ATE381575T1 - Veränderte borrelia burgdorferi ospa - Google Patents

Veränderte borrelia burgdorferi ospa

Info

Publication number
ATE381575T1
ATE381575T1 AT01964163T AT01964163T ATE381575T1 AT E381575 T1 ATE381575 T1 AT E381575T1 AT 01964163 T AT01964163 T AT 01964163T AT 01964163 T AT01964163 T AT 01964163T AT E381575 T1 ATE381575 T1 AT E381575T1
Authority
AT
Austria
Prior art keywords
ospa
modified
alteration
borrelia burgdorferi
ospa polypeptide
Prior art date
Application number
AT01964163T
Other languages
English (en)
Inventor
Benjamin Luft
John Dunn
Catherine I Lawson
Shohei Koide
Original Assignee
Univ New York State Res Found
Brookhaven Sciences Ass Llc
Univ Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found, Brookhaven Sciences Ass Llc, Univ Rochester filed Critical Univ New York State Res Found
Application granted granted Critical
Publication of ATE381575T1 publication Critical patent/ATE381575T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Fats And Perfumes (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT01964163T 2000-08-18 2001-08-17 Veränderte borrelia burgdorferi ospa ATE381575T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22648400P 2000-08-18 2000-08-18

Publications (1)

Publication Number Publication Date
ATE381575T1 true ATE381575T1 (de) 2008-01-15

Family

ID=22849087

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01964163T ATE381575T1 (de) 2000-08-18 2001-08-17 Veränderte borrelia burgdorferi ospa

Country Status (9)

Country Link
US (3) US20040023325A1 (de)
EP (1) EP1311540B1 (de)
AT (1) ATE381575T1 (de)
AU (1) AU2001285049A1 (de)
DE (1) DE60131982T2 (de)
DK (1) DK1311540T3 (de)
ES (1) ES2298249T3 (de)
PT (1) PT1311540E (de)
WO (1) WO2002016421A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7008625B2 (en) * 1993-11-01 2006-03-07 Research Foundation Of The State University Of New York Recombinant constructs of Borrelia burgdorferi
PT1311540E (pt) 2000-08-18 2008-03-20 Univ New York State Res Found Ospa de borrelia burgdorferi modificada
US20110262475A1 (en) * 2008-05-02 2011-10-27 Earnhart Christopher G Lyme disease vaccine
CA2798331C (en) 2010-05-14 2022-03-15 Baxter International Inc. Ospa chimeras and use thereof in vaccines
US10100092B2 (en) 2011-11-03 2018-10-16 Vca, Inc. Compositions and methods to detect various infectious organisms
US8986704B2 (en) * 2012-07-06 2015-03-24 Valneva Austria Gmbh Mutant fragments of OspA and methods and uses relating thereto
KR20200068756A (ko) 2012-07-27 2020-06-15 박스알타 인코퍼레이티드 키메라 ospa 분자를 포함하는 조성물 및 이의 사용 방법
TR201910117T4 (tr) 2014-01-09 2019-07-22 Valneva Austria Gmbh OspA nın mutant fragmanları ve bunlara ilişkin yöntemler ve kullanımları.
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
WO2018189372A1 (en) 2017-04-13 2018-10-18 Valneva Austria Gmbh Multivalent ospa polypeptides and methods and uses relating thereto
CN112512564A (zh) 2018-04-03 2021-03-16 赛诺菲 铁蛋白蛋白
WO2019195314A2 (en) 2018-04-03 2019-10-10 Sanofi Antigenic epstein barr virus polypeptides
KR20210018205A (ko) * 2018-04-03 2021-02-17 사노피 항원성 OspA 폴리펩타이드
US10749235B2 (en) 2018-09-07 2020-08-18 International Business Machines Corporation Well thermalized microstrip formation for flexible cryogenic microwave lines in quantum applications

