SK281928B6 - Taxoidy, spôsob ich prípravy a farmaceutické kompozície obsahujúce tieto taxoidy - Google Patents

Taxoidy, spôsob ich prípravy a farmaceutické kompozície obsahujúce tieto taxoidy Download PDF

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Publication number
SK281928B6
SK281928B6 SK1302-97A SK130297A SK281928B6 SK 281928 B6 SK281928 B6 SK 281928B6 SK 130297 A SK130297 A SK 130297A SK 281928 B6 SK281928 B6 SK 281928B6
Authority
SK
Slovakia
Prior art keywords
group
formula
carbon atoms
compound
alkyl
Prior art date
Application number
SK1302-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK130297A3 (en
Inventor
Herv Bouchard
Jean-Dominique Bourzat
Alain Commercon
Original Assignee
Rhone-Poulenc Rorer S. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9503545A external-priority patent/FR2732340B1/fr
Priority claimed from FR9515381A external-priority patent/FR2742754B1/fr
Application filed by Rhone-Poulenc Rorer S. A. filed Critical Rhone-Poulenc Rorer S. A.
Publication of SK130297A3 publication Critical patent/SK130297A3/sk
Publication of SK281928B6 publication Critical patent/SK281928B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK1302-97A 1995-03-27 1996-03-25 Taxoidy, spôsob ich prípravy a farmaceutické kompozície obsahujúce tieto taxoidy SK281928B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9503545A FR2732340B1 (fr) 1995-03-27 1995-03-27 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR9515381A FR2742754B1 (fr) 1995-12-22 1995-12-22 Procede de preparation de taxoides
PCT/FR1996/000441 WO1996030356A1 (fr) 1995-03-27 1996-03-25 Nouveaux taxoïdes, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
SK130297A3 SK130297A3 (en) 1998-03-04
SK281928B6 true SK281928B6 (sk) 2001-09-11

Family

ID=26231838

Family Applications (2)

Application Number Title Priority Date Filing Date
SK1301-97A SK281927B6 (sk) 1995-03-27 1996-03-25 Taxoidy, spôsob ich prípravy, farmaceutické kompozície s ich obsahom a medziprodukt na ich prípravu
SK1302-97A SK281928B6 (sk) 1995-03-27 1996-03-25 Taxoidy, spôsob ich prípravy a farmaceutické kompozície obsahujúce tieto taxoidy

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SK1301-97A SK281927B6 (sk) 1995-03-27 1996-03-25 Taxoidy, spôsob ich prípravy, farmaceutické kompozície s ich obsahom a medziprodukt na ich prípravu

Country Status (41)

