Impfstoff gegen die lyme-krankheit
CA2072008C (fr) * 1989-12-22 2003-01-28 Renate Fuchs Proteines a activite immunologique provenant de borrelia burgdorferi, trousses de dosage contenant ces proteines et permettant la detection d'anticorps dans des milieux liquides, et utilisation de ces proteines comme vaccins contre les infections causees par differentes souches de borrelia
CA2084413A1 (fr) * 1990-06-15 1991-12-16 Richard A. Flavell Compositions et methodes pour la prevention et le diagnostic de la maladie de lyme
DK0465204T3 (da) * 1990-07-06 2000-10-09 American Home Prod Vaccine mod Lyme sygdom
CA2057536C (fr) * 1990-12-21 1999-10-26 John J. Dunn Clonage et expression des lipoproteines de borrelia
CA2115554A1 (fr) * 1991-08-15 1993-03-04 Yves Lobet Proteines osp-a de sous-groupes de borrelia burgdorferi, genes codant pour ces proteines et vaccins en contenant
EP0642574B1 (fr) * 1991-08-27 1998-12-09 Novo Nordisk A/S Compositions pour detergents
JPH06511154A (ja) * 1991-10-18 1994-12-15 コノート ラボラトリーズ インコーポレイテッド 組換えBorreliaタンパクの製造法
EP0625052A4 (fr) * 1991-10-21 1995-07-19 Medimmune Inc Vecteurs d'expression bacteriens contenant de l'adn codant des signaux de secretion de lipoproteines.

Also Published As

Publication number Publication date
CZ456090A3 (cs) 1998-08-12
FI102248B1 (fi) 1998-11-13
PT95349B (pt) 1997-06-30
NO20014624L (no) 1991-03-20
US5686267A (en) 1997-11-11
JP2001069969A (ja) 2001-03-21
AU651560B2 (en) 1994-07-28
YU49370B (sh) 2005-09-19
GR3032010T3 (en) 2000-03-31
ES2145077T3 (es) 2000-07-01
ES2141182T3 (es) 2000-03-16
CA2025597C (fr) 2004-02-03
SI9011773B (en) 2001-12-31
AU6244490A (en) 1991-03-28
JP2001204467A (ja) 2001-07-31
HU212716B (en) 1996-10-28
NO904062L (no) 1991-03-20
NZ235260A (en) 1993-04-28
US5178859A (en) 1993-01-12
PL170229B1 (pl) 1996-11-29
CZ97095A3 (en) 1995-09-13
HRP940545B1 (en) 2000-06-30
EP0633028A1 (fr) 1995-01-11
NO904062D0 (no) 1990-09-18
DE59010903D1 (de) 2000-05-11
ATE186646T1 (de) 1999-12-15
YU177390A (sh) 1993-05-28
EP0633028B1 (fr) 1999-11-17
EP0861664A3 (fr) 1999-02-24
HRP940545A2 (en) 1997-04-30
ATE191499T1 (de) 2000-04-15
YU9097A (sh) 1999-06-15
DE59010863D1 (de) 1999-02-25
ATE131732T1 (de) 1996-01-15
HK1013620A1 (en) 1999-09-03
US5856447A (en) 1999-01-05
PL169804B1 (pl) 1996-09-30
US5434077A (en) 1995-07-18
SI9011773A (sl) 1998-04-30
GR3033675T3 (en) 2000-10-31
EP0418827A1 (fr) 1991-03-27
DK0633028T3 (da) 2000-04-10
DE4015911A1 (de) 1991-03-28
KR100202128B1 (en) 1999-06-15
EP0633313B1 (fr) 2000-04-05
KR100205462B1 (ko) 1999-07-01
EP0861664A2 (fr) 1998-09-02
DK0633313T3 (da) 2000-07-24
NO311767B1 (no) 2002-01-21
IE990173A1 (en) 2000-11-01
JP3205932B2 (ja) 2001-09-04
SK151098A3 (en) 1999-04-13
HU905816D0 (en) 1991-03-28
KR910005889A (ko) 1991-04-27
ATE175576T1 (de) 1999-01-15
SK283089B6 (sk) 2003-02-04
DK0643974T3 (da) 1999-09-06
JP3418171B2 (ja) 2003-06-16
SK456090A3 (en) 1999-11-08
US5780030A (en) 1998-07-14
SK151198A3 (en) 1999-04-13
PT95349A (pt) 1991-05-22
JP3328644B2 (ja) 2002-09-30
SK280285B6 (sk) 1999-11-08
EP0643974A1 (fr) 1995-03-22
EP0643974B1 (fr) 1999-01-13
ES2082812T3 (es) 1996-04-01
HK1002405A1 (en) 1998-08-21
IE903377A1 (en) 1991-04-10
NO315905B1 (no) 2003-11-10
DE59009978D1 (de) 1996-02-01
HU211228A9 (en) 1995-11-28
DK0418827T3 (da) 1996-05-06
CA2025597A1 (fr) 1991-03-20
JPH03209400A (ja) 1991-09-12
FI102248B (fi) 1998-11-13
CZ284616B6 (cs) 1999-01-13
ES2129551T3 (es) 1999-06-16
CZ284538B6 (cs) 1998-12-16
FI904597A0 (fi) 1990-09-18
HUT59613A (en) 1992-06-29
EP0418827B1 (fr) 1995-12-20
YU48250B (sh) 1997-09-30
GR3018995T3 (en) 1996-05-31
NO20014624D0 (no) 2001-09-24
US6613331B1 (en) 2003-09-02
DE59010888D1 (de) 1999-12-23
EP0633313A1 (fr) 1995-01-11

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