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK590288D0 (da) * 1988-10-24 1988-10-24 Symbicom Ab Kemiske forbindelser
US5777095A (en) * 1988-10-24 1998-07-07 Symbicom Aktiebolag Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90
US5246844A (en) 1991-10-22 1993-09-21 Board Of Regents, The University Of Texas System Virulence associated proteins in borrelia burgdorferi (bb)
DE4015911A1 (de) 1989-09-19 1991-03-28 Max Planck Gesellschaft Impfstoff gegen die lyme-krankheit
AU7058691A (en) 1989-12-22 1991-07-24 Mikrogen Molekularbiologische Entwicklungs-Gmbh Immunologically active proteines from borrelia burgdorferi, related test kits and vaccine
US5217872A (en) * 1990-02-27 1993-06-08 The United States Of America As Represented By The Department Of Health And Human Services Method for detection of borrelia burgdorferi antigens
WO1991013630A1 (en) 1990-03-05 1991-09-19 The United States Of America, Represented By The Secretary, United States Department Of Commerce ANTIGENIC PROTEINS OF $i(BORRELIA BURGDORFERI)
US5470712A (en) * 1990-03-05 1995-11-28 Us Health Antigenic proteins of Borrelia burgdorferi
SG47447A1 (en) * 1990-06-15 1998-04-17 Univ Yale Compositions and methods for the prevention and diagnosis of lyme disease
ES2149759T3 (es) 1990-07-06 2000-11-16 American Home Prod Vacuna contra la enfermedad de lyme.
CA2057536C (en) 1990-12-21 1999-10-26 John J. Dunn Cloning and expression of borrelia lipoproteins
US6221363B1 (en) 1991-07-11 2001-04-24 Baxter Aktiengesellschaft Vaccine for the prevention of lyme disease
CA2115554A1 (en) * 1991-08-15 1993-03-04 Yves Lobet Osp a proteins of borrelia burgdorferi subgroups, encoding genes and vaccines
WO1993008299A1 (en) 1991-10-18 1993-04-29 Connaught Laboratories Inc. Preparation of recombinant borrelia proteins
EP0540457A1 (de) 1991-10-22 1993-05-05 Symbicom Ab Verbesserungen der Diagnose und der Prophylaxe von Borrelia burgdorferi
AU2917892A (en) 1991-11-12 1993-06-15 Regents Of The University Of Minnesota Recombinant vaccine against lyme disease
AU689466B2 (en) 1993-02-26 1998-04-02 Cambridge Biotech Corporation Methods of inducing immunity to lyme disease and a colorimetric assay for borreliacidal activity of antisera
AU6366894A (en) 1993-03-11 1994-09-26 Regents Of The University Of California, The Methods, compositions, and kits for diagnosing lyme disease
DK0701612T3 (da) 1993-04-29 1998-09-21 Immuno Ag Immunogent præparat af OspC-antigenvacciner til forebyggelse og behandling af Lyme sygdom og rekombinantmetode til fremsti
EP0726955B1 (de) * 1993-11-01 2004-04-07 Brookhaven Science Associates Chimere proteine, welche borrelia polypeptide beinhalten, verwendungen dafür
US7008625B2 (en) * 1993-11-01 2006-03-07 Research Foundation Of The State University Of New York Recombinant constructs of Borrelia burgdorferi
US6248562B1 (en) * 1993-11-01 2001-06-19 Research Foundation State University Of New York Chimeric proteins comprising borrelia polypeptides and uses therefor
US5620862A (en) * 1993-11-24 1997-04-15 University Of Connecticut Methods for diagnosing early Lyme disease
US6251405B1 (en) 1995-06-07 2001-06-26 Connaught Laboratories, Inc. Immunological combination compositions and methods
WO1996040718A1 (en) 1995-06-07 1996-12-19 Connaught Laboratories, Inc. Expression of lipoproteins
DE69718903T2 (de) 1996-05-02 2003-12-04 Dakocytomation Denmark As Glos Verwendung von aus osp-c abgeleiteten peptidefragmenten für diagnostische methoden
AUPO069996A0 (en) 1996-06-27 1996-07-18 Australian National University, The Manipulation of plant cellulose
DE19740735A1 (de) 1997-09-16 1999-03-18 Max Planck Gesellschaft Arzneimittel zur Therapie einer manifesten Lyme-Borreliose
DE69938183T2 (de) * 1998-07-31 2009-02-19 Gundersen Lutheran Medical Foundation, Inc., La Crosse Verwendungen eines borreliaziden epitops des aussermembranproteins c von borrelia burgdorferi (ospc) als impstoff
PT1311540E (pt) 2000-08-18 2008-03-20 Univ New York State Res Found Ospa de borrelia burgdorferi modificada

Also Published As

Publication number Publication date
PT1311540E (pt) 2008-03-20
US8992936B2 (en) 2015-03-31
US8680236B2 (en) 2014-03-25
US20040023325A1 (en) 2004-02-05
DE60131982T2 (de) 2008-12-11
WO2002016421A2 (en) 2002-02-28
DE60131982D1 (de) 2008-01-31
WO2002016421A3 (en) 2003-03-06
EP1311540B1 (de) 2007-12-19
US20090326200A1 (en) 2009-12-31
AU2001285049A1 (en) 2002-03-04
US20140030285A1 (en) 2014-01-30
DK1311540T3 (da) 2008-04-28
EP1311540A2 (de) 2003-05-21
WO2002016421A9 (en) 2003-09-04
ES2298249T3 (es) 2008-05-16
WO2002016421A8 (en) 2002-07-11

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