Country Link
US (3) US5889043A (el)
EP (2) EP0817780B1 (el)
JP (2) JP2941951B2 (el)
KR (2) KR100485309B1 (el)
CN (2) CN1213042C (el)
AP (2) AP753A (el)
AR (1) AR001440A1 (el)
AT (2) ATE185562T1 (el)
AU (2) AU703278B2 (el)
BG (2) BG63009B1 (el)
BR (2) BR9607930A (el)
CA (2) CA2214321C (el)
CO (1) CO4700576A1 (el)
CZ (2) CZ287326B6 (el)
DE (2) DE69604653T2 (el)
DK (2) DK0817780T3 (el)
DZ (1) DZ2009A1 (el)
EA (2) EA000709B1 (el)
EE (2) EE03608B1 (el)
ES (2) ES2143187T3 (el)
GE (2) GEP20002211B (el)
GR (2) GR3031526T3 (el)
HU (2) HU223666B1 (el)
IL (1) IL117636A (el)
IS (2) IS2058B (el)
MA (1) MA23823A1 (el)
MY (1) MY121225A (el)
NO (2) NO316379B1 (el)
NZ (2) NZ304901A (el)
OA (2) OA10514A (el)
PE (1) PE51097A1 (el)
PL (2) PL188284B1 (el)
PT (1) PT817779E (el)
RO (2) RO115877B1 (el)
SK (2) SK281927B6 (el)
TN (1) TNSN96043A1 (el)
TR (2) TR199701040T1 (el)
TW (1) TW394765B (el)
UY (2) UY24192A1 (el)
WO (2) WO1996030355A1 (el)
ZA (1) ZA962399B (el)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
FR2771092B1 (fr) * 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides
EP0982027A1 (en) * 1998-08-17 2000-03-01 Aventis Pharma S.A. Taxoid derivatives for treating abnormal cell proliferation of the brain
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
EP0982028A1 (en) * 1998-08-20 2000-03-01 Aventis Pharma S.A. New use of taxoid derivatives
JP2002523364A (ja) * 1998-08-20 2002-07-30 アベンテイス・フアルマ・ソシエテ・アノニム タキソイド誘導体の新規な使用
EP1020188A1 (en) * 1999-01-13 2000-07-19 Aventis Pharma S.A. New use of taxoid derivatives
KR20020002488A (ko) * 2000-02-02 2002-01-09 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 항종양제로서 ｃ10 헤테로치환된 아세테이트 탁산
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
AU2001290636A1 (en) * 2000-09-22 2002-04-02 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
HUP0302599A3 (en) 2000-09-22 2005-05-30 Bristol Myers Squibb Co Method for reducing toxicity of combined chemotherapic compositions
US6593334B1 (en) 2002-05-02 2003-07-15 The University Of North Carolina At Chapel Hill Camptothecin-taxoid conjugates as antimitotic and antitumor agents
EP3332811A1 (en) 2002-09-06 2018-06-13 Cerulean Pharma Inc. Cyclodextrin-based polymers for delivering covalently attached camptothecin
EP1558241A2 (en) * 2002-11-08 2005-08-03 Bristol-Myers Squibb Company Pharmaceutical compositions and methods of using taxane derivatives
WO2004103344A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
GT200500025A (es) * 2004-02-13 2005-09-30 Taxanos sustituidos con esteres de ciclopentilo en c10
HN2005000054A (es) * 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
WO2006088767A2 (en) * 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. C10 cyclopropyl ester substituted taxane compositions
WO2006102758A1 (en) * 2005-03-31 2006-10-05 Bioxel Pharma Inc. Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii
EP2647641A1 (en) * 2005-11-04 2013-10-09 Accord Healthcare Inc. New methods for the preparation of taxanes using chiral auxiliaries
US7847111B2 (en) * 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
WO2008067403A2 (en) * 2006-11-28 2008-06-05 Encore Health Llc Presbyopia treatment by lens alteration
JP2010516625A (ja) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
US20100197944A1 (en) * 2007-07-04 2010-08-05 Dr. Reddy's Laboratories Limited Docetaxel process and polymorphs
FR2926551A1 (fr) * 2008-01-17 2009-07-24 Aventis Pharma Sa Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
JP2011517455A (ja) * 2008-03-31 2011-06-09 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン
EP2331140B1 (en) 2008-08-11 2018-07-04 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
FR2945211A1 (fr) 2009-05-06 2010-11-12 Sanofi Aventis Combinaison antitumorale comprenant la cabazitaxel et la capecitabine
WO2011051894A1 (en) 2009-10-29 2011-05-05 Aventis Pharma S.A. Novel antitumoral use of cabazitaxel
US20110237540A1 (en) * 2009-11-23 2011-09-29 Crawford Thomas C Cyclodextrin-based polymers for therapeutic delivery
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130338216A1 (en) 2010-12-22 2013-12-19 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
CN102060815B (zh) * 2010-12-24 2012-09-26 重庆泰濠制药有限公司 一种紫杉烷类化合物的制备方法
EP2620148A1 (en) 2012-01-27 2013-07-31 Aventis Pharma S.A. Antitumoral combination comprising cabazitaxel and cisplatin
ES2745506T3 (es) 2011-02-25 2020-03-02 Sanofi Mature Ip Combinación antitumoral que comprende cabazitaxel y cisplatino
EP2491925A1 (en) 2011-02-25 2012-08-29 Aventis Pharma S.A. Antitumoral combination comprising cabazitaxel and cisplatin
CN103764637A (zh) * 2011-04-12 2014-04-30 普拉斯化学品有限公司 卡巴他赛的固态形式及其制备方法
BR112014002361A2 (pt) 2011-08-02 2019-05-14 Astellas Pharma Inc. método para tratamento de câncer pelo uso combinado de fármacos
TWI526437B (zh) 2011-09-09 2016-03-21 台灣神隆股份有限公司 卡巴他賽之結晶型
PL2760848T3 (pl) * 2011-09-26 2019-07-31 Fresenius Kabi Oncology Limited Sposoby otrzymywania kabazytakselu powiązane z sililowaniem c(7)-oh i c(13)-oh lub z sililowaniem tylko c(7)-oh
CN102336726B (zh) * 2011-09-30 2014-11-26 重庆泰濠制药有限公司 一种卡巴他赛的制备方法
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
CN102408397B (zh) 2011-10-19 2014-08-20 上海贝美医药科技有限公司 紫杉烷类衍生物及其制备方法
CN102603724B (zh) * 2011-10-20 2014-02-26 江苏红豆杉生物科技股份有限公司 二甲氧基紫杉烷类化合物纯化精制的方法
CN102516281B (zh) * 2011-10-20 2015-02-04 江苏红豆杉生物科技股份有限公司 一种10-脱乙酰基巴卡丁iii及其衍生物甲氧基化的方法
CN102424672A (zh) * 2011-10-20 2012-04-25 江苏红豆杉生物科技有限公司 脱保护基制备二甲氧基紫杉烷类化合物的方法
CN102417491B (zh) * 2011-10-31 2013-11-06 江苏红豆杉生物科技有限公司 以10-去乙酰基-巴卡丁iii为原料制备卡巴他赛的方法
CN103906747A (zh) * 2011-10-31 2014-07-02 台湾神隆股份有限公司 卡巴他赛及其中间体的制备方法
EP2773629B1 (en) * 2011-11-01 2018-04-11 Fresenius Kabi Oncology Limited Process for the preparation of an amorphous form of cabazitaxel
CN103159705B (zh) * 2011-12-12 2015-05-27 福建南方制药股份有限公司 卡巴他赛中间体的制备方法
WO2013088335A1 (en) 2011-12-13 2013-06-20 Aventis Pharma S.A. Crystalline form of cabazitaxel and process for preparing the same
CN102532064B (zh) * 2011-12-13 2015-06-17 重庆泰濠制药有限公司 二甲氧基多西他赛的合成方法
EP2880021A4 (en) * 2012-07-31 2015-06-17 Yung Shin Pharm Ind Co Ltd AMORPHIC CABACITAXEL
CN102775434B (zh) * 2012-08-21 2015-04-08 江苏红豆杉生物科技股份有限公司 一种7,10-二甲氧基紫杉烷化合物中间体的合成方法
CN102775435B (zh) * 2012-08-21 2015-04-08 江苏红豆杉生物科技股份有限公司 一种用于制备7,10-甲氧基多西他赛的中间体的合成方法
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
CN103804323A (zh) * 2012-11-14 2014-05-21 上海希迈医药科技有限公司 一种卡巴他赛溶剂化物及其制备方法和应用
KR101407353B1 (ko) 2012-12-04 2014-06-17 주식회사 삼양바이오팜 10-디아세틸바카틴 iii으로부터 카바지탁셀을 고수율로 제조하는 새로운 방법 및 이를 위한 신규 중간체
EP2743264A1 (en) 2012-12-13 2014-06-18 INDENA S.p.A. New crystalline form of cabazitaxel, process for the preparation and pharmaceutical compositions thereof
EP2815749A1 (en) 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
EP2865675A1 (en) * 2013-10-23 2015-04-29 INDENA S.p.A. A crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof
EP2865674A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. Crystalline solvate forms of Cabazitaxel
CN104650012A (zh) * 2013-11-22 2015-05-27 天士力控股集团有限公司 一种紫杉烷类化合物
CN104086514A (zh) * 2014-06-19 2014-10-08 上海应用技术学院 紫杉醇衍生物及其制备方法
PL3258931T3 (pl) 2015-02-17 2020-12-28 Erasmus University Medical Center Rotterdam Zastosowanie kabazitakselu w leczeniu nowotworu złośliwego prostaty
EP3093014A1 (en) 2015-05-13 2016-11-16 Aventis Pharma S.A. Cabazitaxel and its use for treating cancer
WO2020249507A1 (en) 2019-06-11 2020-12-17 Indena S.P.A. Anhydrous crystalline form of cabazitaxel, a process for its preparation and pharmaceutical compositions containing it
US20210038578A1 (en) 2019-08-08 2021-02-11 Laekna Limited Method of treating cancer
EP3808345A1 (en) 2019-10-15 2021-04-21 Sanofi Mature IP Cabazitaxel in mcrpc patients previously treated with docetaxel and who failed a prior androgen signaling targeted inhibitor agent
EP3797834A1 (en) 2019-09-25 2021-03-31 Sanofi Mature IP Cabazitaxel in mcrpc patients previously treated with docetaxel and who failed a prior androgen signaling targeted inhibitor agent

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5739362A (en) 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5489601A (en) 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5229526A (en) 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5319112A (en) 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
FR2696459B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
MX9308012A (es) 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
ZA94128B (en) * 1993-02-01 1994-08-19 Univ New York State Res Found Process for the preparation of taxane derivatives and betalactam intermediates therefor
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
CA2179490A1 (en) 1993-12-21 1995-06-29 Trimurtulu Golakoti New cryptophycins
MX9700026A (es) 1994-06-28 1997-04-30 Upjohn Co Analogos de 7-eter-taxol, su uso antineoplastico y composiciones farmaceuticas que los contienen.
US6201140B1 (en) 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives
US5481018A (en) 1995-03-31 1996-01-02 The Dow Chemical Company Amino nitrile intermediate for the preparation of alanine diacetic acid
FR2745814B1 (fr) 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2771092B1 (fr) 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides

Also Published As

Publication number Publication date
SK281927B6 (sk) 2001-09-11
PE51097A1 (es) 1997-12-22
MY121225A (en) 2006-01-28
NO316607B1 (no) 2004-03-08
DK0817779T3 (da) 2000-06-19
TW394765B (en) 2000-06-21
KR100297196B1 (ko) 2001-11-22
CZ303097A3 (cs) 1998-01-14
PL322465A1 (en) 1998-02-02
AU703278B2 (en) 1999-03-25
HUP9801204A3 (en) 2000-12-28
NO973923L (no) 1997-08-26
DK0817780T3 (da) 2000-03-27
AP9701093A0 (en) 1997-10-31
IS4536A (is) 1997-07-31
AP785A (en) 1999-11-26
TR199701042T1 (xx) 1998-01-21
HU223666B1 (hu) 2004-11-29
ZA962399B (en) 1996-10-01
BR9607930A (pt) 1998-06-02
IS4567A (is) 1997-09-23
BG63009B1 (bg) 2001-01-31
ATE188471T1 (de) 2000-01-15
IS2058B (is) 2005-10-14
EA199700269A1 (ru) 1998-04-30
IL117636A (en) 2004-08-31
EP0817780A1 (fr) 1998-01-14
US6387946B1 (en) 2002-05-14
BG101917A (en) 1998-10-30
EE9700315A (et) 1998-06-15
CA2214319A1 (fr) 1996-10-03
OA10514A (fr) 2002-04-22
EA000709B1 (ru) 2000-02-28
HUP9801204A1 (hu) 2000-05-28
WO1996030356A1 (fr) 1996-10-03
EE9700323A (et) 1998-06-15
GEP20002188B (en) 2000-07-25
CO4700576A1 (es) 1998-12-29
AU5278096A (en) 1996-10-16
CN1179776A (zh) 1998-04-22
IL117636A0 (en) 1996-07-23
KR19980703287A (ko) 1998-10-15
SK130197A3 (en) 1998-04-08
US20020038038A1 (en) 2002-03-28
JPH11502531A (ja) 1999-03-02
AU5278196A (en) 1996-10-16
AU711227B2 (en) 1999-10-07
CN1152870C (zh) 2004-06-09
EP0817779B1 (fr) 2000-01-05
CA2214319C (fr) 2004-02-17
TR199701040T1 (xx) 1998-01-21
GEP20002211B (en) 2000-08-25
AP9701090A0 (en) 1997-10-31
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US6331635B1 (en) 2001-12-18
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CN1213042C (zh) 2005-08-03
KR100485309B1 (ko) 2005-10-12
UY24370A1 (es) 2001-10-25
CA2214321A1 (fr) 1996-10-03
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NZ304900A (en) 1998-09-24
MA23823A1 (fr) 1996-10-01
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US5889043A (en) 1999-03-30
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BR9607929A (pt) 1998-06-02
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ES2140075T3 (es) 2000-02-16
WO1996030355A1 (fr) 1996-10-03
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AP753A (en) 1999-07-21
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EE03608B1 (et) 2002-02-15
CA2214321C (fr) 2008-01-22
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JP2941951B2 (ja) 1999-08-30
NO316379B1 (no) 2004-01-19

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